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Dietary supplement

Nepro Rella Ingredients & Drug Interactions

by Nestmann Pharma

Nepro Rella label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nepro Rella against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nepro Rella is a dietary supplement by Nestmann Pharma with 1 active ingredient. Its ingredients are commonly taken for general nutrition and 'detox' support, immune support, liver and kidney support.Based on those ingredients, 337 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chlorella pyrenoidosa. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nepro Rella by Nestmann Pharma

Ask about any prescription or over-the-counter medication and we check it for interactions with Nepro Rella by Nestmann Pharma — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nepro Rella by Nestmann Pharma

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Nepro Rella is a single-ingredient supplement: chlorella pyrenoidosa, a freshwater green algae. Chlorella is sold as a whole-food concentrate and has been studied for several health uses.

One note on quality: chlorella products vary a lot in purity and what else they may contain. The inactive ingredient list shows none listed, though the facts note that product quality and purity are not guaranteed, so it's worth checking the manufacturer's testing if that matters to you.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Chlorella's overall clinical evidence instead.

Moderate

Some clinical evidence supports Chlorella for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Pregnancy-related iron deficiency — rated "Possibly Effective" (Natural Medicines).

Chlorella is possibly effective for pregnancy-related iron deficiency based on the evidence we hold. For other uses listed — brain tumor, nonalcoholic fatty liver disease, depression, and fatigue — the evidence isn't strong enough to rate either way.

The evidence, ingredient by ingredient Chlorella

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chlorella is generally well tolerated in the short term, but not enough long-term safety data exists; the product facts advise against use unless your doctor approves. The most common side effects are allergic reactions, abdominal cramping, constipation, diarrhea, fatigue, gas, nausea, sun sensitivity (photosensitivity), and darkened stool — especially during the first two weeks.

Serious allergic reactions, including anaphylaxis, are rare but have been reported in people taking chlorella and in those handling the tablets. For pregnancy, chlorella is rated possibly safe.

For lactation, safety data isn't on file. If you're pregnant or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Chlorella

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chlorella.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 337 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before starting Nepro Rella, especially if you take warfarin (Coumadin) for blood clotting or any drug that increases your skin's sensitivity to sun. You'll want your doctor or pharmacist to weigh the risks.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Nepro Rella might be worth considering if you have pregnancy-related iron deficiency and your doctor agrees, but the evidence for other uses is thin. If you take warfarin or any drug that increases sun sensitivity, you'll need to check with your doctor or pharmacist first — chlorella can interfere with both.

The most common side effects are mild digestive upset early on, but serious allergic reactions are rare.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nepro Rella, straight from the product label.

Brand Nestmann Pharma
Net contents 400 Tablet(s)
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25337
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nepro Rella by Nestmann Pharma, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Tablet(s)
Maximum serving Sizes:
8 Tablet(s)
Servings per container
50
IngredientAmount% DV
Chlorella pyrenoidosa1.6 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Adults take 4 to 8 tablets two to three times daily. Children receive 1/2 or less of the adult amount.

Precautions

Special Comments: Abdominal discomfort may occur during the first week; temporarily reduce amount.

Tamper Evident: Use this product only if tamper evident ring has not been broken or is missing from base of cap.

Seals/Symbols

MPI

General Statements

Green Fresh water Algae

Made in Germany Nestman Pharma Zapfendorf/Bamberg

Expires: 07/2013 Lot No. L0189

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nepro Rella by Nestmann Pharma label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nepro Rella label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nepro Rella by Nestmann Pharma

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.

Chlorella pyrenoidosa

Interacts with
337 drugs
1.6 Gram(s) per serving

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies sugges...

Chlorella pyrenoidosa monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nepro Rella by Nestmann Pharma Drug Interactions

Want to check YOUR meds against Nepro Rella?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
337Drugs
337 Moderate

Ingredients driving the most interactions

Chlorella pyrenoidosa 337

Individual Drug Interactions

The ingredients in Nepro Rella interact with 337 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nepro Rella interact with drugs. Each result below shows which ingredient is responsible. Chlorella pyrenoidosa

Each ingredient & the kinds of drugs it affects

For each ingredient in Nepro Rella with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chlorella pyrenoidosa2 drug types · 337 drugs

Photosensitizing Drugs

Theoretically, chlorella might have additive effects with photosensitizing drugs.
Chlorella has been reported to cause photosensitization. In five case reports, patients who had ingested chlorella exhibited swelling followed by erythematopurpuric lesions on sun-exposed areas of the body. Theoretically, concomitant use with photosensitizing drugs may exacerbate effects.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, chlorella might reduce the clinical effects of warfarin.
Chlorella contains significant amounts of vitamin K. There is at least one case report of warfarin therapy becoming sub-therapeutic after initiation of chlorella supplements.

