Male Optimization Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Male Optimization against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Male Optimization is a dietary supplement by Ancestral Supplements with 5 active ingredients. Its ingredients are commonly taken for anemia and low iron, vitamin b12 support, general energy and fatigue.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Liver. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Male Optimization by Ancestral Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Male Optimization by Ancestral Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Male Optimization by Ancestral Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Male Optimization contains 5 active ingredients: liver extract, heart, prostate, bone marrow, and testicle. These are whole-food concentrates — organ and glandular tissues meant to support corresponding body systems.
The capsules also contain gelatin as an inactive ingredient. Liver extract is the only one with established data in our system.
The others are included for their theoretical nutritional density, but we hold limited interaction and safety information for them.
Does it work?
Not established
The evidence for these ingredients is sparse in our data. Liver extract has been rated possibly ineffective for chronic fatigue syndrome, and there isn't enough reliable evidence to rate it for hepatitis C.
For the other four ingredients — heart, prostate, bone marrow, and testicle — effectiveness ratings aren't on file in our system, so we can't tell you what the science says about whether they work.
How safe is it?
Well-documented data
Liver extract is generally well tolerated in food amounts, but the safety data we hold raises several flags. It can deliver very high levels of vitamin A and iron, which is important to know if you're already getting these nutrients elsewhere.
Liver extract comes from raw animal liver sourced from slaughterhouses, raising concerns about contamination from sick or diseased animals. There's also a historical concern about bovine spongiform encephalitis (BSE, or mad cow disease) in liver products from certain countries — though no human cases from contaminated liver extract have been reported.
A thorough safety review hasn't been done, and safety hasn't been well studied for the other four ingredients, so talk with your doctor before using this product.
Meds to double-check
Minor interactions only
Check with your pharmacist before using this if you take warfarin (Coumadin) or any blood thinners — liver extract's vitamin K content may reduce their effectiveness. Also double-check if you're on iron supplements or iron-containing medications, as combining them could boost your iron intake.
No other interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.
This is an organ-support supplement, but the evidence for how well it works isn't established in our data. If you take warfarin or iron supplements, you need to check this with your pharmacist first.
Talk to your doctor about quality sourcing and whether the high vitamin A and iron content is right for you, especially if you're pregnant.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Male Optimization, straight from the product label.
| Brand | Ancestral Supplements |
|---|---|
| Barcode (UPC) | 675757264472 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2022 |
| DSLD ID | 275564 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult Male (18-50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Male Optimization by Ancestral Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Liver | 300 mg | -- |
| Heart | 300 mg | -- |
| Prostate | 300 mg | -- |
| Bone Marrow | 300 mg | -- |
| Testicle | 1260 mg | -- |
Other ingredients: Gelatin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
For most of human history, we consumed the whole animal (nose-to-tail) with deep respect and profound purpose. For instance, Native Americans and early ancestral healers believed that eating the organs from a healthy animal would strengthen and support the health of the corresponding organ of the individual - also known as "like supports like." The traditional way of treating a person with a weak heart was to feed the person the heart of a healthy animal. Since we've abandoned these ways, the modern world has left us malnourished with an epidemic of declining health. The solution is to find ways to recreate our ancestral environment (sleep, nourishment, movement, sunshine, etc.). It's time we honor our ancestors by putting back in, what the modern world has left out (to return our people back to strength, health and happiness). We walk our talk and we offer a one-of-a-kind "guided" experience. Learn more at www.ancestralsupplements.com Brian Johnson "Liver King"
One small batch at a time
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
MOFO Brad Kearns' MOFO Male optimization formula w/ organs 410 mg ea
Formulation
Pasture raised in New Zealand & Australia 100% Grass-fed & grass-finished
Absolutely no fillers (or) flow agents
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: 6 capsules daily or as directed by a healthcare professional
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Male Optimization by Ancestral Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Male Optimization by Ancestral Supplements
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Liver
Interacts with3 drugs
Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...
Liver monograph & interactionsHeart
Prostate
Bone Marrow
Testicle
Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.
Male Optimization by Ancestral Supplements Drug Interactions
HelloPharmacist Interaction Report
Male Optimization by Ancestral Supplements contains one ingredient we have interaction data for: liver extract.
It interacts with a small number of medications — altogether, these interactions span 3 individual medications.
Read the full breakdown — every affected drug type, severity by severity
The main concern is warfarin (Coumadin), a blood thinner. Liver extract naturally contains small amounts of vitamin K, which can work against warfarin's effect.
If you start, stop, or significantly change how much liver extract you're taking, it could lower your blood thinner's effectiveness and raise your clotting risk. That said, this hasn't been studied directly in people, so the real-world risk is unclear.
Liver extract can also raise your total iron intake because it contains heme iron (the kind from meat). If you're already taking iron supplements or iron-containing medications, combining them could increase stomach upset or lead to too much iron building up in your body — especially if you have a condition that causes iron overload, like hemochromatosis.
We couldn't check the other four ingredients in this product — heart, prostate, bone marrow, and testicle — because we hold no interaction data for them. Use the medication checker on this page to verify your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Male Optimization?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Male Optimization interact with 3 drugs. Click any drug to see the details.
1 of the 5 ingredients in Male Optimization interact with drugs. Each result below shows which ingredient is responsible. Liver
Ferrous SulfateFeosol
How Ferrous Sulfate interacts with Male Optimization — through 1 ingredient. Tap an ingredient for the detail:
LiverIron Minor
Interaction Summary
Liver extract can contain heme iron.
Read the full Liver + Ferrous Sulfate interactionWarfarinWarfarin
How Warfarin interacts with Male Optimization — through 1 ingredient. Tap an ingredient for the detail:
LiverWarfarin (coumadin) Minor
Interaction Summary
Liver extract products may contain small and variable amounts of vitamin K.
Read the full Liver + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Male Optimization — through 1 ingredient. Tap an ingredient for the detail:
LiverWarfarin (coumadin) Minor
Interaction Summary
Liver extract products may contain small and variable amounts of vitamin K.
Read the full Liver + Warfarin Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Male Optimization with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Liver
Iron
Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.
Warfarin (Coumadin)
Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.
Brand information
Manufacturer and brand details for Male Optimization, from the product label.
Ancestral Supplements
See all Ancestral Supplements products- Name
- Ancestral Supplements, LLC
- City
- Willis
- State
- TX
- ZipCode
- 77318
- Web Address
- www.ancestralsupplements.com
Male Optimization by Ancestral Supplements: Common Questions
Does Male Optimization by Ancestral Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe during pregnancy?
What does liver extract do?
Why are there organs in this supplement?
Does it have fillers?
What should I know about the source?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Male Optimization is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Male Optimization’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Male Optimization's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Liver Extract 4 references
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
- Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
- Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
- Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC