NMN Plus Ingredients & Drug Interactions
What is this page for?
First and foremost: checking NMN Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
NMN Plus is a dietary supplement by Esmond Natural with 3 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 846 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Trans Resveratrol, Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against NMN Plus by Esmond Natural
Ask about any prescription or over-the-counter medication and we check it for interactions with NMN Plus by Esmond Natural — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of NMN Plus by Esmond Natural
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
NMN Plus contains three active ingredients: astaxanthin, trans resveratrol, and NMN. The product also includes inactive ingredients — calcium phosphate, stearic acid, magnesium stearate, silicon dioxide, titanium dioxide, and methylcellulose — which are fillers and binding agents that help form and stabilize the tablet.
Does it work?
Not established
For astaxanthin, the evidence we hold shows insufficient reliable data to rate its use for age-related cognitive decline, macular degeneration, aging skin, Alzheimer's disease, athletic performance, or carpal tunnel syndrome. Resveratrol has a mixed picture: it's rated possibly effective for obesity and allergic rhinitis (hay fever), but possibly ineffective for cardiovascular disease and high cholesterol.
We hold no effectiveness data for NMN in our records.
How safe is it?
Well-documented data
Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are abdominal pain, diarrhea, and red-colored stools; at higher doses (40 mg daily), severe stomach pain has been reported in a small number of people.
Resveratrol is generally well tolerated at typical supplement doses, but higher amounts may cause digestive upset — diarrhea, gastrointestinal discomfort, and loose stools are most common. Isolated cases have included headache, fatigue, memory loss (in dialysis patients), and skin rash, though causality wasn't always clear.
The safety data advises against using astaxanthin during pregnancy and while breastfeeding. For resveratrol, concentrated supplements should be avoided in pregnancy, and supplement use should be avoided while breastfeeding.
We hold no pregnancy or breastfeeding data for NMN.
Meds to double-check
Moderate interaction found
Before taking NMN Plus, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (like warfarin or aspirin) — resveratrol may increase bleeding risk. Also double-check if you take medications metabolized by CYP3A4, CYP2B6, CYP2C19, CYP1A2, or CYP2E1 liver enzymes, since both astaxanthin and resveratrol may alter how your body processes them.
We hold no interaction data for NMN.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
NMN Plus may appeal to people interested in age-related health support, though evidence for most claims is limited. If you take blood thinners, antiplatelet drugs like aspirin, or medications metabolized by liver enzymes, you'll want to check your specific medications with your doctor or pharmacist before starting.
The same goes if you're pregnant or breastfeeding — talk it over with your healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about NMN Plus, straight from the product label.
| Brand | Esmond Natural |
|---|---|
| Barcode (UPC) | 641399781738 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jul 23, 2020 |
| DSLD ID | 230944 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for NMN Plus by Esmond Natural, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Astaxanthin | 0 NP | -- |
| Proprietary Blend | 30 mg | -- |
| Trans Resveratrol | 0 NP | -- |
| NMN | 300 mg | -- |
Other ingredients: Calcium Phosphate, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, Methylcellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Esmondnatural integrated health
Esmund Natural Since 1994
Energize your life Cellular energy & function Precursor to NAD+ Change the way you age
Approach aging with science
Formula
Nicotinamide Mononucleotide (NMN) has an important effect on the production of cellular energy and as the precursor to NAD+. NMN is a naturally occurring form of vitamin B3 in our body and can also be found in fruits and vegetables. When it comes to the production of NAD+, NMN plays an important role. Supplementation with NMN promotes positive effect on health, longevity and significantly improves quality of life as you age.
Contains 9000mg Beta-NMN
Precautions
Warning: If your are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.
Keep out of reach of children.
Tamper resistant: Do not use if imprinted seal under cap is broken or missing.
As a reminder, discuss the supplements and medications you take with your health care providers.
Formulation
Discontinue use and consult your doctor if any adverse reactions occur.
Storage
Store in a dry place and avoid excessive heat.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take two (2) tablets daily or as recommended by your healthcare professional.
