Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Lycopene Ingredients & Drug Interactions

by GNC Natural Brand

Lycopene label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lycopene against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lycopene is a dietary supplement by GNC Natural Brand with 1 active ingredient. Its ingredients are commonly taken for heart health, prostate health, antioxidant support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lycopene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lycopene by GNC Natural Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Lycopene by GNC Natural Brand — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Lycopene by GNC Natural Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

GNC Natural Brand Lycopene is a single-ingredient supplement containing lycopene, a red pigment found naturally in tomatoes and other fruits. The softgel also contains inactive ingredients (soybean oil, corn oil, gelatin, glycerin, and beta-carotene) that help deliver the lycopene and keep the capsule intact.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lycopene's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Antioxidant support for cardiovascular health.
  • We looked for evidence on: Cardiovascular disease (CVD), Atherosclerosis, Hyperlipidemia, Hypertension, Heart disease, Coronary artery disease — and 1 related terms.
  • The closest evidence on file: Lycopene is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Lycopene is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia, Hypertension.

The evidence on lycopene is mixed. It's possibly effective for prostate cancer risk — the strongest data point — but possibly ineffective for bladder cancer and diabetes.

For high cholesterol (hyperlipidemia), exercise-induced asthma, and ALS (Lou Gehrig's disease), we don't have enough reliable evidence yet to say whether it works.

The evidence, ingredient by ingredient Lycopene

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lycopene from food is considered safe, and supplement doses are generally well tolerated. The most common side effects reported are gastrointestinal — diarrhea, gas, bloating, nausea, vomiting, indigestion, and loss of appetite.

One case of chest pain was reported in a pregnant woman taking a lycopene product, but it's unclear whether lycopene caused it. Although lycopene from food amounts in pregnancy and breastfeeding appears safe, supplement doses in pregnancy and lactation haven't been well studied; talk with your doctor or pharmacist before taking supplements while pregnant or breastfeeding.

Side effects, ingredient by ingredient Lycopene

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lycopene.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs (anticoagulants or antiplatelets) — including warfarin, aspirin, clopidogrel, or similar medications — check each one with the search tool before taking this lycopene product. The Moderate-severity interaction could increase your bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

GNC Natural Brand Lycopene may be worth considering if you're interested in prostate health and don't take blood thinners or antiplatelet drugs. If you do take those medications, check with your doctor or pharmacist first — the interaction risk is real.

Gastrointestinal side effects are possible, so start low if you're new to it. Run your exact medications through the checker on this page, then confirm with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lycopene, straight from the product label.

Brand GNC Natural Brand
Barcode (UPC) 048107063290
Net contents 60 Softgel Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2252
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lycopene by GNC Natural Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
048107063290
IngredientAmount% DV
Lycopene10 mg--

Other ingredients: Soybean Oil, Corn Oil, Gelatin, Glycerin, Beta-Carotene

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel capsule daily.

Precautions

KEEP OUT OF REACH OF CHILDREN

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

General Statements

Antioxidant support for cardiovascular health

Conforms to USP <2091> for weight.

Lot No./Best By

Lycopene is the red pigment that gives tomatoes the bright red color.

MADE IN THE USA

Meets USP <2040> disintegration.

RED COLORED SOFTGEL

General

CODE 704613 BFG

Formulation

No Sugar, No Starch No Artificial Colors No Artificial Flavors No Preservatives Sodium Free, No Wheat, No Gluten, No Dairy, Yeast Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lycopene by GNC Natural Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lycopene label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lycopene by GNC Natural Brand

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Lycopene

Interacts with
122 drugs
10 mg per serving

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Other (inactive) ingredients: Soybean Oil, Corn Oil, Gelatin, Glycerin, Beta-Carotene. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lycopene by GNC Natural Brand Drug Interactions

Want to check YOUR meds against Lycopene?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Lycopene 122

Individual Drug Interactions

The ingredients in Lycopene interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lycopene interact with drugs. Each result below shows which ingredient is responsible. Lycopene

Each ingredient & the kinds of drugs it affects

For each ingredient in Lycopene with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lycopene, from the product label.

GNC Natural Brand

See all GNC Natural Brand products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Lycopene by GNC Natural Brand: Common Questions

Does Lycopene by GNC Natural Brand interact with any medications?
Yes. Based on its ingredients, Lycopene has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lycopene contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does lycopene actually help with prostate health?
The evidence suggests it possibly helps — that's the strongest data we have for lycopene. For other conditions like bladder cancer and diabetes, the research shows it's probably not effective, and for a few others we just don't have enough reliable evidence yet.
What are the side effects?
Most side effects are digestive — diarrhea, gas, bloating, nausea, vomiting, indigestion, or loss of appetite. These tend to be mild, but if you have a sensitive stomach, start small and see how you feel.
Is it safe to take while I'm pregnant or breastfeeding?
Lycopene from food is fine during pregnancy and breastfeeding, but supplement doses haven't been well studied in either situation. Talk with your doctor or pharmacist before taking a supplement — they can give you personalized advice based on your pregnancy or breastfeeding plan.
Can I take this if I'm on a blood thinner like warfarin?
That's a question for your doctor or pharmacist, because lycopene may increase bleeding risk when combined with blood thinners or aspirin-type drugs. Use the medication checker on this page to see your exact drugs, then confirm with your healthcare provider before starting.
What's in this softgel besides lycopene?
The inactive ingredients are soybean oil, corn oil, gelatin, glycerin, and beta-carotene — they're there to deliver the lycopene and hold the capsule together, not to add therapeutic benefit.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lycopene is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lycopene label
Go deeper

The Full Monographs Behind Lycopene’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph →
Sources

Sources & How We Checked

Lycopene's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
  8. Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
  9. Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
  10. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

See these in context on the Lycopene monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team