Interactions on record — worth a quick check against your medications. Based on 4 of 10 ingredients. Check your meds →
Dietary supplement

NTFactor CoQ10 Chocolate Chewables Ingredients & Drug Interactions

by Allergy Research Group

NTFactor CoQ10 Chocolate Chewables label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NTFactor CoQ10 Chocolate Chewables against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NTFactor CoQ10 Chocolate Chewables is a dietary supplement by Allergy Research Group with 10 active ingredients. Its ingredients are commonly taken for heart health, statin-related muscle aches, migraine prevention.Based on those ingredients, 417 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidyl-Serine, Coenzyme Q10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against NTFactor CoQ10 Chocolate Chewables by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with NTFactor CoQ10 Chocolate Chewables by Allergy Research Group — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of NTFactor CoQ10 Chocolate Chewables by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 10 active ingredients.
  • “NTFactor Proprietary Lipid Blend lol” is a proprietary blend — the label gives one combined amount (900 mg) without saying how much of each component you get.

This product contains 10 active ingredients. The main ones are coenzyme Q10 (an antioxidant your cells use for energy), boron (a mineral), and several phospholipids—phosphatidylcholine, phosphatidyl-serine, and others—that are fat-based compounds found in cell membranes.

The product also includes inactive ingredients like cocoa powder, xylitol, maltodextrin, and stearic acid for texture and taste.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy support with coenzyme Q10.
  • We looked for evidence on: Coenzyme Q10 deficiency, Fatigue, Chronic fatigue syndrome (CFS), mitochondrial function, cellular energy production.
  • The strongest evidence on file: Coenzyme Q10 is rated "Likely Effective" for Coenzyme Q10 deficiency (Natural Medicines).
  • Also on file: Coenzyme Q10 is rated "Possibly Ineffective" for Chemotherapy-related fatigue.
  • Also on file: Coenzyme Q10 is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Fatigue.

Coenzyme Q10 is likely effective for correcting coenzyme Q10 deficiency and possibly effective for fibromyalgia, migraine headache, congestive heart failure, and diabetic neuropathy. Phosphatidyl-serine is possibly effective for age-related cognitive decline and Alzheimer disease.

Boron is likely effective for boron deficiency and possibly effective for vaginal yeast infections and radiation skin damage. We don't have enough evidence to establish how well phosphatidylcholine works for the conditions listed in our data.

The evidence, ingredient by ingredient Coenzyme Q10 Boron Phosphatidylcholine Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coenzyme Q10 is generally well tolerated when used as directed; the most common side effects—mild gastrointestinal upset like nausea, diarrhea, or heartburn—occur in less than 1 percent of people and can be reduced by splitting doses above 100 mg. However, there isn't enough reliable safety data on coenzyme Q10 in pregnancy, so your doctor should advise you before taking it if pregnant.

Boron should be avoided in pregnancy and while breastfeeding due to concerns about high doses harming the fetus and limited breastfeeding data. Phosphatidyl-serine should be avoided during pregnancy and breastfeeding because safety isn't established.

Phosphatidylcholine is generally well tolerated but not well studied in supplement amounts beyond food during pregnancy or breastfeeding—talk with your doctor first.

Side effects, ingredient by ingredient Coenzyme Q10 Boron Phosphatidylcholine Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Coenzyme Q10, Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 417 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take warfarin or other blood thinners (Moderate risk), alkylating chemotherapy drugs like cyclophosphamide (Moderate risk), anticholinergic medications for overactive bladder or Parkinson disease (Moderate risk), or cholinergic drugs for myasthenia gravis or glaucoma (Moderate risk). Also confirm your blood pressure medications, since coenzyme Q10 may lower blood pressure further (Minor risk).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with heart function, energy production, and cognition if you have a deficiency or one of the supported conditions, but it requires a careful medication check before you start. If you take warfarin, any chemotherapy, blood pressure medicine, or drugs for bladder or eye conditions, sit down with your doctor or pharmacist first—the interactions are real and can affect how your medications work.

Pregnancy and breastfeeding require a personalized conversation with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NTFactor CoQ10 Chocolate Chewables, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947770805
Net contents 30 Chewable Wafer(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 233334
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NTFactor CoQ10 Chocolate Chewables by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
713947770805
IngredientAmount% DV
Calories13 Calorie(s)--
Calories from Fat5 Calorie(s)--
Coenzyme Q10100 mg--
Boron150 mcg--
Phosphatidic Acid0 NP--
Phosphatidyl-Choline0 NP--
Phosphatidyl-Ethanolamine0 NP--
Phosphatidyl-Glycerol0 NP--
Phosphatidyl-Inositol0 NP--
Phosphatidyl-Serine0 NP--
Digalactosyldiacylglyceride0 NP--
Monoglactosyldiacylglyceride0 NP--
NTFactor Proprietary Lipid Blend lol900 mg--