Seals/Symbols
GMP Good Manufacturing Practice
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
NMN Plus by Esmond Natural label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in NMN Plus by Esmond Natural
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
NMN
Other (inactive) ingredients: Calcium Phosphate, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, Methylcellulose. These complete the product’s ingredient list but are not active constituents.
NMN Plus by Esmond Natural Drug Interactions
HelloPharmacist Interaction Report
NMN Plus by Esmond Natural contains two ingredients with documented interactions: astaxanthin and trans resveratrol.
The most serious concern is resveratrol's potential to increase bleeding risk when combined with blood thinners or antiplatelet drugs (anticoagulants or aspirin-like medications). Both ingredients may also affect how your body metabolizes certain prescription drugs through liver enzymes, which could alter drug levels in your blood.
Read the full breakdown — every affected drug type, severity by severity
Astaxanthin may theoretically decrease levels of medications broken down by CYP3A4 and CYP2B6 liver enzymes — though these effects haven't been confirmed in humans, only in lab studies. Resveratrol presents a broader picture: it may theoretically increase levels of drugs metabolized by CYP2C19, CYP1A2, CYP3A4, and CYP2E1 enzymes.
The CYP3A4 effect is less clear because a human study at a high resveratrol dose (3000 mg daily for 8 weeks) showed no dose adjustment was needed, though the product dose may differ.
Altogether, these interactions span 847 individual medications. We were unable to check NMN, the third active ingredient, because we hold no data for it.
Before you start NMN Plus, use the search tool on this page to check your exact medications against these enzyme types and blood-thinning drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against NMN Plus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in NMN Plus interact with 846 drugs. Click any drug to see the details.
2 of the 3 ingredients in NMN Plus interact with drugs. Each result below shows which ingredient is responsible. Trans Resveratrol Astaxanthin
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Ado-trastuzumab Emtansine interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Trans Resveratrol + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Abemaciclib interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Abemaciclib interactionAbiraterone
How Abiraterone interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Abiraterone interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Abiraterone Acetate interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Trans Resveratrol + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acalabrutinib interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Trans Resveratrol + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Trans Resveratrol + Acetaminophen, Aspirin, Caffeine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Butalbital, Caffeine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Acetaminophen, Butalbital, Caffeine, Codeine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with NMN Plus — through 1 ingredient. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Caffeine, Codeine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Caffeine, Dihydrocodeine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Caffeine, Isometheptene interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Acetaminophen, Caffeine, Pyrilamine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
AstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionTrans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with NMN Plus — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAstaxanthinCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in NMN Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Trans Resveratrol
Anticoagulant/Antiplatelet Drugs
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.
Astaxanthin
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for NMN Plus, from the product label.
Esmond Natural
See all Esmond Natural products- Name
- Esmond Natural Inc.
- City
- Irwindale
- State
- CA
- ZipCode
- 91706
- Phone Number
- 1-800-814-6866
- Web Address
- www.esmondnatural.com
NMN Plus by Esmond Natural: Common Questions
Does NMN Plus by Esmond Natural interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is NMN Plus safe to use during pregnancy?
What side effects might I notice from NMN Plus?
Does resveratrol really work for weight loss?
Can I take NMN Plus if I'm on aspirin or a blood thinner?
What is astaxanthin in this supplement?
How much resveratrol is in each dose?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if NMN Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind NMN Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Astaxanthin
Interacts with 671 drugsAstaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...
Read the full Astaxanthin monograph → Herb & supplement monographResveratrol
Interacts with 822 drugsResveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...
Read the full Resveratrol monograph →Sources & How We Checked
NMN Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Astaxanthin 3 references
- Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
- Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
- Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed
Resveratrol 24 references
- Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
- Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
- Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
- Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
- Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
- Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
- Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
- Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
- Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
- Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
- Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
- Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
- Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
- Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
- la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
- Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
- Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
- Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
- Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
- Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed
- Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed
- McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep 2022;12(1):10978. PubMed
- Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AY. The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis. Med Clin (Barc) 2022;158(12):576-585. PubMed
- Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC