Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Mental Alertness Ingredients & Drug Interactions

by Woodstock Vitamins

Mental Alertness label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mental Alertness against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Mental Alertness is a dietary supplement by Woodstock Vitamins with 4 active ingredients. Its ingredients are commonly taken for energy and reduced fatigue, focus and mental alertness, mood support.Based on those ingredients, 539 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magtein, TeaCrine, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mental Alertness by Woodstock Vitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with Mental Alertness by Woodstock Vitamins — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mental Alertness by Woodstock Vitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Mental Alertness contains four active ingredients: TeaCrine (theacrine), Vitamin B12, Magtein (a form of magnesium), and magnesium. These are paired with inactive ingredients including hypromellose, microcrystalline cellulose, ascorbyl palmitate, silica, medium chain triglyceride oil, and calcium silicate, which serve as capsule material and binders.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Mental alertness and cognitive support.
  • We looked for evidence on: Mental alertness, Attention, Cognitive function, Cognitive impairment, Age-related cognitive decline, Fatigue — and 3 related terms.
  • The closest evidence on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Cognitive impairment.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Fatigue, Attention.

The evidence supporting these ingredients for mental alertness and cognitive function isn't well established yet. For theacrine, there's insufficient reliable evidence to rate its effects on athletic performance, cognitive function, fatigue, mental alertness, or muscle strength.

Vitamin B12 is effective for treating B12 deficiency itself and is likely effective for cyanide poisoning, but evidence for its role in boosting alertness in people without a deficiency isn't in our data. Magnesium is effective for indigestion and constipation and has been shown to help prevent pre-eclampsia in pregnancy, but again, there's no established evidence here for cognitive benefits in healthy adults.

The evidence, ingredient by ingredient Theacrine Vitamin B12 Magnesium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Theacrine appears generally well tolerated in short-term studies, but long-term safety hasn't been established. Magnesium is generally well tolerated at recommended amounts, though it can cause diarrhea, nausea, vomiting, or gastrointestinal irritation when taken by mouth.

Vitamin B12 is very safe—excess amounts are removed in your urine, and there's no established upper limit. For pregnancy, theacrine has not enough safety data, so avoid use.

Magnesium is needed in pregnancy but should only be used under your doctor's guidance. Vitamin B12 is considered safe at recommended amounts during pregnancy and is important during breastfeeding.

For breastfeeding, avoid theacrine due to insufficient safety data, check with your doctor before using magnesium supplements, and vitamin B12 at normal recommended amounts is considered safe.

Side effects, ingredient by ingredient Theacrine Vitamin B12 Magnesium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Vitamin B12, Magnesium, Theacrine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 539 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take levodopa/carbidopa for Parkinson's disease (Major interaction—the magnesium may drastically reduce how well it works). Also double-check skeletal muscle relaxants, potassium-sparing water pills, blood pressure medications called calcium channel blockers, acid-reducing medications, diabetes drugs called sulfonylureas, quinolone antibiotics, and bisphosphonate bone medications (all Moderate).

If you take metformin for diabetes, note that vitamin B12 may be affected (Minor). And check any sedating or pain medications, since theacrine may theoretically interact.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may appeal to you if you're looking for support with mental alertness, but the evidence for these ingredients hasn't been firmly established in our data. If you take any prescription medication—especially for Parkinson's disease, muscle relaxation, blood pressure, diabetes, or acid reflux—check your specific drugs with the tool on this page before starting.

Talk to your pharmacist to see if Mental Alertness fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mental Alertness, straight from the product label.

Brand Woodstock Vitamins
Barcode (UPC) 669439835975
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 310276
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mental Alertness by Woodstock Vitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
669439835975
IngredientAmount% DV
TeaCrine200 mg--
Vitamin B122000 mcg83333%
Magtein1 Gram(s)--
Magnesium70 mg17%

Other ingredients: Hypromellose, Water, Microcrystalline Cellulose, Ascorbyl Palmitate, Silica, Medium Chain Triglyceride Oil, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Begin with two capsules daily to determine response. Increase to a maximum of two capsules twice daily, or take as directed by your healthcare practitioner.

Precautions

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Consult your healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Storage: Keep closed in a cool dry place out of reach of children.

Formula

Mental Alertness provides a unique blend of patented, stimulant-free, non-habit-forming ingredients. Methylcobalamin supports cognition and contributes to healthy energy metabolism; magnesium L-threonate supplies highly bioavailable magnesium to the brain, which is vital to cognitive function; and theacrine promotes mental and physical energy, focus, and motivation.

Support for clarity and motivation with Magtein

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool dry place out of reach of children.

Formulation

Does not contain: Wheat, gluten, yeast, corn, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Manufactured in a GMP compliant facility.

