Major interaction on record — check this product against your medications before combining. Based on 8 of 10 ingredients. Check your meds →
Dietary supplement

Amino D Tox Ingredients & Drug Interactions

by Designs for Health

Amino D Tox label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amino D Tox against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amino D Tox is a dietary supplement by Designs for Health with 10 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 460 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are N-Acetyl-Cysteine, Taurine, Calcium-D-Glucarate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amino D Tox by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Amino D Tox by Designs for Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Amino D Tox by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Amino D Tox contains 10 active ingredients: glycine, taurine, N-acetyl cysteine, methionine, glutamine, glutathione, ornithine, methylsulfonylmethane, calcium D-glucarate, and alpha-ketoglutarate. These are amino acids and amino acid–related compounds designed to support liver detoxification pathways.

The product also contains two inactive ingredients—microcrystalline cellulose and vegetable stearate—which are a filler and flow agent.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Detoxification and liver support.
  • We looked for evidence on: Acetaminophen poisoning, Alcohol-related liver disease, Chemotherapy-induced hepatotoxicity, Cirrhosis, Critical illness (trauma), Hepatic function — and 2 related terms.
  • The strongest evidence on file: N-acetyl Cysteine (nac) is rated "Effective" for Acetaminophen poisoning (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma).
  • Also on file: Methionine is rated "Insufficient Reliable Evidence To Rate" for Acetaminophen poisoning.

The evidence for these ingredients varies widely. N-acetyl cysteine is effective for acetaminophen poisoning and a few other specialized uses.

Glutamine is effective for sickle cell disease. Glycine is possibly effective for schizophrenia.

Taurine and methionine show possible effectiveness for congestive heart failure and hepatitis (taurine) and neural tube birth defects (methionine), respectively. Glutathione is possibly effective for cisplatin-related nerve damage.

Ornithine and calcium D-glucarate have insufficient or no established evidence for their proposed uses in this product. The data does not establish that this combination works for general "detoxification"—that's not a condition with a standard medical definition, and no effectiveness rating exists for it.

The evidence, ingredient by ingredient Glycine Taurine N-acetyl Cysteine (nac) Methionine Glutamine Glutathione Ornithine Calcium D-glucarate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses, but long-term safety data are limited for the group. Glycine, taurine, N-acetyl cysteine, methionine, and glutamine have been associated with gastrointestinal side effects (nausea, vomiting, diarrhea, or upset stomach) in some users.

N-acetyl cysteine at high doses (above 30 grams daily) may cause additional side effects and can increase bleeding risk. Glutathione, when inhaled, can narrow airways and cause shortness of breath in people with asthma.

A few rare cases of hypersensitivity or allergic reaction have been reported with taurine in people with a history of sulfur-related allergies. Regarding pregnancy and breastfeeding: Taurine, methionine, and glutamine are rated likely safe during pregnancy and lactation based on food sources, but supplement doses have not been well studied for pregnancy.

N-acetyl cysteine, glutathione, calcium D-glucarate, and ornithine lack sufficient safety data and should be avoided during pregnancy unless your doctor directs otherwise. Glutathione should also be avoided during breastfeeding.

Safety data on supplement doses of the remaining ingredients during pregnancy and lactation are not on file.

Side effects, ingredient by ingredient Glycine Taurine N-acetyl Cysteine (nac) Methionine Glutamine Glutathione Ornithine Calcium D-glucarate

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 8 matched ingredients can interact with medications — Calcium D-glucarate, Glutamine, N-acetyl Cysteine (nac), Taurine, Glycine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; lithium.
  • For scale: 460 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before using this product, worst severity first: nitroglycerin (especially intravenous or patch forms), blood pressure–lowering drugs (antihypertensives), blood thinners or antiplatelet drugs such as warfarin or aspirin, anticonvulsants (seizure medications), lithium, chloroquine, and drugs broken down by glucuronidation in the liver. No interactions are documented for methylsulfonylmethane or alpha-ketoglutarate, as we hold no data for them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient amino acid blend meant to support liver detoxification. If you take nitroglycerin, blood pressure medicine, blood thinners, seizure medication, lithium, or chloroquine, check your medications with the tool before starting.

If you're pregnant, breastfeeding, or have kidney or liver disease, talk to your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amino D Tox, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452001718
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 22317
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amino D Tox by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
879452001718
IngredientAmount% DV
Glycine250 mg--
Taurine125 mg--
N-Acetyl-Cysteine125 mg--
Methionine100 mg--
Glutamine250 mg--
Glutathione100 mg--
Ornithine100 mg--
Methylsulfonylmethane200 mg--
Calcium-D-Glucarate100 mg--
Alpha-Ketoglutarate100 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

General Statements

For Professional Use Only

Manufactured in an NSF GMP Registered Facility

Notice: Color, size or shape may appear different between lots.

General

DETSUP

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one packet per day, or as directed by your health care practitioner.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Storage

STORE IN A COOL, DRY PLACE.

Seals/Symbols

Guaranteed GMP COMPLIANT Products

Formulation

Does not contain gluten.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Amino-D-Tox(TM) This product supports detoxification by supplying sulfur containing amino acids needed for phase II liver detox. Used along with PaleoCleanse or prior to PaleoCleanse, Amino-D-Tox will help minimize uncomfortable detox symptoms.*

Amino-D-Tox(TM)

Each packet contains: 1- Detox Antiox(TM) capsule 1- LV-GB Complex(TM) capsule 3- Amino-D-Tox(TM) capsules

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amino D Tox by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amino D Tox label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amino D Tox by Designs for Health

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycine

Interacts with
1 drug
250 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

Glycine monograph & interactions

Taurine

Interacts with
173 drugs
125 mg per serving

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...

