Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Mito Keto Ingredients & Drug Interactions

by Chief Originals

Mito Keto label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mito Keto against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mito Keto is a dietary supplement by Chief Originals with 5 active ingredients. Its ingredients are commonly taken for brain and cognitive health, eye and vision health, fetal and infant development.Based on those ingredients, 912 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nature-fresh cold pressed organic Black Cumin, Omega-3 Fatty Acids. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mito Keto by Chief Originals

Ask about any prescription or over-the-counter medication and we check it for interactions with Mito Keto by Chief Originals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mito Keto by Chief Originals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 7 active ingredients.
  • “Essential Fatty Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Mito Keto is a 7-ingredient liquid formula built around omega fatty acids and plant oils. The active ingredients are omega-3 fatty acids (primarily DHA), omega-6 fatty acids, omega-9 fatty acids, polyunsaturated and monounsaturated fats, black raspberry seed oils, and black cumin—a blend designed to deliver multiple types of healthy fats.

The product also contains natural vanilla flavoring as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“antioxidant support and overall health”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Acne — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Asthma — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Chronic obstructive pulmonary disease (COPD) — rated "Possibly Effective" (Black Seed) (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Black Seed) (Natural Medicines).

The evidence for this product's ingredients is mixed. DHA (from the omega-3 content) is possibly effective for preterm labor prevention and for lowering cholesterol (hyperlipidemia), but possibly ineffective for cognitive function and ADHD.

Omega-6 fatty acids show no clear benefit in our data—they're rated possibly ineffective for cholesterol, heart disease, and multiple sclerosis. Black cumin is possibly effective for acne, hay fever, asthma, and diabetes, and it may help with H. pylori infection.

Black raspberry seed oils lack enough reliable evidence to rate their effectiveness for any condition listed. Overall, the strongest evidence here supports DHA for cholesterol and black cumin for a few inflammatory and metabolic conditions.

The evidence, ingredient by ingredient Docosahexaenoic Acid (dha) Omega-6 Fatty Acids Black Raspberry Black Seed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DHA is generally well tolerated at typical supplement doses. The most common side effects are belching, fishy aftertaste, loose stools, and nausea; serious bleeding is rare but possible at very high doses.

DHA is considered likely safe in pregnancy when you choose a purified, low-mercury source and do so under your doctor's guidance, and it passes into breast milk in amounts that are generally considered acceptable—talk with your doctor about the dose and source if you're nursing. Black cumin is likely safe in food amounts, but supplement doses are less well studied long-term; gastrointestinal upset (nausea, vomiting, constipation, burning sensation) is the most common complaint, and one case of heavier-than-normal menstrual bleeding has been reported.

The safety notes advise against black cumin supplements in pregnancy due to insufficient data, and there isn't enough information to recommend it during breastfeeding. Black raspberry seed oils are likely safe as a food but are less studied in concentrated supplement form.

Omega-6 from food is fine, but concentrated supplements of omega-6 lack well-established long-term safety data.

Side effects, ingredient by ingredient Docosahexaenoic Acid (dha) Omega-6 Fatty Acids Black Raspberry Black Seed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Docosahexaenoic Acid (dha), Black Seed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 912 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Mito Keto, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants or antiplatelet drugs like warfarin or aspirin), blood pressure medications (antihypertensives), diabetes medications, sedating drugs, psychiatric medications that work on serotonin, diuretics, immunosuppressants, or cyclosporine. The black cumin and DHA in this product can interact with all of these at moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Mito Keto is a liquid fat blend best suited for people looking for omega-3 and antioxidant support, with the strongest evidence behind DHA for cholesterol and black cumin for hay fever, asthma, and inflammation. If you take blood pressure medication, blood thinners, diabetes drugs, or psychiatric medications, you'll need to clear this product with your own doctor or pharmacist first—the interactions are real and can shift how your drugs work.

Talk it over with them before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mito Keto, straight from the product label.

Brand Chief Originals
Barcode (UPC) 050742584047
Net contents 2 Fluid Ounce(s); 59 mL
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 229089
Product type Botanical
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mito Keto by Chief Originals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.5 mL
Maximum serving Sizes:
2.5 mL
Servings per container
23
UPC/BARCODE
050742584047
IngredientAmount% DV
Calories17 Calorie(s)--
Omega-3 Fatty Acids330 mg--
Trans Fat0 Gram(s)--
Total Fat1.87 Gram(s)3%
Polyunsaturated Fat1.34 Gram(s)--
Monounsaturated Fat0.34 Gram(s)--
Omega-6 Fatty Acids1010 mg--
Omega-9 Fatty Acids320 mg--
Saturated Fat0.19 Gram(s)1%
Essential Fatty Acids0 NP--
Black Raspberry seed oils0 NP--
Nature-fresh cold pressed organic Black Cumin0 NP--

