Perna Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Perna against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Perna is a dietary supplement by DaVinci Laboratories with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis symptoms, joint stiffness and mobility.Based on those ingredients, 583 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Alfalfa, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Perna by DaVinci Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Perna by DaVinci Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Perna by DaVinci Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Perna contains two active ingredients: New Zealand green-lipped mussel (Perna canaliculus) and alfalfa powder. The product comes in capsule form with cellulose and cinnamon oil as inactive ingredients.
New Zealand green-lipped mussel is a marine source sometimes used in joint and inflammation support. Alfalfa is a plant traditionally used in herbal medicine, though the evidence for most of its uses isn't well established yet.
Does it work?
Not established
The evidence for both ingredients in this product is not yet established in the data we hold. New Zealand green-lipped mussel is marketed for asthma, ADHD, breast cancer, and exercise-related muscle soreness, but we don't have reliable evidence to rate it for any of those uses.
Alfalfa is similarly proposed for diabetes, indigestion, high cholesterol, and menopausal symptoms, but none of those has sufficient evidence to support it either. If you're considering this product for a specific health goal, talk with your pharmacist about what the research actually shows.
How safe is it?
Well-documented data
New Zealand green-lipped mussel is generally well tolerated, but if you have a shellfish allergy, you need to avoid it completely. Common side effects include abdominal pain, acid reflux, diarrhea, flatulence, and nausea.
Rarely, serious liver inflammation (hepatitis) has been reported with a specific brand called Seatone, so if you develop signs of liver problems — yellowing skin or eyes, dark urine, or unusual fatigue — stop and see your doctor. Alfalfa is also generally well tolerated in small food amounts, but supplements carry more risk.
You may experience abdominal discomfort, diarrhea, and gas. Rarely, long-term use has been linked to a lupus-like syndrome, and skin reactions have been documented after chronic use.
During pregnancy, alfalfa in supplement form is best avoided because of its estrogen-like activity. While breastfeeding, there isn't enough safety data, so talk with your doctor or pharmacist before using it.
Meds to double-check
Major interaction found
Before taking Perna, check with your pharmacist if you take warfarin (Coumadin) or another blood thinner — alfalfa can reduce its effectiveness. Also double-check if you use birth control pills, hormone replacement therapy, diabetes medications, immunosuppressants (such as after a transplant), or drugs that increase sun sensitivity.
No interactions are documented for the New Zealand green-lipped mussel ingredient we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
This product may appeal to someone looking for joint or general wellness support, but it comes with real medication interactions you need to check first — especially if you take a blood thinner, birth control, diabetes medication, or an immunosuppressant. Anyone with a shellfish allergy must avoid it entirely.
Talk with your pharmacist before you start, and if you're pregnant or breastfeeding, do the same.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Perna, straight from the product label.
| Brand | DaVinci Laboratories |
|---|---|
| Barcode (UPC) | 026664236418 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 303929 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Perna by DaVinci Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Perna canaliculus | 1000 mg | -- |
| Alfalfa, Powder | 200 mg | -- |
Other ingredients: Cellulose, Cinnamon oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Truth We pledge total truth in labeling. Our family of products contains only the purest and most potent ingredients. Guaranteed.
Formula
Perna mussels naturally contain chondroitin -4 and -6- sulfates as well as amino acids, polypeptides, chelated minerals, numerous enzymes, vitamins, and nucleic acids (RNA and DNA).
A New Zealand Green-Lipped Mussel Supplement to Support Connective Tissue and Joint Functions
Formulation
Color of this product may vary due to color variations of the natural ingredients.
Precautions
Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.
Keep out of reach of children.
To obtain product information or report a serious adverse event, call 1-800-325-1776. Not labeled for sale in California
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 2 capsules, 3 times daily with food for 2 to 4 weeks, then reduce to 1 capsule with meals, 3 times daily, or as directed by your healthcare practitioner.
FDA Statement of Identity
A New Zealand Green-Lipped Mussel Supplement to Support Connective Tissue and Joint Functions
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Perna by DaVinci Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Perna by DaVinci Laboratories
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Perna canaliculus
No knowninteractions
New Zealand green-lipped mussel is a shellfish-derived supplement rich in omega-3 fats that is mostly used for joint pain and arthritis. Some studies...
Perna canaliculus monograph & interactionsAlfalfa, Powder
Interacts with583 drugs
Alfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence for most of...
Alfalfa, Powder monograph & interactionsOther (inactive) ingredients: Cellulose, Cinnamon oil. These complete the product’s ingredient list but are not active constituents.
Perna by DaVinci Laboratories Drug Interactions
HelloPharmacist Interaction Report
Perna by DaVinci Laboratories contains one ingredient — alfalfa powder — that interacts with medications.
The most serious concern is with warfarin (Coumadin), a blood thinner. Alfalfa is high in vitamin K, which can reduce how well warfarin works to prevent clots.
If you take warfarin, you'll need to check with us before starting this product.
Read the full breakdown — every affected drug type, severity by severity
Alfalfa also has documented moderate-severity interactions with several other drug types. It may interfere with birth control pills and hormone therapy because it contains compounds with estrogen-like activity.
