Oregano Oil Ingredients & Drug Interactions
by Vitabase
What is this page for?
First and foremost: checking Oregano Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Oregano Oil is a dietary supplement by Vitabase with 3 active ingredients. Its ingredients are commonly taken for digestive upset, respiratory and cold symptoms, antimicrobial support.Based on those ingredients, 1,015 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ginger Oil, Fennel Oil, Oregano Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Oregano Oil by Vitabase
Ask about any prescription or over-the-counter medication and we check it for interactions with Oregano Oil by Vitabase — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Oregano Oil by Vitabase
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This softgel contains three active ingredients: oregano oil, ginger oil, and fennel oil. Each brings its own traditional uses—oregano and fennel for respiratory and digestive support, and ginger for nausea and joint comfort.
The product also contains inactive ingredients (extra virgin olive oil, gelatin, glycerin, water, enteric coating, and carob) that serve as the capsule base and help deliver the oils to your intestines.
Does it work?
Moderate evidence
The evidence for what this product actually does is thin. Oregano oil has insufficient reliable evidence for acne, bronchitis, asthma, headache, or upper respiratory infections—meaning we don't have solid proof it works for these.
Ginger oil shows some promise for pregnancy-related nausea and vomiting, and possibly for period pain and osteoarthritis, but it appears ineffective for exercise-related muscle soreness. Fennel oil is possibly effective for period pain but has insufficient evidence for bronchitis, anxiety, bedwetting, or cholera.
Overall, the data we hold doesn't establish strong effectiveness for most common reasons people buy oregano oil.
How safe is it?
Well-documented data
All three oils are generally well tolerated in typical food amounts, but concentrated supplements are less studied. Oregano oil and ginger oil are both associated with gastrointestinal upset at higher doses—ginger especially above 5 grams daily.
Both can trigger allergic reactions in sensitive people, and oregano has rarely caused serious systemic allergic responses. Fennel may cause photosensitivity, allergic reactions, and in rare cases seizures.
During pregnancy, the safety data advises against oregano oil and fennel oil in medicinal amounts; ginger is often used for morning sickness but check with your doctor first and keep amounts moderate. While breastfeeding, food amounts of all three are likely fine, but supplement doses are not well studied—discuss with your doctor or pharmacist.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (Moderate risk of increased bleeding). Also check if you're on diabetes medications (Moderate risk of low blood sugar), warfarin or phenprocoumon specifically (Moderate bleeding risk), nifedipine or other heart medications (Moderate bleeding risk with nifedipine), birth control pills or hormone therapy (Moderate risk of reduced effectiveness), the antibiotic ciprofloxacin (Moderate risk of reduced effectiveness), tamoxifen (breast cancer drug; Moderate risk of reduced effectiveness), or medications broken down by the CYP3A4 liver enzyme—including some cancer drugs (Moderate risk of altered drug levels).
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Vitabase Oregano Oil is a blend of three traditional herbal oils, but the evidence that it actually works for most common uses is not established in our data, and all three ingredients interact with several medication types—most seriously with blood thinners and diabetes drugs. If you take any prescription medications, run them through the tool on this page before adding this product.
Talk it over with your doctor or pharmacist, especially if you're on blood thinners, diabetes medications, birth control, or any heart or cancer medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Oregano Oil, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Oregano Oil by Vitabase, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Oregano Oil | 0.2 mL | -- |
| Ginger Oil | 0.02 mL | -- |
| Fennel Oil | 0.02 mL | -- |
Other ingredients: extra virgin Olive Oil, Gelatin, Glycerin, Water, Enteric Coating, Carob
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: As an herbal dietary supplement, take 1 softgel 1-2 times daily, with meals
General Statements
Oregano grows on hillsides and in dry woodlands and has a spicy, aromatic scent. Natural separation of oils may occur in this product.
Vitabase uses only high quality ingredients.
MADE IN THE U.S.A.
Formulation
Contains no sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or preservatives.
Precautions
Warnings: Please discard the inedible freshness packet enclosed.
Caution: Pregnant or lactating women: Do not use unless recommended by your healthcare practitioner.
Seals/Symbols
Vb
Formula
min. 55% Carvacrol
FDA Statement of Identity
DIETARY SUPPLEMENT
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Oregano Oil by Vitabase label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Oregano Oil by Vitabase
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Oregano Oil
Interacts with208 drugs
Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacr...
Oregano Oil monograph & interactionsGinger Oil
Interacts with1,007 drugs
Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomi...
