Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Vital CandiPURE - Part 2 Ingredients & Drug Interactions

by Brenda Watson's Vital Planet

Vital CandiPURE - Part 2 label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vital CandiPURE - Part 2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vital CandiPURE - Part 2 is a dietary supplement by Brenda Watson's Vital Planet with 6 active ingredients. Its ingredients are commonly taken for digestive upset, respiratory and cold symptoms, antimicrobial support.Based on those ingredients, 1,326 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oregon Grape root extract, Fennel seed extract, Thyme Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Vital CandiPURE - Part 2 by Brenda Watson's Vital Planet

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HelloPharmacist Scorecard of Vital CandiPURE - Part 2 by Brenda Watson's Vital Planet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Proprietary Fluid Extract Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Vital CandiPURE - Part 2 contains 6 active ingredients in liquid form. Oregon grape root extract, fennel seed extract, pau d'Arco bark extract, lemon peel extract, oregano leaf extract, and thyme leaf extract are the working components.

The product also contains inactive ingredients—glycerin and purified water—that serve as excipients to deliver and stabilize the formula.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: maintain healthy intestinal yeast balance.
  • We looked for evidence on: Intestinal parasite infection, Urinary tract infections (UTIs), candida overgrowth, yeast infection, dysbiosis.
  • The closest evidence on file: Oregano is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).
  • Also on file: Oregano is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs).

The evidence for most of these ingredients is limited. Oregon grape is possibly effective for psoriasis, but we don't have reliable evidence for its use in eczema, acid reflux, or ulcers.

Fennel is possibly effective for period pain (dysmenorrhea) but lacks solid evidence for bronchitis, anxiety, bedwetting, or cholera. For pau d'Arco, oregano, thyme, and lemon, the data doesn't establish effectiveness for cancer, ulcers, wound healing, period pain, acne, bronchitis, asthma, headache, upper respiratory infections, hay fever, anxiety, high blood pressure, kidney stones, or the common cold.

The evidence, ingredient by ingredient Oregano Oregon Grape Fennel Pau D'arco Lemon Thyme

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oregon grape is generally well tolerated when applied to skin, but oral use is less well studied—use caution. The berberine in it is traditionally avoided in pregnancy and may pass to infants, so don't use it if you're pregnant or breastfeeding.

Fennel is safe as a food but concentrated supplements and essential oils warrant more caution; avoid medicinal amounts in pregnancy. Food amounts are likely fine while breastfeeding, but medicinal doses aren't well studied.

Fennel may cause gastrointestinal upset, sun sensitivity, or allergic reactions—rarely, seizures. One case describes an allergic reaction (sneezing, coughing, wheezing, difficulty breathing) from fennel toothpaste.

Pau d'Arco should be avoided in pregnancy and breastfeeding. At high doses (above 1.5 grams daily of its lapachol component), it may cause anemia, bleeding risk, and severe nausea, vomiting, or diarrhea.

Lemon as food is safe in normal amounts; concentrated supplements or essential oils need doctor approval. Fresh lemon juice at 60 mL twice daily caused gastrointestinal upset in 37% of trial participants versus 8% on placebo.

Oregano is safe as food; medicinal amounts should be avoided in pregnancy unless approved by your doctor. Oral oregano is well tolerated in food amounts; gastrointestinal upset is the most common side effect at higher doses.

Rare systemic allergic reactions including anaphylaxis have been reported. Thyme is generally safe as food and in tea, but the concentrated essential oil can be toxic if swallowed.

Food amounts are likely fine in pregnancy and breastfeeding, but medicinal or essential-oil amounts should be avoided.

Side effects, ingredient by ingredient Oregano Oregon Grape Fennel Pau D'arco Lemon Thyme

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Fennel, Oregon Grape, Lemon, Oregano, Pau D'arco, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check these medication types with your pharmacist: blood thinners (anticoagulants or antiplatelet drugs) at Moderate risk; blood pressure drugs, CNS depressants, and diabetes medications at Moderate risk; and any drug your liver processes via CYP2D6, CYP2C9, or CYP3A4 enzymes at Moderate risk. Birth control pills, hormone replacement therapy, the immunosuppressant cyclosporine, the antibiotic ciprofloxacin, the breast-cancer drug tamoxifen, nerve-signaling medications, and the antifungal itraconazole also carry documented interactions.

If you're on any of these, do not start this supplement without talking to your pharmacist first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product carries real interaction risks, especially with blood thinners, diabetes drugs, blood pressure medications, and drugs your liver processes. If you take any prescription medications—particularly these categories—check them against our medication tool before starting.

Talk to your pharmacist or doctor before adding this to your routine, especially if you're pregnant, breastfeeding, or manage a chronic condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vital CandiPURE - Part 2, straight from the product label.

