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Dietary supplement

Maximum Strength Apple Polyphenols 125 mg Ingredients & Drug Interactions

by Swanson Ultra

Maximum Strength Apple Polyphenols 125 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maximum Strength Apple Polyphenols 125 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maximum Strength Apple Polyphenols 125 mg is a dietary supplement by Swanson Ultra with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high blood pressure, weight management.Based on those ingredients, 13 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apple Polyphenols. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra

Ask about any prescription or over-the-counter medication and we check it for interactions with Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: apple polyphenols at 125 mg per capsule. Apple polyphenols are compounds found naturally in apples that are extracted and concentrated for supplement form.

The capsule also contains gelatin and microcrystalline cellulose (a common binder) as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Apple Polyphenols product and its label doesn't state a use — see Apple Polyphenols's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for apple polyphenols is currently insufficient to rate their effectiveness for the conditions studied—androgenic alopecia (pattern hair loss), obesity, and high cholesterol (hyperlipidemia). That means the data we hold doesn't establish whether this supplement works for these purposes, so we can't say it does or doesn't.

If you're considering it for one of these reasons, talk with your doctor about what the current evidence actually supports.

The evidence, ingredient by ingredient Apple Polyphenols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Apple polyphenols are generally well tolerated when taken by mouth, though some clinical trial participants reported mild gastrointestinal effects, headache, or nasopharyngitis. Headache appeared in roughly one quarter of people taking apple polyphenols in one trial, though placebo was nearly as common.

One study noted loose stools and diarrhea at a 600 mg dose. For pregnancy, the safety data advises against concentrated apple polyphenol supplements unless your doctor approves—apples as food are fine, but supplements haven't been studied in pregnant people.

There isn't enough information on concentrated extracts during breastfeeding either, so caution is advised and you should talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Apple Polyphenols

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Apple Polyphenols.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 13 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take insulin, talk with your doctor or pharmacist before starting this supplement. Apple polyphenols can delay peak blood sugar after meals, which may increase the risk of low blood sugar when combined with insulin.

Monitor your glucose levels closely and discuss timing of the supplement relative to your meals and doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is most relevant if you're interested in apple polyphenols for hair loss, weight management, or cholesterol, though evidence for any of those isn't established yet. If you take insulin, you need to check with your doctor or pharmacist before starting—this supplement can affect blood sugar timing and might raise the risk of low blood sugar.

Pregnant or breastfeeding people should get personalized advice from their own doctor or pharmacist before taking it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maximum Strength Apple Polyphenols 125 mg, straight from the product label.

Brand Swanson Ultra
Barcode (UPC) 087614023014
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 176599
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
087614023014
IngredientAmount% DV
Apple Polyphenols125 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, May contain one or both of the following

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The most advanced nutrition technology Capsules

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Guaranteed purity & potency

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one capsule per day with water.

General

SWU301 Rev 0 08 17 17

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maximum Strength Apple Polyphenols 125 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Apple Polyphenols

Interacts with
13 drugs
125 mg per serving Form: Apple fruit extract

Apple polyphenols are antioxidant plant compounds taken from apples and marketed for heart, weight, and blood sugar health. Early research is interest...

Apple Polyphenols monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, May contain one or both of the following. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra Drug Interactions

Want to check YOUR meds against Maximum Strength Apple Polyphenols 125 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
13Drugs
13 Moderate

Ingredients driving the most interactions

Apple Polyphenols 13

Individual Drug Interactions

The ingredients in Maximum Strength Apple Polyphenols 125 mg interact with 13 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maximum Strength Apple Polyphenols 125 mg interact with drugs. Each result below shows which ingredient is responsible. Apple Polyphenols

Each ingredient & the kinds of drugs it affects

For each ingredient in Maximum Strength Apple Polyphenols 125 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Apple Polyphenols1 drug type · 13 drugs

Insulin

In healthy adults, taking 900-1800 mg of a polyphenol-rich apple extract prior to a meal delays the time to peak postprandial blood glucose levels. Theoretically, apple polyphenols might have additive effects when used concomitantly with certain insulin products and may increase the risk of hypoglycemia. Monitor blood glucose levels closely. Timing of insulin administration may need to be adjusted.

Likelihood Probable Evidence B
Apple Polyphenols full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maximum Strength Apple Polyphenols 125 mg, from the product label.

