Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Longjack Ingredients & Drug Interactions

by VH Nutrition

Longjack label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Longjack against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Longjack is a dietary supplement by VH Nutrition with 1 active ingredient. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Longjack extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Longjack by VH Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Longjack by VH Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Longjack by VH Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

VH Nutrition's Longjack contains one active ingredient: Eurycoma longifolia extract, a plant root used traditionally to support sexual function and athletic performance. The capsule itself is made of gelatin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: boost libido and promote hormone balance in men.
  • We looked for evidence on: Age-related testosterone deficiency, Erectile dysfunction (ED), Male Infertility, Sexual desire, Muscle strength, Athletic performance — and 2 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence suggests Longjack may help with sexual desire, though the data are limited enough that we call it possibly effective. For athletic performance, the research points toward it being possibly ineffective.

The evidence for back pain, osteoporosis, and diabetes is too thin to rate—we simply don't have enough reliable studies to know either way.

The evidence, ingredient by ingredient Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Longjack is generally well tolerated in short-term research, but long-term safety is uncertain and product quality can vary. Because it may raise testosterone levels, the supplement carries a risk of testosterone-related side effects—acne, insulin resistance, and liver stress among them—particularly if your levels climb above normal.

Avoid it during pregnancy and breastfeeding; there isn't enough safety data to know it's okay.

Side effects, ingredient by ingredient Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Longjack, double-check with your doctor or pharmacist if you take propranolol (Inderal) or any other beta-blocker — it can weaken propranolol's effect. Also confirm any medications processed by the liver (CYP1A2, CYP2C19, or CYP2A6 substrates), and mention it if you're on testosterone replacement or any hormone therapy.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Longjack may be worth considering if you're interested in sexual desire support, but it's not a strong evidence case. The main caution is its interaction with propranolol and its potential to shift hormone levels.

If you take any heart, blood-pressure, psychiatric, or hormone medications, check with your doctor or pharmacist before starting. Long-term safety isn't well established, so this isn't a take-it-forever supplement without conversation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Longjack, straight from the product label.

Brand VH Nutrition
Barcode (UPC) X001MIJP1Z
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247610
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Longjack by VH Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
X001MIJP1Z
IngredientAmount% DV
Longjack extract1200 mg--

Other ingredients: Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Taken as a dietary supplement Longjack works with your body to help promote hormone balance and improve a variety of performance factors in adult men Boost libido Promote vitality Boost fertility Combat fatigue Improve sexual function Promote hormone balance

All natural

Boost libido Promote hormone balance Improve sexual health

Longjack is not a drug - results of supplementation may vary. 100% Satisfaction guaranteed 100% Natural product GRAS Generally Recognized as Safe

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration

Longjack is a natural dietary supplement and is not intended to diagnose, prevent, treat, or cure any disease.

General Statements

30 Day supply

Formula

Eurycoma longifolia extract 1200 mg per serving

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for Use: For best results take one serving of Longjack with 8 oz. of fluid once daily.

Precautions

Always consult a physician before beginning any new dietary program.

Read the entire label before use.

Do not use if you are pregnant or nursing.

Seals/Symbols

Made in USA

Brand IP Statement(s)

All rights reserved

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Longjack by VH Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Longjack label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Longjack by VH Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Longjack extract

Interacts with
248 drugs
1200 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Longjack extract monograph & interactions

Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Longjack by VH Nutrition Drug Interactions

Want to check YOUR meds against Longjack?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Longjack extract 248

Individual Drug Interactions

The ingredients in Longjack interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Longjack interact with drugs. Each result below shows which ingredient is responsible. Longjack extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Longjack with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Longjack extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Longjack extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Longjack, from the product label.

VH Nutrition

See all VH Nutrition products
Name
VHNutrition in the USA
Pharmacist Counseling Corner

Longjack by VH Nutrition: Common Questions

Does Longjack by VH Nutrition interact with any medications?
Yes. Based on its ingredients, Longjack has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Longjack contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Longjack do?
Longjack extract may support sexual desire; the evidence suggests it's possibly effective for that. The evidence for athletic performance leans toward it not working well. For back pain, osteoporosis, and diabetes, we don't yet have enough reliable research to say how well it works.
Can I take Longjack if I'm pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, and the supplement's possible effects on hormones are a concern. While breastfeeding, there's also no reliable safety information, so it's best to avoid it. Talk with your doctor or midwife if you have questions about what's okay for you.
Does Longjack have side effects?
In short-term studies it's been generally well tolerated. The main concern is that it can raise testosterone levels, which—if they climb too high—may cause acne, insulin resistance, liver stress, and other hormone-related effects. Long-term safety isn't well studied.
Will Longjack interfere with my heart medication?
If you take propranolol (Inderal), yes—Longjack can reduce how much propranolol your body absorbs and weaken its effect on your heart rate and blood pressure. Check with your doctor or pharmacist before starting Longjack if you take this or any heart medication.
Is Longjack natural and safe because it's from a plant?
Being plant-based doesn't automatically make it safe or effective. Longjack is generally well tolerated short-term, but long-term safety is unclear, and products can vary in quality. It also interacts with certain medications and can affect hormone levels, so it's not risk-free for everyone.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Longjack is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Longjack label
Go deeper

The Full Monographs Behind Longjack’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Longjack's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team