Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Nature's Noni Juice Natural Noni Flavor Ingredients & Drug Interactions

by Nature's Sunshine

Nature's Noni Juice Natural Noni Flavor label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nature's Noni Juice Natural Noni Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nature's Noni Juice Natural Noni Flavor is a dietary supplement by Nature's Sunshine with 4 active ingredients. Its ingredients are commonly taken for antioxidant support, heart and circulation health, vein problems (such as varicose veins).Based on those ingredients, 1,183 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape skin extract, Reconstituted Morinda. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (31 Gram(s)) without saying how much of each component you get.

This product contains 4 active ingredients: grape skin extract, pear fruit juice concentrate, grape fruit juice concentrate, and reconstituted noni (Morinda). The grape and noni are the primary active components; pear contributes juice and minor active compounds.

They're mixed into a liquid formulation, with malic acid, tartaric acid, citric acid, and ascorbic acid added as inactive ingredients for flavor and preservation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support immune and joint health.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Joint inflammation, General immunity.
  • The closest evidence on file: Noni is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis (Natural Medicines).
  • Also on file: Noni is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA).

For grape skin extract, the data shows it's possibly effective for chronic venous insufficiency (heaviness and swelling in the legs from poor circulation), but possibly ineffective for chemotherapy-related nausea, hay fever, and weight loss. Pear fruit juice concentrate's effectiveness is not established in the data we hold—the evidence for athletic performance, weight loss, and hangover relief rates as insufficient.

For noni, the data we hold shows insufficient evidence to rate it for asthma, atherosclerosis, athletic performance, burns, cancer, or heart disease. None of these ingredients have strong evidence backing their use for their marketed purposes in this product.

The evidence, ingredient by ingredient Grape Pear Noni

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Grape skin extract and pear fruit juice concentrate are generally well tolerated when used as food. The most common side effects from grape are abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea; anaphylaxis to grape skin is rare but has been reported.

Noni is also generally well tolerated in moderate amounts, but the most common side effects are abdominal discomfort and nausea. Rare serious risks include liver damage with noni—cases of hepatotoxicity have been documented, though it's unclear whether noni itself or contaminants were responsible.

During pregnancy, concentrated grape supplements and wine should be avoided due to limited safety data; grapes as food are fine. Noni should be avoided entirely during pregnancy—it was traditionally used to cause abortion.

For breastfeeding, eating grape or pear as food is considered safe, but concentrated supplements aren't well studied; noni is best avoided while nursing. Talk with your doctor or pharmacist about whether this product fits your situation.

Side effects, ingredient by ingredient Grape Pear Noni

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Grape, Noni.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 1,184 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this juice, double-check with your doctor or pharmacist if you're on blood pressure medications that raise potassium (ACE inhibitors, ARBs, potassium-sparing diuretics), since noni is potassium-rich (Moderate risk). If you take medications broken down by your liver—including many antidepressants, pain relievers, and heart drugs—the grape content may change their levels (Moderate).

Also flag if you're on blood thinners like warfarin or antiplatelet drugs, seizure medication (phenytoin), cyclosporine, midazolam, ranitidine, or any drugs that can damage the liver (Moderate to Minor risks). No interactions are documented for pear fruit juice concentrate among the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medications, potassium-sparing diuretics, blood thinners, seizure drugs, or any liver-metabolized medication, you'll want to clear this juice with your doctor or pharmacist before starting it. The grape and noni content carries real interaction risks worth checking against your specific prescriptions.

If you're pregnant or breastfeeding, avoid it and discuss alternatives with your healthcare provider. For most other people without those concerns, the product is generally well tolerated, though strong evidence for its stated benefits isn't established yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nature's Noni Juice Natural Noni Flavor, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904040427
Net contents 32 Fluid Ounce(s); 1 QT; 946 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278181
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Ounce(s)
Maximum serving Sizes:
1 Ounce(s)
Servings per container
32
UPC/BARCODE
099904040427
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Added Sugars2 Gram(s)4%
Total Sugars3 Gram(s)--
Grape skin extract0 NP--
Proprietary Blend31 Gram(s)--
Pear fruit juice concentrate0 NP--
Grape fruit juice concentrate0 NP--
Reconstituted Morinda0 NP--

Other ingredients: Malic Acid, Tartaric Acid, Citric Acid, Ascorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Commonly known as Hawaiian Noni or Samoan Nonu, these beneficial Morinda citrifolia plants are found in tropical and subtropical regions of the world. Our product is prepared from the finest Polynesian sources of Morinda citrifolia fruit.

Formulation

Historically, the fruit was used to target many systems, especially the immune and structural systems. It is useful for promoting healthy joints.

Structural & immune support Supports joints & digestion Rich in antioxidants

Guaranteed pure

Suggested/Recommended/Usage/Directions

Recommended Use: Adults take two tablespoons (1 ounce) daily, preferably before meals. Shake well before using.

Storage

Refrigerate after opening.

Precautions

Pregnant or lactating women should consult their health care professional prior to taking this supplement.

Do not use if shrink band is missing or damaged.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Please recycle this bottle. We are committed to you and our planet. Scan to learn more. New look! Same great product

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Natures Sunshine Herbal experts since 1972

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nature's Noni Juice Natural Noni Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Ounce(s) Dosage formLiquid Servings per container32 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Malic Acid, Tartaric Acid, Citric Acid, Ascorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Nature's Noni Juice Natural Noni Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,183Drugs
1,165 Moderate 18 Minor

Ingredients driving the most interactions

Grape skin extract 910
Reconstituted Morinda 542

Individual Drug Interactions

The ingredients in Nature's Noni Juice Natural Noni Flavor interact with 1,183 drugs. Click any drug to see the details.