Vegetarian Caps

Brand IP Statement(s)

MecobalActive is a trademark of Ferrer Health tech. Magtein is protected under US patents 8,178,118; 8,142,803; 8,163,301; and other pending patents. Teacrine is a registered trademark and is protected by Patents Pending, Serial no. 61/903,362; under exclusive global distribution by Compound Solutions, Inc.

General Statements

This package is completely recyclable

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mental Alertness by Woodstock Vitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mental Alertness label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mental Alertness by Woodstock Vitamins

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

TeaCrine

Interacts with
248 drugs
200 mg per serving Form: Theacrine

Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood. Early human studie...

TeaCrine monograph & interactions

Vitamin B12

Interacts with
20 drugs
2000 mcg per serving Form: Mecobalactive

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Magtein

Interacts with
295 drugs
1 Gram(s) per serving Form: Magnesium L-Threonate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magtein monograph & interactions

Magnesium

Interacts with
295 drugs
70 mg per serving Form: Magtein Magnesium L-Threonate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Other (inactive) ingredients: Hypromellose, Water, Microcrystalline Cellulose, Ascorbyl Palmitate, Silica, Medium Chain Triglyceride Oil, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mental Alertness by Woodstock Vitamins Drug Interactions

Want to check YOUR meds against Mental Alertness?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
539Drugs
6 Major 418 Moderate 115 Minor

Ingredients driving the most interactions

Magtein 295
TeaCrine 248
Vitamin B12 20

Individual Drug Interactions

The ingredients in Mental Alertness interact with 539 drugs. Click any drug to see the details.

3 of the 4 ingredients in Mental Alertness interact with drugs. Each result below shows which ingredient is responsible. Magtein TeaCrine Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Mental Alertness with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Magtein15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magtein full monograph & interactions

TeaCrine1 drug type · 248 drugs

Cns Depressants

Theoretically, theacrine might alter the effects of CNS depressants.
Animal research shows that low doses of theacrine have sedating effects, whereas high doses might have stimulant effects. Depending on the dose of theacrine used, it might increase or decrease the effects of CNS depressants. However, these effects have not yet been reported in humans.

Likelihood Possible Evidence D
TeaCrine full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mental Alertness, from the product label.

Woodstock Vitamins

See all Woodstock Vitamins products
Name
Village Vitality LLC
Street Address
79 Tinker Street Fl 2
City
Woodstock
State
NY
ZipCode
12498
Phone Number
(845) 521-7455
Web Address
www.WoodstockVitamins.com
Pharmacist Counseling Corner

Mental Alertness by Woodstock Vitamins: Common Questions

Does Mental Alertness by Woodstock Vitamins interact with any medications?
Yes. Based on its ingredients, Mental Alertness has a known interaction with 539 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mental Alertness contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually help with mental alertness?
The evidence in our data doesn't yet support that theacrine, B12, or magnesium boost alertness in healthy people. All three ingredients show insufficient reliable evidence for cognitive function and mental alertness, so we can't tell you whether it works for that purpose.
Is it safe to take if I'm pregnant?
Theacrine should be avoided—there isn't enough safety data. Magnesium is actually needed in pregnancy, but only use supplements under your doctor's guidance. Vitamin B12 is considered safe at recommended amounts. Talk to your doctor about whether this product is right for you.
Can I take this while breastfeeding?
Theacrine should be avoided due to insufficient safety data. Magnesium at normal dietary amounts is fine, but check with your doctor before taking supplements. Vitamin B12 at recommended amounts is considered safe and is actually important during breastfeeding.
What's TeaCrine, and why is it in here?
TeaCrine is theacrine, a compound related to caffeine that's used in some energy and alertness products. Short-term studies show it's generally well tolerated, but we don't have solid evidence yet that it actually boosts alertness or mental performance.
Why does this product have two forms of magnesium?
The product contains both Magtein and magnesium. Both forms can interact with the same medications, so the interactions you need to watch for are essentially the same. If you take any of the medications listed in our med watch section, you'll want to space them apart from this product.
Can magnesium in this product cause diarrhea?
Yes—diarrhea, nausea, vomiting, and gastrointestinal irritation are the most common side effects of magnesium taken by mouth. If you're sensitive to these, this product may not be for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mental Alertness label
Go deeper

The Full Monographs Behind Mental Alertness’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theacrine

Interacts with 248 drugs

Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood. Early human studies suggest it may give a stimulant-like b...

Read the full Theacrine monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph →
Sources

Sources & How We Checked

Mental Alertness's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 113 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theacrine 1 reference
  1. Xu JK, Kurihara H, Zhao L, Yao XS. Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice. J Asian Nat Prod Res 2007;9(6-8):665-72.

See these in context on the Theacrine monograph →

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
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See these in context on the Vitamin B12 monograph →

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See these in context on the Magnesium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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