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Dietary supplement

Pau D'Arco Bark 2,000 mg Ingredients & Drug Interactions

by Nature's Answer

Pau D'Arco Bark 2,000 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco Bark 2,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco Bark 2,000 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco Bark 2,000 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco Bark 2,000 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau D'Arco Bark 2,000 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pau d'arco bark extract, dosed at 2,000 mg per serving. The inactive ingredients are glycerin and purified water, which make up the liquid formulation.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Healthy immune support.
  • We looked for evidence on: Infection, Immune function, Inflammation.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold rates pau d'arco as having insufficient reliable evidence for cancer, peptic ulcers, wound healing, and irregular menstrual pain (dysmenorrhea). That means clinical studies are either too small, too few, or inconclusive to know whether it works for these uses.

If you're considering it for one of these reasons, talk it over with your doctor about what the research actually shows.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at typical doses, but human safety data is limited. At higher doses — particularly when the lapachol compound reaches above 1.5 grams daily — it may cause anemia, severe nausea, vomiting, diarrhea, and increased bleeding risk.

Occupational exposure to pau d'arco sawdust has caused asthma and skin reactions, though that's less relevant to oral use. The safety data advises against pau d'arco during pregnancy due to possible harm to a developing baby.

There isn't enough data to know whether it's safe while breastfeeding, so talk with your doctor or pharmacist before using it in either situation.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you're on blood thinners or antiplatelet drugs — warfarin, aspirin, clopidogrel, dabigatran, rivaroxaban, and similar medications. Pau d'arco may increase your bleeding risk, especially at doses above 1.5 grams daily.

Your doctor or pharmacist can tell you whether it's safe to combine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco may be of interest to someone exploring traditional herbal remedies, but the clinical evidence for its purported uses isn't established. If you take any blood thinners or antiplatelet medications, you'll want to clear this with your doctor or pharmacist first — the interaction is real and dose-dependent.

Avoid it during pregnancy and breastfeeding unless your healthcare provider advises otherwise, and watch for nausea, vomiting, or unusual bruising at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco Bark 2,000 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000006524
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 264091
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco Bark 2,000 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
15
UPC/BARCODE
083000006524
IngredientAmount% DV
Pau d'Arco Bark Extract2000 mg--

Other ingredients: Glycerin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Gluten Free

Non GMO Project Verified nongmoproject.org

Healthy Immune Support

Alcohol-Free

Our alcohol-free extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

Seals/Symbols

K Parve (Kosher)

Bio-Chelated Cold Extraction Process

Non GMO Project Verified nongmoproject.org

Formula

K Parve (Kosher)

Pau D'Arco Bark 2,000 mg per serving

FDA Statement of Identity

Herbal Supplement

Brand IP Statement(s)

Nature's Answer Since 1972

Discover Nature's Answer

Copyright 2020 Nature's Answer

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1-2 mL (29-58 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco Bark 2,000 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco Bark 2,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco Bark 2,000 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Pau d'Arco Bark Extract

Interacts with
122 drugs
2000 mg per serving Form: Tabebuia avellaneda Bark Extract

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco Bark Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco Bark 2,000 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Pau D'Arco Bark 2,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco Bark Extract 122

Individual Drug Interactions

The ingredients in Pau D'Arco Bark 2,000 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco Bark 2,000 mg interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco Bark Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco Bark 2,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco Bark Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco Bark Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco Bark 2,000 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Pau D'Arco Bark 2,000 mg by Nature's Answer: Common Questions

Does Pau D'Arco Bark 2,000 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Pau D'Arco Bark 2,000 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco Bark 2,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Pau D'Arco during pregnancy?
No. The safety data advises against pau d'arco during pregnancy due to possible harm to your developing baby. Talk with your doctor about what's safe for you instead.
What dose is in this bottle?
Each serving contains 2,000 mg of pau d'arco bark extract in liquid form.
Does pau d'arco actually work for cancer, ulcers, or wound healing?
The evidence we hold rates it as having insufficient reliable evidence for any of those uses. That means clinical studies are too small or inconclusive to say whether it works. If you're considering it for one of those reasons, talk with your doctor about proven treatments instead.
What are the side effects at higher doses?
At doses above 1.5 grams daily of the active lapachol compound, pau d'arco may cause anemia, severe nausea, vomiting, diarrhea, and increased bleeding risk. Human safety data is limited, so use at typical doses and watch for these symptoms.
Is it safe to breastfeed while taking this?
There isn't enough data to know whether pau d'arco is safe while breastfeeding. Talk with your doctor or pharmacist to decide what's best for you and your baby.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco Bark 2,000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco Bark 2,000 mg label
Go deeper

The Full Monographs Behind Pau D'Arco Bark 2,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco Bark 2,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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