Brand Brenda Watson's Vital Planet
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 320710
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vital CandiPURE - Part 2 by Brenda Watson's Vital Planet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
28
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)--
Oregon Grape root extract0 NP--
Fennel seed extract0 NP--
Pau d'Arco Bark Extract0 NP--
Lemon Peel Extract0 NP--
Oregano Leaf Extract25 mg--
Thyme Leaf Extract0 NP--
Proprietary Fluid Extract Blend1000 mg--

Other ingredients: Glycerin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Brenda Watson's Vital Planet Natural digestive care experts

Formulation

Targeted yeast cleanse Helps maintain balance of intestinal yeast Supports a healthy urinary tract

Non GMO Gluten Free Soy Free

Vegan

Vital CandiPURE is a 14 day, 2-part cleanse formulated to maintain a healthy balance of intestinal yeast.

Part 2 of CandiPure is a fluid extract designed to enter your body quickly, working in combination with the concentrated capsule of Part 1.

Quality, Purity and potency guaranteed through expiration.

Contains no: GMOs, yeast, wheat, gluten, psyllium, soy, dairy, salt, sugar, animal products, or artificial ingredients.

Formula

Unique blend with uva ursi, undecenoic acid & berberine

Vital CandiPURE Part 2 Formula Contains a potent herbal extract blend which includes Thyme, Pau D'Arco and Oregano.

Seals/Symbols

Vegan

Assembled in USA Assembled in a Facility in the USA that is GMP (Good Manufacturing Practices)

General Statements

14-Day

Free product specialist support line Call toll-free: 1-866-787-9001 At Vital Planet, we're always here to help! If you have questions or want additional information on any of our products, talk to one of out product specialist who will be happy to guide you on your journey to vibrant health. Hi, I'm Brenda Watson, founder of Vital Planet. For more than 25 years my team and I have been formulating exceptional natural health products. At Vital Planet we use the most effective wholesome ingredients to help people balance their digestive system and as a result, achieve vibrant energy and lasting health. Breda Watson Founder of Vital Planet

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

For ideal results Brenda recommends: Use during this detox program: Vital Fiber, Vital Flora, Vital Lax (if constipated) Use as daily maintenance after this detox program: Vital Fiber, Vital Flora Directions: Take one (1) full dropper (36 drops) in the morning on an empty stomach. Repeat in the evening. Take with Vital CandiPURE Part 1. Wait 20 minutes before eating.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store at 86 degrees F (30 degrees C) or below.

Precautions

Keep out of reach of children.

Consult you physician prior to using this or any product if you are pregnant, nursing, taking any medication or have a medical condition.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vital CandiPURE - Part 2 by Brenda Watson's Vital Planet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vital CandiPURE - Part 2 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vital CandiPURE - Part 2 by Brenda Watson's Vital Planet

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Oregano Leaf Extract

Interacts with
208 drugs
25 mg per serving

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacr...

Oregano Leaf Extract monograph & interactions

Proprietary Fluid Extract Blend

1000 mg per serving

Other (inactive) ingredients: Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vital CandiPURE - Part 2 by Brenda Watson's Vital Planet Drug Interactions

Want to check YOUR meds against Vital CandiPURE - Part 2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,326Drugs
1,326 Moderate

Ingredients driving the most interactions

Oregon Grape root extract 1,219
Fennel seed extract 742
Thyme Leaf Extract 379
Oregano Leaf Extract 208
Pau d'Arco Bark Extract 122

Individual Drug Interactions

The ingredients in Vital CandiPURE - Part 2 interact with 1,326 drugs. Click any drug to see the details.

6 of the 6 ingredients in Vital CandiPURE - Part 2 interact with drugs. Each result below shows which ingredient is responsible. Oregon Grape root extract Fennel seed extract Thyme Leaf Extract Oregano Leaf Extract Pau d'Arco Bark Extract Lemon Peel Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Vital CandiPURE - Part 2 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Oregon Grape root extract9 drug types · 1,219 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro and in vivo research suggests that berberine, a constituent of Oregon grape, can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, Oregon grape might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research suggests that berberine, a constituent of Oregon grape, can lower blood glucose levels.

Likelihood Possible Evidence A
Antihypertensive Drugs

Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that berberine, a constituent of Oregon grape, can have hypotensive effects. Also, an analysis of clinical evidence suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, Oregon grape might increase the sedative effects of CNS depressants.
Animal research suggests that berberine, a constituent of Oregon grape, can have sedative effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, Oregon grape might increase the effects and adverse effects of cyclosporine.
Berberine, a constituent of Oregon grape, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of Oregon grape, can inhibit cytochrome P450 2C9 (CYP2C9).

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of Oregon grape, can inhibit cytochrome P450 2D6 (CYP2D6).

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of Oregon grape, moderately inhibits cytochrome P450 3A4 (CYP3A4).

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.
In vitro research suggests that Oregon grape extracts inhibit P-gp efflux.

Likelihood Possible Evidence D
Oregon Grape root extract full monograph & interactions

Fennel seed extract6 drug types · 742 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel seed extract full monograph & interactions

Thyme Leaf Extract4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Thyme Leaf Extract full monograph & interactions

Oregano Leaf Extract2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
Oregano Leaf Extract full monograph & interactions

Pau d'Arco Bark Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco Bark Extract full monograph & interactions

Lemon Peel Extract1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
Lemon Peel Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vital CandiPURE - Part 2, from the product label.

Brenda Watson's Vital Planet

See all Brenda Watson's Vital Planet products
Name
Vital Planet
Street Address
133 Candy Ln.
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
800.938.8482
Web Address
VitalPlanet.com
Pharmacist Counseling Corner

Vital CandiPURE - Part 2 by Brenda Watson's Vital Planet: Common Questions

Does Vital CandiPURE - Part 2 by Brenda Watson's Vital Planet interact with any medications?
Yes. Based on its ingredients, Vital CandiPURE - Part 2 has a known interaction with 1,326 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vital CandiPURE - Part 2 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I'm pregnant or breastfeeding?
No, you should avoid this product during pregnancy and breastfeeding. Oregon grape and pau d'Arco are traditionally avoided in pregnancy due to possible harm, and berberine may pass to infants. Fennel should be avoided in medicinal amounts during pregnancy due to hormone-like effects and limited safety data. Oregano medicinal amounts should also be avoided in pregnancy. Talk with your doctor about what's safe for you.
Does this product actually work?
The evidence is limited. Oregon grape is possibly effective for psoriasis, and fennel is possibly effective for period pain. For the other conditions this product might be marketed for—bronchitis, asthma, anxiety, common cold, and others—we don't have reliable evidence that these ingredients work.
What are the side effects?
Most common are gastrointestinal issues (nausea, vomiting, diarrhea, heartburn, upset stomach) and allergic reactions in sensitive people. Oregon grape applied to skin may cause itching, burning, or irritation. Thyme and oregano can cause contact dermatitis if applied topically. Rare but serious: fennel and oregano have been linked to seizures and anaphylaxis in very sensitive individuals.
Can I take this with blood thinners like warfarin or aspirin?
No, not without talking to your doctor first. Oregon grape, fennel, pau d'Arco, oregano, and thyme all carry Moderate interaction risks with blood thinners and may increase your bleeding risk. This is a serious interaction that needs professional review.
What is the proprietary blend, and what does it do?
The proprietary fluid extract blend in this product is made up of the six individual extract ingredients listed on the label (Oregon grape, fennel, pau d'Arco, lemon peel, oregano, and thyme). We can't tell you the exact amount of each one because the brand keeps that proportion confidential.
Will this raise or lower my blood sugar?
Oregon grape and oregano both contain compounds that research suggests can lower blood glucose levels. If you take diabetes medications, this product could increase your risk of low blood sugar (hypoglycemia). Check with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vital CandiPURE - Part 2 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vital CandiPURE - Part 2 label
Go deeper

The Full Monographs Behind Vital CandiPURE - Part 2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph → Herb & supplement monograph

Oregon Grape

Interacts with 1,219 drugs

Oregon grape is a shrub whose root contains berberine and related compounds. The strongest (though still modest) evidence is for topical creams that may slightly ease psoriasis; evidence for...

Read the full Oregon Grape monograph → Herb & supplement monograph

Fennel

Interacts with 742 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph → Herb & supplement monograph

Lemon

Interacts with 1 drug

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...

Read the full Lemon monograph → Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph →
Sources

Sources & How We Checked

Vital CandiPURE - Part 2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 76 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oregon Grape 21 references
  1. Wiesenauer M, Lydtke R. Mahonia aquifolium in patients with Psoriasis vulgaris; an intraindividual study. Phytomedicine 1996;3:231-5.
  2. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  3. Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
  4. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  5. Gulliver WP, Donsky HJ. A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. Am J Ther 2005;12:398-406. PubMed
  6. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
  7. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  8. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
  9. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  10. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
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Fennel 17 references
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Pau D'arco 6 references
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See these in context on the Pau D'arco monograph →

Lemon 2 references
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See these in context on the Lemon monograph →

Oregano 12 references
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  12. Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.

See these in context on the Oregano monograph →

Thyme 18 references
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  18. Erol S, Aydin B, Dilli D, Okumus N, Zenciroglu A, Gündüz M. An interesting newborn case of fructose 1-6 diphosphatase deficiency triggered after thyme juice ingestion. Clin Lab. 2014;60(1):151-3. PubMed

See these in context on the Thyme monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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