Peppermint Leaf Ingredients & Drug Interactions
by TerraVita
What is this page for?
First and foremost: checking Peppermint Leaf against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Peppermint Leaf is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for irritable bowel syndrome (ibs), indigestion and gas, nausea.Based on those ingredients, 796 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Peppermint Leaf Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Peppermint Leaf by TerraVita
Ask about any prescription or over-the-counter medication and we check it for interactions with Peppermint Leaf by TerraVita — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Peppermint Leaf by TerraVita
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: peppermint leaf glycerite liquid extract. Peppermint is traditionally used to ease digestive discomfort and gas.
The extract is suspended in glycerin, which is an inactive ingredient (a common base for liquid herbal products).
Does it work?
Strong evidence
Peppermint leaf is likely effective for irritable bowel syndrome (IBS). It's possibly effective for dyspepsia (indigestion), chemotherapy-induced nausea and vomiting, spasm during barium enema exams, and reducing side effects during endoscopy.
The strength of evidence varies by condition — IBS has the most robust support, while the others are based on smaller or limited studies.
How safe is it?
Well-documented data
Peppermint leaf taken by mouth is generally well tolerated. The most common side effects are abdominal pain, anal burning, belching, diarrhea, dry mouth, heartburn, nausea, and vomiting — typically mild.
Rare cases of allergic reaction, including anaphylaxis, have been reported. In very large amounts, peppermint oil can cause burns in the mouth and throat, though this is uncommon with normal use.
Peppermint tea and culinary amounts are considered safe, but concentrated supplements should be used with caution and only with your provider's approval.
Meds to double-check
Moderate interaction found
Before starting this product, double-check any cyclosporine (transplant or autoimmune medication) you're on. Also screen medications processed by your liver's CYP2C19, CYP2C9, or CYP3A4 enzymes — a category that includes many heart, blood pressure, anti-seizure, antidepressant, anxiety, and cancer drugs.
Use the search tool on this page to look up your exact medications, and talk with your doctor or pharmacist if you take any of these.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Peppermint leaf is a solid choice if you have IBS or indigestion and want an herbal option — the evidence is there. But because it affects how your liver processes many medications, you'll want to run your full medication list through the interaction checker on this page before you start.
If you take cyclosporine, heart or blood pressure drugs, or immunosuppressants, check with your doctor or pharmacist first. Otherwise, it's generally well tolerated.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Peppermint Leaf, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Peppermint Leaf by TerraVita, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Peppermint Leaf Glycerite Liquid Extract | 0.13 mL | -- |
Other ingredients: Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Formula
Glycerite liquid extract (1:5)
Formulation
Alcohol free No flavor
Suggested/Recommended/Usage/Directions
Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.
Precautions
Keep away from children.
Do not use if safety seal around cap is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Peppermint Leaf by TerraVita label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Peppermint Leaf by TerraVita
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.
Peppermint Leaf Glycerite Liquid Extract
Interacts with796 drugs
Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...
Peppermint Leaf Glycerite Liquid Extract monograph & interactionsOther (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.
Peppermint Leaf by TerraVita Drug Interactions
HelloPharmacist Interaction Report
TerraVita Peppermint Leaf Liquid Extract contains peppermint, which interacts with a large number of medications through its effects on how your liver breaks down drugs.
The most serious documented interaction is with cyclosporine (a transplant and autoimmune medication), where peppermint may raise cyclosporine levels and increase side effects — this is rated Moderate severity. Additionally, peppermint theoretically increases levels of drugs processed by three major liver pathways (CYP2C19, CYP2C9, and CYP3A4 substrates), also rated Moderate.
A fourth Moderate group covers cyclosporine specifically. Minor interactions are documented for CYP1A2 substrates, though clinical research suggests this effect may be small in practice.
Read the full breakdown — every affected drug type, severity by severity
Although no interactions have been reported in actual patients for most of these liver pathways, the in vitro and animal evidence is consistent enough that caution is warranted. Altogether, these interactions span 797 individual medications.
Before you start this product, check your exact medications using the tool on this page. If you take cyclosporine, any heart or blood pressure medication, immunosuppressants, or drugs for seizures, depression, anxiety, or cancer — all common CYP3A4, CYP2C9, or CYP2C19 substrates — talk with your doctor or pharmacist first.
The peppermint amount in food is considered safe for most people, but this is a concentrated supplement, so it deserves the same screening you'd give any herbal product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Peppermint Leaf?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Peppermint Leaf interact with 796 drugs. Click any drug to see the details.