Ginger Oil monograph & interactionsFennel Oil
Interacts with740 drugs
Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some sm...
Fennel Oil monograph & interactionsOther (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerin, Water, Enteric Coating, Carob. These complete the product’s ingredient list but are not active constituents.
Oregano Oil by Vitabase Drug Interactions
HelloPharmacist Interaction Report
Vitabase Oregano Oil contains three active ingredients—oregano oil, ginger oil, and fennel oil—and together they interact with a substantial number of medications.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs: all three ingredients may increase bleeding risk, a Moderate-severity interaction that affects how your blood clots.
Read the full breakdown — every affected drug type, severity by severity
Beyond blood thinners, ginger oil raises particular concerns. It may lower blood sugar when taken with diabetes medications, increase bleeding risk specifically with warfarin (Coumadin) and phenprocoumon (anticoagulants similar to warfarin), and interact with nifedipine (a heart medication) to raise bleeding risk.
Ginger may also alter how your body processes certain cancer drugs and other medications broken down by the CYP3A4 enzyme pathway, and it could increase losartan (blood pressure medication) levels and cause too-low blood pressure.
Fennel oil adds interactions with birth control pills and hormone replacement therapy—it may weaken their effects—and with the antibiotic ciprofloxacin (Cipro), which it could make less effective. Fennel may also interfere with tamoxifen (a breast cancer drug).
Oregano oil and fennel oil both interact with blood-sugar-lowering drugs, raising hypoglycemia risk.
Altogether, these interactions span 1,026 individual medications. Before starting this product, check your exact prescriptions with the search tool on this page, and talk it over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Oregano Oil?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Oregano Oil interact with 1,015 drugs. Click any drug to see the details.
3 of the 3 ingredients in Oregano Oil interact with drugs. Each result below shows which ingredient is responsible. Ginger Oil Fennel Oil Oregano Oil
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Fennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Ado-trastuzumab Emtansine interactionGinger OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Oregano Oil — through 3 ingredients. Tap an ingredient for the detail:
Ginger OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ginger Oil + Abciximab interactionFennel OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fennel Oil + Abciximab interactionOregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregano Oil + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Abemaciclib interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Fennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Abiraterone interactionGinger OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Abiraterone Acetate interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Oregano Oil — through 3 ingredients. Tap an ingredient for the detail:
Fennel OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fennel Oil + Abrocitinib interactionOregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregano Oil + Abrocitinib interactionGinger OilCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP2C9 substrates.
Read the full Ginger Oil + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Fennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acalabrutinib interactionGinger OilCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ginger Oil + Acarbose interactionOregano OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
Read the full Oregano Oil + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Oregano Oil — through 3 ingredients. Tap an ingredient for the detail:
Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregano Oil + Acenocoumarol interactionGinger OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Ginger Oil + Acenocoumarol interactionFennel OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fennel Oil + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Oregano Oil — through 3 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Oil + Acetaminophen, Aspirin interactionFennel OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fennel Oil + Acetaminophen, Aspirin interactionOregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregano Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Oregano Oil — through 3 ingredients. Tap an ingredient for the detail:
Fennel OilAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Fennel Oil + Acetaminophen, Aspirin, Caffeine interactionOregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Oregano Oil + Acetaminophen, Aspirin, Caffeine interactionGinger OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Oil + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Oil + Acetaminophen, Butalbital, Caffeine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Caffeine, Codeine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Fennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Caffeine, Isometheptene interactionGinger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Oil + Acetaminophen, Caffeine, Pyrilamine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Fennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionGinger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Fennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionGinger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Phenylephrine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Oregano Oil — through 2 ingredients. Tap an ingredient for the detail:
Ginger OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger Oil + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionFennel OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel Oil + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Oregano Oil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Ginger Oil
Anticoagulant/Antiplatelet Drugs
Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Antidiabetes Drugs
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.
Losartan (Cozaar)
Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.
Nifedipine (Procardia)
Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.
P-Glycoprotein Substrates
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Phenprocoumon (Marcoumar, Others)
Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.
Warfarin (Coumadin)
Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.
Calcium Channel Blockers
Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.
Cyclosporine (Neoral, Sandimmune)
Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.
Metronidazole (Flagyl)
Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.
Fennel Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.
Ciprofloxacin (Cipro)
Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.
Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.
Contraceptive Drugs
Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.
Some constituents of fennel have estrogenic activity.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.
