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Dietary supplement

Liquid Chlorophyll ES Ingredients & Drug Interactions

by Nature's Sunshine

Liquid Chlorophyll ES label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Liquid Chlorophyll ES against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Liquid Chlorophyll ES is a dietary supplement by Nature's Sunshine with 2 active ingredients. Its ingredients are commonly taken for body and breath odor control, wound and skin care, internal deodorant for ostomy or incontinence.Based on those ingredients, 796 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spearmint Oil, Sodium Copper Chlorophyllin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Liquid Chlorophyll ES by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Liquid Chlorophyll ES by Nature's Sunshine — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Liquid Chlorophyll ES by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Chlorophyll Complex” is a proprietary blend — the label gives one combined amount (40 mg) without saying how much of each component you get.

Liquid Chlorophyll ES has two active ingredients. The first is a proprietary chlorophyll complex — a blend of chlorophyll compounds — whose specific components aren't individually listed on the label.

The second is sodium copper chlorophyllin, a lab-made form of chlorophyll. The liquid base contains purified water and vegetable glycerin as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: intestinal and circulatory system support.
  • We looked for evidence on: Body odor, Fecal odor, Flatulence, Irritable bowel syndrome (IBS), Wound healing, blood cleansing — and 2 related terms.
  • The closest evidence on file: Chlorophyllin is rated "Insufficient Reliable Evidence To Rate" for Flatulence (Natural Medicines).
  • Also on file: Chlorophyllin is rated "Insufficient Reliable Evidence To Rate" for Wound healing, Body odor, Fecal odor.
  • Also on file: Spearmint is rated "Insufficient Reliable Evidence To Rate" for Flatulence, Irritable bowel syndrome (IBS).

The data we hold doesn't establish that chlorophyllin works for the conditions it's often marketed for. For urinary odor reduction, it's rated possibly ineffective.

For acne, cancer prevention, constipation, gas, and low white blood cell count, the evidence is insufficient to rate either way. Spearmint's ingredients similarly lack established evidence for cognitive decline, cognitive function, gas, IBS, nausea after surgery, or osteoarthritis.

The evidence, ingredient by ingredient Chlorophyllin Spearmint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium copper chlorophyllin is generally well tolerated short-term, but long-term safety data are limited. Oral chlorophyll has been reported to cause photosensitization (sun sensitivity) and in case reports, pseudoporphyria — blistering similar to a blood-disorder symptom — with a handful of people developing easily bruised, blistering hands after drinking chlorophyll supplements.

Spearmint is generally safe in food or tea amounts, but as a concentrated supplement or oil, more caution applies. Topically, spearmint oil has caused allergic dermatitis and allergic reactions of the lips in sensitive people.

One person in a trial reported anxiety after taking spearmint extract, though it's unclear whether spearmint caused it. For pregnancy, the safety data advise against chlorophyllin use — there isn't enough reliable information to know it's safe.

Spearmint carries mixed data: it's likely safe in pregnancy, but also rated possibly unsafe, so you and your doctor will need to weigh the evidence together. For breastfeeding, chlorophyllin's safety is unknown and avoidance is the safer choice; spearmint is likely safe via breast milk.

Side effects, ingredient by ingredient Chlorophyllin Spearmint

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Chlorophyllin, Spearmint.
  • The most serious interaction on file is rated Moderate.
  • For scale: 797 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on photosensitizing drugs (medications that make your skin more sensitive to sunlight), sedatives or other CNS depressants, or drugs that can damage the liver. No interactions are documented for the proprietary chlorophyll complex component, since its individual ingredients aren't specified.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Liquid Chlorophyll ES isn't proven to work for most of the uses people buy it for, and it interacts with hundreds of medications across several important drug categories. If you take any blood pressure medications, heart drugs, sedatives, or anything that affects your liver or skin's sun sensitivity, you need to check with your own doctor or pharmacist before adding this product.

