Lithium Orotate 5 mg Ingredients & Drug Interactions
by Swanson
What is this page for?
First and foremost: checking Lithium Orotate 5 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lithium Orotate 5 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for mood support, bipolar disorder (prescription), healthy mental function.Based on those ingredients, 515 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lithium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lithium Orotate 5 mg by Swanson
Ask about any prescription or over-the-counter medication and we check it for interactions with Lithium Orotate 5 mg by Swanson — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lithium Orotate 5 mg by Swanson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: lithium, a mineral that's been studied for mood and neurological conditions. Lithium Orotate supplies 5 mg of lithium per capsule in a chelated form (bound to orotic acid for absorption).
The capsule also contains inactive ingredients — microcrystalline cellulose, hypromellose, magnesium stearate, and silica — which are standard binders and flow agents used to hold and fill the capsule.
Does it work?
Not established
The evidence for lithium orotate at this dose isn't established in the data we hold. The product has been studied for conditions including alcohol use disorder, Alzheimer disease, ALS, and anorexia nervosa, but the findings show insufficient reliable evidence to rate it as effective for any of these.
If you're considering this for a specific health concern, talk with your doctor about whether the evidence supports it and whether prescription lithium might be a better-studied option.
How safe is it?
Well-documented data
Prescription lithium is generally well tolerated when monitored, but it has a narrow safety margin and requires regular blood tests to prevent toxicity. Supplement-form lithium hasn't been studied as thoroughly, so how the lower doses affect side effects isn't clear.
Common side effects of lithium include tremor, fatigue, muscle weakness, increased thirst and urination, weight gain, and digestive symptoms. Lithium can also cause or worsen skin conditions like acne and psoriasis.
Pregnancy and breastfeeding are concerns: lithium crosses the placenta and has been linked to birth defects, so the safety data advises against use in pregnancy unless a doctor directs and monitors it closely. Lithium passes into breast milk and may affect an infant, so it's not recommended while breastfeeding unless supervised by a doctor.
If you stop taking lithium suddenly, bipolar symptoms can return quickly — it should be tapered over at least 14 days under medical guidance.
Meds to double-check
Major interaction found
Before taking this product, double-check with your doctor or pharmacist if you take serotonergic drugs like SSRIs (antidepressants), diuretics (water pills), NSAIDs (ibuprofen, naproxen), antipsychotics, ACE inhibitors or other blood pressure medications, calcium channel blockers, anticonvulsants (seizure medications), or skeletal muscle relaxants. Lithium has a narrow safety margin and can interact dangerously with these drug types.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
Lithium orotate carries serious interaction risks, especially with blood pressure medications, diuretics, antidepressants, and antipsychotics — and its effectiveness at supplement doses isn't established. Because lithium has such a narrow safety window, this isn't a product to take casually or without close medical oversight.
If you're interested in lithium for a health condition, talk with your doctor about whether prescription lithium with blood monitoring might be more appropriate, and always check your medications before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lithium Orotate 5 mg, straight from the product label.
| Brand | Swanson |
|---|---|
| Barcode (UPC) | 087614029139 |
| Net contents | 60 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 266893 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lithium Orotate 5 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lithium | 5 mg | -- |
Other ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
swanson.com or call 1-800-437-4148
Science-Backed Quality Since 1969
Formulation
Supports healthy mood, emotional wellness, behavior and memory Provides antioxidant protection Supports neurotransmitter activity
Brain and Nervous System Health
5 mg per capsule
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take one veggie capsule per day with food and water.
Precautions
Warning: For adults only. This product should only be used under the supervision of a healthcare professional.
Do not take this product if you are pregnant, nursing or taking any prescription medications, especially antidepressants or MAOIs.
Keep out of reach of children.
Do not use if seal is broken.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Mineral Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lithium Orotate 5 mg by Swanson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lithium Orotate 5 mg by Swanson
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Lithium
Interacts with515 drugs
Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipola...
Lithium monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Lithium Orotate 5 mg by Swanson Drug Interactions
HelloPharmacist Interaction Report
Swanson Lithium Orotate 5 mg interacts with several major medication types through its lithium content.