Taurine monograph & interactions

N-Acetyl-Cysteine

Interacts with
294 drugs
125 mg per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl-Cysteine monograph & interactions

Methionine

No known
interactions
100 mg per serving

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...

Methionine monograph & interactions

Glutamine

Interacts with
50 drugs
250 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

Glutamine monograph & interactions

Glutathione

No known
interactions
100 mg per serving

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...

Glutathione monograph & interactions

Ornithine

No known
interactions
100 mg per serving

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...

Ornithine monograph & interactions

Methylsulfonylmethane

200 mg per serving

Calcium-D-Glucarate

Interacts with
126 drugs
100 mg per serving

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...

Calcium-D-Glucarate monograph & interactions

Alpha-Ketoglutarate

100 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amino D Tox by Designs for Health Drug Interactions

Want to check YOUR meds against Amino D Tox?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
460Drugs
1 Major 458 Moderate 1 Minor

Ingredients driving the most interactions

N-Acetyl-Cysteine 294
Taurine 173
Calcium-D-Glucarate 126
Glutamine 50
Glycine 1

Individual Drug Interactions

The ingredients in Amino D Tox interact with 460 drugs. Click any drug to see the details.

5 of the 10 ingredients in Amino D Tox interact with drugs. Each result below shows which ingredient is responsible. N-Acetyl-Cysteine Taurine Calcium-D-Glucarate Glutamine Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in Amino D Tox with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

N-Acetyl-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl-Cysteine full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
Taurine full monograph & interactions

Calcium-D-Glucarate3 drug types · 126 drugs

Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Calcium-D-Glucarate full monograph & interactions

Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amino D Tox, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

Amino D Tox by Designs for Health: Common Questions

Does Amino D Tox by Designs for Health interact with any medications?
Yes. Based on its ingredients, Amino D Tox has a known interaction with 460 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amino D Tox contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are these amino acids supposed to do?
They support liver detoxification pathways. N-acetyl cysteine and methionine are particularly involved in how your liver processes and clears waste and certain drugs. Glutamine and glutathione are antioxidants that protect cells.
Can I take this if I'm pregnant?
Taurine, methionine, and glutamine are likely safe at normal food levels during pregnancy, but supplement doses haven't been well studied. N-acetyl cysteine, glutathione, calcium D-glucarate, and ornithine lack enough safety data and should be avoided unless your doctor approves. Talk to your doctor or pharmacist before starting.
What side effects might I notice?
Most common are gastrointestinal: nausea, vomiting, diarrhea, upset stomach, or loss of appetite. These are usually mild and dose-related. In people with asthma, inhaled glutathione can trigger shortness of breath; however, this product is oral. Stop and call your pharmacist if you experience any unexpected reactions.
Is this safe to take long-term?
Long-term safety data are limited for most of these ingredients. They're generally well tolerated short-term, but there isn't robust evidence on safety beyond several months. If you plan to use this regularly, discuss it with your doctor.
Why does it say 'tox' — does this detoxify toxins?
The name refers to liver detoxification support, which is a normal liver function. The product is not a poison remedy or a replacement for emergency care if you've been exposed to something harmful.
What if I'm allergic to sulfonamides or sulfites?
Taurine contains sulfur, and a case of allergic reaction has been reported in someone with a history of sulfur-related allergies. If you have a known allergy to sulfonamides or sulfites, check with your pharmacist before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Amino D Tox is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amino D Tox label
Go deeper

The Full Monographs Behind Amino D Tox’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Glutathione

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefits. However, strong human evidence is lim...

Read the full Glutathione monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

Calcium D-glucarate

Interacts with 126 drugs

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence...

Read the full Calcium D-glucarate monograph →
Sources

Sources & How We Checked

Amino D Tox's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 142 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
  4. Bichler, A., Swenson, A., and Harris, M. A. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 2006;31(4):471-476. PubMed
  5. Iyadurai, S. J. and Chung, S. S. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav 2007;10(3):504-508. PubMed
  6. Berger, A. J. and Alford, K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks". Med J Aust. 1-5-2009;190(1):41-43. PubMed
  7. Worthley, M. I., Prabhu, A., De, Sciscio P., Schultz, C., Sanders, P., and Willoughby, S. R. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 2010;123(2):184-187. PubMed
  8. Morchon, Simon D. and Perez Castrillon, J. L. [Hypoglycemia by intake of taurine]. Rev.Clin Esp. 2010;210(1):49.
  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
  10. Schoffl, I., Kothmann, J. F., Schoffl, V., Rupprecht, H. D., and Rupprecht, T. "Vodka energy": too much for the adolescent nephron? Pediatrics 2011;128(1):e227-e231. PubMed
  11. Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
  12. Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
  13. Darling, P. B., Lepage, G., Leroy, C., Masson, P., and Roy, C. C. Effect of taurine supplements on fat absorption in cystic fibrosis. Pediatr Res 1985;19(6):578-582. PubMed
  14. Fukuyama, Y. and Ochiai, Y. Therapeutic trial by taurine for intractable childhood epilepsies. Brain Dev. 1982;4(1):63-69. PubMed
  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
  16. Stohs SJ, Miller M. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. Food Chem Toxicol. 2014 Jan;63:240-3. PubMed
  17. Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
  18. Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
  19. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol 2020;885:173533. PubMed
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N-acetyl Cysteine (nac) 86 references
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Methionine 12 references
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Glutamine 11 references
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Glutathione 1 reference
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Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

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Calcium D-glucarate 5 references
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