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Dietary supplement

Passionflower Ingredients & Drug Interactions

by Alvita

Passionflower label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Passionflower against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Passionflower is a dietary supplement by Alvita with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, restlessness.Based on those ingredients, 836 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Passionflower. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Passionflower by Alvita

Ask about any prescription or over-the-counter medication and we check it for interactions with Passionflower by Alvita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Passionflower by Alvita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Alvita Passionflower is a simple product: it contains one active ingredient, passionflower, as a tea bag with no fillers or other inactive ingredients listed. Passionflower is a dried herb used traditionally and in clinical research to ease anxiety and sleep problems.

Its active compounds include flavonoids (apigenin and vitexin, among others) that appear to affect how your central nervous system calms down.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: ease nervous tension and support restful sleep.
  • We looked for evidence on: Insomnia, Stress, Pre-procedural anxiety, anxiety, sleep quality, relaxation.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Insomnia.
  • Also on file: Passion Flower is rated "Insufficient Reliable Evidence To Rate" for Stress.

Passionflower is rated possibly effective for insomnia and pre-procedural anxiety — the kind of worry you might feel before a medical or dental procedure. The evidence supports its use for these two purposes, though it's not ironclad.

For attention deficit-hyperactivity disorder (ADHD) and benzodiazepine withdrawal (easing off anti-anxiety medications), the evidence isn't established well enough to say whether it works. If you're considering it for either of those, talk it over with your doctor or pharmacist.

The evidence, ingredient by ingredient Passion Flower

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Passionflower is generally well tolerated when taken short-term. The most common side effects are drowsiness, dizziness, confusion, and sensitivity reactions — which is why you shouldn't drive or operate machinery after taking it.

Avoid this product during pregnancy because the safety data is sparse and passionflower may affect the uterus. There isn't enough safety information for breastfeeding either, so it's best not used if you're nursing.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before using it.

Side effects, ingredient by ingredient Passion Flower

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Passion Flower.
  • The most serious interaction on file is rated Moderate.
  • For scale: 837 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Alvita Passionflower, double-check with your doctor or pharmacist if you're on any sedatives, sleep aids, benzodiazepines, or other central nervous system depressants — including alcohol. Also mention any medications that rely on the enzymes or transporters CYP3A4 and OATP for how your body processes them, since passionflower may lower their blood levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Alvita Passionflower may help you wind down if you're dealing with insomnia or anxiety before a procedure. But if you take any sedatives, sleep aids, anti-anxiety drugs, or other prescription medications, you need to check them against this product first — the risk of too much drowsiness or reduced drug effect is real.

Avoid it in pregnancy and while breastfeeding. Talk with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Passionflower, straight from the product label.

Brand Alvita
Net contents 24 Tea Bag(s); 1.13 Oz(s); 32 Gram(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 268651
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Passionflower by Alvita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tea Bag(s)
Maximum serving Sizes:
1 Tea Bag(s)
Servings per container
24
IngredientAmount% DV
Passionflower1.33 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Organic

Traditionally used to help ease occasional nervous tension and support restful sleep

NSF Certified Gluten-Free Naturally caffeine free

Certified Organic by QAI.

Certified Gluten-Free by NSF.

Brand IP Statement(s)

Alvita Since 1922

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

NSF Certified Gluten-Free USDA Organic

Quality Assurance International Certified Organic Star-K (Kosher)

Suggested/Recommended/Usage/Directions

Preparation Place one tea bag in a cup and add 8 oz of boiling water. Cover and steep for 10 minutes. Gently squeeze tea bag and remove. Directions for use: We recommend 3 cups daily. Add sweetener if desired

How to brew Pour 8 oz 1 Temp 212 Degrees F 2 Steep 10 min 3

Formula

Star-K (Kosher)

Passionflower First documented in 1569 by Spanish explorers in Peru, passionflower (Passiflora incarnata) is so named because of the blossom's symbolic resemblance to elements in Christian theology. The herb's primary traditional uses include easing occasional nervous tension and supporting restful sleep.

Alvita Passionflower Tea is made with premium-quality, organic passionflower, and has a pleasantly smoky aroma and flavor.

General Statements

The Alvita Story… In 1922, a new era for tea consumption began in America. The herb alfalfa, long known for its beneficial nutrients, was packaged in tea bags and sold to an emerging health food market. This product became known as Alvita and set the standard for future herbal teas. Today, Alvita represents more than forty single-ingredient teas, each one uniquely distinct, just like the individuals who drink them. Alvita chooses only the highest quality organic, wildcrafted, or cultivated botanicals, perfectly prepared to provide you with the best Mother Nature has to offer. Historical and scientific literature is painstakingly studied to ensure that the correct traditional plant and most appropriate servings are used, delivering premium flavor and quality. Herbs are gifts from the earth. Alvita takes its stewardship seriously by offering carefully harvested teas in earth-friendly packaging. Our beautifully illustrated boxes are made using recycled paperboard and our English, pillow style tea bags are oxygen bleached, not chlorine treated. You won’t find a better product, with a cleaner package… anywhere. Alvita… brewed with confidence, steeped in tradition. 100% Recycled Paperboard Recyclable

Precautions

WARNING: If you are pregnant or nursing, taking any medication or have any medical condition, consult a healthcare professional before use.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Passionflower by Alvita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Passionflower label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Passionflower by Alvita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tea Bag(s) Dosage formOther (e.g. Tea Bag) Servings per container24 Amounts shown are per serving.

Passionflower

Interacts with
836 drugs
1.33 Gram(s) per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passionflower monograph & interactions
Interaction report

Passionflower by Alvita Drug Interactions

Want to check YOUR meds against Passionflower?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
836Drugs
248 Moderate 588 Minor

Ingredients driving the most interactions

Passionflower 836

Individual Drug Interactions

The ingredients in Passionflower interact with 836 drugs. Click any drug to see the details.

1 of the 1 ingredient in Passionflower interact with drugs. Each result below shows which ingredient is responsible. Passionflower

Each ingredient & the kinds of drugs it affects

For each ingredient in Passionflower with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Passionflower3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passionflower full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Passionflower, from the product label.

Alvita

See all Alvita products
Name
Twinlab Corporation
City
American Fork
State
UT
ZipCode
84003
Phone Number
1-800-645-5626
Pharmacist Counseling Corner

Passionflower by Alvita: Common Questions

Does Passionflower by Alvita interact with any medications?
Yes. Based on its ingredients, Passionflower has a known interaction with 836 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Passionflower contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Alvita Passionflower if I'm pregnant?
No — the safety data is not enough, and passionflower may affect the uterus. Avoid it during pregnancy and talk with your doctor or pharmacist for alternatives.
Can I take Alvita Passionflower if I'm breastfeeding?
There isn't enough safety information, so it's best not to use it while nursing. Talk with your doctor or pharmacist to see if it's right for you.
Will Alvita Passionflower make me drowsy?
Yes — drowsiness and dizziness are the most common side effects. Don't drive or operate machinery after taking it, and avoid it if you're already on sedative medications.
Does Alvita Passionflower actually work for insomnia?
It's rated possibly effective for insomnia, which means there's some research support for it, but the evidence isn't conclusive. It may help some people; results vary.
What does passionflower do in the body?
Passionflower contains flavonoids that interact with your central nervous system to promote calm and sleep. It's been used traditionally for anxiety and sleep, and some research backs those uses.
Does Alvita Passionflower have any fillers or additives?
No — it's just passionflower in a tea bag with no other inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Passionflower label
Go deeper

The Full Monographs Behind Passionflower’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph →
Sources

Sources & How We Checked

Passionflower's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
  8. Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
  9. Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
  10. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
  12. Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
  15. Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
  16. Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
  17. da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
  18. Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
  19. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Passion Flower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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