Major interaction on record — check this product against your medications before combining. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

Pe Min Kan Wan Ingredients & Drug Interactions

by Plum Flower

Pe Min Kan Wan label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pe Min Kan Wan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Pe Min Kan Wan is a dietary supplement by Plum Flower with 9 active ingredients. Its ingredients are commonly taken for eye irritation and tired eyes, cooling and 'heat-clearing' in traditional chinese medicine, cold and flu symptoms.Based on those ingredients, 909 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Xanthium sibiricum Fruit Extract, Magnolia biondii Flower Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pe Min Kan Wan by Plum Flower

Ask about any prescription or over-the-counter medication and we check it for interactions with Pe Min Kan Wan by Plum Flower — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pe Min Kan Wan by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,500 mg) without saying how much of each component you get.

Pe Min Kan Wan is a 9-ingredient blend that combines traditional herbal extracts. The active ingredients include Magnolia biondii, Xanthium sibiricum, Isatis indigotica, Chrysanthemum morifolium, Mentha haplocalyx (Japanese mint), Perilla frutescens, and extracts of Pogostemon cablin, Saposhnikovia divaricata, and Centipeda minima.

The tablet also contains inactive ingredients — maltose, microcrystalline cellulose, magnesium silicate, activated charcoal, and china wax — which serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Gingivitis — rated "Possibly Effective" (Magnolia) (Natural Medicines).
  • On file: Psoriasis — rated "Possibly Effective" (Isatis) (Natural Medicines).

The evidence for most of these ingredients is limited. Magnolia is possibly effective for gingivitis, but for its other uses — including hay fever and anxiety — the data isn't established enough to rate.

Isatis shows possibly effective evidence for psoriasis. For the remaining ingredients' uses — Chrysanthemum for angina, headache, common cold, diabetes, and HIV/AIDS; Japanese mint for bronchitis, cancer, headache, cold, and cough; and Perilla for cognitive decline, hay fever, asthma, bone health, cancer, and headache — we hold insufficient reliable evidence to rate any of them.

We have no effectiveness data on file for Xanthium sibiricum, Pogostemon cablin, Saposhnikovia divaricata, or Centipeda minima.

The evidence, ingredient by ingredient Chrysanthemum Japanese Mint Perilla Magnolia Siberian Cocklebur Isatis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Xanthium sibiricum is the biggest safety concern in this product. The fruit contains toxic compounds and has caused serious poisoning; it's regarded as generally unsafe for use.

It must be avoided during pregnancy and breastfeeding. Chrysanthemum is generally well tolerated as a tea but can cause allergic reactions — an estimated 60% of Europeans are allergic — and safety during pregnancy and breastfeeding has not been established.

Japanese mint in small amounts is fine, but the concentrated oil can be irritating or toxic; it should be avoided while breastfeeding. Perilla seems well tolerated orally as food but supplement amounts are not well studied; medicinal doses should be avoided in pregnancy and breastfeeding because anaphylaxis has been reported with perilla seeds.

Magnolia is generally well tolerated short-term, but safety data in humans are limited, and it should be avoided in pregnancy and breastfeeding. We hold no adverse-effect data for Isatis, Pogostemon cablin, Saposhnikovia divaricata, or Centipeda minima.

Side effects, ingredient by ingredient Chrysanthemum Japanese Mint Perilla Magnolia Siberian Cocklebur Isatis

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 6 matched ingredients can interact with medications — Magnolia, Siberian Cocklebur.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 910 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your pharmacist if you're on diabetes medications (blood sugar can drop dangerously), kidney-harming drugs, liver-harming drugs, blood thinners or aspirin-type drugs (bleeding risk), or sedating medications like sleep aids or anxiety drugs. No interactions are documented for the three ingredients we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product carries serious safety and interaction concerns, particularly because of Xanthium sibiricum. If you take any blood sugar medications, blood thinners, sedating drugs, or drugs that stress your kidneys or liver, you must check with your pharmacist first — these combinations could cause real harm.

