Pantethine 300 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pantethine 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pantethine 300 mg is a dietary supplement by Protocol For Life Balance with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pantethine 300 mg by Protocol For Life Balance
Ask about any prescription or over-the-counter medication and we check it for interactions with Pantethine 300 mg by Protocol For Life Balance — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Pantethine 300 mg by Protocol For Life Balance
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This softgel contains one active ingredient, pantethine, at 300 mg. The facts we hold identify pantethine as the active ingredient and tie it to the conditions covered in the effectiveness section below.
The remaining listed ingredients are inactive ingredients: bovine gelatin, glycerin, water, carob, rice bran oil, sunflower lecithin, and beeswax. These are not active ingredients, and they are the materials that make up the softgel and its contents.
Does it work?
Moderate evidence
The one rating we hold as Possibly Effective is for hyperlipoproteinemia, a condition with high fat levels in the blood. Hyperlipidemia, athletic performance, and pantothenate kinase-associated neurodegeneration (PKAN, a rare inherited brain condition) are each rated Insufficient Reliable Evidence To Rate, which means we don't have enough reliable evidence to judge them.
How safe is it?
Well-documented data
Pantethine is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild stomach complaints, including nausea, vomiting, diarrhea, stomach discomfort, bloating, and gas.
Mild itching has been reported but is uncommon. We hold no pregnancy entry for pantethine, so we can't tell you what the data shows for pregnancy; talk with your doctor or pharmacist for personalized advice.
For breastfeeding, the safety notes say it hasn't been well studied and caution is advised.
Meds to double-check
Moderate interaction found
Anticoagulant and antiplatelet drugs, meaning blood thinners and medicines that keep platelets from clumping, are the one medication type to double-check, with a Moderate severity. Confirm with your own doctor or pharmacist before combining them, and use the search tool on this page for your exact medication.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This may be worth a conversation if you're looking at pantethine for high blood fats, given its Possibly Effective rating for hyperlipoproteinemia. If you take a blood thinner or an antiplatelet medicine, talk it over with your own doctor or pharmacist before starting, because the interaction is rated Moderate.
If you are pregnant or breastfeeding, get personalized advice from your own healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pantethine 300 mg, straight from the product label.
| Brand | Protocol For Life Balance |
|---|---|
| Barcode (UPC) | 707359104877 |
| Net contents | 60 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 326467 |
| Product type | Vitamin |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pantethine 300 mg by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pantethine | 300 mg | -- |
Other ingredients: Bovine Gelatin, Glycerin, Water, Carob, Rice Bran Oil, Sunflower Lecithin, Beeswax
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested usage: Take 1 softgel 2 to 3 times daily with food, or as directed by your healthcare practitioner.
Formula
How it works: Pantethine, a biologically active form of pantothenic acid (vitamin B-5), is the precursor of coenzyme A (CoA) and acyl-carrier protein (ACP), which are both essential cofactors in the metabolism of carbohydrates, lipids and amino acids. Pantethine has been shown to promote liver and vascular health through its ability to support healthy lipid metabolism in these tissues. Clinical and non-clinical studies suggest that pantethine can support healthy serum lipid levels that are already within the normal range.
Biologically active form of vitamin B5
Precautions
Cautions/Interactions: Pantethine may interact with anti-coagulant and anti-platelet medications, including warfarin, clopidogrel, NSAIDs, and others. If you are taking any of these medications, or if you are planning a surgical procedure, consult your healthcare practitioner before using this product.
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product. Supports healthy serum lipids already within the normal range
Non-GMO
Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.
FDA Statement of Identity
A Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pantethine 300 mg by Protocol For Life Balance label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pantethine 300 mg by Protocol For Life Balance
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.
Pantethine
Interacts with122 drugs
Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...
Pantethine monograph & interactionsOther (inactive) ingredients: Bovine Gelatin, Glycerin, Water, Carob, Rice Bran Oil, Sunflower Lecithin, Beeswax. These complete the product’s ingredient list but are not active constituents.
Pantethine 300 mg by Protocol For Life Balance Drug Interactions
HelloPharmacist Interaction Report
Protocol For Life Balance Pantethine 300 mg interacts with blood-thinning medications through its one active ingredient, pantethine.
The most serious interaction is with anticoagulant and antiplatelet drugs, meaning blood thinners (anticoagulants) and medicines that stop platelets from clumping (antiplatelet drugs). The severity is Moderate.
Theoretically, pantethine might increase the risk of bleeding with these medicines, and some evidence suggests it reduces platelet clumping.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 122 individual medications. The anticoagulant and antiplatelet category is the only drug type documented for this product, so it is the one to look at closely.
Search your exact medications with the checker on this page before starting. Your own doctor or pharmacist is the right person to weigh any match against your health history.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pantethine 300 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pantethine 300 mg interact with 122 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pantethine 300 mg interact with drugs. Each result below shows which ingredient is responsible. Pantethine
DabigatranPradax, Pradaxa
How Dabigatran interacts with Pantethine 300 mg — through 1 ingredient. Tap an ingredient for the detail:
PantethineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Pantethine + Dabigatran interactionReteplaseRetevase
How Reteplase interacts with Pantethine 300 mg — through 1 ingredient. Tap an ingredient for the detail:
PantethineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Pantethine + Reteplase interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pantethine 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pantethine
Anticoagulant/Antiplatelet Drugs
Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.
Brand information
Manufacturer and brand details for Pantethine 300 mg, from the product label.
Protocol For Life Balance
See all Protocol For Life Balance products- Name
- Protocol For Life Balance
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- protocolforlife.com
Pantethine 300 mg by Protocol For Life Balance: Common Questions
Does Pantethine 300 mg by Protocol For Life Balance interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is it safe to take during pregnancy?
Does it work for cholesterol?
What side effects might I notice?
Can I take it while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pantethine 300 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pantethine 300 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pantethine 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 9 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pantethine 9 references
- Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
- Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
- Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
- Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
- Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
- Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
- McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
- Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
- Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC