Part 2 Ingredients & Drug Interactions
by Brenda Watson's Vital Planet
What is this page for?
First and foremost: checking Part 2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Part 2 is a dietary supplement by Brenda Watson's Vital Planet with 5 active ingredients. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 1,543 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Clove leaf oil, Black Cumin seed Oil, Cinnamon leaf Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Part 2 by Brenda Watson's Vital Planet
Ask about any prescription or over-the-counter medication and we check it for interactions with Part 2 by Brenda Watson's Vital Planet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Part 2 by Brenda Watson's Vital Planet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Part 2 contains five active ingredients. Cinnamon leaf oil (from cassia cinnamon), oregano oil, thyme oil, and clove leaf oil are all concentrated essential oils or extracts from culinary herbs.
Black cumin seed oil is an oil pressed from black cumin seeds, also called black seed or nigella sativa. The product also contains one inactive ingredient: a non-GMO vegan capsule (the shell holding everything together).
Does it work?
Moderate evidence
The evidence we hold doesn't establish that any of these ingredients work reliably for their traditional or marketed uses. Cinnamon leaf oil, oregano oil, thyme oil, and clove leaf oil all show insufficient reliable evidence for a range of conditions—respiratory infections, skin problems, digestion, and blood sugar control among them.
Black cumin seed oil fares better: the data we hold rates it possibly effective for acne, hay fever, asthma, Helicobacter pylori infection (a bacterium linked to ulcers), and type 2 diabetes. However, 'possibly effective' means the evidence is preliminary; it's not proof the ingredient will work for you.
How safe is it?
Well-documented data
Each ingredient is generally well tolerated at food amounts, but this product delivers them as concentrated supplements—a different story. Cinnamon leaf oil poses a liver-safety concern with long-term high-dose use due to its coumarin content; very high doses of coumarin from other sources have caused liver injury in humans, though most clinical trial participants taking cinnamon doses of 360 mg to 12 grams daily for three months showed no significant liver enzyme changes.
Oregano oil, thyme oil, and clove leaf oil can all cause allergic reactions in sensitive people, ranging from mild rash or contact dermatitis to, rarely, anaphylaxis. Thyme's concentrated essential oil can be toxic if swallowed.
Black cumin seed oil commonly causes nausea, vomiting, constipation, and gastric burning; one clinical trial reported unspecified GI complaints in 20% of participants, and one patient was hospitalized for nausea and vomiting thought related to the oil. Regarding pregnancy: cinnamon, thyme, and clove are rated likely safe in pregnancy based on available data; oregano is possibly unsafe at medicinal doses; black cumin seed is rated likely unsafe in pregnancy.
For breastfeeding, safety data is insufficient for oregano and black cumin—talk with your doctor or pharmacist about breastfeeding safety if you're taking this product.
Meds to double-check
Moderate interaction found
Before taking this product, check the following medication types with your doctor or pharmacist: serotonergic drugs (certain antidepressants and pain relievers), antidiabetes or diabetes medications, anticoagulant or antiplatelet drugs (blood thinners like warfarin, clopidogrel, or aspirin), blood pressure medications, CNS depressants (sedating drugs), immunosuppressants, diuretics, and cyclosporine. Additionally, check any drugs broken down by your liver's cytochrome P450 enzymes (CYP1A2, CYP2C9, CYP2D6, CYP3A4), including many antidepressants, pain relievers, and antihistamines.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Part 2 is a blend of five herbal oils with a substantial medication-interaction profile—most notably with blood thinners, blood pressure drugs, diabetes medications, and serotonergic antidepressants. Black cumin seed oil has possibly effective evidence for a few conditions (acne, hay fever, asthma, diabetes), but the other four ingredients lack established efficacy in our data.
Concentrated herbal oils like these carry more risk of side effects and GI upset than food amounts. If you're on any medications—especially blood thinners, diabetes drugs, antidepressants, or blood pressure medications—check each one against this product with your doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Part 2, straight from the product label.
| Brand | Brenda Watson's Vital Planet |
|---|---|
| Net contents | 28 Vegetable Liquid Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 24, 2021 |
| DSLD ID | 254662 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Part 2 by Brenda Watson's Vital Planet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cinnamon leaf Oil | 0 NP | -- |
| Intestinal Balancing Blend | 220 mg | -- |
| organic Oregano Oil | 0 NP | -- |
| Thyme Oil | 0 NP | -- |
| Clove leaf oil | 0 NP | -- |
| Black Cumin seed Oil | 0 NP | -- |
Other ingredients: non-GMO Vegan Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Relieves occasional gas & bloating
Supports a healthy balance of intestinal yeast & bacteria Supports liver health Enhances natural detoxification
Non GMO
Vegan
Gluten free
Vital Detox is a 14-day, 2-part advanced support system designed to stimulate liver detoxification and rebalance the bacteria and yeast in the digestive tract. By supporting healthy bacteria levels, especially in the upper GI tract, Vital Detox can help address occasional gas, bloating, abdominal discomfort and other digestive issues resulting from an imbalance of bacteria and yeast.
Contains no: GMOs, yeast, wheat, gluten, psyllium, soy, dairy, tree nuts, salt, sugar, animal products, binders, fillers, or artificial ingredients
Manufactured in a facility in the USA that is GMP
General Statements
2-Part, 14-Day program Part 1-28 Vegetable capsules Part 2-28 Vegetable liquid-capsules
Quality, purity and potency guaranteed through expiration.
Hi, I'm Brenda Watson, founder of Vital Planet. For more than 25 years my team and I have been formulating exceptional natural health products. At Vital Planet we use the most effective wholesome ingredients to help people balance their digestive system and as a result, achieve vibrant energy and lasting health. Brenda Watson Founder of Vital Planet
For ideal results Brenda recommends: Use during this detox program: Vital Viber Vital LAX (if constipated) Vital Gut Renew
Use as daily maintenance after this detox program: Vital Flora Vital Fiber Vital Gut Renew
FDA Statement of Identity
Dietary Supplement
Formula
Vital Detox Part 2 is delivered in a unique liquid vegetable capsule and features concentrated essential oils from oregano, thyme, clove, black seed and cinnamon leaf. Brenda Watson formulated Vital Detox part 2 to target unwanted bacteria and yeast that have overgrown in the upper small intestine.
Suggested/Recommended/Usage/Directions
Vital Detox - Part 2 Directions: Take one (1) capsule in the morning on an empty stomach. Repeat in the evening. Take with Vital Detox Part 1. Wait 20 minutes before eating.
Storage
Store at 86 degrees F (30 degrees C) or below.
Precautions
Keep out of reach of children.
Consult your physician prior to using this or any product if you are pregnant, nursing, taking any medication or have a medical condition.
Seals/Symbols
Manufactured in USA
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Part 2 by Brenda Watson's Vital Planet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Part 2 by Brenda Watson's Vital Planet
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container28 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Intestinal Balancing Blend
Other (inactive) ingredients: Non-GMO Vegan Capsule. These complete the product’s ingredient list but are not active constituents.
Part 2 by Brenda Watson's Vital Planet Drug Interactions
HelloPharmacist Interaction Report
Brenda Watson's Vital Planet Part 2 has documented interactions across multiple medication types through its cinnamon leaf oil, oregano oil, thyme oil, clove leaf oil, and black cumin seed oil.
The most serious interaction involves black cumin seed oil with serotonergic drugs (antidepressants, certain pain relievers)—animal research suggests black seed may increase brain serotonin levels, raising the theoretical risk of serotonin syndrome, though this has only been reported in one human case.
Read the full breakdown — every affected drug type, severity by severity
Cinnamon leaf oil interacts with antidiabetes drugs and hepatotoxic drugs (medications that stress the liver), both at Moderate severity. Oregano oil and thyme oil both interact with anticoagulant or antiplatelet drugs (blood thinners) at Moderate severity; oregano also affects antidiabetes drugs.
Clove leaf oil interacts with five different cytochrome P450 enzyme systems (metabolic pathways your liver uses to break down many medications), all Moderate severity, as well as antidiabetes drugs and blood thinners at Minor severity. Black cumin seed oil has the broadest interaction profile: it affects CNS depressants (sedating drugs), serotonergic drugs, blood pressure medications, blood thinners, immunosuppressants, antidiabetes drugs, diuretics, and cyclosporine (an immunosuppressant)—all Moderate severity.
Additionally, these ingredients were not checked: we hold no interaction data for the Intestinal Balancing Blend itself, since it's a container of components listed separately. Altogether, these interactions span 1,544 individual medications.
Before starting this product, use the interaction checker below with every medication you take.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Part 2?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Part 2 interact with 1,543 drugs. Click any drug to see the details.
5 of the 5 ingredients in Part 2 interact with drugs. Each result below shows which ingredient is responsible. Clove leaf oil Black Cumin seed Oil Cinnamon leaf Oil Thyme Oil organic Oregano Oil
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + 6-mercaptopurine interactionBlack Cumin Seed OilImmunosuppressants Moderate
Interaction Summary
Theoretically, black seed might interfere with immunosuppressive therapy.
