Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Gut Motility Ingredients & Drug Interactions

by Enzymedica

Gut Motility label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut Motility against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gut Motility is a dietary supplement by Enzymedica with 3 active ingredients. Its ingredients are commonly taken for blood sugar support, weight management, digestive upset.Based on those ingredients, 1,146 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ginger Root Extract, Artichoke Leaf Extract, Apple Cider Vinegar. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gut Motility by Enzymedica

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut Motility by Enzymedica — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gut Motility by Enzymedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “ProDigest” is listed as a grouped ingredient — the label gives one combined amount (320 mg) without saying how much of each component you get.

Gut Motility contains 3 active ingredients: apple cider vinegar, ginger root extract, and artichoke leaf extract, plus a proprietary blend called ProDigest (whose individual components are listed separately in the supplement facts). These three work together to support digestive function.

The capsules also contain inactive ingredients — cellulose, water, and rice concentrate — that serve as fillers and the capsule material itself.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promotes healthy digestive motility and gastric emptying.
  • We looked for evidence on: Constipation, Dyspepsia, Gastroparesis, Irritable bowel syndrome (IBS), bloating, digestive transit — and 1 related terms.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Dyspepsia (Natural Medicines).
  • Also on file: Apple Cider Vinegar is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Gastroparesis.
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Irritable bowel syndrome (IBS).

The evidence for these ingredients is mixed. Ginger root extract is possibly effective for pregnancy-induced nausea and vomiting, dysmenorrhea (period pain), and osteoarthritis.

Artichoke leaf extract is possibly effective for high cholesterol (hyperlipidemia) and dyspepsia (indigestion). Apple cider vinegar has insufficient evidence for the conditions we have data on — acne, athletic performance, cognitive function, dental plaque, depression, and eczema.

If you're taking Gut Motility for digestive motility specifically, the evidence we hold doesn't establish effectiveness for that purpose.

The evidence, ingredient by ingredient Apple Cider Vinegar Ginger Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ginger root extract is generally well tolerated at typical food and supplement doses, though doses above 5 grams per day increase the risk of side effects like heartburn, burping, diarrhea, and a burning sensation in the mouth and throat. Apple cider vinegar in food amounts is well tolerated, but large medicinal doses used long-term may cause serious effects including low potassium, high renin levels, and bone loss — and there's a case report of someone who took 250 mL daily for 6 years and developed all three.

Artichoke leaf extract is generally well tolerated short-term, but carries a rare risk of severe allergic reactions (anaphylaxis) in people sensitive to inulin or to the ragweed plant family. Common mild side effects of artichoke include abdominal pain, diarrhea, flatulence, and nausea.

Side effects, ingredient by ingredient Apple Cider Vinegar Ginger Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Apple Cider Vinegar, Artichoke, Ginger.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,147 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Gut Motility, tell your doctor or pharmacist if you take blood thinners (warfarin, phenprocoumon, or other anticoagulants or antiplatelet drugs) — ginger raises bleeding risk. Also flag digoxin or other heart medications, diuretics, blood pressure medications, antidiabetes drugs, or cancer drugs metabolized through CYP3A4 or transported by P-glycoprotein.

No interactions are documented for ProDigest itself — we have no data on file for that blend.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gut Motility may be worth considering if you want digestive support and tolerate these three ingredients well — but the biggest caution is if you're on blood thinners, heart medications, diabetes drugs, or blood pressure medications. Check with your doctor or pharmacist about whether this product and your current medications are compatible before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut Motility, straight from the product label.

Brand Enzymedica
Barcode (UPC) 670480140567
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 296540
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut Motility by Enzymedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
670480140567
IngredientAmount% DV
Apple Cider Vinegar250 mg--
Ginger Root Extract0 NP--
ProDigest320 mg--
Artichoke Leaf Extract0 NP--

Other ingredients: Cellulose, Water, Rice Concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Enzymedica Natural Digestive Health & Wellness

ProDigest is a registered trademark of Indena S.p.A. Italy.

Formula

With Apple Cider Vinegar! Contains artichoke leaf, ginger root & apple cider vinegar

The Power of Artichoke and Ginger This formula includes ProDigest - a clinically studied, synergistic combination of standardized Artichoke leaf and Ginger root extracts that support healthy digestive transport.

Clinically Studied Blend for Guaranteed Support Gut Motility features ProDigest - a synergistic blend that has been clinically studied to deliver gentle support every time. Non-addictive and plant-based, it works with your body to promote gut comfort, improved motility and regular, healthy bowel movements.

Formulation

Digestive Transport Support Promotes healthy GI motility & gastric emptying Helps alleviate occasional bloating & constipation

NON GMO

Vegan Dietary Supplement

For Optimal Digestive Speed Gut Motility promotes the transport of food to keep the digestive system moving smoothly. It supports motility and gastric emptying, the speed at which food leaves the stomach for the small intestine. Supports Better Digestion Raw and unfiltered Apple Cider Vinegar with the "Mother" helps optimize metabolism and supports a balanced pH in the digestive system.