Estrogens
Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.
Some constituents of fennel have estrogenic activity.
Tamoxifen (Nolvadex)
Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.
Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.
Oregano Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.
Antidiabetes Drugs
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.
Brand information
Manufacturer and brand details for Oregano Oil, from the product label.
Vitabase
See all Vitabase products- Name
- Vitabase.com
- City
- Monroe
- State
- GA
- ZipCode
- 30656
- Phone Number
- 888.559.3802
Oregano Oil by Vitabase: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Oregano Oil’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Oregano
Interacts with 208 drugsOregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...
Read the full Oregano monograph → Herb & supplement monographGinger
Interacts with 1,007 drugsGinger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...
Read the full Ginger monograph → Herb & supplement monographFennel
Interacts with 740 drugsFennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...
Read the full Fennel monograph →Sources & How We Checked
Oregano Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 93 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oregano 12 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Benito M, Jorro G, Morales C, et al. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996;76:416-8. PubMed
- Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
- Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
- Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
- Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
- Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed
- Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256. PubMed
- McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
- Ragi, J., Pappert, A., Rao, B., Havkin-Frenkel, D., and Milgraum, S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J.Drugs Dermatol. 2011;10(10):1168-1172.
- Singletary K. Oregano: overview of the literature on health benefits. Nutrition Today 2010;45(3):129-38.
- Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.
Ginger 64 references
- Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19-24. PubMed
- Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2000;(2):CD000145. PubMed
- Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577-82. DOI
- Backon J. Ginger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gynecol Reprod Biol 1991;42:163-4. PubMed
- Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids 1989;35:183-5. PubMed
- Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991;42:111-20. PubMed
- Smith C, Crowther C, Willson K, et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639-45. PubMed
- Portnoi G, Chng LA, Karimi-Tabesh L, et al. Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol 2003;189:1374-7.. PubMed
- Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003;11:783-9. PubMed
- Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol 2005;45:74-80. PubMed
- Thomson M, Al-Qattan KK, Al-Sawan SM, et al. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids 2002;67:475-8. PubMed
- Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
- Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol 2004;56:101-5.
- Kruth P, Brosi E, Fux R, et al. Ginger-associated overanticoagulation by phenprocoumon. Ann Pharmacother 2004;38:257-60. PubMed
- Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2005;59:425-32. PubMed
- Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol 2005;105:849-56. PubMed
- Smith C, Crowther C, Wilson K et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639-45. PubMed
- Jiang X, Blair EY, McLachlan AJ. Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approach. J Clin Pharmacol 2006;46:1370-8. PubMed
- Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
- Ozgoli G, Goli M, Moattar F. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med 2009;15:129-32. PubMed
- Black CD, Herring MP, Hurley DJ, O'Connor PJ. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain 2010;11:894-903. PubMed
- Heitmann K, Nordeng H, Holst L. Safety of ginger use in pregnancy: results from a large population-based cohort study. Eur J Clin Pharmacol 2012 Jun 17. PubMed
- Ryan JL, Heckler CE, Roscoe JA, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20:1479-89. PubMed
- Backon J. Ginger as an antiemetic: possible side effects due to its thromboxane synthetase activity. Anaesthesia. 1991;46(8):705-6.. PubMed
- Abebe W. Herbal medication: potential for adverse interactions with analgesic drugs. J Clin Pharm Ther. 2002;27:391-401. PubMed
- Argento A, Tiraferri E, Marzaloni M. [Oral anticoagulants and medicinal plants. An emerging interaction]. Ann Ital Med Int. 2000;15:139-43.
- Young HY, Liao JC, Chang YS, et al. Synergistic effect of ginger and nifedipine on human platelet aggregation: a study in hypertensive patients and normal volunteers. Am J Chin Med. 2006;34:545-51. PubMed
- Greenway FL, Liu Z, Martin CK, et al. Safety and efficacy of NT, an herbal supplement, in treating human obesity. Int J Obes (Lond). 2006;30:1737-41. PubMed
- Shalansky S, Lynd L, Richardson K, et al. Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis. Pharmacotherapy. 2007;27:1237-47. PubMed
- Lesho EP, Saullo L, Udvari-Nagy S. A 76-year-old woman with erratic anticoagulation. Cleve Clin J Med. 2004;71:651-6. PubMed
- Okonta JM, Uboh M, Obonga WO. Herb-Drug Interaction: A Case Study of Effect of Ginger on the Pharmacokinetic of Metronidazole in Rabbit. Indian Journal of Pharmaceutical Sciences (India) 2008;70(230):232. PubMed
- Chiang HM, Chao PD, Hsiu SL, et al. Ginger significantly decreased the oral bioavailability of cyclosporine in rats. Am J Chin Med. 2006;34:845-55. PubMed
- Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol. 2005;97:227-30. PubMed
- Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res. 2006;20:764-72.
