Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Part 2 Ingredients & Drug Interactions

by Brenda Watson's Vital Planet

Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Part 2 is a dietary supplement by Brenda Watson's Vital Planet with 5 active ingredients. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 1,543 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Clove leaf oil, Black Cumin seed Oil, Cinnamon leaf Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Part 2 by Brenda Watson's Vital Planet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Intestinal Balancing Blend” is a proprietary blend — the label gives one combined amount (220 mg) without saying how much of each component you get.

Part 2 contains five active ingredients. Cinnamon leaf oil (from cassia cinnamon), oregano oil, thyme oil, and clove leaf oil are all concentrated essential oils or extracts from culinary herbs.

Black cumin seed oil is an oil pressed from black cumin seeds, also called black seed or nigella sativa. The product also contains one inactive ingredient: a non-GMO vegan capsule (the shell holding everything together).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Relieve gas and bloating, support digestive and liver health.
  • We looked for evidence on: Flatulence, Dyspepsia, Diarrhea, Constipation, Gastritis, Nonalcoholic fatty liver disease (NAFLD) — and 4 related terms.
  • The strongest evidence on file: Black Seed is rated "Possibly Effective" for Helicobacter pylori (Natural Medicines).
  • Also on file: Clove is rated "Insufficient Reliable Evidence To Rate" for Cough, Diarrhea, Dyspepsia, Flatulence.
  • Also on file: Oregano is rated "Insufficient Reliable Evidence To Rate" for Cough, Dyspepsia.

The evidence we hold doesn't establish that any of these ingredients work reliably for their traditional or marketed uses. Cinnamon leaf oil, oregano oil, thyme oil, and clove leaf oil all show insufficient reliable evidence for a range of conditions—respiratory infections, skin problems, digestion, and blood sugar control among them.

Black cumin seed oil fares better: the data we hold rates it possibly effective for acne, hay fever, asthma, Helicobacter pylori infection (a bacterium linked to ulcers), and type 2 diabetes. However, 'possibly effective' means the evidence is preliminary; it's not proof the ingredient will work for you.

The evidence, ingredient by ingredient Cassia Cinnamon Oregano Thyme Clove Black Seed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Each ingredient is generally well tolerated at food amounts, but this product delivers them as concentrated supplements—a different story. Cinnamon leaf oil poses a liver-safety concern with long-term high-dose use due to its coumarin content; very high doses of coumarin from other sources have caused liver injury in humans, though most clinical trial participants taking cinnamon doses of 360 mg to 12 grams daily for three months showed no significant liver enzyme changes.

Oregano oil, thyme oil, and clove leaf oil can all cause allergic reactions in sensitive people, ranging from mild rash or contact dermatitis to, rarely, anaphylaxis. Thyme's concentrated essential oil can be toxic if swallowed.

Black cumin seed oil commonly causes nausea, vomiting, constipation, and gastric burning; one clinical trial reported unspecified GI complaints in 20% of participants, and one patient was hospitalized for nausea and vomiting thought related to the oil. Regarding pregnancy: cinnamon, thyme, and clove are rated likely safe in pregnancy based on available data; oregano is possibly unsafe at medicinal doses; black cumin seed is rated likely unsafe in pregnancy.

For breastfeeding, safety data is insufficient for oregano and black cumin—talk with your doctor or pharmacist about breastfeeding safety if you're taking this product.

Side effects, ingredient by ingredient Cassia Cinnamon Oregano Thyme Clove Black Seed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Clove, Oregano, Thyme, Black Seed, Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,544 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check the following medication types with your doctor or pharmacist: serotonergic drugs (certain antidepressants and pain relievers), antidiabetes or diabetes medications, anticoagulant or antiplatelet drugs (blood thinners like warfarin, clopidogrel, or aspirin), blood pressure medications, CNS depressants (sedating drugs), immunosuppressants, diuretics, and cyclosporine. Additionally, check any drugs broken down by your liver's cytochrome P450 enzymes (CYP1A2, CYP2C9, CYP2D6, CYP3A4), including many antidepressants, pain relievers, and antihistamines.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Part 2 is a blend of five herbal oils with a substantial medication-interaction profile—most notably with blood thinners, blood pressure drugs, diabetes medications, and serotonergic antidepressants. Black cumin seed oil has possibly effective evidence for a few conditions (acne, hay fever, asthma, diabetes), but the other four ingredients lack established efficacy in our data.

Concentrated herbal oils like these carry more risk of side effects and GI upset than food amounts. If you're on any medications—especially blood thinners, diabetes drugs, antidepressants, or blood pressure medications—check each one against this product with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Part 2, straight from the product label.

Brand Brenda Watson's Vital Planet
Net contents 28 Vegetable Liquid Capsule(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 254662
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Part 2 by Brenda Watson's Vital Planet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
28
IngredientAmount% DV
Cinnamon leaf Oil0 NP--
Intestinal Balancing Blend220 mg--
organic Oregano Oil0 NP--
Thyme Oil0 NP--
Clove leaf oil0 NP--
Black Cumin seed Oil0 NP--

Other ingredients: non-GMO Vegan Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Relieves occasional gas & bloating

Supports a healthy balance of intestinal yeast & bacteria Supports liver health Enhances natural detoxification

Non GMO

Vegan

Gluten free

Vital Detox is a 14-day, 2-part advanced support system designed to stimulate liver detoxification and rebalance the bacteria and yeast in the digestive tract. By supporting healthy bacteria levels, especially in the upper GI tract, Vital Detox can help address occasional gas, bloating, abdominal discomfort and other digestive issues resulting from an imbalance of bacteria and yeast.

