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Dietary supplement

Periwinkle Chocolate Flavor Ingredients & Drug Interactions

by TerraVita

Periwinkle Chocolate Flavor label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Periwinkle Chocolate Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Periwinkle Chocolate Flavor is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, circulation problems, dizziness and ringing in the ears.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Periwinkle Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Periwinkle Chocolate Flavor by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Periwinkle Chocolate Flavor by TerraVita — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Periwinkle Chocolate Flavor by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Periwinkle Glycerite Liquid Extract. Periwinkle is a plant whose leaves and stems are traditionally used in herbal medicine.

The extract here is made using glycerin, a common extraction method. The product also contains glycerin and chocolate flavoring as inactive ingredients to improve taste.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: cognitive function, memory enhancement, cerebral circulation.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness data on file for Periwinkle in our records. That doesn't mean it doesn't work — it means the evidence for this particular ingredient hasn't been established in the data we hold.

The evidence, ingredient by ingredient Periwinkle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Periwinkle is considered unsafe for oral use. It contains vinca alkaloids, strong plant compounds that can damage the liver, kidneys, and nervous system, especially at higher doses.

Common side effects include stomach upset, skin flushing, and low blood pressure. Because of the strength and toxicity risk of its alkaloids, periwinkle should only be used under professional medical guidance.

Periwinkle is unsafe during pregnancy and while breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, do not use this product.

Talk with your doctor or pharmacist about whether it's appropriate for you.

Side effects, ingredient by ingredient Periwinkle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Periwinkle.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood pressure medications (antihypertensives), periwinkle may make them work too well, dropping your pressure dangerously low. Talk with your doctor or pharmacist before combining this product with any blood pressure drug.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Periwinkle is a potent herbal extract with real safety concerns — it's considered unsafe for routine oral use without professional oversight. If you take blood pressure medication, you'll need to check with your doctor or pharmacist before considering this product.

Given the toxicity profile and pregnancy/breastfeeding cautions, this is one to discuss with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Periwinkle Chocolate Flavor, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435172053
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 281499
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Periwinkle Chocolate Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435172053
IngredientAmount% DV
Periwinkle Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin, Chocolate flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2006 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Chocolate flavored Glycerite liquid extract (1:5)

Formulation

Alcohol free

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Periwinkle Chocolate Flavor by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Periwinkle Chocolate Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Periwinkle Chocolate Flavor by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Periwinkle Glycerite Liquid Extract

Interacts with
172 drugs
0.13 mL per serving

Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circulation. Evi...

Periwinkle Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Chocolate flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Periwinkle Chocolate Flavor by TerraVita Drug Interactions

Want to check YOUR meds against Periwinkle Chocolate Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Periwinkle Glycerite Liquid Extract 172

Individual Drug Interactions

The ingredients in Periwinkle Chocolate Flavor interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Periwinkle Chocolate Flavor interact with drugs. Each result below shows which ingredient is responsible. Periwinkle Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Periwinkle Chocolate Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Periwinkle Glycerite Liquid Extract1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constituent of periwinkle.

Likelihood Probable Evidence D
Periwinkle Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Periwinkle Chocolate Flavor, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Periwinkle Chocolate Flavor by TerraVita: Common Questions

Does Periwinkle Chocolate Flavor by TerraVita interact with any medications?
Yes. Based on its ingredients, Periwinkle Chocolate Flavor has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Periwinkle Chocolate Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. Periwinkle is unsafe during pregnancy and while breastfeeding because of its potent alkaloids and lack of safety data. If you're pregnant, planning pregnancy, or nursing, do not use this product.
What are the side effects of periwinkle?
Periwinkle can cause gastrointestinal upset, skin flushing, and low blood pressure. More seriously, the vinca alkaloids in it can damage your liver, kidneys, and nervous system, especially with higher doses. This is why professional medical guidance is essential.
Why is periwinkle considered unsafe?
Periwinkle contains vinca alkaloids — strong plant compounds that are toxic and can harm the liver, kidneys, and nervous system. Because of this serious toxicity risk, it's only appropriate under professional medical supervision.
Why is there such a large number of interacting medications listed?
The 172 medications reflect all the different blood pressure drugs on the market. Periwinkle may increase the effects of any antihypertensive medication, so the total count covers the entire drug class. Check your specific medications using the tool on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Periwinkle Chocolate Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Periwinkle Chocolate Flavor label
Go deeper

The Full Monographs Behind Periwinkle Chocolate Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Periwinkle

Interacts with 172 drugs

Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circulation. Evidence in humans is limited and mixed, an...

Read the full Periwinkle monograph →
Sources

Sources & How We Checked

Periwinkle Chocolate Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Periwinkle 5 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Periwinkle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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