Read the full Black Cumin Seed Oil + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Part 2 — through 1 ingredient. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove Leaf Oil + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Part 2 — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Part 2 — through 1 ingredient. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Part 2 — through 4 ingredients. Tap an ingredient for the detail:
Black Cumin Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Black Cumin Seed Oil + Abciximab interactionThyme OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Oil + Abciximab interactionOrganic Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Organic Oregano Oil + Abciximab interactionClove Leaf OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Clove Leaf Oil + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Part 2 — through 1 ingredient. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove Leaf Oil + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove Leaf Oil + Abiraterone interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Abiraterone Acetate interactionClove Leaf OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove Leaf Oil + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Part 2 — through 4 ingredients. Tap an ingredient for the detail:
Clove Leaf OilAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Clove Leaf Oil + Abrocitinib interactionOrganic Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Organic Oregano Oil + Abrocitinib interactionThyme OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Oil + Abrocitinib interactionBlack Cumin Seed OilAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Black Cumin Seed Oil + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Part 2 — through 1 ingredient. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove Leaf Oil + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Part 2 — through 4 ingredients. Tap an ingredient for the detail:
Organic Oregano OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
Read the full Organic Oregano Oil + Acarbose interactionClove Leaf OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Clove Leaf Oil + Acarbose interactionBlack Cumin Seed OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Black Cumin Seed Oil + Acarbose interactionCinnamon Leaf OilAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon Leaf Oil + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acebutolol interactionBlack Cumin Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Black Cumin Seed Oil + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Part 2 — through 4 ingredients. Tap an ingredient for the detail:
Thyme OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Oil + Acenocoumarol interactionBlack Cumin Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Black Cumin Seed Oil + Acenocoumarol interactionOrganic Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Organic Oregano Oil + Acenocoumarol interactionClove Leaf OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Clove Leaf Oil + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Black Cumin Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Cumin Seed Oil + Acepromazine interactionThyme OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Oil + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen interactionClove Leaf OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
Read the full Clove Leaf Oil + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Part 2 — through 5 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
Read the full Clove Leaf Oil + Acetaminophen, Aspirin interactionOrganic Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Organic Oregano Oil + Acetaminophen, Aspirin interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Aspirin interactionThyme OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Oil + Acetaminophen, Aspirin interactionBlack Cumin Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Black Cumin Seed Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Part 2 — through 5 ingredients. Tap an ingredient for the detail:
Black Cumin Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Black Cumin Seed Oil + Acetaminophen, Aspirin, Caffeine interactionThyme OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Oil + Acetaminophen, Aspirin, Caffeine interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Aspirin, Caffeine interactionClove Leaf OilAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Clove Leaf Oil + Acetaminophen, Aspirin, Caffeine interactionOrganic Oregano OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Organic Oregano Oil + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
Read the full Clove Leaf Oil + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Butalbital interactionClove Leaf OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
Read the full Clove Leaf Oil + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
Read the full Clove Leaf Oil + Acetaminophen, Butalbital, Caffeine interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Part 2 — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionBlack Cumin Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Cumin Seed Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionClove Leaf OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
Read the full Clove Leaf Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Part 2 — through 3 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
Read the full Clove Leaf Oil + Acetaminophen, Butalbital, Codeine interactionBlack Cumin Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Cumin Seed Oil + Acetaminophen, Butalbital, Codeine interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Part 2 — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Butalbital, Codeine Phosphate interactionBlack Cumin Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Cumin Seed Oil + Acetaminophen, Butalbital, Codeine Phosphate interactionClove Leaf OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
Read the full Clove Leaf Oil + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Part 2 — through 4 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
Read the full Clove Leaf Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionBlack Cumin Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Cumin Seed Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionThyme OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Part 2 — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Caffeine, Codeine interactionBlack Cumin Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Cumin Seed Oil + Acetaminophen, Caffeine, Codeine interactionClove Leaf OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove Leaf Oil + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Part 2 — through 3 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
Read the full Clove Leaf Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionBlack Cumin Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Cumin Seed Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Part 2 — through 3 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionBlack Cumin Seed OilCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Black Cumin Seed Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionClove Leaf OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove Leaf Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Part 2 — through 2 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
Read the full Clove Leaf Oil + Acetaminophen, Caffeine, Isometheptene interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Part 2 — through 4 ingredients. Tap an ingredient for the detail:
Cinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Caffeine, Pyrilamine interactionBlack Cumin Seed OilDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Read the full Black Cumin Seed Oil + Acetaminophen, Caffeine, Pyrilamine interactionThyme OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Oil + Acetaminophen, Caffeine, Pyrilamine interactionClove Leaf OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
Read the full Clove Leaf Oil + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Part 2 — through 4 ingredients. Tap an ingredient for the detail:
Clove Leaf OilCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
Read the full Clove Leaf Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionBlack Cumin Seed OilSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Black Cumin Seed Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionCinnamon Leaf OilHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cinnamon Leaf Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionThyme OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Part 2 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Clove leaf oil
Antidiabetes Drugs
Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.