The most serious concern is with serotonergic drugs (antidepressants like SSRIs) — lithium may both mask and increase the risk of serotonin syndrome, a potentially dangerous condition involving confusion, agitation, and rapid heartbeat. There's also a Major-level interaction with diuretics (water pills), which can trap lithium in your body and raise it to toxic levels.
Read the full breakdown — every affected drug type, severity by severity
Several Moderate-severity interactions exist as well. NSAIDs (ibuprofen, naproxen) can reduce how your kidneys clear lithium.
Antipsychotics used with lithium carry a risk of encephalopathic syndrome — a serious neurological condition with confusion and weakness. ACE inhibitors (blood pressure and heart medications) and calcium channel blockers can alter lithium levels.
Anticonvulsants (seizure medications) may raise the risk of neurotoxicity. Skeletal muscle relaxants might prolong their effects unpredictably.
Lithium has a very narrow safety window, meaning the difference between an effective dose and a toxic one is small. Prescription lithium requires regular blood tests to stay safe; supplement doses aren't well studied in this regard.
Altogether, these interactions span 515 individual medications.
Before you start this product, check your exact medications with the search tool on this page, and talk with your doctor or pharmacist — especially if you take any blood pressure, heart, diuretic, pain, antidepressant, antipsychotic, or seizure medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lithium Orotate 5 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lithium Orotate 5 mg interact with 515 drugs. Click any drug to see the details.
1 of the 1 ingredient in Lithium Orotate 5 mg interact with drugs. Each result below shows which ingredient is responsible. Lithium
Amitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs, Phenothiazines +1 Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amitriptyline, Perphenazine interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Ammonium Chloride interactionAmoxapineAsendin
How Amoxapine interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs, Antipsychotic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumAntipsychotic Drugs, Serotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Read the full Lithium + Aripiprazole Lauroxil interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumNonsteroidal Anti-inflammatory Drugs (nsaids), Serotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
Read the full Lithium + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Atenolol, Chlorthalidone interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, PhenylAtrosept
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl SalicylateUrinary Antiseptic 2, Urised
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Atropine, Meperidine interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Azilsartan, Chlorthalidone interactionBelladonna Alkaloids, Chlorpheniramine, Phenylephrine, PhenylpropanolamineRespa ARM
How Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumAce Inhibitors (aceis), Diuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Read the full Lithium + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Benzhydrocodone, Acetaminophen interactionBenzocaine, DextromethorphanTetra-Formula
How Benzocaine, Dextromethorphan interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Benzocaine, Dextromethorphan interactionBenzthiazideExna
How Benzthiazide interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Benzthiazide interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bisoprolol, Hydrochlorothiazide interactionBrexpiprazoleRexulti
How Brexpiprazole interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumAntipsychotic Drugs, Serotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Read the full Lithium + Brexpiprazole interactionBrompheniramine, Dextromethorphan, PhenylephrineDimetapp DM
How Brompheniramine, Dextromethorphan, Phenylephrine interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Brompheniramine, Dextromethorphan, Phenylephrine interactionBumetanideBurinex
How Bumetanide interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bumetanide interactionBumetanide, PotassiumBurinex K
How Bumetanide, Potassium interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Bumetanide, Potassium interactionBuprenorphineBrixadi, Butrans, Sublocade, Subutex
How Buprenorphine interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Buprenorphine interactionBuproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Lithium Orotate 5 mg — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Buproprion, Dextromethorphan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lithium Orotate 5 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Lithium
Diuretic Drugs
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Thiazide diuretics and loop diuretics might reduce lithium excretion, particularly in sodium-restricted patients. If lithium is clinically indicated and other treatment options are unavailable or inadequate in patients using diuretics, lithium treatment can be initiated with extreme caution. Serum lithium should be measured frequently and the doses used should be the lowest dose ordinarily tolerated. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Serotonergic Drugs
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
In a case report, a 67-year-old female with depression and bipolar disorder using lithium in combination with selective serotonin reuptake inhibitors (SSRIs) and other medications developed serotonin syndrome with symptoms of deep tendon hyperreflexia, muscle rigidity, tremor, and hyperthermia. However, agitation, one classical symptom of serotonin syndrome, was lacking. This was thought to be due to masking by lithium toxicity. Lithium can increase serotonin levels, thus, combining serotonergic drugs with lithium might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Ace Inhibitors (Aceis)
Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Concomitant administration of ACEIs with lithium may increase lithium concentrations. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Anticonvulsants
Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.
