Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Menopause Relief Ingredients & Drug Interactions

by Solgar

Menopause Relief label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Menopause Relief against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Menopause Relief is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for depression and low mood, anxiety, pms symptoms.Based on those ingredients, 996 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ERr 731, Affron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Menopause Relief by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Menopause Relief by Solgar — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Menopause Relief by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “ERr 731” is listed as a grouped ingredient — the label gives one combined amount (4 mg) without saying how much of each component you get.

This product has three active ingredients. Affron is a saffron extract — a spice used in traditional medicine that some research suggests may help with certain nerve pain and brain health concerns.

The other two actives are rhaponticin and desoxyrhaponticin, both compounds from rhubarb root. The tablet also contains several inactive ingredients — binders, fillers, and capsule materials like microcrystalline cellulose and vegetable stearic acid — that help hold the pill together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Saffron's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: relieve menopausal symptoms and promote mood.
  • We looked for evidence on: Menopausal symptoms, Anxiety, Postpartum depression, hot flashes, night sweats, mood swings.
  • The closest evidence on file: Saffron is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Saffron is rated "Insufficient Reliable Evidence To Rate" for Postpartum depression, Menopausal symptoms.

The evidence for saffron in this product is modest. Our data shows it is possibly effective for chemotherapy-induced peripheral neuropathy (nerve pain from cancer treatment) and possibly effective for Alzheimer disease.

We hold no effectiveness ratings for the other two active ingredients, rhaponticin and desoxyrhaponticin, so we cannot speak to what they may or may not do based on research we have on file.

The evidence, ingredient by ingredient Saffron Rhubarb

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saffron is generally well tolerated at typical doses, though some people report nausea, stomach upset, sedation, or vomiting. Rarely, allergic reactions including anaphylaxis (a severe, rapid allergic reaction) have occurred — if you have a known spice allergy, mention that to your pharmacist.

There is one important caution: high doses of saffron may stimulate the uterus, so it should be avoided in pregnancy. For breastfeeding, we do not hold enough safety data to say either way — talk with your doctor or pharmacist about whether it is right for you.

A few people in trials reported anxiety, agitation, or mood elevation at higher doses, though these were uncommon.

Side effects, ingredient by ingredient Saffron Rhubarb

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saffron.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 521 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood pressure medications — saffron can lower blood pressure and combining them might drop it too far. Also check if you use sedating medications like sleep aids or anxiety drugs (saffron adds to drowsiness), diabetes medications (risk of low blood sugar), or high-dose caffeine products (saffron may slow how your body clears caffeine).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Solgar's Menopause Relief may be worth considering if you're interested in saffron's possible benefits for nerve pain or brain health and you don't take blood pressure, sedating, or diabetes medications. If you do take any of those, or if you're pregnant, check with your doctor or pharmacist first — the interactions and pregnancy caution are real concerns.

Either way, review your full medication list on this page before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Menopause Relief, straight from the product label.

Brand Solgar
Barcode (UPC) 033984005891
Net contents 30 Mini Tablet(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 264117
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Women (not pregnant or lactating), Adult Female (18 - 50 Years), Menopause, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Menopause Relief by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
033984005891
IngredientAmount% DV
Rhaponticin2.2 mg--
Desoxyrhaponticin1 mg--
Affron28 mg--
ERr 7314 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Vegetable Cellulose, Silica, Vegetable Stearic Acid, Sodium Alginate, Vegetable Magnesium Stearate, Ammonium Hydroxide, Medium Chain Triglycerides, Oleic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Only Solgar Menopause Relief combines the clinically studied ingredients Siberian Rhubarb (ERr-731) and affron Saffron: Siberian Rhubarb (ERr-731) has been clinically studied to help relieve a full range of the most common symptoms women experience during menopause. affron Saffron has been clinically shown to help you to maintain a positive mood and supports your emotional well-being. As studied on Siberian Rhubarb and measured by the Menopause Rating Scale II; individual variations in symptoms or severity of symptoms experienced during menopause may exist

Siberian rhubarb and saffron

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

For more information, call toll-free 1-877-SOLGAR 4, www.solgar.com

Disruptive hot flashes. Uncomfortable night sweats. Irritability and mood swings that can leave you feeling out of sorts. When menopausal symptoms strike, they can get in the way of your life. Now, there’s a first-of-its-kind approach to help with that.

Brand IP Statement(s)

Copyright 2020 Solgar, Inc. Since 1947

ERr 731 is a registered trademark of Health Research Services GMBH affron is a trademark owned by Pharmactive Biotech Products, SL

Formulation

Relieves a full range of symptoms Promotes a positive mood

Certified Gluten Free GFCO.org Non GMO Certified by NSF Non-GMO Gluten, wheat & dairy free

Suitable for vegans

Due to the natural variation of the raw material, tablet color and appearance may vary from batch to batch.

Free of: Gluten, wheat, dairy, soy, yeast, sugar, artificial flavor, sweetener and color.

More than 90% of women showed improvements in menopausal symptoms Clinically shown to help relieve a full range of menopausal symptoms Hot flashes Night sweats Irritability Anxiety Mood swings Sleep disturbances Exhaustion Joint & muscle discomfort Vaginal dryness Urinary difficulties Decreased sexual desire & satisfaction In clinical studies on Siberian rhubarb after 12 weeks of continued use. Individual results may vary.

Solgar Menopause Relief – just one small tablet, once a day can make a real difference in the way you feel day after day.

