Major interaction on record — check this product against your medications before combining. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Made with Organic D3 + Vitamin K2 Ingredients & Drug Interactions

by Enzymedica

Made with Organic D3 + Vitamin K2 label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Made with Organic D3 + Vitamin K2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Made with Organic D3 + Vitamin K2 is a dietary supplement by Enzymedica with 4 active ingredients. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are K2Vital. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Made with Organic D3 + Vitamin K2 by Enzymedica

Ask about any prescription or over-the-counter medication and we check it for interactions with Made with Organic D3 + Vitamin K2 by Enzymedica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Made with Organic D3 + Vitamin K2 by Enzymedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This formula has 4 active ingredients. The two we can speak to are vitamin K (listed as K2Vital) — a nutrient your body needs to make clotting factors and maintain bone health — and vitamin D3 (VegD3), the active form of vitamin D your skin makes from sunlight.

The formula also contains Shiitake Mushroom Powder and Prebiotic Fiber, ingredients we don't have detailed information on in our system. The rest is inactive ingredients: rice husk, rice extract, gum arabic, sunflower oil, rice bran extract, cellulose, and water.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: immune health and bone support.
  • We looked for evidence on: Osteoporosis, Vitamin K-dependent clotting factors deficiency (VKCFD), Hemorrhagic disease, Hypoprothrombinemia, Intraventricular hemorrhage, Warfarin anticoagulation — and 4 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Hypoprothrombinemia, Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Vitamin K is effective for correcting vitamin K deficiency, replacing vitamin K-dependent clotting factors, managing hemorrhagic disease, and maintaining warfarin's anticoagulation when dietary intake is stable. It's possibly effective for osteoporosis.

We don't have effectiveness data on file for the vitamin D3, Shiitake Mushroom, or Prebiotic Fiber in this product.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin K taken by mouth is generally well tolerated in healthy people at typical dietary and supplement doses. The most common side effects are mild — nausea, stomach upset, diarrhea, and abdominal pain.

The data notes that vitamin K is likely safe during pregnancy and lactation. We don't have safety information on file for the other ingredients.

If you're pregnant, breastfeeding, or have any health conditions, check with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check if you're on warfarin (Coumadin) or any other blood thinner — vitamin K will reduce how well it works. We couldn't review two of the ingredients for interactions, so run your complete medication list through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a straightforward D3 and K2 supplement for people looking to cover those two nutrients. If you take warfarin or other blood thinners, you need to talk with your doctor first — vitamin K directly interferes with those drugs.

If you're generally healthy and not on blood thinners, a quick medication check below is still a good idea.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Made with Organic D3 + Vitamin K2, straight from the product label.

Brand Enzymedica
Barcode (UPC) 670480101292
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328889
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Made with Organic D3 + Vitamin K2 by Enzymedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
670480101292
IngredientAmount% DV
Shiitake Mushroom, Powder150 mg--
Prebiotic Fiber50 mg--
K2Vital90 mcg75%
VegD3125 mg625%

Other ingredients: Rice Husk, Rice extract, Gum Arabic, Sunflower Oil, Rice Bran Extract, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Algae-derived D3

5000 IU (D3) 90 mcg (K2) With shiitake mushroom & prebiotic fiber

Vegetarian & kosher

Benefits you can feel Immune health An all-in-one combination of vitamins D3, K2 and shiitake mushrooms to provide triple strength immune support. Bone support Vitamin D3, combined with vitamin K2, plus inulin helps proper absorption of calcium into the bones.

Star-K (Kosher) Pareve

Vitamin K2 in the superior MK7 form is demonstrated to deliver exceptional bioavailability and supports your bone health. Shiitake Mushrooms have been harvested and processed with extreme care to preserve their potent health- promoting effects. Inulin, a naturally occurring prebiotic fiber originates from agave.

Formulation

Immune Bone

Vegetarian & kosher

Microbiome Fuel When you microbiome is happy, your body thrives. The human microbiome is the powerhouse for up to 70% of you immune system. Radiant health Shiitake mushroom are known to promote health benefits especially for immunity, blood circulation and skin health.

