Universal Omega EFA Ingredients & Drug Interactions
by Universal
What is this page for?
First and foremost: checking Universal Omega EFA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Universal Omega EFA is a dietary supplement by Universal with 1 active ingredient. Its ingredients are commonly taken for source of omega-3 (ala) fatty acids, heart and cholesterol health, dry skin and inflammation.Based on those ingredients, 379 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are High Lignan Flaxseed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Universal Omega EFA by Universal
Ask about any prescription or over-the-counter medication and we check it for interactions with Universal Omega EFA by Universal — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Universal Omega EFA by Universal
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Universal Omega EFA is a softgel supplying four active fatty acids and lipid compounds: linoleic acid, oleic acid, alpha-linolenic acid, and a blend of other fatty acids plus lignans from high-lignan flaxseed oil. The product is filled out with inactive ingredients including gelatin, glycerine, purified water, and carob extract.
Does it work?
Moderate evidence
Oleic acid in this product is rated possibly effective for high cholesterol (hypercholesterolemia) and possibly effective for helping prevent coronary heart disease. The evidence isn't established in our data for the other fatty acids and lignans in the blend.
How safe is it?
Some data gaps
Oleic acid is generally recognized as safe in the amounts found in foods like olive oil. However, concentrated supplement doses haven't been well studied in pregnancy or during breastfeeding — food-level amounts are considered safe, but these supplements are a different story.
There are no adverse effects reported in our data.
Meds to double-check
Moderate interaction found
If you take antidiabetes drugs (blood sugar medications), double-check them before starting this product — oleic acid may increase their effects and lower your blood glucose more than expected. We could not check linoleic acid, alpha-linolenic acid, or the other fatty acids and lignans for interactions, so mention those ingredients to your pharmacist as well.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.
Universal Omega EFA may be worth considering if you're looking to support cholesterol levels or heart health with oleic acid. If you take any diabetes medication, check it against our interaction tool first — oleic acid can strengthen blood sugar drug effects.
Talk to your pharmacist about whether this product fits your health plan.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Universal Omega EFA, straight from the product label.
| Brand | Universal |
|---|---|
| Barcode (UPC) | 039442047908 |
| Net contents | 90 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Oct 22, 2016 |
| DSLD ID | 65615 |
| Product type | Other Combinations |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Universal Omega EFA by Universal, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 9 Calorie(s) | -- |
| Calories from Fat | 9 Calorie(s) | -- |
| Saturated Fat | 0 Gram(s) | -- |
| Cholesterol | 0 mg | -- |
| Total Fat | 1 Gram(s) | 2% |
| Linoleic Acid | 0 NP | -- |
| Oleic Acid | 0 NP | -- |
| Alpha-Linolenic Acid | 0 NP | -- |
| Other Fatty Acids, Lignans | 0 NP | -- |
| High Lignan Flaxseed Oil | 1000 mg | -- |
Other ingredients: Gelatin, Glycerine, purified Water, Carob extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.
Warning: Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Dosage: Take 1-6 softgels daily, or as directed by your health care professional.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Plant #3001104580 EAC
Made proudly in the U.S.A.
As time passes, certain ideals never go out of style. Honesty. Integrity. Respect. These are the values we uphold and are the bedrock upon which we built our business.
HOW WE BACK IT UP What is on the label is in the bottle and hat is in the bottle will help you reach your goals. We believe it and proudly stand behind every product we manufacture. Our word is our bond.
Optimum purity & potency
Brand IP Statement(s)
2015 Universal Nutrition
WHAT IT IS Universal's Omega EFA contains only the purest ingredients. Our Omega EFA is clear, amber liquid, cold pressed from the highest grade flax seeds available.
FDA Statement of Identity
Dietary Supplement
Formula
WHO WE ARE Universal Nutrition has been providing cutting edge and staple nutritional supplements to bodybuilders and hard training athletes the world over since 1977.
Specially coated for convenience and freshness, these softgel capsules contain 1000mg of flax oil optimally balanced in omega-3 and omega-6 fatty acids.
Perfect for hard training athletes and bodybuilders alike.
1000mg Essential premium-grade Omega 3,6 & 9 Fatty Acids
General
D2015-G-32802
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Universal Omega EFA by Universal label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Universal Omega EFA by Universal
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.
High Lignan Flaxseed Oil
Interacts with293 drugs
Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...
High Lignan Flaxseed Oil monograph & interactions- › Linoleic Acid
- › Oleic Acid
- › Alpha-Linolenic Acid
- › Other Fatty Acids, Lignans
Other (inactive) ingredients: Gelatin, Glycerine, Purified Water, Carob extract. These complete the product’s ingredient list but are not active constituents.
Universal Omega EFA by Universal Drug Interactions
HelloPharmacist Interaction Report
Universal Omega EFA contains four active ingredients, and we can document interactions for one of them.
Oleic acid may increase the effects of antidiabetes drugs (blood sugar medications). Research in people with type 2 diabetes shows that a diet rich in oleic acid from olive oil can lower fasting blood glucose levels more than a diet high in linoleic acid, which means your blood sugar medication might work more strongly than expected.
Read the full breakdown — every affected drug type, severity by severity
We were not able to check the interaction data for linoleic acid, alpha-linolenic acid, or the other fatty acids and lignans in this product — we hold no monographs for those. This doesn't mean they don't interact; it means we simply don't have the information on file.
Altogether, these interactions span 85 individual medications.
Before you start Universal Omega EFA, especially if you take any diabetes medication, run your exact drugs through the interaction checker on this page to see if they're among those affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Universal Omega EFA?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Universal Omega EFA interact with 379 drugs. Click any drug to see the details.
1 of the 1 ingredient in Universal Omega EFA interact with drugs. Each result below shows which ingredient is responsible. High Lignan Flaxseed Oil
AbciximabReoPro
How Abciximab interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full High Lignan Flaxseed Oil + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Universal Omega EFA — through 1 ingredient. Tap an ingredient for the detail:
High Lignan Flaxseed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full High Lignan Flaxseed Oil + Anacaulase-bcdb interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Universal Omega EFA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
High Lignan Flaxseed Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.
Antihypertensive Drugs
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.
Ezetimibe (Zetia)
Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.
Brand information
Manufacturer and brand details for Universal Omega EFA, from the product label.
Universal
See all Universal products- Name
- Universal Nutrition
- City
- New Brunswick
- State
- New Jersey
- ZipCode
- 08901
- Phone Number
- 800-872-0101
- Web Address
- www.UniversalUSA.com
Universal Omega EFA by Universal: Common Questions
Does Universal Omega EFA by Universal interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is oleic acid, and why is it in this supplement?
Will this supplement lower my cholesterol?
Can I take this while pregnant or breastfeeding?
What's the flaxseed oil doing in here?
Does this have any fillers or extra stuff I should know about?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Universal Omega EFA is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Universal Omega EFA’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Flaxseed Oil
Interacts with 293 drugsFlaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...
Read the full Flaxseed Oil monograph → Herb & supplement monographOleic Acid
Interacts with 86 drugsOleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...
Read the full Oleic Acid monograph →Sources & How We Checked
Universal Omega EFA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 40 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oleic Acid 19 references
- Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
- Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
- Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
- Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
- Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
- Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
- Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
- Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
- Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
- Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
- Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
- de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
- Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
- Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
- Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed
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