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Dietary supplement

Pau D'Arco (Ipe Roxo) Ingredients & Drug Interactions

by TerraVita

Pau D'Arco (Ipe Roxo) label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco (Ipe Roxo) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco (Ipe Roxo) is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco (Ipe Roxo) by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco (Ipe Roxo) by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau D'Arco (Ipe Roxo) by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Pau d'Arco Glycerite Liquid Extract, a concentrated botanical extract from the pau d'arco tree. It's delivered in liquid form using glycerin as the inactive carrier.

You won't find added fillers or binders—the formula is straightforward.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for pau d'arco doesn't establish that it works for cancer, peptic ulcers, wound healing, or dysmenorrhea (menstrual cramps). The research to date is insufficient to rate it as effective for any of these uses.

If you're considering it for a specific health goal, talk it over with your doctor or pharmacist about what the current science actually supports.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at typical doses, but human safety data is limited and higher doses carry real risks. The lapachol compound, especially above 1.5 grams daily, may cause anemia, increased bleeding, severe nausea, vomiting, and diarrhea.

Occupational exposure to pau d'arco sawdust can trigger asthma and dermatitis—less relevant for the finished extract, but worth knowing. Do not take this during pregnancy; the safety data advises against it due to possible harm to the developing baby.

There isn't enough information to know if it's safe while breastfeeding, so avoid it then too. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before using any pau d'arco product.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any blood thinners or antiplatelet drugs—warfarin, dabigatran, apixaban, clopidogrel, aspirin, or similar—check with your doctor or pharmacist before using this product. The moderate risk of increased bleeding is something they need to weigh for your situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'Arco works as a liquid extract, but we don't yet have solid evidence it treats cancer, ulcers, wounds, or menstrual pain. If you take blood thinners or antiplatelet drugs, this product isn't for you without checking first—the bleeding risk is real.

Pregnancy and breastfeeding are off-limits. Run your medications through the checker below, and talk with your doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco (Ipe Roxo), straight from the product label.

Brand TerraVita
Barcode (UPC) 064434280179
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279415
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco (Ipe Roxo) by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064434280179
IngredientAmount% DV
Pau d'Arco Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco (Ipe Roxo) by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco (Ipe Roxo) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco (Ipe Roxo) by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Pau d'Arco Glycerite Liquid Extract

Interacts with
122 drugs
0.13 mL per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco (Ipe Roxo) by TerraVita Drug Interactions

Want to check YOUR meds against Pau D'Arco (Ipe Roxo)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco Glycerite Liquid Extract 122

Individual Drug Interactions

The ingredients in Pau D'Arco (Ipe Roxo) interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco (Ipe Roxo) interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco (Ipe Roxo) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco Glycerite Liquid Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco (Ipe Roxo), from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Pau D'Arco (Ipe Roxo) by TerraVita: Common Questions

Does Pau D'Arco (Ipe Roxo) by TerraVita interact with any medications?
Yes. Based on its ingredients, Pau D'Arco (Ipe Roxo) has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco (Ipe Roxo) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Pau D'Arco if I'm pregnant or breastfeeding?
No. Pau d'arco is not safe during pregnancy because of possible harm to the developing baby and lack of safety data. There also isn't enough information to know if it's safe while breastfeeding, so avoid it then too. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing and want to discuss alternatives.
What dose of pau d'arco is safe?
The facts we hold don't specify a safe dose range for this product. What we do know is that lapachol (a compound in pau d'arco) at doses above 1.5 grams daily can cause anemia, bleeding, and severe nausea or vomiting. Since this is a liquid extract and human safety data is limited, ask your pharmacist or doctor about dosing before you start.
Does Pau D'Arco actually work for cancer or ulcers?
The research we have doesn't establish that it works for either. The evidence for cancer, peptic ulcers, wound healing, and menstrual cramps is all insufficient to say whether pau d'arco helps. If you're considering it for one of these conditions, talk with your doctor about treatments with better evidence behind them.
What are the side effects?
At higher doses, pau d'arco—especially the lapachol compound above 1.5 grams daily—can cause anemia, increased bleeding risk, severe nausea, vomiting, and diarrhea. Human safety data is limited, so side effects at other doses aren't fully documented. If you notice unusual bleeding, bruising, or stomach trouble, stop and talk with your pharmacist or doctor.
Is this product just pau d'arco, or does it have anything else in it?
It's pau d'arco extract with glycerin as the liquid carrier. There are no added fillers or binders—just the active ingredient and the base.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco (Ipe Roxo) is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco (Ipe Roxo) label
Go deeper

The Full Monographs Behind Pau D'Arco (Ipe Roxo)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco (Ipe Roxo)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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