Other ingredients: Xylitol, Fructooligosaccharides, Cocoa powder, Stearic Acid, Maltodextrin, Magnesium Stearate, Silicon Dioxide, natural Chocolate flavor, Pantethine, Rosemary extract, Natural color, Natural flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

NTFactor EnergyLipids with Coenzyme Q10, in convenient and delicious chocolate chewable tablets! Patented phosphoglycolipids from soy, in proprietary and scientifically selected ratios of phosphatidylcholine, glycolipids, and other phosphatidyl nutrients, researched and blended to optimize cellular uptake and membrane utilization.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 chewable tablet two times daily, or as directed by a healthcare practitioner. May be taken with or without food.

Precautions

Contains: Soy. (NTFactor EnergyLipids are extracted from soy.)

Formulation

Contains No: milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, rice, beef, pork. Contains no artificial sweeteners, flavors, or colors.

General Statements

Not a significant source of saturated fat, trans-fat or cholesterol.

Storage

Store in cool, dry place, tightly capped.

Brand IP Statement(s)

NTFactor and NTFactor Lipids are registered trademarks of Nutritional Therapeutics, Inc.

NTFACTOR Lipids (Patent # 8,877,239)

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NTFactor CoQ10 Chocolate Chewables by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NTFactor CoQ10 Chocolate Chewables label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NTFactor CoQ10 Chocolate Chewables by Allergy Research Group

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Coenzyme Q10

Interacts with
198 drugs
100 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q10 monograph & interactions

Boron

No known
interactions
150 mcg per serving Form: Sodium Borate

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron monograph & interactions

NTFactor Proprietary Lipid Blend lol

900 mg per serving Form: Soy Lecithin extract
  • › Phosphatidic Acid
  • › Phosphatidyl-Choline
  • › Phosphatidyl-Ethanolamine
  • › Phosphatidyl-Glycerol
  • › Phosphatidyl-Inositol
  • › Phosphatidyl-Serine
  • › Digalactosyldiacylglyceride
  • › Monoglactosyldiacylglyceride

Other (inactive) ingredients: Xylitol, Fructooligosaccharides, Cocoa powder, Stearic Acid, Maltodextrin, Magnesium Stearate, Silicon Dioxide, Natural Chocolate flavor, Pantethine, Rosemary extract, Natural color, Natural flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

NTFactor CoQ10 Chocolate Chewables by Allergy Research Group Drug Interactions

Want to check YOUR meds against NTFactor CoQ10 Chocolate Chewables?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
417Drugs
245 Moderate 172 Minor

Ingredients driving the most interactions

Phosphatidyl-Serine 219
Coenzyme Q10 198

Individual Drug Interactions

The ingredients in NTFactor CoQ10 Chocolate Chewables interact with 417 drugs. Click any drug to see the details.

2 of the 10 ingredients in NTFactor CoQ10 Chocolate Chewables interact with drugs. Each result below shows which ingredient is responsible. Phosphatidyl-Serine Coenzyme Q10

Each ingredient & the kinds of drugs it affects

For each ingredient in NTFactor CoQ10 Chocolate Chewables with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidyl-Serine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidyl-Serine full monograph & interactions

Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q10 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NTFactor CoQ10 Chocolate Chewables, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800-545-9960
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

NTFactor CoQ10 Chocolate Chewables by Allergy Research Group: Common Questions

Does NTFactor CoQ10 Chocolate Chewables by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, NTFactor CoQ10 Chocolate Chewables has a known interaction with 417 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NTFactor CoQ10 Chocolate Chewables contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is coenzyme Q10 and why is it in this product?
Coenzyme Q10 (CoQ10) is a compound your cells use to make energy. It's in this product because it's likely effective for correcting CoQ10 deficiency and possibly helpful for heart function, migraines, fibromyalgia, and nerve damage from diabetes.
Can I take this if I'm pregnant or breastfeeding?
No, not without talking to your doctor first. Boron should be avoided entirely during pregnancy and breastfeeding. Coenzyme Q10 and phosphatidyl-serine don't have enough safety data in pregnancy or while breastfeeding, so your doctor needs to weigh the benefits against the unknowns for your situation.
What are the most common side effects?
Most side effects from coenzyme Q10 are mild and affect the stomach—nausea, diarrhea, or heartburn—and happen in less than 1 percent of people. Phosphatidylserine may cause flatulence, nausea, insomnia, or headache. Splitting larger doses can help reduce stomach upset.
What is phosphatidyl-serine and what does it do?
Phosphatidyl-serine is a fat-based compound in cell membranes. It's possibly effective for age-related memory decline and Alzheimer disease, and it may work by increasing a brain chemical called acetylcholine.
Is this product safe for people on heart or blood pressure medications?
Coenzyme Q10 carries real risks with warfarin and blood pressure drugs—talk to your doctor or pharmacist before starting. It may make warfarin less effective at preventing clots, and it could lower your blood pressure too much if you're already on medications for that.
Why do you say you couldn't check some ingredients?
Four of the ingredients in this product—phosphatidic acid, phosphatidyl-ethanolamine, phosphatidyl-glycerol, and phosphatidyl-inositol—don't have published interaction data available to us, so we can't tell you whether they interact with any drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NTFactor CoQ10 Chocolate Chewables is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NTFactor CoQ10 Chocolate Chewables label
Go deeper