Contains no: Gluten, milk, casein, soy, egg, artificial colors or flavors

Certified organic by 'Where Food Comes From Organic' applies only to the vitamin D3 in this formula

Unparalleled quality

Enzymedica sources the planet for the finest ingredients Our organic D3 is plant-based and sources from sustainable algae.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Recommended usage: Take 1 capsule daily with food.

Precautions

For adults only.

Consult with a physician prior to use if pregnant, nursing, taking medication or have a medical condition. Warning: If taking a blood-thinning medication, consult with a healthcare professional before using.

Do not use if safety seal is broken or missing.

Please keep out of reach of children

Seals/Symbols

Star-K (Kosher) Pareve

Where Food Comes From Organic North America Mushrooms

Storage

Keep closed in dry place; avoid excessive heat.

Brand IP Statement(s)

VegD3 is a trademark of Avlaan, Inc. VegD3 is a plant-based, vegan vitamin D3 exclusively distributed by AIDP, Inc. K2VITAL is a registered trademark of Kappa Bioscience.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Made with Organic D3 + Vitamin K2 by Enzymedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Made with Organic D3 + Vitamin K2 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Made with Organic D3 + Vitamin K2 by Enzymedica

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Shiitake Mushroom, Powder

150 mg per serving

Prebiotic Fiber

50 mg per serving Form: Inulin

K2Vital

Interacts with
2 drugs
90 mcg per serving Form: Vitamin K2

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

K2Vital monograph & interactions

VegD3

125 mg per serving Form: Vitamin D3

Other (inactive) ingredients: Rice Husk, Rice extract, Gum Arabic, Sunflower Oil, Rice Bran Extract, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Made with Organic D3 + Vitamin K2 by Enzymedica Drug Interactions

Want to check YOUR meds against Made with Organic D3 + Vitamin K2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

K2Vital 2

Individual Drug Interactions

The ingredients in Made with Organic D3 + Vitamin K2 interact with 2 drugs. Click any drug to see the details.

1 of the 4 ingredients in Made with Organic D3 + Vitamin K2 interact with drugs. Each result below shows which ingredient is responsible. K2Vital

Each ingredient & the kinds of drugs it affects

For each ingredient in Made with Organic D3 + Vitamin K2 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

K2Vital1 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
K2Vital full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Made with Organic D3 + Vitamin K2, from the product label.

Enzymedica

See all Enzymedica products
Name
Enzymedica, Inc.
Street Address
771 Commerce Drive
City
Venice
State
FL
ZipCode
34292
Phone Number
1-888-918-1118
Web Address
enzymedica.com
Pharmacist Counseling Corner

Made with Organic D3 + Vitamin K2 by Enzymedica: Common Questions

Does Made with Organic D3 + Vitamin K2 by Enzymedica interact with any medications?
Yes. Based on its ingredients, Made with Organic D3 + Vitamin K2 has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Made with Organic D3 + Vitamin K2 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
Not without talking to your doctor first. Vitamin K in this product directly counteracts warfarin and can reduce how well it prevents clots. Your doctor may need to adjust your warfarin dose or choose a different supplement.
What are the most common side effects?
Nausea, stomach upset, diarrhea, and abdominal pain are the side effects reported with vitamin K. Most people tolerate it well when taken by mouth.
Is this safe to take during pregnancy?
Vitamin K is rated as likely safe during pregnancy. The other active ingredients don't have pregnancy safety data on file for us. Talk with your doctor or pharmacist about whether this product is right for you right now.
What is vitamin K2 for?
Vitamin K2 helps your body make clotting factors so blood clots properly, and research suggests it may support bone health. It's effective for vitamin K deficiency and related bleeding disorders.
What's in the capsule besides the active ingredients?
The inactive ingredients are rice husk, rice extract, gum arabic, sunflower oil, rice bran extract, cellulose, and water — basically fillers and binders to hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Made with Organic D3 + Vitamin K2 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Made with Organic D3 + Vitamin K2 label
Go deeper

The Full Monographs Behind Made with Organic D3 + Vitamin K2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Made with Organic D3 + Vitamin K2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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