Anticoagulant/Antiplatelet Drugs
Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.
Ibuprofen (Advil, Others)
Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.
Black Cumin seed Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.
Antidiabetes Drugs
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.
Antihypertensive Drugs
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.
Clopidogrel (Plavix)
Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.
Cns Depressants
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.
Cyclosporine (Neoral, Sandimmune)
Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.
Diuretic Drugs
Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.
Immunosuppressants
Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.
Phenytoin (Dilantin)
Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.
Serotonergic Drugs
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.
Sildenafil (Viagra)
Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.
Prednisolone
Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.
Cinnamon leaf Oil
Antidiabetes Drugs
Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.
Hepatotoxic Drugs
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.
Thyme Oil
Anticholinergic Drugs
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.
Anticoagulant/Antiplatelet Drugs
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.
Cholinergic Drugs
Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.
Estrogens
Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.
organic Oregano Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.
Antidiabetes Drugs
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.
Brand information
Manufacturer and brand details for Part 2, from the product label.
Brenda Watson's Vital Planet
See all Brenda Watson's Vital Planet products- Name
- Vital Planet
- Street Address
- 133 Candy Ln.
- City
- Palm Harbor
- State
- FL
- ZipCode
- 34683
- Phone Number
- 800.938.8482
- Web Address
- VitalPlanet.com
Part 2 by Brenda Watson's Vital Planet: Common Questions
Does Part 2 by Brenda Watson's Vital Planet interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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What does black cumin seed actually do?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Part 2 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Part 2’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Cassia Cinnamon
Interacts with 442 drugsCassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...
Read the full Cassia Cinnamon monograph → Herb & supplement monographOregano
Interacts with 208 drugsOregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...
Read the full Oregano monograph → Herb & supplement monographThyme
Interacts with 379 drugsThyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...
Read the full Thyme monograph → Herb & supplement monographClove
Interacts with 977 drugsClove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...
Read the full Clove monograph → Herb & supplement monographBlack Seed
Interacts with 912 drugsBlack seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...
Read the full Black Seed monograph →Sources & How We Checked
Part 2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 136 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cassia Cinnamon 20 references
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
- De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
- Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
- Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
- Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
- Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
- Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
- Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
- Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
- Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
- Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
- Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
- Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
- Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
- Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
- Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
- Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
- Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
- Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed
Oregano 12 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Benito M, Jorro G, Morales C, et al. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996;76:416-8. PubMed
- Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
- Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
- Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
- Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
- Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed
- Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256. PubMed
- McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
- Ragi, J., Pappert, A., Rao, B., Havkin-Frenkel, D., and Milgraum, S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J.Drugs Dermatol. 2011;10(10):1168-1172.
- Singletary K. Oregano: overview of the literature on health benefits. Nutrition Today 2010;45(3):129-38.
- Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.
Thyme 18 references
- Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Okazaki K, Kawazoe K, Takaishi Y. Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). Phytother Res 2002;16:398-9. .
- Spiewak R, Skorska C, Dutkiewicz J. Occupational airborne contact dermatitis caused by thyme dust. Contact Dermatitis 2001;44:235-9. . PubMed
- Ernst E, Marz R, Sieder C. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine 1997;4:287-93. PubMed
- Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
- Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
- Mackiewicz, B., Skorska, C., Dutkiewicz, J., Michnar, M., Milanowski, J., Prazmo, Z., Krysinska-Traczyk, E., and Cisak, E. Allergic alveolitis due to herb dust exposure. Ann Agric Environ Med 1999;6(2):167-170.
- Martinez-Gonzalez, M. C., Goday Bujan, J. J., Martinez, Gomez W., and Fonseca, Capdevila E. Concomitant allergic contact dermatitis due to Rosmarinus officinalis (rosemary) and Thymus vulgaris (thyme). Contact Dermatitis 2007;56(1):49-50.
- Jukic, M., Politeo, O., Maksimovic, M., Milos, M., and Milos, M. In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother.Res 2007;21(3):259-261.
- Marzian, O. [Treatment of acute bronchitis in children and adolescents. Non-interventional postmarketing surveillance study confirms the benefit and safety of a syrup made of extracts from thyme and ivy leaves]. MMW.Fortschr.Med 6-28-2007;149(27-28 Suppl
- Cuzzolin, L. and Benoni, G. Attitudes and knowledge toward natural products safety in the pharmacy setting: an Italian study. Phytother.Res 2009;23(7):1018-1023. PubMed
- Berova, N., Stransky, L., and Krasteva, M. Studies on contact dermatitis in stomatological staff. Dermatol.Monatsschr. 1990;176(1):15-18.
- Smeenk, G., Kerckhoffs, H. P., and Schreurs, P. H. Contact allergy to a reaction product in Hirudoid cream: an example of compound allergy. Br.J Dermatol. 1987;116(2):223-231.
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