Swanson Ultra

See all Swanson Ultra products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra: Common Questions

Does Maximum Strength Apple Polyphenols 125 mg by Swanson Ultra interact with any medications?
Yes. Based on its ingredients, Maximum Strength Apple Polyphenols 125 mg has a known interaction with 13 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maximum Strength Apple Polyphenols 125 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
For pregnancy, the safety data advises against concentrated apple polyphenol supplements unless your doctor approves—eating apples is fine, just not the concentrated extract. There isn't enough information on concentrated extracts during breastfeeding either. Talk with your doctor or pharmacist before taking this if you're pregnant or breastfeeding.
Does this actually work for hair loss, weight loss, or high cholesterol?
We don't have reliable evidence that it does for any of those. The studies we hold show insufficient evidence to rate apple polyphenols for androgenic alopecia (pattern hair loss), obesity, or high cholesterol. That means we can't say whether it works for these purposes.
What side effects should I watch for?
Apple polyphenols are generally well tolerated. Some people report mild gastrointestinal effects, headache, or nasopharyngitis. In one trial, about 26% of people taking 330 mg daily reported headache over 4 weeks—though 24% of those on placebo did too. Higher doses may cause loose stools or diarrhea.
Is this safe to take long-term?
Apples as food are fine long-term, but concentrated apple polyphenol supplements haven't been studied extensively for long-term safety, so caution is advised. If you're thinking about taking this regularly, talk with your doctor or pharmacist about what the evidence supports.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maximum Strength Apple Polyphenols 125 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maximum Strength Apple Polyphenols 125 mg label
Go deeper

The Full Monographs Behind Maximum Strength Apple Polyphenols 125 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Apple Polyphenols

Interacts with 13 drugs

Apple polyphenols are antioxidant plant compounds taken from apples and marketed for heart, weight, and blood sugar health. Early research is interesting, but there is not enough reliable hu...

Read the full Apple Polyphenols monograph →
Sources

Sources & How We Checked

Maximum Strength Apple Polyphenols 125 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Polyphenols 10 references
  1. Akazome Y, Kametani N, Kanda T, et al. Evaluation of safety of excessive intake and efficacy of long-term intake of beverages containing apple polyphenols. J Oleo Sci. 2010;59(6):321-38. PubMed
  2. Auclair S, Chironi G, Milenkovic D, et al. The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults. Eur J Clin Nutr. 2010;64(10):1158-65. PubMed
  3. Deley G, Guillemet D, Allaert FA, Babault N. An Acute Dose of Specific Grape and Apple Polyphenols Improves Endurance Performance: A Randomized, Crossover, Double-Blind versus Placebo Controlled Study. Nutrients. 2017;9(8). pii: E917. PubMed
  4. Kamimura A, Takahashi T, Watanabe Y. Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent. Phytomedicine. 2000;7(6):529-36. PubMed
  5. Kishi K, Saito M, Saito T, et al. Clinical efficacy of apple polyphenol for treating cedar pollinosis. Biosci Biotechnol Biochem. 2005;69(4):829-32. PubMed
  6. Nagasako-Akazome Y, Kanda T, Ohtake Y, Shimasaki H, Kobayashi T. Apple polyphenols influence cholesterol metabolism in healthy subjects with relatively high body mass index. J Oleo Sci. 2007;56(8):417-28. PubMed
  7. Takahashi T, Kamimura A, Kagoura M, et al. Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair-growing agent. J Cosmet Dermatol. 2005;4(4):245-9. PubMed
  8. Tenore GC, Caruso D, Buonomo G, et al. A Healthy Balance of Plasma Cholesterol by a Novel Annurca Apple-Based Nutraceutical Formulation: Results of a Randomized Trial. J Med Food. 2017;20(3):288-300. PubMed
  9. Saarenhovi M, Salo P, Scheinin M, et al. The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure. Nutr. J 2017;16(1):73. PubMed
  10. Prpa EJ, Corpe CP, Atkinson B, et al. Apple polyphenol-rich drinks dose-dependently decrease early-phase postprandial glucose concentrations following a high-carbohydrate meal: a randomized controlled trial in healthy adults and in vitro studies. J Nutr B PubMed

See these in context on the Apple Polyphenols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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