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Dietary supplement

Pascoflair Ingredients & Drug Interactions

by Pascoe

Pascoflair label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pascoflair against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pascoflair is a dietary supplement by Pascoe with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, restlessness.Based on those ingredients, 836 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Passionflower Flower, Leaf, Stem Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pascoflair by Pascoe

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HelloPharmacist Scorecard of Pascoflair by Pascoe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pascoflair contains one active ingredient: passionflower flower, leaf, and stem extract. The extract is intended to help with sleep and reduce anxiety before procedures.

The tablet also contains several inactive ingredients — fillers, binders, and coating materials — including sucrose, maltodextrin, talc, calcium carbonate, cellulose, silica, and others that help hold the tablet together and make it easy to swallow.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: relieve stress and calm the mind.
  • We looked for evidence on: Stress, Pre-procedural anxiety, Anxiety, Nervousness, Tension.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Passion Flower is rated "Insufficient Reliable Evidence To Rate" for Stress.

The data we hold shows passionflower is possibly effective for insomnia and for calming anxiety before medical procedures. For ADHD and benzodiazepine withdrawal, the evidence isn't yet established enough to rate it.

If you're considering Pascoflair for sleep or pre-procedure jitters, the science suggests it may help, though results vary from person to person.

The evidence, ingredient by ingredient Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Passionflower is generally well tolerated when used short-term, but drowsiness is common — so don't drive or operate machinery until you know how it affects you. The most frequent side effects reported in trials are confusion, dizziness, and sedation itself.

One case report describes severe nausea, vomiting, and heart rhythm changes in someone who took very high doses (1500–2000 mg), with all symptoms resolving when the supplement was stopped. Passionflower is rated possibly unsafe in pregnancy due to lack of safety data and potential effects on the uterus, and there isn't enough safety information to recommend it while breastfeeding — talk with your doctor or pharmacist for personalized guidance if you're pregnant or nursing.

Side effects, ingredient by ingredient Passion Flower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Passion Flower.
  • The most serious interaction on file is rated Moderate.
  • For scale: 837 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pascoflair, check with your doctor or pharmacist if you're on any sedating medications — including sleep aids, anti-anxiety drugs, or opioids — because passionflower can add to drowsiness (Moderate severity). Also double-check if you take medications that require OATP or CYP3A4 enzyme transport, as passionflower may theoretically affect how well your body absorbs or processes them (Minor severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pascoflair may help you sleep or ease pre-procedure anxiety, and passionflower extract is generally well tolerated at usual doses. The main thing to watch for is the additive drowsy effect with sedating medications, so check your exact prescriptions before starting.

If you're pregnant, nursing, or taking any medications, talk it over with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pascoflair, straight from the product label.

Brand Pascoe
Barcode (UPC) 4039343169170
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 303463
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pascoflair by Pascoe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
UPC/BARCODE
4039343169170
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Passionflower Flower, Leaf, Stem Extract425 mg--

Other ingredients: Sucrose, Maltodextrin, Talc, Calcium Carbonate, Croscarmellose Sodium, Silica, Cellulose, Stearic Acid, Hypromellose, Acacia Gum, Magnesium Stearate, Glucose Syrup, Tragacanth, Shellac, White Beeswax, Carnauba Wax, Iron Oxide Yellow

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Adults, adolescents 12 years and older: take 1 tablet, twice daily. Pascoflair Should be swallowed whole with a glass of water, and the doses should be spread evenly throughout the day.

Recommended uses: helps to relieve stress and calms the mind Herbal medicine to help relieve restlessness and nervousness, calms the mind to help support healthy and restful sleep

Precautions

Cautions: do not use if you are hypersensitive to passionflower or any other ingredients. Contains sucrose and glucose. Consult a healthcare practitioner prior to use if you are intolerant to certain sugars.

Consult a healthcare provider before use if you are taking other supplements or medications or if you are pregnant or breastfeeding.

Avoid taking with alcohol or products that cause drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Stop use if hypersensitivity or any adverse reaction occurs. Consult a healthcare provider if your symptoms persist or worsen.

Formula

425 mg Passionflower extract

Formulation

Helps to relieve stress and calms the mind

Gluten free Nut free

FDA Statement of Identity

Herbal Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

FSC Mix Verpackung FSC C113446

Brand IP Statement(s)

Pascoe Natural Healthcare since 1895

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pascoflair by Pascoe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pascoflair label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pascoflair by Pascoe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Passionflower Flower, Leaf, Stem Extract

Interacts with
836 drugs
425 mg per serving Form: Passionflower Flower Extract, Passionflower leaf extract, Passionflower Stem Extract

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passionflower Flower, Leaf, Stem Extract monograph & interactions

Other (inactive) ingredients: Sucrose, Maltodextrin, Talc, Calcium Carbonate, Croscarmellose Sodium, Silica, Cellulose, Stearic Acid, Hypromellose, Acacia Gum, Magnesium Stearate, Glucose Syrup, Tragacanth, Shellac, White Beeswax, Carnauba Wax, Iron Oxide Yellow. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pascoflair by Pascoe Drug Interactions

Want to check YOUR meds against Pascoflair?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
836Drugs
248 Moderate 588 Minor

Ingredients driving the most interactions

Passionflower Flower, Leaf, Stem Extract 836

Individual Drug Interactions

The ingredients in Pascoflair interact with 836 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pascoflair interact with drugs. Each result below shows which ingredient is responsible. Passionflower Flower, Leaf, Stem Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pascoflair with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Passionflower Flower, Leaf, Stem Extract3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passionflower Flower, Leaf, Stem Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pascoflair, from the product label.

Pascoe

See all Pascoe products
Name
Pascoe pharmazeutische Praparate GmbH
Street Address
35394 Giessen
Phone Number
1-866-535-0099
Web Address
www.pascoe.ca
Pharmacist Counseling Corner

Pascoflair by Pascoe: Common Questions

Does Pascoflair by Pascoe interact with any medications?
Yes. Based on its ingredients, Pascoflair has a known interaction with 836 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pascoflair contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Pascoflair make me drowsy?
Yes, drowsiness is the most common side effect. The extract is intended to be calming, so you may feel sedated or confused, especially at first. Don't drive or use machinery until you see how it affects you.
Can I take Pascoflair if I'm pregnant?
No, passionflower is rated possibly unsafe in pregnancy because there isn't enough safety data and it may affect the uterus. Talk with your doctor or pharmacist about alternatives.
Is Pascoflair safe to take while breastfeeding?
There isn't enough safety information to recommend passionflower while breastfeeding. Speak with your doctor or pharmacist about whether it's right for you.
What is passionflower extract used for?
Passionflower is possibly effective for insomnia and for reducing anxiety before medical procedures. It's not established for ADHD or benzodiazepine withdrawal based on the current evidence.
Can I take Pascoflair with my sleep medication?
Not without checking first — passionflower adds to the drowsy effects of sedating drugs like sleep aids or anxiety medications, which could make you too sedated or impaired. Talk with your doctor or pharmacist before combining them.
Does Pascoflair have fillers?
Yes, Pascoflair contains several inactive ingredients to make the tablet stable and easy to take — including sucrose, talc, cellulose, and others. If you're sensitive to any of these, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pascoflair label
Go deeper

The Full Monographs Behind Pascoflair’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Pascoflair's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
  8. Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
  9. Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
  10. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
  15. Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
  16. Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
  17. da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
  18. Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
  19. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Passion Flower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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