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Dietary supplement

Omega-3 Ingredients & Drug Interactions

by Endurance Products Company

Omega-3 label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Omega-3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Omega-3 is a dietary supplement by Endurance Products Company with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Superba Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Omega-3 by Endurance Products Company

Ask about any prescription or over-the-counter medication and we check it for interactions with Omega-3 by Endurance Products Company — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Omega-3 by Endurance Products Company

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Superba Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This Omega-3 softgel contains 5 active ingredients: eicosapentaenoic acid and docosahexaenoic acid (the main omega-3 fatty acids), phospholipids, astaxanthin (a carotenoid antioxidant), and total omega-3 fatty acids from Superba krill oil. The softgel itself is made with gelatin, glycerin, sorbitol, water, and ethyl vanillin as inactive ingredients.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: brain health and cognitive function.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Alzheimer disease.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease.

The effectiveness data we hold for astaxanthin — one of the active ingredients — shows insufficient reliable evidence to rate it for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome. We don't have effectiveness ratings on file for the other active ingredients in this product.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects from oral astaxanthin are abdominal pain, diarrhea, and red-colored stools.

At lower doses (6 mg daily), a small number of people reported increased bowel movements and red stools; at higher doses (40 mg daily), two patients experienced severe stomach or abdominal pain. There isn't enough safety data to know whether astaxanthin is safe during pregnancy or while breastfeeding — the safety data advises against use in both situations.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any medications broken down by CYP3A4 enzymes (a Moderate concern — astaxanthin may lower their levels) or CYP2B6 enzymes (also Moderate). These include many common drugs, so it's worth the quick review.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're taking medications that your liver processes (especially through CYP3A4 or CYP2B6 pathways), astaxanthin in this product warrants a conversation with your doctor or pharmacist before you start. If you're pregnant or breastfeeding, talk with your healthcare provider about whether this product is right for you — the safety data are too limited to recommend it.

Use the medication checker on this page to see if your prescriptions are affected.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Omega-3, straight from the product label.

Brand Endurance Products Company
Barcode (UPC) 729135600182
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 259529
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Omega-3 by Endurance Products Company, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
90
UPC/BARCODE
729135600182
IngredientAmount% DV
Eicosapentaenoic Acid120 mg--
Docosahexaenoic Acid56 mg--
Phospholipids400 mg--
Astaxanthin80 mcg--
Total Omega-3 Fatty Acids220 mg--
Superba Krill Oil1000 mg--

Other ingredients: Gelatin, Glycerin, Sorbitol, Water, Ethyl Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Mag-Amide delivers targeted brain health benefits by helping to maintain healthy neurons and cognitive function as well as fuel cellular energy production.

Natural color variation occurs in tablets. Formulated for steady release over 3–5 hours.

Promotes heart and cellular health

Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking any medications, or are pregnant or nursing.

Keep out of reach of children.

Do not use if seal is broken or missing.

Contains: Shellfish (krill).

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

Formula

100% Pure Krill oil

Phospholipid

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take two (2) softgels, twice daily, with a meal or snack.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Omega-3 by Endurance Products Company label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Omega-3 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Omega-3 by Endurance Products Company

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Superba Krill Oil

Interacts with
208 drugs
1000 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Superba Krill Oil monograph & interactions
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Phospholipids
  • › Astaxanthin
  • › Total Omega-3 Fatty Acids

Other (inactive) ingredients: Gelatin, Glycerin, Sorbitol, Water, Ethyl Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Omega-3 by Endurance Products Company Drug Interactions

Want to check YOUR meds against Omega-3?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Superba Krill Oil 208

Individual Drug Interactions

The ingredients in Omega-3 interact with 838 drugs. Click any drug to see the details.

1 of the 1 ingredient in Omega-3 interact with drugs. Each result below shows which ingredient is responsible. Superba Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Omega-3 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Superba Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Superba Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Omega-3, from the product label.

Endurance Products Company

See all Endurance Products Company products
Name
Endurance Products Company
Street Address
PO Box 3810
City
Tualatin
State
OR
ZipCode
97062
Phone Number
1-800-483-2532
Web Address
www.endur.com
Pharmacist Counseling Corner

Omega-3 by Endurance Products Company: Common Questions

Does Omega-3 by Endurance Products Company interact with any medications?
Yes. Based on its ingredients, Omega-3 has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Omega-3 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the omega-3 fatty acids in here doing?
This softgel delivers eicosapentaenoic acid and docosahexaenoic acid, the main omega-3 fatty acids from krill oil. We don't have effectiveness data on file for these specific ingredients in this product, so I'd ask your doctor what you're taking it for and whether the evidence supports that use.
What's astaxanthin, and why is it in here?
Astaxanthin is a carotenoid antioxidant from krill. We don't have reliable evidence it works for age-related cognitive decline, macular degeneration, skin aging, Alzheimer disease, athletic performance, or carpal tunnel syndrome — the conditions we hold data on.
Can I take this while I'm pregnant or breastfeeding?
The safety data for astaxanthin are too limited during pregnancy and breastfeeding — the data we hold advise against it in both situations. Talk it over with your doctor or midwife to weigh the risks and benefits for you.
What side effects should I watch for?
Astaxanthin commonly causes abdominal pain, diarrhea, and red-colored stools. At typical doses (6 mg daily) a few people reported increased bowel movements and red stools; at much higher doses (40 mg daily) a couple of people had severe stomach pain. Stop and call your pharmacist or doctor if anything worries you.
Does astaxanthin interact with my blood pressure or blood thinner medications?
We don't have documented interactions between astaxanthin and those drug types in our data. Use the medication search tool on this page to look up your exact prescriptions and see what we do hold for them.
How long can I safely take this supplement?
Astaxanthin is generally well tolerated in studies, but long-term safety data are limited — we don't have strong evidence on how it holds up over months or years. Ask your doctor or pharmacist how long they'd recommend you take it and whether a follow-up check makes sense.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Omega-3 label
Go deeper

The Full Monographs Behind Omega-3’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Omega-3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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