Major interaction on record — check this product against your medications before combining. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

N'SANE Ingredients & Drug Interactions

by CellShock Research

N'SANE label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking N'SANE against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

N'SANE is a dietary supplement by CellShock Research with 4 active ingredients. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 1,367 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against N'SANE by CellShock Research

Ask about any prescription or over-the-counter medication and we check it for interactions with N'SANE by CellShock Research — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of N'SANE by CellShock Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 15 active ingredients.
  • “N'SANE Proprietary Blend” is a proprietary blend — the label gives one combined amount (5.42 Gram(s)) without saying how much of each component you get.
  • “Complex 1” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Complex 2” is a proprietary blend — the label doesn't break down how much of each component you get.

N'SANE is a 15-ingredient powder containing a mix of amino acids, vitamins, minerals, and herbal extracts. The active ingredients include thiamine (a B vitamin), L-histidine, caffeine anhydrous, L-tyrosine, vanadyl sulfate, yohimbe bark, creatine (as Kre-Alkalyn), L-arginine, and alpha-lipoic acid, along with evodiamine, phenylethylamine HCl, AKG, and glycine propionyl-L-carnitine (GlycoCarn) in proprietary blends.

Bitter orange extract (Advantra Z) rounds out the active list. The product also contains several inactive ingredients — silica, maltodextrin, natural and artificial flavors, citric acid, sodium citrate, sucralose, malic acid, and purple carrot — which serve as fillers, binders, and flavorings.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: High-energy pre-workout formula for athletic performance.
  • We looked for evidence on: Athletic performance, Muscle strength and endurance, Exercise performance, Workout recovery.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance.

Evidence of effectiveness is mixed and varies by ingredient. Thiamine is effective for thiamine deficiency and Wernicke-Korsakoff syndrome (a brain condition from severe deficiency); it is possibly effective for period pain but possibly ineffective as a mosquito repellent or for heart failure.

Caffeine is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance. Creatine (Kre-Alkalyn) is possibly effective for muscle strength and athletic performance but possibly ineffective for Huntington disease and bone loss.

Alpha-lipoic acid is possibly effective for diabetic nerve damage, high cholesterol, and obesity. For several other active ingredients — L-histidine, L-tyrosine, vanadyl sulfate, yohimbe, L-arginine, and bitter orange — the evidence we hold is insufficient to rate their effectiveness for the conditions studied, or the ratings are not established in our data.

The proprietary blends and some individual ingredients (Evodiamine, Phenylethylamine HCl, AKG, GlycoCarn) also lack effectiveness data in our monographs.

The evidence, ingredient by ingredient Thiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 11 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 11 of 11.
  • General safety write-ups exist for 11 of 11.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated in healthy adults, though some carry cautions. Thiamine is safe in normal amounts and needed during pregnancy and breastfeeding — use supplement doses only as your provider advises.

Caffeine is generally safe in moderate doses but can cause anxiety, insomnia, tremors, and nausea; high doses are risky, and pregnant or breastfeeding people should limit intake and check with their doctor. Beta-alanine (CarnoSyn) is well tolerated but commonly causes harmless tingling and skin flushing, and is best avoided in pregnancy and while breastfeeding.

Yohimbe carries significant safety concerns — it can cause serious heart and blood pressure effects, and supplement potency is unpredictable; it is unsafe in pregnancy and breastfeeding. Vanadyl sulfate is generally well tolerated below 1.8 mg daily but can cause stomach upset, diarrhea, and nausea at higher doses, with rare kidney damage at very high long-term doses; avoid in pregnancy and breastfeeding.

Bitter orange may raise heart rate and blood pressure, especially with caffeine or other stimulants, and is possibly unsafe in pregnancy. L-arginine and alpha-lipoic acid should be used under medical supervision and are best avoided in pregnancy and breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Thiamine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 8 of the 11 matched ingredients can interact with medications — Vanadium, Yohimbe, Alpha-lipoic Acid, L-arginine, Thiamine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,368 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking N'SANE, double-check these medication types with your pharmacist: monoamine oxidase inhibitors (MAOIs) — yohimbe and bitter orange both carry Major-severity risk; ephedrine — caffeine has a Major interaction; midazolam and other sedatives — bitter orange may raise levels to unsafe degrees. Also check antihypertensive (blood pressure) drugs, anticoagulants and antiplatelets (blood thinners), antidiabetes drugs, seizure medications, tricyclic antidepressants, antipsychotics, stimulant drugs, thyroid hormone, liver-metabolized drugs, and any heart medications.

