Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Pau D'Arco Bark Ingredients & Drug Interactions

by Gaia Herbs

Pau D'Arco Bark label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco Bark against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco Bark is a dietary supplement by Gaia Herbs with 3 active ingredients. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d' Arco inner bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco Bark by Gaia Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco Bark by Gaia Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau D'Arco Bark by Gaia Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

Pau D'Arco Bark is a liquid extract with 3 ingredients. The active ingredient is pau d'arco inner bark extract, which comes from the inner bark of the pau d'arco tree and is used traditionally for various conditions.

The product also contains water and grain alcohol (42–52% pure), which serves as a preservative and extraction medium in this liquid form.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pau d'arco is insufficient to establish whether it works for cancer, peptic ulcers, wound healing, or dysmenorrhea. We don't have reliable clinical data on file to support its use for these purposes.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at typical doses, but higher doses carry real risks. If you take lapachol (the active compound in pau d'arco) in doses above 1.5 grams daily, you may develop anemia, severe nausea, vomiting, diarrhea, and increased bleeding.

Occupational exposure to pau d'arco sawdust can cause asthma and severe skin reactions, though that's not a concern with the finished product. The safety data advises against use during pregnancy due to possible harm to the developing baby.

There isn't enough information to know whether it's safe while breastfeeding, so talk with your doctor or pharmacist before taking it if you're nursing.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main concern is blood thinners and antiplatelet drugs (such as warfarin, aspirin, or clopidogrel) — pau d'arco may raise your bleeding risk when combined with them. We could not check the water or grain alcohol content for interactions, so if you have questions about those components, ask your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco may be worth considering if you're interested in traditional herbal use, but the evidence for its effectiveness hasn't been established. If you take any blood thinner or antiplatelet medication, you need to check with your doctor or pharmacist before starting this product.

Pregnant people should avoid it, and breastfeeding people should confirm safety with their own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco Bark, straight from the product label.

Brand Gaia Herbs
Barcode (UPC) 751063378604
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Dec 21, 2012
DSLD ID 16351
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco Bark by Gaia Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.33 mL
Maximum serving Sizes:
2 mL
Servings per container
23
UPC/BARCODE
751063378604
IngredientAmount% DV
Water0 NP--
Pau d' Arco inner bark extract0 NP--
42-52% pure Grain Alcohol0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Use only as directed on label. Safety sealed for your protection.

Keep away from children.

Not to be used during pregnancy or lactation. If you have a medical condition or take pharmaceutical drugs, please consult with your doctor before use.

General Statements

Liquid Herbal Extract

500 mg/ml herb equivalency

FDA Statement of Identity

DIETARY SUPPLEMENT

General

[02] 1093-0510

Suggested/Recommended/Usage/Directions

Suggested Use Take 40-60 drops of extract in a small amount of water 3-4 times daily between meals. Shake well before using.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco Bark by Gaia Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco Bark label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco Bark by Gaia Herbs

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1.33 mL Dosage formLiquid Servings per container23 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Water

0 NP per serving

Pau d' Arco inner bark extract

Interacts with
122 drugs
0 NP per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d' Arco inner bark extract monograph & interactions

42-52% pure Grain Alcohol

0 NP per serving
Interaction report

Pau D'Arco Bark by Gaia Herbs Drug Interactions

Want to check YOUR meds against Pau D'Arco Bark?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d' Arco inner bark extract 122

Individual Drug Interactions

The ingredients in Pau D'Arco Bark interact with 122 drugs. Click any drug to see the details.

1 of the 3 ingredients in Pau D'Arco Bark interact with drugs. Each result below shows which ingredient is responsible. Pau d' Arco inner bark extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco Bark with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d' Arco inner bark extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d' Arco inner bark extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco Bark, from the product label.

Gaia Herbs

See all Gaia Herbs products
Web Address
GaiaHerbs.com
Pharmacist Counseling Corner

Pau D'Arco Bark by Gaia Herbs: Common Questions

Does Pau D'Arco Bark by Gaia Herbs interact with any medications?
Yes. Based on its ingredients, Pau D'Arco Bark has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco Bark contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
The safety data advises against pau d'arco during pregnancy because of possible harm to the developing baby. If you're breastfeeding, there isn't enough information to know whether it's safe, so talk with your doctor or pharmacist before taking it.
What does pau d'arco do?
Pau d'arco has been used traditionally for cancer, peptic ulcers, wound healing, and dysmenorrhea, but the evidence to support these uses is insufficient. We don't have reliable clinical data on file to confirm it works for any of these purposes.
Are there any side effects at normal doses?
Pau d'arco is generally well tolerated at typical doses. However, if doses of the lapachol compound exceed 1.5 grams daily, you may experience anemia, severe nausea, vomiting, diarrhea, and increased bleeding risk.
What's in the liquid — is it just the herb?
The liquid contains pau d'arco inner bark extract, water, and grain alcohol (42–52% pure). The grain alcohol acts as a preservative and extraction medium in this liquid form. There are no other inactive ingredients listed.
I take a blood thinner — is this safe for me?
Pau d'arco may increase your bleeding risk when combined with blood thinners or antiplatelet drugs. Check with your doctor or pharmacist before starting this product if you take any of these medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco Bark is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco Bark label
Go deeper

The Full Monographs Behind Pau D'Arco Bark’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco Bark's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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