The Full Monographs Behind NTFactor CoQ10 Chocolate Chewables’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

NTFactor CoQ10 Chocolate Chewables's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coenzyme Q10 40 references
  1. Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-51. PubMed
  2. Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;S265-72. PubMed
  3. Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;334:1372-3. PubMed
  4. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8. PubMed
  5. Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84. PubMed
  6. Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6. PubMed
  7. Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-3. PubMed
  8. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  9. Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-7.
  10. Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94. PubMed
  11. Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7. PubMed
  12. The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;57:397-404.
  13. Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42. PubMed
  14. Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003;246:75-82. DOI
  15. Porterfield LM. Why did the response to warfarin change? RN 2000;63:107.
  16. Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology 2005;64:713-5. PubMed
  17. Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87:1075-6. DOI
  18. Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004;27:295–9. PubMed
  19. Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. Arch Neurol 2007;64:938-44. DOI
  20. Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994;15 Suppl:s257-63. PubMed
  21. Yamagami T, Takagi M, Akagami H, et al. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. In: Folkers KA, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 5. Amsterdam: Elsevier Science Publications, 19
  22. Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension (review). Cochrane Database Syst Rev 2009;(4):CD007435. PubMed
  23. Rosenfeldt, F. L., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J. Y., and Watts, G. F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum.Hypertens. 2007;21(4):297-306. PubMed
  24. Stamelou, M., Reuss, A., Pilatus, U., Magerkurth, J., Niklowitz, P., Eggert, K. M., Krisp, A., Menke, T., Schade-Brittinger, C., Oertel, W. H., and Hoglinger, G. U. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, place DOI
  25. Keogh A, Fenton S, Leslie C, et al. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003;12:135-41.
  26. Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A., and Murphy, M. P. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C
  27. Lynch, D. R., Perlman, S. L., and Meier, T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67(8):941-947. PubMed
  28. Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., and George, P. M. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the me
  29. Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. Jpn.Heart J 1976;17(1):32-42. PubMed
  30. Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O'Connor, D., Sherwin, A., Karpati, G., Andermann, F., and Arnold, D. L. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993;43(5
  31. Malm, C., Svensson, M., Sjoberg, B., Ekblom, B., and Sjodin, B. Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiol Scand. 1996;157(4):511-512. PubMed
  32. Singh, R. B., Wander, G. S., Rastogi, A., Shukla, P. K., Mittal, A., Sharma, J. P., Mehrotra, S. K., Kapoor, R., and Chopra, R. K. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc. PubMed
  33. Digiesi V, Cantini F, and Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Current Therapeutic Research 1990;47(5):841-845.
  34. Parkinson Study Group QE3 Investigators, Beal MF, Oakes D, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014;71(5):543-52.
  35. Alehagen U, Johansson P, Bjornstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citi
  36. Ho MJ, Li EC, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2016 Mar 3;3:CD007435. doi: 10.1002/14651858.CD007435.pub3. PubMed
  37. Tabrizi R, Akbari M, Sharifi N, Lankarani KB, Moosazadeh M, Kolahdooz F, et al. The effects of coenzyme Q10 supplementation on blood pressures among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. PubMed
  38. Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV. Effectiveness of coenzyme Q10 supplementation for reducing fatigue: A systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 2022;13:883251. PubMed
  39. Yaghini O, Hoseini N, Ghazavi MR, et al. A comparative study on the efficacy of coenzyme Q10 and amitriptyline in the prophylactic treatment of migraine headaches in children: A randomized controlled trial. Adv Biomed Res 2022;11:43. PubMed
  40. Hansen KS, Mogensen TH, Agergaard J, et al. High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition: A randomized, phase 2, crossover trial. Lancet Reg Health Eur 2022. PubMed

See these in context on the Coenzyme Q10 monograph →

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
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See these in context on the Boron monograph →

Phosphatidylcholine 15 references
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  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
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  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Phosphatidylserine 9 references
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  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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