Drugs such as carbamazepine and phenytoin seem to increase the risk of neurotoxicity. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Antipsychotic Drugs
Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Encephalopathic syndrome has been reported in multiple patients taking prescription lithium and antipsychotics concomitantly. Symptoms have included weakness and lethargy, fever, confusion, and extrapyramidal symptoms. In some patients, resulting brain damage was irreversible. Although there is no established causal relationship between these symptoms and the combination of lithium and antipsychotic medications, there is a theoretical relationship. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Calcium Channel Blockers
Theoretically, taking lithium supplements with calcium channel blockers might reduce lithium levels and might also increase the risk of certain adverse effects.
Calcium channel blockers might reduce lithium concentrations. Monitor lithium levels with concurrent use. Calcium channel blockers might also increase the adverse neurological and gastrointestinal adverse effects of lithium. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.
Methyldopa (Aldomet)
Theoretically, taking lithium supplements with methyldopa might increase the risk of lithium toxicity.
Concurrent use of methyldopa with lithium increases the risk of lithium toxicity. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Methylxanthines
Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Xanthines such as aminophylline, caffeine, and theophylline (Theo-Dur, Theo-24, others) might increase the clearance of lithium. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
NSAIDs can decrease the renal clearance of lithium and increase lithium levels. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Phenothiazines
Theoretically, taking lithium supplements with phenothiazines might decrease the levels and clinical effects of phenothiazines.
Concomitant use of lithium with phenothiazines might reduce lithium concentrations. Lithium might also reduce phenothiazine concentrations, making the pharmacokinetic effect unpredictable. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.
Skeletal Muscle Relaxants
Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Lithium might prolong neuromuscular blockade. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Brand information
Manufacturer and brand details for Lithium Orotate 5 mg, from the product label.
Swanson
See all Swanson products- Name
- Swanson Health Products
- City
- Fargo
- State
- ND
- ZipCode
- 58104
- Phone Number
- 1-800-437-4148
- Web Address
- swanson.com
Lithium Orotate 5 mg by Swanson: Common Questions
Does Lithium Orotate 5 mg by Swanson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is lithium orotate, and how is it different from prescription lithium?
Can I take this if I'm on an antidepressant?
Does this product work for depression or bipolar disorder?
Is it safe to take while pregnant or breastfeeding?
What are the common side effects?
Can I just stop taking this if I decide it's not working?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Lithium Orotate 5 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lithium Orotate 5 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Lithium Orotate 5 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lithium 26 references
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Perlis RH, Sachs GS, Lafer B, et al. Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry 2002;159:1155-9.. PubMed
- Pinelli JM, Symington AJ, Cunningham KA, Paes BA. Case report and review of the perinatal implications of maternal lithium use. Am J Obstet Gynecol 2002;187:245-9.. PubMed
- Sawagashira R, Sasagawa Y, Matsukura M, Takamaru Y. Case of myxedema coma induced by lithium carbonate in a patient with schizophrenia. Psychiatry Clin Neurosci. 2018;72(2):131. PubMed
- Foulser P, Abbasi Y, Mathilakath A, Nilforooshan R. Do not treat the numbers: lithium toxicity. BMJ Case Rep. 2017;2017. pii: bcr-2017-220079. PubMed
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017812s028,018421s027lbl.pdf. Accessed Nov. 21, 2018
- Fornaro M, Maritan E, Ferranti R, et al. Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes. Am J Psychiatry. 2020;177(1):76-92. DOI
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