CONTAINS NO: Gluten, milk, casein, soy, egg, artificial colors or flavors

Enzymedica does not use ingredients produced using biotechnology.

Slight color variation in capsules may exist due to the natural variation of botanical extracts. This does not affect product quality.

Motility Means Movement The body knows how to keep food moving through the GI tract to ensure healthy digestion, nutrient absorption and elimination. GI motility is the normal, natural movement of muscles and digestive organs. When motility is out of balance or sluggish, issues such as occasional bloating or constipation can result. What Impacts GI Motility? Some medications and physical conditions can impact or slow digestive motility, leading to occasional fullness and other discomforts like bloating, nausea and gas.

FDA Statement of Identity

Vegan Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Recommended Use: Take 1 capsule, twice a day, before your largest meals.

Precautions

Consult with a physician if you are pregnant or nursing, taking medications or have a medical condition.

Do not use if safety seal is broken or missing.

Please keep out of the reach of children.

Storage

Keep closed in dry place; avoid excessive heat.

General Statements

Actual size

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut Motility by Enzymedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut Motility label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut Motility by Enzymedica

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Apple Cider Vinegar

Interacts with
162 drugs
250 mg per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar monograph & interactions

ProDigest

320 mg per serving

Other (inactive) ingredients: Cellulose, Water, Rice Concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut Motility by Enzymedica Drug Interactions

Want to check YOUR meds against Gut Motility?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,146Drugs
1,066 Moderate 80 Minor

Ingredients driving the most interactions

Ginger Root Extract 1,007
Artichoke Leaf Extract 363
Apple Cider Vinegar 162

Individual Drug Interactions

The ingredients in Gut Motility interact with 1,146 drugs. Click any drug to see the details.

3 of the 3 ingredients in Gut Motility interact with drugs. Each result below shows which ingredient is responsible. Ginger Root Extract Artichoke Leaf Extract Apple Cider Vinegar

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut Motility with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ginger Root Extract14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger Root Extract full monograph & interactions

Artichoke Leaf Extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke Leaf Extract full monograph & interactions

Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut Motility, from the product label.

Enzymedica

See all Enzymedica products
Name
Enzymedica, Inc.
Street Address
771 Commerce Drive
City
Venice
State
FL
ZipCode
34292
Phone Number
1-888-918-1118
Web Address
enzymedica.com
Pharmacist Counseling Corner

Gut Motility by Enzymedica: Common Questions

Does Gut Motility by Enzymedica interact with any medications?
Yes. Based on its ingredients, Gut Motility has a known interaction with 1,146 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut Motility contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is ginger safe if I'm pregnant?
Ginger root extract is rated likely safe or possibly safe in pregnancy — many people use it for morning sickness. That said, talk with your doctor first and keep amounts moderate; there's not a ton of safety data on supplement doses, so your doctor can help you weigh the benefit against any personal risks.
What about artichoke leaf extract and pregnancy or breastfeeding?
The safety data advises against using artichoke leaf extract in supplement form during pregnancy and breastfeeding. If you're pregnant or nursing and interested in this product, ask your doctor or pharmacist whether it's right for you.
Can ginger cause side effects?
Ginger is generally well tolerated, but higher doses — above 5 grams per day — increase the risk of side effects. Common mild ones are heartburn, burping, diarrhea, nausea, and a burning or peppery sensation in the mouth and throat. Using an encapsulated form instead of powder may reduce some of these.
What is artichoke leaf extract supposed to do?
Artichoke leaf extract is possibly effective for lowering cholesterol and easing indigestion. It may also modestly reduce fasting blood sugar, which is why it could increase the risk of low blood sugar if you're already on diabetes medication.
Does apple cider vinegar in this product carry the same risks as drinking it straight?
We don't have the specific dose of apple cider vinegar in Gut Motility, so we can't say for certain. The main concern is long-term use of large amounts — case reports describe serious potassium loss, bone loss, and other problems with very high intakes over years. Ask your pharmacist what the dose is in this product and whether it's safe for your situation.
Can I take this if I have allergies to ragweed or similar plants?
You should be careful. Artichoke leaf extract can trigger allergic reactions in people sensitive to ragweed, chrysanthemums, daisies, and other plants in the same family — and rare severe allergic reactions have been reported. If you have a known allergy to any of these plants, check with your doctor or pharmacist before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut Motility label
Go deeper

The Full Monographs Behind Gut Motility’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Gut Motility's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 91 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Ginger 64 references
  1. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19-24. PubMed
  2. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2000;(2):CD000145. PubMed
  3. Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577-82. DOI
  4. Backon J. Ginger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gynecol Reprod Biol 1991;42:163-4. PubMed
  5. Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids 1989;35:183-5. PubMed
  6. Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991;42:111-20. PubMed
  7. Smith C, Crowther C, Willson K, et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639-45. PubMed
  8. Portnoi G, Chng LA, Karimi-Tabesh L, et al. Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol 2003;189:1374-7.. PubMed
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See these in context on the Ginger monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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