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Dietary supplement

L-Tyrosine Ingredients & Drug Interactions

by Pure Encapsulations

L-Tyrosine label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Tyrosine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Tyrosine is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 21 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Tyrosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Tyrosine by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Tyrosine by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Tyrosine by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-tyrosine, an amino acid your body uses to make brain chemicals and thyroid hormones. Pure Encapsulations L-Tyrosine delivers 500 mg per capsule (based on the single-ingredient formula), along with two inactive ingredients—cellulose and water—that serve as a capsule filler and base.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports dopamine synthesis for emotional wellness and cognitive function.
  • We looked for evidence on: Cognitive function, Depression, Stress, Fatigue, Sleep deprivation, Athletic performance — and 4 related terms.
  • The strongest evidence on file: Tyrosine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Effective" for Memory.
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.

L-Tyrosine is effective for phenylketonuria (PKU), a genetic condition that prevents your body from processing it normally. It's possibly effective for supporting cognitive function and memory.

For athletic performance, the evidence suggests it's possibly ineffective. The data we hold is insufficient to rate its use for alcohol use disorder or dementia.

The evidence, ingredient by ingredient Tyrosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tyrosine is generally well tolerated in healthy adults, though you should talk with your healthcare provider before using it regularly. A thorough safety review hasn't been done, so avoid supplemental doses unless a doctor recommends it.

The most common side effects in studies were fatigue, headache, heartburn, and nausea. Higher doses can increase headache and fatigue, and these effects often improve with a lower dose.

Safety data during breastfeeding is limited, so talk with your doctor or pharmacist if you're nursing.

Side effects, ingredient by ingredient Tyrosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tyrosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 21 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take levodopa (for Parkinson's disease) or thyroid hormone medications—both have Moderate interactions with L-tyrosine and may need dosing adjustments or timing changes. Your doctor or pharmacist can help you use them safely together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-Tyrosine is worth considering if a doctor has recommended it for PKU, or if you're interested in cognitive or memory support with possibly-effective evidence. If you take levodopa or thyroid hormones, you'll need to check with your doctor or pharmacist first—the timing and dosing matter.

Talk it over with your own healthcare provider before starting, especially if you take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Tyrosine, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298016375
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299062
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Tyrosine by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
766298016375
IngredientAmount% DV
L-Tyrosine500 mg--

Other ingredients: Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 1-4 times daily, between meals.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

Seals/Symbols

GFCO.org (Gluten-Free Certification Organization) Certified Gluten-Free by the Gluten-Free Certified Organization www.gluten.org

Formulation

GFCO.org (Gluten-Free Certification Organization) Certified Gluten-Free by the Gluten-Free Certified Organization www.gluten.org

Supports dopamine synthesis for emotional wellness and cognitive function

Gluten-Free, Non-GMO & Hypoallergenic

Gluten-Free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Tyrosine by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Tyrosine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Tyrosine by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

L-Tyrosine

Interacts with
21 drugs
500 mg per serving

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...

L-Tyrosine monograph & interactions

Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Tyrosine by Pure Encapsulations Drug Interactions

Want to check YOUR meds against L-Tyrosine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
21Drugs
21 Moderate

Ingredients driving the most interactions

L-Tyrosine 21

Individual Drug Interactions

The ingredients in L-Tyrosine interact with 21 drugs. Click any drug to see the details.

1 of the 1 ingredient in L-Tyrosine interact with drugs. Each result below shows which ingredient is responsible. L-Tyrosine

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Tyrosine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Tyrosine, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

L-Tyrosine by Pure Encapsulations: Common Questions

Does L-Tyrosine by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, L-Tyrosine has a known interaction with 21 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Tyrosine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-tyrosine and what does it do in my body?
L-tyrosine is an amino acid—a building block your body uses to make important brain chemicals (neurotransmitters) and thyroid hormones. You eat it naturally in protein-rich foods, and supplements provide extra amounts.
Can L-tyrosine help with focus and memory?
Evidence suggests it's possibly effective for cognitive function and memory, though the research isn't definitive. If you're interested in trying it, talk with your doctor to see if it's right for you.
What are the most common side effects?
The most common ones reported are fatigue, headache, heartburn, and nausea. These are usually mild, and lowering your dose can often reduce them. If they persist, talk to your pharmacist or doctor.
Is it safe to take while pregnant or breastfeeding?
There isn't enough safety data to know either way. If you're pregnant or breastfeeding, talk with your doctor or pharmacist before taking this supplement to get personalized advice for your situation.
Why do I need to separate L-tyrosine from my levodopa dose?
Tyrosine and levodopa use the same pathway to get absorbed in your intestines, so they compete with each other. Spacing them 2 hours apart helps ensure each one gets absorbed properly and works as intended.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Tyrosine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Tyrosine label
Go deeper

The Full Monographs Behind L-Tyrosine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph →
Sources

Sources & How We Checked

L-Tyrosine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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