Other ingredients: natural Vanilla flavoring

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Chief Originals Mito Keto is a specially formulated oil blend that’s packed with powerful antioxidants to support your overall health. It combines black raspberry seed oil, organic black cumin seed oil, and natural vanilla flavoring to deliver beneficial nutrients such as thymoquinone, vitamin E, omega-3 and -6 Alpha Linolenic Acids (ALA), and other fatty acids. Our potent formula is cold-pressed to retain maximum nutrition and it has a characteristic aroma with vanilla and citrus notes.

It is vegan, non-GMO, non-China and Kosher, and is lab tested for glyphosate, heavy metals and microbiology.

Formulation

Our potent formula is cold-pressed to retain maximum nutrition and it has a characteristic aroma with vanilla and citrus notes. It is vegan, non-GMO, non-China and Kosher, and is lab tested for glyphosate, heavy metals and microbiology.

It is vegan, non-GMO, non-China and Kosher, and is lab tested for glyphosate, heavy metals and microbiology.

Core Immune Support Essentials

Glyphosate tested Laboratory verified GMO Guard Natural Food Certifiers Apple K Natural Food Certifiers (Kosher)

Seals/Symbols

GMO Guard Natural Food Certifiers Apple K Natural Food Certifiers (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mito Keto by Chief Originals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mito Keto label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mito Keto by Chief Originals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.5 mL Dosage formLiquid Servings per container23 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Essential Fatty Acids

0 NP per serving

Black Raspberry seed oils

No known
interactions
0 NP per serving

Black raspberry is a nutrient-rich fruit packed with antioxidants like anthocyanins and ellagic acid, and as a food it is generally safe and healthy....

Black Raspberry seed oils monograph & interactions

Nature-fresh cold pressed organic Black Cumin

Interacts with
912 drugs
0 NP per serving

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with ear...

Nature-fresh cold pressed organic Black Cumin monograph & interactions

Other (inactive) ingredients: Natural Vanilla flavoring. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mito Keto by Chief Originals Drug Interactions

Want to check YOUR meds against Mito Keto?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
912Drugs
912 Moderate

Ingredients driving the most interactions

Nature-fresh cold pressed organic Black Cumin 912
Omega-3 Fatty Acids 375

Individual Drug Interactions

The ingredients in Mito Keto interact with 912 drugs. Click any drug to see the details.

2 of the 5 ingredients in Mito Keto interact with drugs. Each result below shows which ingredient is responsible. Nature-fresh cold pressed organic Black Cumin Omega-3 Fatty Acids

Each ingredient & the kinds of drugs it affects

For each ingredient in Mito Keto with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Nature-fresh cold pressed organic Black Cumin14 drug types · 912 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Prednisolone

Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.

Likelihood Possible Evidence D
Nature-fresh cold pressed organic Black Cumin full monograph & interactions

Omega-3 Fatty Acids3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
In people with type 2 diabetes, including those taking oral hypoglycemic medications, DHA seems to increase fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B
Omega-3 Fatty Acids full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mito Keto, from the product label.

Chief Originals

See all Chief Originals products
Name
Chief Originals LLC
Street Address
3820 Central Ave. Unit #109
City
Cheyenne
State
WY
ZipCode
82001
Phone Number
1-888-959-6415
Web Address
chieforiginals.com
Pharmacist Counseling Corner

Mito Keto by Chief Originals: Common Questions

Does Mito Keto by Chief Originals interact with any medications?
Yes. Based on its ingredients, Mito Keto has a known interaction with 912 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mito Keto contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant?
The omega-3 (DHA) content is considered likely safe in pregnancy when you use a purified, low-mercury source and do so under your doctor's guidance. However, the black cumin in this product is rated likely unsafe in pregnancy, so you should not take this formula while pregnant. Talk with your doctor about whether a DHA supplement alone might work for you instead.
What's the fishy aftertaste I might get?
That's a common side effect of DHA and fish oil supplements—belching, fishy aftertaste, loose stools, and nausea are the most frequent complaints people report. These usually settle down if you keep taking it, but if they bother you, talk with your pharmacist about timing or form options.
Will this help my cholesterol?
DHA is rated possibly effective for lowering cholesterol (hyperlipidemia), so there's some evidence it may help. However, this product also contains omega-6 fatty acids, which are rated possibly ineffective for cholesterol in our data. If cholesterol is your main goal, ask your doctor whether a DHA-focused supplement might be a better fit.
Does black cumin really work for asthma or hay fever?
Black cumin is rated possibly effective for both hay fever and asthma, so there's evidence supporting its use for these conditions. It's also possibly effective for acne and diabetes. However, remember that 'possibly effective' means the evidence exists but isn't yet strong, so results can vary from person to person.
What about side effects from the black cumin?
The most common side effects are gastrointestinal—nausea, vomiting, constipation, and a burning sensation in the stomach. One case of heavier menstrual bleeding has been reported. Black cumin is generally well tolerated, but if you have a sensitive stomach, start with a small amount and see how you do.
Can I take this while breastfeeding?
DHA passes into breast milk in amounts generally considered acceptable, but check with your doctor on the dose and source. We don't have enough safety information on file for black cumin during lactation, so ask your doctor or pharmacist whether this product is right for you if you're nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mito Keto label
Go deeper