Seals/Symbols

Certified Gluten Free GFCO.org Non GMO Certified by NSF

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Once Daily Suggested use: For adults, take one (1) tablet daily, preferably with a meal or as directed by a healthcare practitioner.

Precautions

This product is intended to be used by pre- and peri-menopausal women. Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your healthcare practitioner before use.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur. Not intended for use by men or persons under the age of 18. Do not use if outer bottle seal is missing or damaged.

Not intended for use by men or persons under the age of 18. Keep out of reach of children.

Storage

Store at room temperature.

Suggested use: As a dietary supplement for adults, take one (1) tablet daily, preferably with a meal or as directed by a healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Menopause Relief by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Menopause Relief label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Menopause Relief by Solgar

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Affron

Interacts with
521 drugs
28 mg per serving Form: Saffron Stigma Extract

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Affron monograph & interactions

ERr 731

Interacts with
658 drugs
4 mg per serving Form: Rhapontic Rhubarb Root Extract

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal clai...

ERr 731 monograph & interactions
  • › Rhaponticin
  • › Desoxyrhaponticin

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Vegetable Cellulose, Silica, Vegetable Stearic Acid, Sodium Alginate, Vegetable Magnesium Stearate, Ammonium Hydroxide, Medium Chain Triglycerides, Oleic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Menopause Relief by Solgar Drug Interactions

Want to check YOUR meds against Menopause Relief?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
996Drugs
996 Moderate

Ingredients driving the most interactions

ERr 731 658
Affron 521

Individual Drug Interactions

The ingredients in Menopause Relief interact with 996 drugs. Click any drug to see the details.

2 of the 2 ingredients in Menopause Relief interact with drugs. Each result below shows which ingredient is responsible. ERr 731 Affron

Each ingredient & the kinds of drugs it affects

For each ingredient in Menopause Relief with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

ERr 7318 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
ERr 731 full monograph & interactions

Affron4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Affron full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Menopause Relief, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Menopause Relief by Solgar: Common Questions

Does Menopause Relief by Solgar interact with any medications?
Yes. Based on its ingredients, Menopause Relief has a known interaction with 996 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Menopause Relief contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this during pregnancy?
No — the safety data advises against using medicinal amounts of saffron in pregnancy because it may stimulate the uterus. If you're pregnant or planning to be, talk with your doctor or pharmacist before taking this product.
Will this make me drowsy?
It may. Saffron in this product can cause drowsiness and sedation, especially at higher doses or with regular use. If you drive or operate machinery, be aware of how you feel after taking it.
What are the most common side effects?
Stomach complaints, nausea, vomiting, and sedation are the most commonly reported side effects in trials. Serious reactions like allergic anaphylaxis are rare but have been reported.
Does this product work for menopause symptoms?
Our data doesn't contain an effectiveness rating for menopause relief specifically. The saffron in it is possibly effective for chemotherapy-related nerve pain and possibly effective for Alzheimer disease, but we cannot speak to menopausal symptom relief from the evidence we hold.
What is Affron?
Affron is a saffron extract — a concentrated form of saffron, the spice from crocus flowers. It's used in this product because some research suggests saffron may have benefits for nerve pain and brain health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Menopause Relief label
Go deeper

The Full Monographs Behind Menopause Relief’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph → Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph →
Sources

Sources & How We Checked

Menopause Relief's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saffron 22 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Feo F, Martinez J, Martinez A, et al. Occupational allergy in saffron workers. Allergy 1997;52:633-41. PubMed
  5. Wuthrich B, Schmid-Grendelmeyer P, Lundberg M. Anaphylaxis to saffron. Allergy 1997;52:476-7. PubMed
  6. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005;19:148-51.
  7. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
  8. Fatehi, M., Rashidabady, T., and Fatehi-Hassanabad, Z. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol. 2003; PubMed
  9. Modaghegh, M. H., Shahabian, M., Esmaeili, H. A., Rajbai, O., and Hosseinzadeh, H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15(12):1032-1037. PubMed
  10. Imenshahidi, M., Hosseinzadeh, H., and Javadpour, Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother.Res 12-9-2009;
  11. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol.Pharm Bull. 1994;17(2):217-221. PubMed
  12. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
  13. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and plac
  14. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial. Ph PubMed
  15. Kianbakht S, Ghazavi A. Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. Phytother Res. 2011 Dec;25(12):1801-5. PubMed
  16. Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J C
  17. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed
  18. Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, Mohajeri SA. Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord. 2 PubMed
  19. Azimi P, Ghiasvand R Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes. Rev Diabet Stud. 2014 Fall-Winter;11(3-4
  20. Begas E, Bounitsi M, Kilindris T, et al. Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food Chem Toxicol. 2019;130:32-43. PubMed
  21. Moravej Aleali A, Amani R, Shahbazian H, Namjooyan F, Latifi SM, Cheraghian B. The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabet
  22. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed

See these in context on the Saffron monograph →

Rhubarb 20 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  6. Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Hong Kong Med J 2006;12:394-7.
  7. Fairbairn JW. The anthraquinone laxatives. Biological assay and its relation to chemical structure. Pharmacology 1976;14:48-61. PubMed
  8. Siegers, C. P., Hertzberg-Lottin, E., Otte, M., and Schneider, B. Anthranoid laxative abuse--a risk for colorectal cancer? Gut 1993;34(8):1099-1101. PubMed
  9. Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380.
  10. Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. J Ethnopharmacol. 4-15-2006; PubMed
  11. Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Chin Med J (Engl.) 1990;103(10):788-793.
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See these in context on the Rhubarb monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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