If no interactions are documented for an ingredient we could check, we note that plainly — but absence of documented data is not proof none exist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

N'SANE is a multi-ingredient stimulant and workout supplement aimed at athletic performance and mental focus. If you take any prescription medications — especially blood pressure drugs, antidepressants, seizure drugs, sleep aids, diabetes medications, blood thinners, or heart drugs — you need to check your specific medications against this product's ingredient list before starting.

The presence of yohimbe, bitter orange, and caffeine together creates a potent and potentially risky stimulant combination; talk with your pharmacist about whether this product is right for you, particularly if you have high blood pressure, heart issues, or anxiety.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about N'SANE, straight from the product label.

Brand CellShock Research
Net contents 0 Not Present
Market status On market
Date entered into DSLD Sep 24, 2019
DSLD ID 206777
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for N'SANE by CellShock Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7.6 Gram(s)
Maximum serving Sizes:
7.6 Gram(s)
Servings per container
40
IngredientAmount% DV
Thiamine10 mg667%
L-Histidine0 NP--
Caffeine Anhydrous0 NP--
Evodiamine0 NP--
CarnoSyn0 NP--
Tyrosine0 NP--
Vanadyl Sulfate0 NP--
Phenylethylamine HCl0 NP--
Yohimbe HCl0 NP--
AKG0 NP--
Kre-Alkalyn0 NP--
L-Arginine AKG0 NP--
DL-6,8-Thioctic Acid0 NP--
N'SANE Proprietary Blend5.42 Gram(s)--
Complex 10 NP--
GlycoCarn (GPLC) Glycine Propionyl-L-Carnitine HCl0 NP--
Complex 20 NP--
Complex 30 NP--
Advantra Z Bitter Orange (Citrus aurantium) extract0 NP--

Other ingredients: Silica, Maltodextrin, Natural & Artificial flavors, Citric Acid, Sodium Citrate, Sucralose, Malic Acid, Purple Carrot

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

A hard-hitting, high-energy, pre-workout formula utilizing L-Arginine AKG (2:1), GlycoCarn (GPLC) Glycine Propionyl-L-Carnitine HCl, USP, CarnoSyn Beta-Alanine, Kre-Alkalyn (buffered creatine monohydrate) and other sought after pre-workout ingredients. This formula is designed to push you to your limits in the gym and is not intended for beginners!

CarnoSyn Carnosine Synthesizer Advantra Z

General Statements

Available in: Mixed berry Sour apple Tangy orange

Suggested/Recommended/Usage/Directions

Stacks well with: N'JECT N'FUZE HGH-191 ARABOL

Brand IP Statement(s)

Natural Alternatives International (NAI) is the owner of patents as listed on www.carnosyn.com and registered trademark CarnoSyn. GlycoCarn is a registered trademark of Sigma-tau Health Science and is manufactured under USA patent #6703042 and worldwide patent #EP1202956. Kre-Alkalyn is a registered trademark of Bioceutical Research & Development Laboratory. Kre-Alkalyn is a patented product (Patent #6,399,661) registered to Bioceutical Research & Development. Advantra is a registered trademark of Nutratech, Inc., under U.S. Patents 6,224,873; 6,316,499; 6,340,482.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

N'SANE by CellShock Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

N'SANE label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in N'SANE by CellShock Research

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size7.6 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Thiamine

Interacts with
3 drugs
10 mg per serving Form: Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

N'SANE Proprietary Blend

5.42 Gram(s) per serving
  • › Complex 1
  • › Complex 2
  • › Complex 3

Other (inactive) ingredients: Silica, Maltodextrin, Natural & Artificial flavors, Citric Acid, Sodium Citrate, Sucralose, Malic Acid, Purple Carrot. These complete the product’s ingredient list but are not active constituents.

Interaction report

N'SANE by CellShock Research Drug Interactions

Want to check YOUR meds against N'SANE?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,367Drugs
18 Major 1,320 Moderate 29 Minor

Ingredients driving the most interactions

Thiamine 3

Individual Drug Interactions

The ingredients in N'SANE interact with 1,367 drugs. Click any drug to see the details.

1 of the 4 ingredients in N'SANE interact with drugs. Each result below shows which ingredient is responsible. Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in N'SANE with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for N'SANE, from the product label.

