Period Relief Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Period Relief against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Period Relief is a dietary supplement by Herbal Terra with 3 active ingredients. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 583 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Alfalfa Leaf Extract, Dry, Wild Yam Tuber Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Period Relief by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Period Relief by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Period Relief by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Period Relief contains three active ingredients. Wild yam tuber and alfalfa leaf are provided as dry extracts — concentrated plant material — while the third active, vitex berry, is also a dry extract.
All three are combined in a proprietary blend, so you're getting a mix designed for period support. The product is delivered in liquid form with alcohol, water, and glycerin as inactive ingredients.
Does it work?
Not established
The evidence supporting these ingredients for period-related concerns is thin. Wild yam has been rated possibly ineffective for menopausal symptoms, and we don't have enough reliable evidence to say whether it helps with painful periods (dysmenorrhea), sexual dysfunction, infertility, or gallbladder issues.
Alfalfa hasn't been rated as effective for any of the conditions listed — the evidence base is insufficient. We hold no effectiveness data for vitex berry.
How safe is it?
Well-documented data
Wild yam is generally well tolerated for short-term use, but long-term safety hasn't been well studied. The most common side effects are fever, headache, upset stomach, and vomiting, especially at higher doses.
Serious reactions like anaphylaxis are rare. Alfalfa is also generally well tolerated but can cause abdominal discomfort, diarrhea, and intestinal gas, particularly in the first week.
A lupus-like syndrome has been reported very rarely after long-term use. Because both wild yam and alfalfa have estrogen-like activity, the safety data advises against use during pregnancy and breastfeeding.
Meds to double-check
Major interaction found
Before you take this, check if you're on warfarin or any blood thinner — alfalfa can reduce how well it works, and that's a serious concern. Also double-check birth control pills, estrogen therapy, diabetes medications, photosensitizing drugs (medications that make you more sensitive to sun), and immunosuppressants.
If you're unsure, run your medications through the checker below.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
This product is designed for period support, but the evidence that wild yam or alfalfa actually work for that purpose isn't strong. More importantly, if you take warfarin, birth control, hormone therapy, diabetes medication, or immunosuppressants, you need to check your exact drugs with the tool on this page before starting.
Talk to your pharmacist or doctor about whether it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Period Relief, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7439500834892 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 325289 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Period Relief by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 983 mg | -- |
| Wild Yam Tuber Extract, Dry | 0 NP | -- |
| Vitex Berry Extract, Dry | 0 NP | -- |
| Alfalfa Leaf Extract, Dry | 0 NP | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
Organic alcohol
No artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Organic alcohol
FDA Statement of Identity
Herbal Supplement
General Statements
Extraction rate: about 1/3-4 (up to 333 mg of dry raw material per 1 ml of extract).
Seals/Symbols
Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Period Relief by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Period Relief by Herbal Terra
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
- › Wild Yam Tuber Extract, Dry
- › Vitex Berry Extract, Dry
- › Alfalfa Leaf Extract, Dry
Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Period Relief by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Period Relief by Herbal Terra contains wild yam and alfalfa, both of which interact with medications.
The most serious concern is alfalfa's interaction with warfarin (Coumadin), a blood thinner — alfalfa is high in vitamin K, which can reduce how well warfarin works and raise your clot risk.
Read the full breakdown — every affected drug type, severity by severity
Alfalfa also interacts with birth control pills and hormone therapy (estrogen replacement). Because alfalfa has estrogen-like compounds, it may interfere with how these drugs work.
Additionally, alfalfa may lower blood sugar and could increase the risk of low blood sugar (hypoglycemia) if you're on diabetes medications. It can also theoretically reduce the effectiveness of immunosuppressant drugs and add to the light-sensitizing effects of certain medications.
Wild yam may increase or decrease the effects of estrogen-based hormone therapy. We could not check Vitex Berry Extract for interactions — no data is on file for it.
Altogether, these interactions span 577 individual medications. Use the medication checker below with your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Period Relief?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Period Relief interact with 583 drugs. Click any drug to see the details.
2 of the 3 ingredients in Period Relief interact with drugs. Each result below shows which ingredient is responsible. Alfalfa Leaf Extract, Dry Wild Yam Tuber Extract, Dry
WarfarinWarfarin
How Warfarin interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryWarfarin (coumadin) Major
Interaction Summary
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Read the full Alfalfa Leaf Extract, Dry + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryWarfarin (coumadin) Major
Interaction Summary
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Read the full Alfalfa Leaf Extract, Dry + Warfarin Sodium interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa Leaf Extract, Dry + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa Leaf Extract, Dry + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Alfalfa Leaf Extract, Dry + Acarbose interactionAcepromazineAtravet
How Acepromazine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acepromazine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Ibuprofen interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acetohexamide interactionAcitretinSoriatane
How Acitretin interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Extract, Dry + Acitretin interactionAdalimumabHumira
How Adalimumab interacts with Period Relief — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf Extract, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa Leaf Extract, Dry + Adalimumab interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Period Relief with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Alfalfa Leaf Extract, Dry
Warfarin (Coumadin)
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Alfalfa contains a large amount of vitamin K. This could theoretically interfere with the activity of warfarin.
Antidiabetes Drugs
Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that alfalfa decreases blood sugar in diabetic mice. Also, in one case report, a diabetic patient experienced hypoglycemia after consuming alfalfa extract. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Contraceptive Drugs
Theoretically, alfalfa might interfere with the activity of contraceptive drugs.
Alfalfa contains coumestrol, a phytoestrogen, and isoflavonoids, which have estrogenic effects.
Estrogens
Theoretically, alfalfa might interfere with hormone therapy.
Alfalfa contains coumestrol, a phytoestrogen, and isoflavonoids, which have estrogenic effects.
Immunosuppressants
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
In vitro research and human case reports suggest that alfalfa may have immunostimulant effects.
Photosensitizing Drugs
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Animal research suggests that excessive doses of alfalfa may increase photosensitivity, possibly due to its chlorophyll content. It is unclear if this effect would be clinically relevant in humans.
Wild Yam Tuber Extract, Dry
Estrogens
Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.
Brand information
Manufacturer and brand details for Period Relief, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Period Relief by Herbal Terra: Common Questions
Does Period Relief by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Period Relief if I'm on birth control?
Will Period Relief actually help with my period symptoms?
What are the most common side effects?
Is it safe to take while pregnant or breastfeeding?
What's in the liquid formula besides the active ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Period Relief is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Period Relief’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Wild Yam
Interacts with 41 drugsWild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...
Read the full Wild Yam monograph → Herb & supplement monographAlfalfa
Interacts with 583 drugsAlfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence for most of these uses is limited. It is best avoid...
Read the full Alfalfa monograph →Sources & How We Checked
Period Relief's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 39 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Wild Yam 7 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
- Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
- Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
- Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
- Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
- Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus
Alfalfa 32 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
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