The same goes for pregnancy or breastfeeding — talk it over with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liquid Chlorophyll ES, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904014855
Net contents 16 fl. Oz.; 460 mL
Market status On market
Date entered into DSLD Feb 26, 2014
DSLD ID 29373
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liquid Chlorophyll ES by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 tsp
Maximum serving Sizes:
1 tsp
Servings per container
92
UPC/BARCODE
099904014855
IngredientAmount% DV
Proprietary Chlorophyll Complex40 mg--
Sodium Copper Chlorophyllin0 NP--
Spearmint Oil0 NP--

Other ingredients: purified Water, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Intestinal and Circulatory System Support*

Go extra green with Liquid Chlorophyll ES. This Extra Strength paraben free formula features a more potent level of chlorophyll - the green pigment in plants responsible for harvesting the sun's energy in photosynthesis. Known to support your body on both a molecular and cellular level, chlorophyll promotes circulatory, intestinal, digestive and immune health. Featuring a proprietary chlorophyll complex, this minty fresh formula also helps neutralize body odors and acts as a natural, "internal" deodorant. Boost your energy and overall well being today with Liquid Chlorophyll ES.*

Nature's Sunshine uses natural source materials in its products that are subject to color variation. Product of U.S.A.

Herb Specialists Since 1972

~Helps promote the natural blood-cleansing functions of the body* ~Promotes circulatory, intestinal, digestive and immune health* ~Protects and strengthens healthy cells* ~Deodorizes the body, including the bowel*

pH Balancing QUALITY, SERVICE, INTEGRITY

This product is sold as a 2-pk item. NOT FOR INDIVIDUAL RESALE.

GUARANTEED PURE

LOT: Full Potency Through:

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

This Extra Strength paraben free formula features a more potent level of chlorophyll - the green pigment in plants responsible for harvesting the sun's energy in photosynthesis.

Precautions

This bottle was sealed for your protection. Do not use if inner seal is missing or damaged.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

RECOMMENDATION Take 1 tsp (5 mL) in a glass (8 ounces) of Nature's Spring water twice daily.

Storage

Refrigerate after opening.

Brand IP Statement(s)

(C)2013 Nature's Sunshine Products, Inc.

Seals/Symbols

Ko PAREVE

General

Stock No. 1485-7

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Liquid Chlorophyll ES by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Liquid Chlorophyll ES label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Liquid Chlorophyll ES by Nature's Sunshine

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 tsp Dosage formLiquid Servings per container92 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Chlorophyll Complex

40 mg per serving

Other (inactive) ingredients: Purified Water, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liquid Chlorophyll ES by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Liquid Chlorophyll ES?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
796Drugs
796 Moderate

Ingredients driving the most interactions

Spearmint Oil 579
Sodium Copper Chlorophyllin 335

Individual Drug Interactions

The ingredients in Liquid Chlorophyll ES interact with 796 drugs. Click any drug to see the details.

2 of the 2 ingredients in Liquid Chlorophyll ES interact with drugs. Each result below shows which ingredient is responsible. Spearmint Oil Sodium Copper Chlorophyllin

Each ingredient & the kinds of drugs it affects

For each ingredient in Liquid Chlorophyll ES with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Spearmint Oil2 drug types · 579 drugs

Cns Depressants

Theoretically, spearmint might alter the sedative effects of CNS depressants.
Animal research suggests that (-)-carvone, a major constituent of spearmint, has sedative effects. However, in humans, chewing spearmint-flavored gum induced arousal effects.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Animal research suggests that drinking spearmint tea for 30 days can increase markers of liver damage, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and cause liver degeneration and necrosis, in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Spearmint Oil full monograph & interactions

Sodium Copper Chlorophyllin1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Sodium Copper Chlorophyllin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Liquid Chlorophyll ES, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Liquid Chlorophyll ES by Nature's Sunshine: Common Questions

Does Liquid Chlorophyll ES by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Liquid Chlorophyll ES has a known interaction with 796 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liquid Chlorophyll ES contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with bad-smelling urine?
The data rates it possibly ineffective for that use. It's one of the reasons people buy chlorophyll supplements, but evidence doesn't support it working.
Is it safe during pregnancy?
The safety data advise against it — there isn't enough reliable information. Talk with your doctor or pharmacist about whether it's right for you.
What's the difference between the chlorophyll complex and sodium copper chlorophyllin?
The proprietary chlorophyll complex is a blend, but its exact makeup isn't listed on the label. Sodium copper chlorophyllin is a lab-made chlorophyll derivative — a single, identified ingredient.
Can it cause sun sensitivity?
Yes. Chlorophyll has been reported to cause photosensitization, and people taking it may have a higher risk of sun-related skin reactions, especially if they're also on medications that affect sun sensitivity.
What's pseudoporphyria, and should I worry about it?
It's a blistering condition that mimics a blood disorder. Case reports link oral chlorophyll to it, though it's rare — a couple of people developed easily bruised, blistering hands after chlorophyll drinks. Long-term safety data are limited, so quality evidence on risk is lacking.
Is it safe while breastfeeding?
Chlorophyllin's safety during breastfeeding is unknown, so avoidance is the safer choice. Spearmint in the product is likely safe. Talk with your doctor or pharmacist for personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Liquid Chlorophyll ES is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liquid Chlorophyll ES label
Go deeper

