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Dietary supplement

Pau d'Arco Inner Bark 500 mg Ingredients & Drug Interactions

by Wonder Laboratories

Pau d'Arco Inner Bark 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau d'Arco Inner Bark 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau d'Arco Inner Bark 500 mg is a dietary supplement by Wonder Laboratories with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau d'Arco Inner Bark 500 mg by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau d'Arco Inner Bark 500 mg by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau d'Arco Inner Bark 500 mg by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pau d'arco inner bark at 500 mg per capsule. Pau d'arco comes from the inner bark of a South American tree and has been used traditionally for a range of purposes, though clinical evidence for most uses remains limited.

The capsule itself is made from gelatin, vegetable cellulose, and vegetable magnesium stearate—inactive ingredients that hold and deliver the active bark.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that pau d'arco is effective for cancer, peptic ulcers (sores in the stomach or small intestine), wound healing, or menstrual cramps. For each of these uses, the reliable evidence is insufficient to say whether it works.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at lower doses, but human safety data is limited. At higher doses—particularly when the lapachol constituent exceeds 1.5 grams daily—it may cause anemia (low red blood cells), increased bleeding risk, severe nausea, vomiting, and diarrhea.

The safety data advises against pau d'arco during pregnancy due to the risk of harm to the developing baby and lack of safety information. There isn't enough data to know whether it's safe while breastfeeding—talk with your doctor or pharmacist for personalized advice if you're nursing or planning to.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before taking it if you're on blood thinners or antiplatelet drugs—such as warfarin, apixaban, dabigatran, rivaroxaban, clopidogrel, or aspirin. Pau d'arco may raise your bleeding risk with these medications.

Check your exact medications with the search tool on this page, and confirm with your doctor or pharmacist before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco may be considered by people interested in traditional plant remedies, but the evidence for what it does isn't established in our data. If you take any blood thinner or antiplatelet drug, you should check with your doctor or pharmacist before starting it, because it may increase your bleeding risk.

Avoid it during pregnancy, and don't use it while breastfeeding without talking to your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau d'Arco Inner Bark 500 mg, straight from the product label.

Brand Wonder Laboratories
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 260660
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau d'Arco Inner Bark 500 mg by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
100
IngredientAmount% DV
Pau d'Arco500 mg--

Other ingredients: k-Gelatin, Vegetable Cellulose, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Formulation

Mfg. in an FDA Registered Facility, using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Made in USA

Inner bark

Gluten free

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

Formula

Tabebuia impetiginosa species Lapachol Lapacho tea

Ko Kosher Service

Wonder's Premium Wildcrafted Brazilian Pau d' Arco is harvested from its natural, wild environment high in the Brazilian mountains.

Seals/Symbols

Ko Kosher Service

General Statements

Formula 326

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 to 3 capsules three times daily, with a large glass of water.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau d'Arco Inner Bark 500 mg by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau d'Arco Inner Bark 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau d'Arco Inner Bark 500 mg by Wonder Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Pau d'Arco

Interacts with
122 drugs
500 mg per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco monograph & interactions

Other (inactive) ingredients: K-Gelatin, Vegetable Cellulose, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau d'Arco Inner Bark 500 mg by Wonder Laboratories Drug Interactions

Want to check YOUR meds against Pau d'Arco Inner Bark 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco 122

Individual Drug Interactions

The ingredients in Pau d'Arco Inner Bark 500 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau d'Arco Inner Bark 500 mg interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau d'Arco Inner Bark 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau d'Arco Inner Bark 500 mg, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Pau d'Arco Inner Bark 500 mg by Wonder Laboratories: Common Questions

Does Pau d'Arco Inner Bark 500 mg by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, Pau d'Arco Inner Bark 500 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau d'Arco Inner Bark 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No—the safety data advises against pau d'arco during pregnancy because of possible harm to the baby. While breastfeeding, there isn't enough information to know if it's safe. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to be, or nursing.
What are the side effects?
At standard doses, side effects aren't well documented. But at higher doses—when the lapachol compound goes above 1.5 grams daily—it may cause anemia, increased bleeding, severe nausea, vomiting, and diarrhea. Human safety data is limited overall, so caution is advised at higher doses.
Does pau d'arco actually work for cancer or ulcers?
The reliable evidence we have doesn't establish that it works for cancer, peptic ulcers, wound healing, or menstrual cramps. The evidence for each of these uses is insufficient to say either way.
How much pau d'arco is in each capsule?
Each capsule contains 500 mg of pau d'arco inner bark.
What if I take multiple capsules—could I reach the higher doses mentioned?
Possibly. One study flagged increased bleeding risk when the lapachol compound in pau d'arco exceeded 1.5 grams daily. Taking three or more capsules daily could approach that dose, especially combined with blood thinners. Check with your doctor or pharmacist before taking more than one capsule, particularly if you're on anticoagulant or antiplatelet medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau d'Arco Inner Bark 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau d'Arco Inner Bark 500 mg label
Go deeper

The Full Monographs Behind Pau d'Arco Inner Bark 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau d'Arco Inner Bark 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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