The Full Monographs Behind Mito Keto’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Docosahexaenoic Acid (dha)

Interacts with 375 drugs

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the stronges...

Read the full Docosahexaenoic Acid (dha) monograph → Herb & supplement monograph

Omega-6 Fatty Acids

Omega-6 fatty acids are essential fats your body needs but cannot make on its own, and most people get plenty from everyday foods like vegetable oils, nuts, and seeds. Supplements such as ev...

Read the full Omega-6 Fatty Acids monograph → Herb & supplement monograph

Black Raspberry

Black raspberry is a nutrient-rich fruit packed with antioxidants like anthocyanins and ellagic acid, and as a food it is generally safe and healthy. Some early research explores it for canc...

Read the full Black Raspberry monograph → Herb & supplement monograph

Black Seed

Interacts with 912 drugs

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...

Read the full Black Seed monograph →
Sources

Sources & How We Checked

Mito Keto's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 133 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Docosahexaenoic Acid (dha) 49 references
  1. Akedo I, Ishikawa H, Nakamura T, et al. Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules (abstract). Jpn J Clin Oncol PubMed
  2. Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
  3. Grimsgaard S, Bonaa KH, Hansen JB, Nordoy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr 1997;66:649-59.
  4. Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
  5. Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
  6. Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
  7. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
  8. Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed
  9. Ito Y, Suzuki K, Imai H, et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. Cancer Lett 2001;163:171-8. PubMed
  10. Kris-Ehterton PM, Harris WS, Appel LJ, et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-57. PubMed
  11. Woodman RJ, Mori TA, Burke V, et al. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr 2002;76:1007-15.. PubMed
  12. Marangell LB, Martinez JM, Zboyan HA, et al. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003;160:996-8.. PubMed
  13. Leng GC, Smith FB, Fowkes FG, et al. Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors. Prostaglandins Leukot Essent Fatty Acids 1994;51:101-8. PubMed
  14. Nelson GJ, Schmidt PS, Bartolini GL, et al. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids 1997;32:1129-36. PubMed
  15. Wheaton DH, Hoffman DR, Locke KG, et al. Biological safety assessment of docosahexaenoic acid supplementation in a randomized clinical trial for X-linked retinitis pigmentosa. Arch Ophthalmol 2003;121:1269-78. PubMed
  16. Malcolm CA, McCulloch DL, Montgomery C, et al. Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial. Arch Dis Child Fetal Neonatal Ed 2003;88: DOI
  17. Sanjurjo P, Ruiz-Sanz JI, Jimeno P, et al. Supplementation with docosahexaenoic acid in the last trimester of pregnancy: maternal-fetal biochemical findings. J Perinat Med 2004;32:132-6.
  18. Montgomery C, Speake BK, Cameron A, et al. Maternal docosahexaenoic acid supplementation and fetal accretion. Br J Nutr 2003;90:135-45. DOI
  19. Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Pediatr Res 2005;58:235-42. PubMed
  20. Hawkes JS, Bryan DL, Makrides M, et al. A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. Am J Clin Nutr 2002;75:75
  21. Uauy R, Hoffman DR, Mena P, et al. Term infant studies of DHA and ARA supplementation on neurodevelopment: Results of randomized controlled trials. J Pediatr 2003;143:S17-25. PubMed
  22. Decsi, T., Campoy, C., and Koletzko, B. Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial. Adv.Exp Med Biol 2005;569:109-113. PubMed
  23. Mori, T. A., Bao, D. Q., Burke, V., Puddey, I. B., and Beilin, L. J. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 1999;34(2):253-260. PubMed
  24. Otto, S. J., van Houwelingen, A. C., and Hornstra, G. The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. Prostaglandins Le PubMed
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Omega-6 Fatty Acids 20 references
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Black Raspberry 4 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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