CellShock Research

See all CellShock Research products
Name
CellShock Research
Pharmacist Counseling Corner

N'SANE by CellShock Research: Common Questions

Does N'SANE by CellShock Research interact with any medications?
Yes. Based on its ingredients, N'SANE has a known interaction with 1,367 medications, including 18 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
N'SANE contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's caffeine anhydrous and how much is in N'SANE?
Caffeine anhydrous is powdered caffeine without water — it's the form commonly used in supplements and pre-workout powders. The product facts don't specify the exact amount per serving, so check the label or contact the manufacturer for dosing details.
I'm taking an SSRI antidepressant. Can I use this product?
Don't start without checking first. Yohimbe in N'SANE interacts with tricyclic antidepressants and can cause severe anxiety, agitation, and tremor. SSRIs may carry different risks, but the combination of yohimbe, bitter orange, and caffeine — all stimulants — makes this risky. Talk to your pharmacist or doctor before using.
What is beta-alanine (CarnoSyn) and will it cause side effects?
Beta-alanine is an amino acid studied for athletic performance. It commonly causes harmless tingling and flushing, especially on the scalp and face, usually starting within 20 minutes and lasting about an hour. These effects are dose-dependent and decrease at lower doses.
Is N'SANE safe to use while pregnant or breastfeeding?
No. Several key ingredients — beta-alanine, vanadyl sulfate, yohimbe, and bitter orange — carry safety data advising against use during pregnancy and breastfeeding. Caffeine should be limited in pregnancy and passes into breast milk. Talk to your doctor or pharmacist for personalized guidance.
Why does the product have so many ingredients, and will they all work together?
N'SANE combines stimulants (caffeine, yohimbe, bitter orange), amino acids for muscle and brain support (tyrosine, arginine, beta-alanine), and minerals and antioxidants (creatine, vanadium, alpha-lipoic acid) targeting energy, focus, and athletic performance. The proprietary blends mean exact doses aren't fully transparent — check the label for the full breakdown.
I'm taking a blood thinner for my heart. Is N'SANE safe?
Probably not without checking first. Several ingredients — vanadyl sulfate, L-arginine, and alpha-lipoic acid — theoretically increase bleeding risk when combined with blood thinners. Run your specific medication and dose through the checker on this page, and talk to your pharmacist or doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if N'SANE is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

N'SANE label
Go deeper

The Full Monographs Behind N'SANE’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph →
Sources

Sources & How We Checked

N'SANE's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 591 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Caffeine 236 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  3. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  4. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  5. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
  6. Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
  7. Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
  8. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  9. Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. PubMed
  10. Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. PubMed
  11. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. PubMed
  12. The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.
  13. Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med 1999;341:1639-44. PubMed
  14. Eskenazi B. Caffeine—filtering the facts. N Engl J Med 1999;341:1688-9. PubMed
  15. Fernandes O, Sabharwal M, Smiley T, et al. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol 1998;12:435-44. PubMed
  16. Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. PubMed
  17. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. PubMed
  18. Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. PubMed
  19. FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).
  20. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  21. Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. PubMed
  22. Tobias JD. Caffeine in the treatment of apnea associated with respiratory syncytial virus infection in neonates and infants. South Med J 2000;93:297-304. DOI
  23. Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. PubMed
  24. Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. PubMed
  25. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. PubMed
  26. Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9.
  27. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. PubMed
  28. Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13. PubMed
  29. Ardlie NG, Glew G, Schultz BG, Schwartz CJ. Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 1967;18:670-3. DOI
  30. Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. PubMed
  31. Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother 2002;36:992-5.. PubMed
  32. Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. PubMed
  33. Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. PubMed
  34. Bracken MB, Triche EW, Belanger K, et al. Association of maternal caffeine consumption with decrements in fetal growth. Am J Epidemiol 2003;157:456-66.. PubMed
  35. McGowan JD, Altman RE, Kanto WP Jr. Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. South Med J 1988;81:1092-4.. PubMed
  36. Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. PubMed
  37. Dreher HM. The effect of caffeine reduction on sleep quality and well-being in persons with HIV. J Psychosom Res 2003;54:191-8.. PubMed
  38. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  39. Schechter MD, Timmons GD. Objectively measured hyperactivity--II. Caffeine and amphetamine effects. J Clin Pharmacol 1985;25:276-80.. PubMed
  40. Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183. DOI
  41. Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2. PubMed
  42. Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4. PubMed
  43. Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam 2003;20:1-30. PubMed
  44. May DC, Jarboe CH, VanBakel AB, Williams WM. Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther 1982;31:656-61. PubMed
  45. Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985;28:425-8. PubMed
  46. Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. PubMed
  47. Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72. DOI
  48. Wahllander A, Paumgartner G. Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers. Eur J Clin Pharmacol 1989;37:279-83. PubMed
  49. Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53. PubMed
  50. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
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Alpha-lipoic Acid 48 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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