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Dietary supplement

Pau D'Arco Ingredients & Drug Interactions

by Herbs Etc.

Pau D'Arco label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco is a dietary supplement by Herbs Etc. with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco by Herbs Etc.

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco by Herbs Etc. — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau D'Arco by Herbs Etc.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This liquid contains one active ingredient: pau d'arco, a tree bark extract used in herbal medicine. The liquid itself is made with 70% grain alcohol and purified water as inactive carriers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pau d'arco isn't established. We have insufficient reliable data to know whether it works for cancer, peptic ulcers, wound healing, or dysmenorrhea—the conditions most commonly listed for it.

If you're considering it for one of these reasons, talk it over with your doctor about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at standard doses, but human safety data is limited. At higher doses—specifically, if the lapachol content exceeds 1.5 grams daily—it may cause anemia, severe nausea, vomiting, diarrhea, and increased bleeding risk.

Do not use pau d'arco during pregnancy; the safety data advises against it due to possible harm to a developing baby. There isn't enough safety information for breastfeeding, so avoid it then as well.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pau D'Arco, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs like warfarin, aspirin, or clopidogrel. Pau d'arco may raise your bleeding risk with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco may be worth considering if you're interested in herbal remedies, but the evidence for its benefits isn't clear. The main caution is its interaction with blood thinners and antiplatelet drugs—a moderate-severity concern.

If you take any blood-thinning medication, check with your doctor or pharmacist before starting this. Avoid it if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco, straight from the product label.

Brand Herbs Etc.
Net contents 8 fl. Oz.; 236 mL
Market status On market
Date entered into DSLD Sep 25, 2015
DSLD ID 50567
Product type Botanical
Supplement form Liquid
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco by Herbs Etc., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0 Not Present
Maximum serving Sizes:
0 Not Present
IngredientAmount% DV
Pau d'Arco0 NP--

Other ingredients: 70% Grain Alcohol, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Tabebuia impetiginosa

General Statements

Professional strength

Dried inner bark extract

For dispensing purposes only

Herbal Single

FDA Statement of Identity

Fast- Acting Dietary Supplement

General

99156

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco by Herbs Etc. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco by Herbs Etc.

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0 Not Present Dosage formLiquid Amounts shown are per serving.

Pau d'Arco

Interacts with
122 drugs
0 NP per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco monograph & interactions

Other (inactive) ingredients: 70% Grain Alcohol, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco by Herbs Etc. Drug Interactions

Want to check YOUR meds against Pau D'Arco?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco 122

Individual Drug Interactions

The ingredients in Pau D'Arco interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco, from the product label.

Herbs Etc.

Name
Herbs, Etc
Street Address
1340 Rufina Cr.
City
Santa Fe
State
NM
ZipCode
87507
Web Address
www.herbsetc.com
Pharmacist Counseling Corner

Pau D'Arco by Herbs Etc.: Common Questions

Does Pau D'Arco by Herbs Etc. interact with any medications?
Yes. Based on its ingredients, Pau D'Arco has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Pau D'Arco if I'm pregnant?
No—the safety data advises against it. Pau d'arco is rated possibly unsafe in pregnancy due to possible harm to a developing baby and lack of safety data. Talk with your doctor or pharmacist before considering it.
What dose is safe?
Standard doses are generally well tolerated, but we don't have clear human safety data. Doses of lapachol above 1.5 grams daily may cause anemia, severe nausea, vomiting, diarrhea, and bleeding risk. Stick to the label dose, and talk with your pharmacist if you're unsure.
Does Pau D'Arco actually work for cancer or ulcers?
We don't have enough reliable evidence to say. The data rates both cancer and peptic ulcers as having insufficient evidence. If you're considering it for these conditions, discuss it with your doctor instead of relying on this product alone.
Why is this a liquid with alcohol in it?
The 70% grain alcohol is an inactive ingredient that helps extract and preserve the pau d'arco. If you need to avoid alcohol, let your pharmacist know and they can suggest alternatives.
What are the side effects I should watch for?
At higher doses, pau d'arco may cause nausea, vomiting, diarrhea, anemia, and increased bleeding. If you notice any of these, stop and talk with your pharmacist. Occupational exposure to pau d'arco sawdust can cause asthma and dermatitis, though that's less relevant when taking the liquid form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco label
Go deeper

The Full Monographs Behind Pau D'Arco’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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