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Dietary supplement

Pau D'Arco Ingredients & Drug Interactions

by Nature's Sunshine

Pau D'Arco label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco is a dietary supplement by Nature's Sunshine with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco inner bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pau D'Arco by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pau d'arco inner bark extract. Pau d'arco is a traditional herbal remedy derived from the inner bark of a South American tree and has been used in folk medicine for a range of purposes.

The liquid also contains water and alcohol as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Immune system support.
  • We looked for evidence on: Infection, Inflammation, Immune function.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for pau d'arco isn't established in the data we hold. Its effectiveness for cancer, peptic ulcers, wound healing, and dysmenorrhea all carry a rating of insufficient reliable evidence — meaning there isn't enough solid research yet to say whether it works for these uses.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at standard doses, but the safety data comes with caution: at higher doses — particularly when the lapachol component exceeds 1.5 grams daily — it may cause anemia, increased bleeding risk, severe nausea, vomiting, and diarrhea. Human safety data is limited overall.

The safety data advises against pau d'arco during pregnancy due to possible harm to the developing baby and lack of safety information. There isn't enough data to know whether it's safe while breastfeeding, so talk with your doctor or pharmacist before using it if you're nursing.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs — such as warfarin, aspirin, clopidogrel, or similar medications — double-check with your doctor or pharmacist before adding pau d'arco. The risk of increased bleeding is a Moderate concern you'll want to clear before combining them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco may be considered by people interested in traditional herbal remedies, but anyone taking blood thinners or antiplatelet medications needs to check their specific drugs first — the interaction risk is real. Pregnant or breastfeeding?

Talk with your doctor or pharmacist before starting. Because the evidence for what it actually does isn't established, discuss with your healthcare provider whether it makes sense for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904017740
Net contents 2 fl. Oz.; 59 mL
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 278198
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.5 mL
Maximum serving Sizes:
2.5 mL
Servings per container
23
UPC/BARCODE
099904017740
IngredientAmount% DV
Pau d'Arco inner bark extract120 mg--

Other ingredients: Water, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Be a force of nature: Please recycle this bottle. We are committed to you and our planet. Scan to learn more. We source the the world's purest ingredients, no matter where they are gown, to ensure the active nutrients are delivered just as nature intended.

New look! Same great product

Formula

One mL equals two capsules of pau d' arco.

Ko Parve (Kosher)

Liquid herbal extract

Precautions

Do not use if inner seal is missing or damaged.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Ko Parve (Kosher)

Formulation

Immune System Support

Guaranteed Pure

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Natures Sunshine Herbal experts since 1972

Suggested/Recommended/Usage/Directions

Recommended use: Take 1/2 teaspoon (2.5 mL) in water with a meal three times daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco by Nature's Sunshine

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2.5 mL Dosage formLiquid Servings per container23 Amounts shown are per serving.

Pau d'Arco inner bark extract

Interacts with
122 drugs
120 mg per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco inner bark extract monograph & interactions

Other (inactive) ingredients: Water, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Pau D'Arco?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco inner bark extract 122

Individual Drug Interactions

The ingredients in Pau D'Arco interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco inner bark extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco inner bark extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco inner bark extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Pau D'Arco by Nature's Sunshine: Common Questions

Does Pau D'Arco by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Pau D'Arco has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pau d'arco if I'm pregnant?
The safety data advises against it. Pau d'arco is rated possibly unsafe in pregnancy due to possible harm to the developing baby and lack of safety information. Talk with your doctor or pharmacist before using it if you're pregnant or planning to become pregnant.
Is pau d'arco safe while breastfeeding?
There isn't enough data to know either way. The safety information we have isn't sufficient to say it's safe while nursing, so speak with your doctor or pharmacist for personalized advice if you're breastfeeding.
What side effects can pau d'arco cause?
At standard doses, it's generally well tolerated. But at higher doses — especially when the lapachol component exceeds 1.5 grams daily — it can cause anemia, increased bleeding risk, severe nausea, vomiting, and diarrhea. Human safety data is limited, so be cautious with larger amounts.
Does pau d'arco actually work for cancer or ulcers?
The evidence isn't established. For cancer, peptic ulcers, wound healing, and dysmenorrhea, pau d'arco has insufficient reliable evidence to rate its effectiveness — meaning there isn't enough solid research yet to say whether it works.
What is pau d'arco used for traditionally?
Pau d'arco is derived from the inner bark of a South American tree and has been used in folk medicine for various purposes, including cancer, peptic ulcers, wound healing, and dysmenorrhea. However, the evidence for these uses isn't established in current research data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco label
Go deeper

The Full Monographs Behind Pau D'Arco’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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