The Full Monographs Behind Liquid Chlorophyll ES’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph → Herb & supplement monograph

Spearmint

Interacts with 579 drugs

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facia...

Read the full Spearmint monograph →
Sources

Sources & How We Checked

Liquid Chlorophyll ES's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chlorophyllin 6 references
  1. Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. PubMed
  2. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  3. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
  6. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

See these in context on the Chlorophyllin monograph →

Spearmint 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Akdogan M, Ozguner M, Aydin G, Gokalp O. Investigation of biochemical and histopathological effects of Mentha piperita Labiatae and Mentha spicata Labiatae on liver tissue in rats. Hum Exp Toxicol 2004;23:21-8.
  3. Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
  4. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  5. de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268.
  6. Larsen, W., Nakayama, H., Fischer, T., Elsner, P., Frosch, P., Burrows, D., Jordan, W., Shaw, S., Wilkinson, J., Marks, J., Jr., Sugawara, M., Nethercott, M., and Nethercott, J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II PubMed
  7. Guney, M., Oral, B., Karahanli, N., Mungan, T., and Akdogan, M. The effect of Mentha spicata Labiatae on uterine tissue in rats. Toxicol.Ind.Health 2006;22(8):343-348.
  8. Masumoto, Y., Morinushi, T., Kawasaki, H., Ogura, T., and Takigawa, M. Effects of three principal constituents in chewing gum on electroencephalographic activity. Psychiatry Clin.Neurosci. 1999;53(1):17-23. PubMed
  9. Bulat, R., Fachnie, E., Chauhan, U., Chen, Y., and Tougas, G. Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers. Aliment.Pharmacol Ther. 1999;13(6):805-812. PubMed
  10. Francalanci, S., Sertoli, A., Giorgini, S., Pigatto, P., Santucci, B., and Valsecchi, R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis 2000;43(4):216-222. PubMed
  11. Bonamonte, D., Mundo, L., Daddabbo, M., and Foti, C. Allergic contact dermatitis from Mentha spicata (spearmint). Contact Dermatitis 2001;45(5):298.
  12. Tomson, N., Murdoch, S., and Finch, T. M. The dangers of making mint sauce. Contact Dermatitis 2004;51(2):92-93. PubMed
  13. Clayton, R. and Orton, D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis 2004;51(5-6):314-315. PubMed
  14. Dal Sacco, D., Gibelli, D., and Gallo, R. Contact allergy in the burning mouth syndrome: a retrospective study on 38 patients. Acta Derm.Venereol. 2005;85(1):63-64. PubMed
  15. Goncalves, J. C., Oliveira, Fde S., Benedito, R. B., de Sousa, D. P., de Almeida, R. N., and de Araujo, D. A. Antinociceptive activity of (-)-carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull. 2008;31(5):1017- PubMed
  16. Ormerod, A. D. and Main, R. A. Sensitisation to "sensitive teeth" toothpaste. Contact Dermatitis 1985;13(3):192-193. PubMed
  17. Skrebova, N., Brocks, K., and Karlsmark, T. Allergic contact cheilitis from spearmint oil. Contact Dermatitis 1998;39(1):35. PubMed
  18. Damiani E, Aloia AM, Priore MG, et al. Allergy to mint (Mentha spicata). J Investig Allergol Clin Immunol 2012;22:309-10.
  19. Connelly AE, Tucker AJ, Tulk H, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 2014;17:1361-7. PubMed
  20. Lasrado JA, Nieman KM, Fonseca BA, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol 2017;86:167-176. PubMed

See these in context on the Spearmint monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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