Likelihood Possible Evidence D
Chlorella pyrenoidosa full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nepro Rella, from the product label.

Nestmann Pharma

See all Nestmann Pharma products
Name
Marco Pharma Int'l
City
Roseburg
State
OR
ZipCode
97470
Pharmacist Counseling Corner

Nepro Rella by Nestmann Pharma: Common Questions

Does Nepro Rella by Nestmann Pharma interact with any medications?
Yes. Based on its ingredients, Nepro Rella has a known interaction with 337 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nepro Rella contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does chlorella really cause sun sensitivity?
Yes, sun sensitivity (photosensitivity) has been reported with chlorella, including five case reports of swelling and rash on sun-exposed skin after people took it. If you take chlorella, limit direct sun or use sunscreen.
What are the most common side effects I might feel?
Most people experience digestive upset — nausea, diarrhea, cramping, gas, or constipation — especially in the first two weeks. Some people also report fatigue or allergic reactions. These are usually mild and temporary.
Can I take this while pregnant?
Chlorella is rated possibly safe in pregnancy, but there isn't a lot of safety data. Talk with your doctor or pharmacist before starting it — they know your full medical picture and can give you personalized advice.
Is this proven to work for fatigue or depression?
The evidence isn't strong enough to say either way. Chlorella is possibly effective for pregnancy-related iron deficiency, but for fatigue and depression, we don't have reliable evidence yet.
Why does the label say to avoid it unless my doctor approves?
Chlorella's long-term safety hasn't been well established in studies. The product facts recommend using it only under medical supervision to make sure it's appropriate for your situation.
Does Nepro Rella have any fillers or other ingredients?
No — the inactive ingredient list is empty, so it's just the chlorella itself in tablet form. Quality and purity can vary between manufacturers though, so check the label.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nepro Rella is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nepro Rella label
Go deeper

The Full Monographs Behind Nepro Rella’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chlorella

Interacts with 337 drugs

Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small studies suggest possible benefits for cholesterol, blo...

Read the full Chlorella monograph →
Sources

Sources & How We Checked

Nepro Rella's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chlorella 13 references
  1. Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York, NY: William Morrow and Co., 1999.
  2. Ng TP, Tan WC, Lee YK. Occupational asthma in a pharmacist induced by chlorella, a unicellular algae preparation. Resp Med 1994;88:555-7. PubMed
  3. Jitsukawa K, Suizu R, Hidano A. Chlorella photosensitization. New phytophotodermatosis. Int J Dermatol 1984;23:263-8. PubMed
  4. Merchant RE, Carmack CA, Wise CM. Nutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study. Phytother Res 2000;14:167-73.
  5. Merchant RE, Rice CD, Young HF. Dietary Chlorella pyrenoidosa for patients with malignant glioma: effects on immunocompetence, quality of life, and survival. Phytother Res 1990;4:220-31.
  6. Halperin SA, Smith B, Nolan C, et al. Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial. CMAJ 2003;169:111-7..
  7. Ohtake, T., Negishi, K., Okamoto, K., Oka, M., Maesato, K., Moriya, H., and Kobayashi, S. Manganese-induced Parkinsonism in a patient undergoing maintenance hemodialysis. Am J Kidney Dis 2005;46(4):749-753. PubMed
  8. Ng, T. P., Tan, W. C., and Lee, Y. K. Occupational asthma in a pharmacist induced by Chlorella, a unicellular algae preparation. Respir.Med. 1994;88(7):555-557. PubMed
  9. Ohkawa, S., Yoneda, Y., Ohsumi, Y., and Tabuchi, M. [Warfarin therapy and chlorella]. Rinsho Shinkeigaku 1995;35(7):806-807.
  10. Azocar J, Diaz A. Efficacy and safety of chlorella supplementation in adults with chronic hepatitis C virus infection. World J Gastroenterol 2013;19(7):1085-90. PubMed
  11. Panahi Y, Badeli R, Karami GR, Badeli Z, Sahebkar A. A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder. Complement Ther Med 2015;23(4):598-602. PubMed
  12. Nakano S, Takekoshi H, Nakano M. Chlorella pyrenoidosa supplementation reduces the risk of anemia, proteinuria and edema in pregnant women. Plant Foods Hum Nutr 2010;65(1):25-30. PubMed
  13. Yavasoglu I, Turgutkaya A, Bolaman Z. Chlorella-induced thrombocytopenia. Sao Paulo Med J 2018;136(6):602-3. PubMed

See these in context on the Chlorella monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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