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Dietary supplement

Magnolia Extract Ingredients & Drug Interactions

by BulkSupplements.com

Powder Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Magnolia Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 351 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Magnolia Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Magnolia Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is a single-ingredient magnolia bark extract powder. The extract contains the active compounds honokiol and magnolol, which are the constituents responsible for magnolia's observed effects in research.

The only other ingredient is dextrin, an inactive filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Magnolia's overall clinical evidence instead.

Moderate

Some clinical evidence supports Magnolia for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Gingivitis — rated "Possibly Effective" (Natural Medicines).

Magnolia extract shows possibly effective evidence for gingivitis (gum inflammation). For allergic rhinitis (hay fever), anxiety, and dental plaque, the evidence we hold is insufficient to rate — meaning either the studies are limited or the data doesn't yet support a clear claim.

If you're considering this for one of those uses, that's a conversation to have with your doctor or dentist about whether it's the right choice for you.

The evidence, ingredient by ingredient Magnolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, magnolia is generally well tolerated in most adults over the short term, though human safety data overall is limited. The main topical side effect reported is contact dermatitis (skin irritation).

In clinical trials of combination products containing magnolia, a small number of participants reported sexual dysfunction, hand tremors, numbness around the mouth, fatigue, and headache — but it's unclear whether magnolia was the cause. Magnolia is rated unsafe in pregnancy because some sources caution it may affect the uterus.

There is no reliable safety data during breastfeeding, so it's best avoided if you're nursing. If you're pregnant, breastfeeding, or planning to become pregnant, talk with your doctor or pharmacist before taking this.

Side effects, ingredient by ingredient Magnolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Magnolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 351 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take magnolia extract, double-check your medications against two groups: blood thinners and antiplatelet drugs (warfarin, aspirin, clopidogrel, and others), where there's a moderate risk of increased bleeding, and CNS depressants like sedatives and anti-anxiety medications, where there's a moderate risk of added drowsiness or impairment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Magnolia extract may be worth considering if you're looking into options for gingivitis and you don't take blood thinners or sedating medications. If you're on any anticoagulant, antiplatelet drug, or CNS depressant, check with your doctor or pharmacist before adding it.

Pregnant and breastfeeding individuals should not use it. Talk it over with your own healthcare provider to see if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Magnolia Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X0019YZO9J
Net contents 500 Gram(s); 17.6 Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294805
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Magnolia Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
800 mg
Maximum serving Sizes:
800 mg
Servings per container
625
UPC/BARCODE
X0019YZO9J
IngredientAmount% DV
Magnolia Bark Extract720 mg--

Other ingredients: Dextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of reach of children.

Always consult a physician before taking any dietary supplement.

Formulation

Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, Additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 800 mg (about 1/3 tsp) once daily, or as directed by a physician.

Storage

Store in a dry, cool place

General Statements

New

See for yourself

Magnolia Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Magnolia Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size800 mg Dosage formPowder Servings per container625 Amounts shown are per serving.

Magnolia Bark Extract

Interacts with
351 drugs
720 mg per serving

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human r...

Magnolia Bark Extract monograph & interactions

Other (inactive) ingredients: Dextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Magnolia Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Magnolia Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
351Drugs
351 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Magnolia Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnolia Bark Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Magnolia Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Magnolia Extract by BulkSupplements.com: Common Questions

Does Magnolia Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Magnolia Extract has a known interaction with 351 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Magnolia Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No — magnolia is rated unsafe in pregnancy because some sources caution it may affect the uterus. Talk with your doctor or pharmacist before taking it if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
There is no reliable safety data during breastfeeding, so it's best avoided. If breastfeeding and interested in magnolia, check with your doctor or pharmacist for guidance on your situation.
What side effects have been reported?
When taken by mouth, magnolia is generally well tolerated. Topically, contact dermatitis (skin irritation) has been reported. In clinical trials, a small number of participants reported sexual dysfunction, hand tremors, numbness around the mouth, fatigue, and headache, though it's unclear if magnolia was responsible.
Does magnolia extract actually work for gingivitis?
The evidence we hold rates magnolia as possibly effective for gingivitis. For allergic rhinitis, anxiety, and dental plaque, the evidence is insufficient to rate — meaning the studies are too limited or mixed to make a clear claim.
Why does the product have so many medication interactions listed?
The two ingredients in magnolia bark — honokiol and magnolol — can theoretically interact with blood thinners and CNS depressants. The total count of 351 reflects the combined number of individual medications across those two drug categories, not separate interactions per ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Magnolia Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Magnolia Extract label
Sources

Sources & How We Checked

Magnolia Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

See these in context on the Magnolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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