Pregnant or breastfeeding people should avoid it. If you're allergic to chrysanthemums or ragweed family plants, this may not be for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pe Min Kan Wan, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934839614
Net contents 500 Pill(s); 4.41 Ounce(s); 125 Gram(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 331236
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pe Min Kan Wan by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Pill(s)
Maximum serving Sizes:
6 Pill(s)
Servings per container
83
UPC/BARCODE
739934839614
IngredientAmount% DV
Proprietary Extract Blend1500 mg--
Pogostemon cablin Herb Extract0 NP--
Chrysanthemum morifolium Flower Extract0 NP--
Mentha haplocalyx herb extract0 NP--
Perilla frutescens leaf extract0 NP--
Saposhnikovia divaricata Root Extract0 NP--
Magnolia biondii Flower Extract0 NP--
Xanthium sibiricum Fruit Extract0 NP--
Isatis indigotica Root Extract0 NP--
Centipeda minima Herb Extract0 NP--

Other ingredients: Maltose, Microcrystalline Cellulose, Magnesium Silicate, Carbon, Activated, China Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Quality

Plum Flower Guarantee

US owned & operated since 1969 Made in China

General Statements

Economy size

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Take 6 pills 3 times daily or as directed by your health care practitioner

Precautions

Caution during pregnancy

Keep out of reach of children

Seals/Symbols

Sourced Sustainably FDA Registered cGMP Compliant Made at a cGMP Certified Facility Lab Tested Quality Verified Species Verified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pe Min Kan Wan by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pe Min Kan Wan label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pe Min Kan Wan by Plum Flower

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Pill(s) Dosage formTablet Or Pill Servings per container83 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

1500 mg per serving

Other (inactive) ingredients: Maltose, Microcrystalline Cellulose, Magnesium Silicate, Carbon, Activated, China Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pe Min Kan Wan by Plum Flower Drug Interactions

Want to check YOUR meds against Pe Min Kan Wan?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
909Drugs
662 Major 247 Moderate

Ingredients driving the most interactions

Xanthium sibiricum Fruit Extract 662
Magnolia biondii Flower Extract 351

Individual Drug Interactions

The ingredients in Pe Min Kan Wan interact with 909 drugs. Click any drug to see the details.

2 of the 9 ingredients in Pe Min Kan Wan interact with drugs. Each result below shows which ingredient is responsible. Xanthium sibiricum Fruit Extract Magnolia biondii Flower Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pe Min Kan Wan with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Xanthium sibiricum Fruit Extract3 drug types · 662 drugs

Antidiabetes Drugs

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans. Hypoglycemia occurs soon after consumption and worsens with time in most cases. Do not use Siberian cocklebur in people taking medications that also lower blood glucose.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Likely Evidence B
Hepatotoxic Drugs

Siberian cocklebur can adversely affect the liver. It has been linked to many cases of hepatotoxicity and some cases of liver failure. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (TriCor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo).

Likelihood Likely Evidence B
Nephrotoxic Drugs

Siberian cocklebur can adversely affect the kidney. Theoretically, combining Siberian cocklebur with potentially nephrotoxic drugs might have additive harmful effects on kidney function.
Some potentially nephrotoxic drugs include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

Likelihood Likely Evidence B
Xanthium sibiricum Fruit Extract full monograph & interactions

Magnolia biondii Flower Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia biondii Flower Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pe Min Kan Wan, from the product label.

Plum Flower

Name
Mayway Herbs
City
Oakland
State
CA
Web Address
plumflowerherbs.com
Pharmacist Counseling Corner

