Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

OncoProtect ES Ingredients & Drug Interactions

by Pure TheraPro Rx

OncoProtect ES label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OncoProtect ES against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OncoProtect ES is a dietary supplement by Pure TheraPro Rx with 2 active ingredients. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are TrueBroc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against OncoProtect ES by Pure TheraPro Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with OncoProtect ES by Pure TheraPro Rx — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of OncoProtect ES by Pure TheraPro Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “TrueBroc” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

OncoProtect ES contains two active ingredients: broccoli seed extract and TrueBroc, a branded broccoli component blend. Broccoli seed extract is a concentrated source of glucosinolates — compounds that your body converts into sulforaphane, a plant chemical being studied for potential protective effects against certain cancers.

The product also contains hypromellose as an inactive ingredient (the capsule material).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Broccoli's overall clinical evidence instead.

Moderate

Some clinical evidence supports Broccoli for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Colorectal cancer — rated "Possibly Effective" (Natural Medicines).

The evidence for broccoli extract is mixed. It's rated possibly effective for colorectal cancer prevention based on available research.

However, for bladder cancer, breast cancer, fibromyalgia, and gastric cancer, there isn't enough reliable evidence yet to make a rating. The science is still developing in these areas.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is well tolerated in normal amounts, but concentrated supplements like this one are less studied and the facts note caution is warranted unless your doctor approves. The main side effects reported from broccoli seed extracts are digestive — loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses.

Topically, allergic reactions causing contact dermatitis have occurred in some people. The product is rated likely safe in pregnancy and lactation, though concentrated extracts haven't been extensively studied in these situations.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, ask your doctor or pharmacist to check whether you take any medications metabolized by CYP2A6 or CYP1A2 enzymes. Broccoli extract can speed up how your liver breaks down these drugs, potentially making them less effective.

Examples include certain smoking-cessation aids, some antiarrhythmics, and some pain relievers, but the full list is long — use the checker on this page to verify your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

OncoProtect ES may appeal to you if you're interested in broccoli extract for potential cancer-related support, especially if you have a family history of colorectal cancer. However, if you take any prescription medications — particularly those cleared by your liver — you'll want to check them against this product's interactions before starting.

Talk with your doctor or pharmacist about whether it's right for you and safe alongside your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OncoProtect ES, straight from the product label.

Brand Pure TheraPro Rx
Barcode (UPC) X000S6LPC9
Net contents 60 Acid-Resistant Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 269059
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OncoProtect ES by Pure TheraPro Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
X000S6LPC9
IngredientAmount% DV
Broccoli Seed Extract769 mg--
TrueBroc100 mg--
Myrosinase2 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule daily, or as directed by a healthcare practitioner.

Precautions

Warning: Children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Warning: Children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Do not use if tamper seal is damaged.

Keep out of reach of children.

Formula

OncoProtect ES Extra Strength is an advanced antioxidant formula containing both Glucoraphanin (from truebroc) and active Myrosinase enzymes in a delayed release capsule. Utilizing a patented process. Glucoraphanin is extracted from broccoli seeds to provide a patent source of bioavailable sulforaphane (SFN). Published in over 500 journal publications since 1992, research shows SFN plays a vital role in antioxidant activity and is key to the production of detoxification enzymes in the body. When combined with Myrosinase (an activator of sulforaphane), this powerful formula provides efficient and long-lasting support for the body's detoxification processes while promoting optimal cellular health.

Storage

Storage: Keep tightly closed in a cool, dry place.

Formulation

Formulated to Exclude: Fillers, gluten, wheat, soy, corn, yeast, animal or dairy products, shellfish, fish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMO's), preservatives, artificial sweeteners or colors.

Patented. Highly Concentrated. Max Sulforaphane Production

Formulated, Tested & Packaged in the USA

Vegan

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

GMP Certified Good Manufacturing Practice

FDA Statement of Identity

Professional Dietary Supplement

Brand IP Statement(s)

Truebroc is a trademark of Brassica Protection Products, LLC Produced under US patents 5,725,895; 5,968,505; 5,968,567; 6,177,122; and 6,242,018 licensed from Brassica Protection Products LLC. DRcaps & logo are trademarks of Lonza or its affiliates.

Copyright 2021 Pure Therapro Rx

General Statements

Please Recycle

Purity is Priority

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

OncoProtect ES by Pure TheraPro Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OncoProtect ES label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OncoProtect ES by Pure TheraPro Rx

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

TrueBroc

Interacts with
187 drugs
100 mg per serving Form: Glucoraphanin

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

TrueBroc monograph & interactions

Myrosinase

2 mg per serving Form: Radish Seed Extract

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

OncoProtect ES by Pure TheraPro Rx Drug Interactions

Want to check YOUR meds against OncoProtect ES?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

TrueBroc 187

Individual Drug Interactions

The ingredients in OncoProtect ES interact with 187 drugs. Click any drug to see the details.

1 of the 2 ingredients in OncoProtect ES interact with drugs. Each result below shows which ingredient is responsible. TrueBroc

Each ingredient & the kinds of drugs it affects

For each ingredient in OncoProtect ES with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

TrueBroc2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
TrueBroc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OncoProtect ES, from the product label.

Pure TheraPro Rx

See all Pure TheraPro Rx products
Name
Pure TheraPro RX
Street Address
9888 W. Belleview Ave. #2006
City
Denver
State
Colorado
ZipCode
80123
Phone Number
888-655-4648
Web Address
Purethera.com
Pharmacist Counseling Corner

OncoProtect ES by Pure TheraPro Rx: Common Questions

Does OncoProtect ES by Pure TheraPro Rx interact with any medications?
Yes. Based on its ingredients, OncoProtect ES has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OncoProtect ES contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does broccoli extract really work for cancer prevention?
The evidence is promising for colorectal cancer — it's rated possibly effective based on research. For bladder, breast, and gastric cancers, there isn't enough reliable evidence yet to know if it helps. Talk with your doctor about how it might fit into your own health plan.
Will this give me the same effect as eating broccoli?
No — this is a concentrated extract, not whole broccoli food. Concentrated supplements interact with medications differently and carry risks that whole broccoli doesn't. The facts note that concentrated extracts are less studied than broccoli as a food, so caution is advised unless your doctor approves.
What are the side effects?
The main ones are digestive: loose stools, diarrhea, abdominal pain, and cramping, especially if you take a high dose. Allergic contact dermatitis has been reported in some people. Most side effects are mild, but stop and talk to your pharmacist if they bother you.
Is it safe to take while pregnant or breastfeeding?
The broccoli seed extract in this product is rated likely safe for pregnancy and lactation. That said, concentrated extracts haven't been extensively studied in these situations, so it's worth discussing with your doctor or midwife before starting.
Why does the label mention 'TrueBroc'?
TrueBroc is a branded blend of broccoli components — its individual ingredients are listed separately, so we can check them for interactions. Myrosinase, another ingredient in the product, we don't have interaction data for on file.
How much broccoli is actually in each capsule?
The product facts don't list the amount per capsule, so check the label on your bottle or contact the manufacturer for that detail.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OncoProtect ES label
Go deeper

The Full Monographs Behind OncoProtect ES’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

OncoProtect ES's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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