2 of the 4 ingredients in Nature's Noni Juice Natural Noni Flavor interact with drugs. Each result below shows which ingredient is responsible. Grape skin extract Reconstituted Morinda

Each ingredient & the kinds of drugs it affects

For each ingredient in Nature's Noni Juice Natural Noni Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Grape skin extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Grape skin extract full monograph & interactions

Reconstituted Morinda8 drug types · 542 drugs

Ace Inhibitors (Aceis)

Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.

Likelihood Possible Evidence D
Ranitidine (Zantac)

Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.

Likelihood Possible Evidence B
Reconstituted Morinda full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nature's Noni Juice Natural Noni Flavor, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc.
Pharmacist Counseling Corner

Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine: Common Questions

Does Nature's Noni Juice Natural Noni Flavor by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Nature's Noni Juice Natural Noni Flavor has a known interaction with 1,183 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nature's Noni Juice Natural Noni Flavor contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking first. Noni in this juice may reduce how well warfarin works, raising your clot risk. The grape content can also thin your blood slightly. Talk with your doctor or pharmacist before starting—they may need to monitor you more closely or adjust your dose.
Is this safe during pregnancy?
No. Noni should be avoided during pregnancy entirely—it was traditionally used to cause abortion. Concentrated grape supplements also aren't recommended due to limited safety data. Talk with your doctor about safer options.
What are the common side effects?
Most people tolerate it well, but some experience abdominal discomfort, nausea, abdominal pain, diarrhea, dry mouth, indigestion, headache, or joint pain. Rarely, allergic reactions to grape have occurred. Stop and contact your doctor if symptoms are bothersome or you feel the signs of liver trouble (yellowing skin, dark urine, unusual fatigue).
Does this juice actually work for what it's meant to do?
The grape extract may help with chronic venous insufficiency—the heavy, swollen feeling in the legs from poor circulation—based on 'possibly effective' evidence. For other uses, the evidence is either insufficient or suggests it doesn't work. This isn't a proven remedy for general health.
Can I take this if I'm on blood pressure medication?
It depends on which one. Noni may lower your blood pressure further, which could cause dizziness. More importantly, if you're on an ACE inhibitor, ARB, or potassium-sparing diuretic, noni's high potassium content could push your potassium to unsafe levels. Check with your doctor or pharmacist before starting.
Is it safe while breastfeeding?
There isn't enough safety data to know. Pear as food and grapes as food are considered safe while breastfeeding, but concentrated noni supplements aren't well studied. Talk with your doctor or pharmacist about whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nature's Noni Juice Natural Noni Flavor label
Go deeper

The Full Monographs Behind Nature's Noni Juice Natural Noni Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

Pear

Pear is a common, nutritious fruit that provides fiber, water, vitamin C, and antioxidants, and it is a healthy part of most diets. Beyond its value as a food, evidence for pears as a medici...

Read the full Pear monograph → Herb & supplement monograph

Noni

Interacts with 542 drugs

Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...

Read the full Noni monograph →
Sources

Sources & How We Checked

Nature's Noni Juice Natural Noni Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 54 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Grape 34 references
  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
  3. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
  4. Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
  5. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
  6. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
  7. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
  8. Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
  9. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  11. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
  12. de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. PubMed
  13. Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. PubMed
  14. Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. PubMed
  15. de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314 PubMed
  16. Etheridge, A. S., Black, S. R., Patel, P. R., So, J., and Mathews, J. M. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constitu
  17. Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734. PubMed
  18. Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221. PubMed
  19. Oliveira-Freitas, V. L., Dalla, Costa T., Manfro, R. C., Cruz, L. B., and Schwartsmann, G. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr. 2010;20(5):309-313. PubMed
  20. Hollis, J. H., Houchins, J. A., Blumberg, J. B., and Mattes, R. D. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll.Nutr. 2009;28(5):574-582. PubMed
  21. Dohadwala, M. M., Hamburg, N. M., Holbrook, M., Kim, B. H., Duess, M. A., Levit, A., Titas, M., Chung, W. B., Vincent, F. B., Caiano, T. L., Frame, A. A., Keaney, J. F., Jr., and Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in
  22. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc. PubMed
  23. Trotta, M., Cesaretti, M., Conzi, R., Derchi, L. E., and Borgonovo, G. Elderly male with mesogastric pain. Small bowel obstruction caused by an intact fresh grape. Ann.Emerg.Med 2011;58(4):e1-e2. PubMed
  24. McCurdy, S. A., Wiggins, P., Schenker, M. B., Munn, S., Shaieb, A. M., Weinbaum, Z., Goldsmith, D., McGillis, S. T., Berman, B., and Samuels, S. Assessing dermatitis in epidemiologic studies: occupational skin disease among California grape and tomato ha
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See these in context on the Grape monograph →

Pear 4 references
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  2. Conceição de Oliveira M, Sichieri R, Sanchez Moura A. Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutrition 2003;19:253-6. PubMed
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See these in context on the Pear monograph →

Noni 16 references
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  3. Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
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  7. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
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  12. Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
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  16. Yu-Chan Kang, Ming-Hong Chen, Shung-Lon Lai. Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. Acta Neurol Taiwan. 2015 Jun;24(2):43-6.

See these in context on the Noni monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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