Pe Min Kan Wan by Plum Flower: Common Questions

Does Pe Min Kan Wan by Plum Flower interact with any medications?
Yes. Based on its ingredients, Pe Min Kan Wan has a known interaction with 909 medications, including 662 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pe Min Kan Wan contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant?
No. Xanthium sibiricum is rated likely unsafe in pregnancy due to toxicity risk. Magnolia, Chrysanthemum, Japanese mint, and Perilla all lack enough safety data, and their makers advise against use. Talk with your doctor before taking this if you're pregnant or trying to conceive.
Can I use this while breastfeeding?
Safety data for breastfeeding are not reliable for most ingredients in this product. Xanthium sibiricum should be avoided entirely, and the others lack enough information to say they're safe. It's best to talk with your pharmacist or doctor for personalized advice.
What's Xanthium sibiricum, and why is it concerning?
Xanthium sibiricum, also called Siberian cocklebur, is a fruit extract that contains toxic compounds. It's linked to serious poisoning cases, including dangerous drops in blood sugar, liver and kidney damage, heart rhythm problems, and bleeding. It should never be combined with diabetes, blood thinner, or kidney or liver drugs.
Can Japanese mint extract cause breathing problems?
The concentrated essential oil can, especially if applied to the face or inhaled — it may trigger asthma, bronchial spasm, or even respiratory failure in sensitive people. This product is an extract, not pure oil, but if you have asthma or breathing trouble, mention it to your pharmacist before taking it.
What does Magnolia do in this formula?
Magnolia is possibly effective for gingivitis. For other uses like hay fever and anxiety, the evidence is insufficient to say whether it works. It may also have mild sedating effects, which is why it shouldn't be combined with sleep aids or anxiety medications.
Are there any fillers or additives I should know about?
Yes, the inactive ingredients are maltose, microcrystalline cellulose, magnesium silicate, activated charcoal, and china wax. These are standard tablet binders and fillers. If you have a sensitivity to any of them, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pe Min Kan Wan label
Go deeper

The Full Monographs Behind Pe Min Kan Wan’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chrysanthemum

Chrysanthemum flowers are most often used as a soothing tea in traditional Chinese medicine and as a folk remedy for eye irritation, colds, and minor inflammation. Solid human evidence for t...

Read the full Chrysanthemum monograph → Herb & supplement monograph

Japanese Mint

Japanese mint is a menthol-rich plant used mainly for its essential oil in topical rubs, inhalants, and digestive remedies. There is some support for menthol's soothing and cooling effects,...

Read the full Japanese Mint monograph → Herb & supplement monograph

Perilla

Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human evidence is limited or preliminary, so it...

Read the full Perilla monograph → Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph → Herb & supplement monograph

Siberian Cocklebur

Interacts with 662 drugs

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. Human evidence is very limited, and the p...

Read the full Siberian Cocklebur monograph → Herb & supplement monograph

Isatis

Isatis is a plant long used in traditional Chinese medicine, mainly for sore throats, fevers, and colds. Modern evidence in people is very limited, so its benefits are not well proven. Talk...

