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Dietary supplement

Phase II Rx Ingredients & Drug Interactions

by HoltraCeuticals

Phase II Rx label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phase II Rx against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phase II Rx is a dietary supplement by HoltraCeuticals with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Broccoli seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phase II Rx by HoltraCeuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Phase II Rx by HoltraCeuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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Computed from our clinical databases

HelloPharmacist Scorecard of Phase II Rx by HoltraCeuticals

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so intended use can't be graded.

Why this rating?
  • None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Broccoli seed extract” is listed as a grouped ingredient — the label gives one combined amount (230 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phase II Rx, straight from the product label.

Brand HoltraCeuticals
Barcode (UPC) 871149006280
Net contents 120 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 19834
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phase II Rx by HoltraCeuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
871149006280
IngredientAmount% DV
Broccoli seed extract230 mg--
Providing 30 mg Sulforaphane Glucosinolate30 mg--

Other ingredients: HPMC, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one capsule daily or as directed by your healthcare practitioner.

Seals/Symbols

Vegetable CAPSULES

sgs(TM)

{recycle}

Formula

Each Phase II Rx capsule contains 30 mg sulforaphane glucosinolate (SGS(TM)).

Sulforaphane Gluconsinolate

Precautions

CAUTION: Keep out of reach of children.

Storage

STORAGE: Keep tightly closed in a cool, dry place.

Formulation

DOES NOT CONTAIN: Wheat, gluten, corn protein, yeast, soy, diary products, artificial colors, sweeteners or preservatives.

FDA Statement of Identity

Dietary Supplement

General Statements

HOLTORF MEDICAL GROUP, INC. CENTER FOR HORMONE IMBALANCE, HYPOTHYROIDISM AND FATIGUE

This package is completely recyclable

Brand IP Statement(s)

Produced under U.S. Patents 5,725,895; 5,968,505; 5,968,567; 6,277,122 and 6,242,018 licensed from Brassica Protection Products LLC; SGS is a trademark of Brassica Protection Products.

Scientists identified SGS(TM) as a natural long-lasting antioxidant and detoxifier found in broccoli and broccoli sprouts. SGS(TM) contributes to the integrity of all cells, promoting health and well-being. Since its discovery, more than 200 publications from universities worldwide have underscored the significance of sulforaphane glucosinolate. SGS(TM) activates the body's natural detoxification and antioxidant enzymes, protecting cells from free radical damage.*

FDA Disclaimer Statement

*This is a statement of nutritional support. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phase II Rx by HoltraCeuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phase II Rx label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phase II Rx by HoltraCeuticals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Broccoli seed extract

Interacts with
187 drugs
230 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli seed extract monograph & interactions
  • › Providing 30 mg Sulforaphane Glucosinolate

Other (inactive) ingredients: HPMC, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phase II Rx by HoltraCeuticals Drug Interactions

Phase II Rx contains a single active ingredient, and it has known interactions with 187 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Phase II Rx?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

Broccoli seed extract 187

Individual Drug Interactions

The ingredients in Phase II Rx interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phase II Rx interact with drugs. Each result below shows which ingredient is responsible. Broccoli seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Phase II Rx with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Broccoli seed extract2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phase II Rx, from the product label.

HoltraCeuticals

See all HoltraCeuticals products
Name
Kent Holtorf, M.D., & the Holtorf Medical Group., Inc
City
Torrance
State
CA
Pharmacist Counseling Corner

Phase II Rx by HoltraCeuticals: Common Questions

Does Phase II Rx by HoltraCeuticals interact with any medications?
Yes. Based on its ingredients, Phase II Rx has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phase II Rx contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phase II Rx is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phase II Rx label
Go deeper

The Full Monographs Behind Phase II Rx’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

Phase II Rx's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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