Contains no: GMOs, yeast, wheat, gluten, psyllium, soy, dairy, tree nuts, salt, sugar, animal products, binders, fillers, or artificial ingredients

Manufactured in a facility in the USA that is GMP

General Statements

2-Part, 14-Day program Part 1-28 Vegetable capsules Part 2-28 Vegetable liquid-capsules

Quality, purity and potency guaranteed through expiration.

Hi, I'm Brenda Watson, founder of Vital Planet. For more than 25 years my team and I have been formulating exceptional natural health products. At Vital Planet we use the most effective wholesome ingredients to help people balance their digestive system and as a result, achieve vibrant energy and lasting health. Brenda Watson Founder of Vital Planet

For ideal results Brenda recommends: Use during this detox program: Vital Viber Vital LAX (if constipated) Vital Gut Renew

Use as daily maintenance after this detox program: Vital Flora Vital Fiber Vital Gut Renew

FDA Statement of Identity

Dietary Supplement

Formula

Vital Detox Part 2 is delivered in a unique liquid vegetable capsule and features concentrated essential oils from oregano, thyme, clove, black seed and cinnamon leaf. Brenda Watson formulated Vital Detox part 2 to target unwanted bacteria and yeast that have overgrown in the upper small intestine.

Suggested/Recommended/Usage/Directions

Vital Detox - Part 2 Directions: Take one (1) capsule in the morning on an empty stomach. Repeat in the evening. Take with Vital Detox Part 1. Wait 20 minutes before eating.

Storage

Store at 86 degrees F (30 degrees C) or below.

Precautions

Keep out of reach of children.

Consult your physician prior to using this or any product if you are pregnant, nursing, taking any medication or have a medical condition.

Seals/Symbols

Manufactured in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Part 2 by Brenda Watson's Vital Planet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Part 2 by Brenda Watson's Vital Planet

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Intestinal Balancing Blend

220 mg per serving

Other (inactive) ingredients: Non-GMO Vegan Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Part 2 by Brenda Watson's Vital Planet Drug Interactions

Want to check YOUR meds against Part 2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,543Drugs
1,543 Moderate

Ingredients driving the most interactions

Thyme Oil 379

Each ingredient & the kinds of drugs it affects

For each ingredient in Part 2 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove leaf oil7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D

Black Cumin seed Oil14 drug types · 912 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.

Likelihood Possible Evidence D
Prednisolone

Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.

Likelihood Possible Evidence D

Cinnamon leaf Oil2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D

Thyme Oil4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D

organic Oregano Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Part 2, from the product label.

Brenda Watson's Vital Planet

See all Brenda Watson's Vital Planet products
Name
Vital Planet
Street Address
133 Candy Ln.
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
800.938.8482
Web Address
VitalPlanet.com
Pharmacist Counseling Corner

Part 2 by Brenda Watson's Vital Planet: Common Questions

Does Part 2 by Brenda Watson's Vital Planet interact with any medications?
Yes. Based on its ingredients, Part 2 has a known interaction with 1,543 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Part 2 contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data differs by ingredient. Cinnamon, thyme, and clove are rated likely safe in pregnancy at the amounts typically studied, but oregano is possibly unsafe at medicinal doses, and black cumin seed is rated likely unsafe. Food amounts of oregano and black cumin are probably fine, but this product delivers concentrated supplements. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I breastfeed while taking this?
For cinnamon, thyme, and clove, we have safety data supporting likely safety. For oregano and black cumin seed, there isn't enough reliable safety data on supplement doses while breastfeeding. Ask your doctor or pharmacist whether it's safe for you and your baby.
What does black cumin seed actually do?
In our data, black cumin seed is possibly effective for acne, hay fever, asthma, Helicobacter pylori infection, and type 2 diabetes. That means preliminary evidence suggests it may help with these conditions, but it's not a guarantee—more research is needed. The other four ingredients in this product (cinnamon, oregano, thyme, clove) lack established evidence in our data for any specific use.
What side effects might I get from this product?
The most common are GI upset—nausea, vomiting, constipation, and stomach burning, especially from the black cumin seed oil. The concentrated essential oils (cinnamon, oregano, thyme, clove) can also cause allergic reactions like rash or contact dermatitis in sensitive people. Thyme oil and clove oil in high amounts can cause dizziness or headache. Long-term high-dose cinnamon raises a theoretical liver-safety concern.
Is this safe to take long-term?
There isn't much long-term safety data for these concentrated oils used together as a supplement. Cinnamon at very high doses over extended periods poses a liver concern due to coumarin. The others are less studied at supplement doses over months or years. Stick to the label dose, and if you plan to use this long-term, check in with your doctor or pharmacist.
Will this interact with my blood thinner?
Yes—oregano, thyme, clove, and black cumin seed all have theoretical antiplatelet effects that could increase bleeding risk. This is Moderate severity for all but clove (Minor). Don't start this product without checking with your doctor or pharmacist first, especially if you're on warfarin, clopidogrel, aspirin, or another blood thinner.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Part 2 label
Go deeper

The Full Monographs Behind Part 2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Part 2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 136 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
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Oregano 12 references
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Thyme 18 references
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Clove 26 references
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Black Seed 60 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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