Read the full Isatis monograph →
Sources

Sources & How We Checked

Pe Min Kan Wan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 47 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chrysanthemum 25 references
  1. Kuno Y, Kawabe Y, Sakakibara S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40:224-5. PubMed
  2. deJong NW, Vermeulen AM, van Wijik RG, deGroot H. Occupational allergy caused by flowers. Allergy 1998;53:204-9. PubMed
  3. Camplimi P, Sertoli A, Fabbri P, Panconesi E. Alantolactone sensitivity in chrysanthemum contact dermatitis. Contact Dermatitis 1978;4:93-102. PubMed
  4. Bleumink E, Mitchell JC, Geismann TA, Towers GH. Contact hypersensitivity to sesquiterpene lactones in Chrysanthemum dermatitis. Contact Dermatitis 1976;2:81-8.
  5. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  6. Hausen BM. The sensitizing capacity of Compositae plants. III. Test results and cross-reactions in Compositae-sensitive patients. Dermatologica 1979;159:1-11. DOI
  7. Kuno, Y., Kawabe, Y., and Sakakibara, S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40(4):224-225. PubMed
  8. Schulz, K. H., Hausen, B. M., Wallhofer, L., and Schmidt-Loffler, P. Chrysanthemum allergy. Pt. II: Experimental studies on the causative agents. Arch.Dermatol.Forsch. 1975;251(3):235-244.
  9. Singhal, V. and Reddy, B. S. Common contact sensitizers in Delhi. J Dermatol 2000;27(7):440-445. PubMed
  10. Kuroume, T., Todokoro, M., Tomidokoro, H., Kanbe, Y., and Matsumura, T. Chrysanthemum pollinosis in Japan. Int.Arch.Allergy Appl.Immunol. 1975;48(6):800-811.
  11. Groenewoud, G. C., de Jong, N. W., Burdorf, A., de Groot, H., and van Wyk, R. G. Prevalence of occupational allergy to Chrysanthemum pollen in greenhouses in the Netherlands. Allergy 2002;57(9):835-840.
  12. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  13. Hashimoto, Y., Kawada, A., Aragane, Y., and Tezuka, T. Occupational contact dermatitis from chrysanthemum in a mortician. Contact Dermatitis 2003;49(2):106-107. PubMed
  14. Groenewoud, G. C., de Groot, H., and van Wijk, R. G. Impact of occupational and inhalant allergy on rhinitis-specific quality of life in employees of bell pepper greenhouses in the Netherlands. Ann Allergy Asthma Immunol 2006;96(1):92-97. PubMed
  15. Sharma, S. C. and Kaur, S. Airborne contact dermatitis from Compositae plants in northern India. Contact Dermatitis 1989;21(1):1-5. PubMed
  16. Sharma, S. C., Tanwar, R. C., and Kaur, S. Contact dermatitis from chrysanthemums in India. Contact Dermatitis 1989;21(2):69-71. PubMed
  17. Tanaka, T., Moriwaki, S. I., and Horio, T. Occupational dermatitis with simultaneous immediate and delayed allergy to chrysanthemum. Contact Dermatitis 1987;16(3):152-154. PubMed
  18. Frain-Bell, W., Hetherington, A., and Johnson, B. E. Contact allergic sensitivity to chrysanthemum and the photosensitivity dermatitis and actinic reticuloid syndrome. Br.J.Dermatol. 1979;101(5):491-501. PubMed
  19. Diener, C., Schlenvoigt, G., Jager, L., Prater, E., and Schubert, H. Allergens of chrysanthemum pollen. Allergol.Immunopathol.(Madr.) 1986;14(1):49-53.
  20. Zeller, W., de Gols, M., and Hausen, B. M. The sensitizing capacity of Compositae plants. VI. Guinea pig sensitization experiments with ornamental plants and weeds using different methods. Arch Dermatol.Res 1985;277(1):28-35. PubMed
  21. Schmidt, R. J. When is a chrysanthemum dermatitis not a chrysanthemum dermatitis? The case for describing florists' chrysanthemums as Dendranthema cultivars. Contact Dermatitis 1985;13(2):115-119.
  22. Schmidt, R. J. and Kingston, T. Chrysanthemum dermatitis in South Wales; diagnosis by patch testing with feverfew (Tanacetum parthenium) extract. Contact Dermatitis 1985;13(2):120-121.
  23. Mitchell, J. C., Geissman, T. A., Dupuis, G., and Towers, G. H. Allergic contact dermatitis caused by Artemisia and Chrysanthemum species. The role of sesquiterpene lactones. J.Invest Dermatol. 1971;56(2):98-101. PubMed
  24. Sugai, T., Takahashi, Y., and Okuno, F. Chrysanthemum dermatitis in Japan. Contact Dermatitis 1980;6(2):155. PubMed
  25. Wakelin, S. H., Marren, P., Young, E., and Shaw, S. Compositae sensitivity and chronic hand dermatitis in a seven-year-old boy. Br J Dermatol 1997;137(2):289-291. PubMed

See these in context on the Chrysanthemum monograph →

Japanese Mint 2 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Japanese Mint monograph →

Perilla 4 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
  3. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
  4. Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed

See these in context on the Perilla monograph →

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

See these in context on the Magnolia monograph →

Siberian Cocklebur 4 references
  1. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI
  2. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
  3. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
  4. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.

See these in context on the Siberian Cocklebur monograph →

Isatis 3 references
  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source
  3. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source

See these in context on the Isatis monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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