1 of the 1 ingredient in Peppermint Leaf interact with drugs. Each result below shows which ingredient is responsible. Peppermint Leaf Glycerite Liquid Extract
BrexpiprazoleRexulti
How Brexpiprazole interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Brexpiprazole interactionBrigatinibAlunbrig
How Brigatinib interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Brigatinib interactionBrivaracetamBriviact
How Brivaracetam interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Brivaracetam interactionBromocriptineParlodel
How Bromocriptine interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Bromocriptine interactionBudenosidePulmicort Flexhaler, Pulmicort Turbuhaler
How Budenoside interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Budenoside interactionBudesonideEntocort EC, Eohilia, Pulmicort, Tarpeyo, Uceris
How Budesonide interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Budesonide interactionBudesonide, FormoterolSymbicort
How Budesonide, Formoterol interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Budesonide, Formoterol interactionBupivacaine, MeloxicamZynrelef Kit
How Bupivacaine, Meloxicam interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Bupivacaine, Meloxicam interactionBuprenorphineBrixadi, Butrans, Sublocade, Subutex
How Buprenorphine interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Buprenorphine interactionBuprenorphine HydrochlorideBelbuca, Probuphine
How Buprenorphine Hydrochloride interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Buprenorphine Hydrochloride interactionBuprenorphine Hydrochloride, Naloxone HydrochlorideBunavail
How Buprenorphine Hydrochloride, Naloxone Hydrochloride interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Buprenorphine Hydrochloride, Naloxone Hydrochloride interactionBuprenorphine, NaloxoneCassipa, Zubsolv
How Buprenorphine, Naloxone interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Buprenorphine, Naloxone interactionBuprenorphine/naloxoneSuboxone
How Buprenorphine/naloxone interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Buprenorphine/naloxone interactionBuproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Buproprion, Dextromethorphan interactionBuspironeBuSpar
How Buspirone interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Buspirone interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Busulfan interactionCabazitaxelCabazitaxel, Jetvana
How Cabazitaxel interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Cabazitaxel interactionCabotegravir, RilpivirineCabenuva
How Cabotegravir, Rilpivirine interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Cabotegravir, Rilpivirine interactionCabozantinibCometriq
How Cabozantinib interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Cabozantinib interactionCabozantinib S-malateCabometyx
How Cabozantinib S-malate interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Cabozantinib S-malate interactionCaffeine (otc Drug)Molie, Overtime, Vivarin
How Caffeine (otc Drug) interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Caffeine (otc Drug) interactionCaffeine (prescription Drug)Caffeine, Dextrophin
How Caffeine (prescription Drug) interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Caffeine (prescription Drug) interactionCaffeine , Sodium BenzoateCaffeine and Sodium Benzoate
How Caffeine , Sodium Benzoate interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Caffeine , Sodium Benzoate interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine (prescription Drug)Migergot
How Caffeine, Ergotamine (prescription Drug) interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Caffeine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine Tartrate (prescription Drug)Cafergot, Wigraine
How Caffeine, Ergotamine Tartrate (prescription Drug) interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Caffeine, Ergotamine Tartrate (prescription Drug) interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Caffeine, Potassium Salicylate, Salicylamide interactionCalcifediolRayaldee
How Calcifediol interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Calcifediol interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Cannabidiol (prescription Drug) interactionCapivasertibTruqap
How Capivasertib interacts with Peppermint Leaf — through 1 ingredient. Tap an ingredient for the detail:
Peppermint Leaf Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint Leaf Glycerite Liquid Extract + Capivasertib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Peppermint Leaf with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Peppermint Leaf Glycerite Liquid Extract
Cyclosporine (Neoral, Sandimmune)
Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.
Brand information
Manufacturer and brand details for Peppermint Leaf, from the product label.
TerraVita
See all TerraVita products- Name
- ZooScape LLC
- Phone Number
- 844-449-0444
- Web Address
- www.ZooScape.com
Peppermint Leaf by TerraVita: Common Questions
Does Peppermint Leaf by TerraVita interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is peppermint leaf safe during pregnancy and while breastfeeding?
What are the most common side effects?
Does this product really work for IBS?
Is peppermint leaf different from peppermint oil, and is one safer than the other?
What if I'm already on a medication for my heart, seizures, or depression?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Peppermint Leaf is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Peppermint Leaf’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Peppermint Leaf's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Peppermint 41 references
- Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
- Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
- Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
- Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
- May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
- Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
- Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
- May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
- Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
- Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
- Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
- Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
- Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
- Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
- Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
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