- Al-Amin ZM, Thomson M, Al-Qattan KK, et al. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr. 2006;96:660-6.
- Islam MS, Choi H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J Med Food. 2008;11:152-9.
- Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
- Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
- Sripramote, M. and Lekhyananda, N. A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy. J Med Assoc.Thai. 2003;86(9):846-853.
- Lohsiriwat, S., Rukkiat, M., Chaikomin, R., and Leelakusolvong, S. Effect of ginger on lower esophageal sphincter pressure. J.Med.Assoc.Thai. 2010;93(3):366-372.
- Liu, P. H. and Ho, H. L. Ginger and drug bezoar induced small bowel obstruction. J R.Coll.Surg.Edinb. 1983;28(6):397-398.
- Maghbooli M, Golipour F, Moghimi Esfandabadi A, Yousefi M. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res 2014;28(3):412-5. PubMed
- Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr 2013;64(6):682-6.
- Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement PubMed
- Paramdeep G. Efficacy and tolerability of ginger (Zingiber officinale) in patients of osteoarthritis of knee. Indian J Physiol Pharmacol 2013;57(2):177-83.
- Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med 2012;12:92. PubMed
- Viljoen E, Visser J, Koen N, Musekiwa A. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J 2014;13:20. PubMed
- Bartels EM, Folmer VN, Bliddal H, et al. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis Cartilage. 2015;23(1):13-21. PubMed
- Choi JS, Han JY, Ahn HK, et al. Assessment of fetal and neonatal outcomes in the offspring of women who had been treated with dried ginger (Zingiberis rhizoma siccus) for a variety of illnesses during pregnancy. J Obstet Gynaecol. 2015;35(2):125-30.
- Marx W, McKavanagh D, McCarthy AL, Bird R, Ried K, Chan A, Isenring L. The effect of ginger (Zingiber officinale) on platelet aggregation: A systematic literature review. PLoS One. 2015;10(10):e0141119. PubMed
- Crichton M, Marshall S, Marx W, McCarthy AL, Isenring E. Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: A systematic review update and meta-analysis. J Acad Nutr Diet. 2 PubMed
- Martins LB, Rodrigues AMDS, Monteze NM, et al. Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine. Cephalalgia. 2020;40(1):88-95.
- Martins LB, Rodrigues AMDS, Rodrigues DF, Dos Santos LC, Teixeira AL, Ferreira AVM. Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment. Cephalalgia. 2019;39(1):68-76.
- Ahad A, Raish M, Bin Jardan YA, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effect of Hibiscus sabdariffa and Zingiber officinale on the antihypertensive activity and pharmacokinetic of losartan in hypertensive rats. Xenobiotica. 2020:1-11.
- Okuhira H, Nakatani Y, Furukawa F, Kanazawa N. Anaphylaxis to ginger induced by herbal medicine. Allergol Int. 2020;69(1):159-160. PubMed
- Yamprasert R, Chanvimalueng W, Mukkasombut N, Itharat A. Ginger extract versus Loratadine in the treatment of allergic rhinitis: a randomized controlled trial. BMC Complement Med Ther. 2020;20(1):116. PubMed
- Ebrahimzadeh A, Ebrahimzadeh A, Mirghazanfari SM, Hazrati E, Hadi S, Milajerdi A. The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. PubMed
- Alam MA, Bin Jardan YA, Alzenaidy B, et al. Effect of Hibiscus sabdariffa and Zingiber officinale on pharmacokinetics and pharmacodynamics of amlodipine. J Pharm Pharmacol 2021;73(9):1151-60.
- Akbarzadeh E, Heydari M, Atarzadeh F, Jaladat AM. Chronic dysuria following ginger (Zingiber officinale) use: a case report. Galen Med J 2018;7:e1086. DOI
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Rostamkhani H, Veisi P, Niknafs B, Jafarabadi MA, Ghoreishi Z. The effect of zingiber officinale on prooxidant-antioxidant balance and glycemic control in diabetic patients with ESRD undergoing hemodialysis: a double-blind randomized control trial. BMC Co PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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