It could increase your risk of low blood sugar (hypoglycemia) if you take diabetes medications, so you'd need to monitor your levels closely. Additionally, it might reduce the effectiveness of immunosuppressant drugs used after organ transplants, and theoretically it could increase sensitivity to sunburn if you're on photosensitizing medications.
The other ingredient, New Zealand green-lipped mussel (Perna canaliculus), was checked and no interactions are documented in our data — though that is not a guarantee none exist.
Altogehter, these interactions span 577 individual medications. Use the medication checker on this page to look up your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Perna?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Perna interact with 583 drugs. Click any drug to see the details.
1 of the 2 ingredients in Perna interact with drugs. Each result below shows which ingredient is responsible. Alfalfa, Powder
WarfarinWarfarin
How Warfarin interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderWarfarin (coumadin) Major
Interaction Summary
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Read the full Alfalfa, Powder + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderWarfarin (coumadin) Major
Interaction Summary
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Read the full Alfalfa, Powder + Warfarin Sodium interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa, Powder + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa, Powder + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Alfalfa, Powder + Acarbose interactionAcepromazineAtravet
How Acepromazine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acepromazine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Ibuprofen interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acetohexamide interactionAcitretinSoriatane
How Acitretin interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa, Powder + Acitretin interactionAdalimumabHumira
How Adalimumab interacts with Perna — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa, Powder + Adalimumab interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Perna with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Alfalfa, Powder
Warfarin (Coumadin)
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Alfalfa contains a large amount of vitamin K. This could theoretically interfere with the activity of warfarin.
Antidiabetes Drugs
Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that alfalfa decreases blood sugar in diabetic mice. Also, in one case report, a diabetic patient experienced hypoglycemia after consuming alfalfa extract. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Contraceptive Drugs
Theoretically, alfalfa might interfere with the activity of contraceptive drugs.
Alfalfa contains coumestrol, a phytoestrogen, and isoflavonoids, which have estrogenic effects.
Estrogens
Theoretically, alfalfa might interfere with hormone therapy.
Alfalfa contains coumestrol, a phytoestrogen, and isoflavonoids, which have estrogenic effects.
Immunosuppressants
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
In vitro research and human case reports suggest that alfalfa may have immunostimulant effects.
Photosensitizing Drugs
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Animal research suggests that excessive doses of alfalfa may increase photosensitivity, possibly due to its chlorophyll content. It is unclear if this effect would be clinically relevant in humans.
Brand information
Manufacturer and brand details for Perna, from the product label.
DaVinci Laboratories
See all DaVinci Laboratories products- Name
- DaVinci Laboratories a division of FoodScience LLC
- Street Address
- 929 Harvest Lane
- City
- Williston
- State
- VT
- ZipCode
- 05495
- Phone Number
- 1-800-325-1776
- Web Address
- www.davincilabs.com
Perna by DaVinci Laboratories: Common Questions
Does Perna by DaVinci Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I have a shellfish allergy?
What side effects might I notice?
Is it safe to take while I'm pregnant?
Can I take this while breastfeeding?
Does this product actually work for what it claims?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Perna is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Perna’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
New Zealand Green-lipped Mussel
New Zealand green-lipped mussel is a shellfish-derived supplement rich in omega-3 fats that is mostly used for joint pain and arthritis. Some studies suggest a modest benefit for osteoarthri...
Read the full New Zealand Green-lipped Mussel monograph → Herb & supplement monographAlfalfa
Interacts with 583 drugsAlfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence for most of these uses is limited. It is best avoid...
Read the full Alfalfa monograph →Sources & How We Checked
Perna's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 44 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
New Zealand Green-lipped Mussel 12 references
- Miller T, Wu H. In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. N Z Med J 1984;97:355-7.
- Gibson SLM, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial. Complement Ther Med 1998;6:122-6.
- Gibson RG, Gibson SL, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner 1980;224:955-60.
- Fabrin, B. [Possible toxic hepatitis after intake of an alternative preparation]. Ugeskr.Laeger 6-13-1988;150(24):1474-1475.
- Gibson, R. G. and Gibson, S. L. Green-lipped mussel extract in arthritis. Lancet 2-21-1981;1(8217):439. PubMed
- Ahern, M. J., Milazzo, S. C., and Dymock, R. Granulomatous hepatitis and Seatone. Med J Aust 8-9-1980;2(3):151-152. PubMed
- Croft, J. E. Granulomatous hepatitis and Seatone. Med J Aust 10-4-1980;2(7):401-402. PubMed
- Lau, S., Chiu, P. K., Chu, E. M. Y., Cheng, I. Y. W., Tang, W. M., Man, R. Y. K., and Halpern, G. M. Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study. Progress in Nutrition
- Gruenwald, J., Graubaum, H., Hansen, K., and Grube, B. Efficacy and tolerability of a combination of LYPRINOL and high concentrations of EPA and DHA in inflammatory rheumatoid disorders... eicosapentaenoic acid... decosahexaenoid acid. Advances in Therap PubMed
- Coulson S, Vecchio P, Gramotnev H, Vitetta L. Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study. Inflammopharmacology 2012;20:71-6. PubMed
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See these in context on the New Zealand Green-lipped Mussel monograph →
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