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Dietary supplement

Phenibut 250 mg Ingredients & Drug Interactions

by AN Amazing Nutrition Amazing Formulas

Phenibut 250 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phenibut 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phenibut 250 mg is a dietary supplement by AN Amazing Nutrition Amazing Formulas with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, insomnia and sleep problems, stress relief.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phenibut. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phenibut, a synthetic compound that works on GABA receptors in your brain — the same target as some anxiety and sleep medications. Each capsule delivers 250 mg.

The capsules themselves are made from gelatin and microcrystalline cellulose (a plant-based filler).

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: reduce insomnia, anxiety and muscle tension.
  • We looked for evidence on: Anxiety, Insomnia, stress relief, mood support, nervousness, muscle relaxation.
  • The closest evidence on file: Phenibut is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Phenibut is rated "Insufficient Reliable Evidence To Rate" for Insomnia.

The evidence isn't established in our data for any of phenibut's claimed uses — anxiety, ADHD, depression, insomnia, cognitive function, or alcohol use disorder all carry a rating of insufficient reliable evidence. That means we don't have enough solid research to say whether it actually works for these purposes.

The evidence, ingredient by ingredient Phenibut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This one warrants a serious conversation with us: phenibut is not approved as a supplement or drug in the United States, and it carries a high risk of dependence and dangerous withdrawal. Most people who take it experience dizziness, drowsiness, nausea, or balance problems.

The real red flag is withdrawal — after just 3 or more consecutive days of use, you can develop serious symptoms including seizures, hallucinations, agitation, anxiety, and dangerous changes in heart rate and blood pressure. Case reports also document respiratory depression, especially at high doses, and rapid tolerance (meaning it stops working quickly).

Because phenibut is a CNS depressant and there's no safety data in pregnancy, it should be avoided if you're pregnant. The same goes for breastfeeding — we don't know if it passes into breast milk, so it's not recommended.

Side effects, ingredient by ingredient Phenibut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phenibut.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking phenibut, check with your pharmacist if you take any CNS depressants (Moderate severity) — that includes sleep aids, benzodiazepines, opioid pain relievers, or any other sedating medication. Also check if you're on pregabalin (Lyrica) for nerve pain (Moderate severity).

Given that 248 individual medications interact with this product, a full medication review with your pharmacist is not optional.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phenibut is not approved in the U.S. and carries real risks of dependence, severe withdrawal, and respiratory depression — benefits here don't outweigh those dangers for most people. If you're taking any sedating medication, opioid, benzodiazepine, or pregabalin, you cannot safely use this product without a serious medication check.

Talk to your pharmacist before even considering it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phenibut 250 mg, straight from the product label.

Brand AN Amazing Nutrition Amazing Formulas
Barcode (UPC) 819209024157
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 251684
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
819209024157
IngredientAmount% DV
Phenibut250 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

We believe that Amazing Nutrition is the key for healthy living. We are passionate about bringing you the finest selection of products which can perfectly complement a healthy diet and active lifestyle.

Shop online at: amazingnutrition.com Call toll-free: 1-800-526-0177 Vitamin angels Proud Supporter

Amazing Nutrition an FDA regulated facility

Formulation

Amazing Formulas Phenibut helps reduce insomnia, anxiety and muscle tension, much like GABA. Like GABA, it may help to improve mood, ease nervousness, reduce stress, support relaxationa nd relieve dull pain. Phenibut may also reduce symptoms of depression.

Helps reduce anxiety & stress Calming & relaxing effect Promotes positive mood & restful sleep

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution: Consult your physician before use if you are taking any medications. Do not use Phenibut if you are pregnant, nursing, suffering from liver disease or are under the age of 18.

Caution: Consult your physician before use if you are taking any medications. Do not use Phenibut if you are pregnant, nursing, suffering from liver disease or are under the age of 18.

Do not combine Phenibut with alcohol, benzodiazipines or other sedatives. Discontinue use and consult your doctor immediately if any adverse reactions occur.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA GMP Good Manufacturing Practice Quality Product

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take one (1) to two (2) capsules as needed. It is not recommended to take Phenibut more than twice per week as doing so will cause a tolerance to form rapidly.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phenibut 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Phenibut

Interacts with
248 drugs
250 mg per serving

Phenibut is a synthetic, lab-made central nervous system depressant—not a natural herb—that some people use for anxiety and sleep, but it carries a se...

Phenibut monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas Drug Interactions

Want to check YOUR meds against Phenibut 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Phenibut 248

Individual Drug Interactions

The ingredients in Phenibut 250 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phenibut 250 mg interact with drugs. Each result below shows which ingredient is responsible. Phenibut

Each ingredient & the kinds of drugs it affects

For each ingredient in Phenibut 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phenibut2 drug types · 248 drugs

Cns Depressants

Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.
Phenibut has been associated with sedation and respiratory depression in several case reports, especially when taken at high doses.

Likelihood Possible Evidence D
Pregabalin (Lyrica)

Theoretically, phenibut might increase the risk for additive adverse effects, including sedation, when taken with pregabalin.
Phenibut is structurally related to pregabalin, and both chemicals act at GABA receptors in the brain. In a case report, a patient who had experienced tolerance to the effects of pregabalin for treatment of chronic neuropathic pain experienced a reduction in tolerance when phenibut was taken concurrently.

Likelihood Possible Evidence D
Phenibut full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phenibut 250 mg, from the product label.

AN Amazing Nutrition Amazing Formulas

See all AN Amazing Nutrition Amazing Formulas products
Name
Amazing Nutrition
City
Jersey City
State
NJ
Phone Number
1-800-526-0177
Web Address
www.amazingnutrition.com
Pharmacist Counseling Corner

Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas: Common Questions

Does Phenibut 250 mg by AN Amazing Nutrition Amazing Formulas interact with any medications?
Yes. Based on its ingredients, Phenibut 250 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phenibut 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is phenibut, and how is it supposed to work?
Phenibut is a synthetic compound that acts on GABA receptors in your brain — the same system that some anti-anxiety and sleep medications target. It's used in some countries as a prescription medication, but it's not approved as a supplement or drug in the U.S.
Can I take this if I'm pregnant or breastfeeding?
No. There's no safety data for pregnancy and phenibut is a CNS depressant, so it should be avoided if you're pregnant. The same applies to breastfeeding — we don't know if it passes into breast milk, so it's not recommended.
What are the side effects I should watch for?
The most common ones are dizziness, drowsiness, nausea, and balance problems. The bigger concern is withdrawal — if you use it for 3 or more days in a row, you can develop serious symptoms like seizures, hallucinations, anxiety, agitation, and dangerous changes in heart rate and blood pressure, even after you stop.
Does phenibut actually work for anxiety or sleep?
We don't have enough reliable research to say. For anxiety, sleep, ADHD, depression, cognitive function, and alcohol use disorder, the evidence is rated insufficient — meaning we can't confirm it works for any of these.
Why does the product facts list so many medication interactions?
Phenibut interacts with 248 individual medications because it's a CNS depressant — anything that slows your brain and nervous system (like sedatives, opioids, or benzodiazepines) can have additive effects with it. That's why checking every medication you take is essential.
What's the dependence risk really about?
Phenibut has a high risk of dependence — you can develop tolerance within 3 days of use, meaning it stops working. And withdrawal after regular use includes serious symptoms. That's why it's not approved in the U.S., and why we'd strongly recommend talking to your pharmacist before considering it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phenibut 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phenibut 250 mg label
Go deeper

The Full Monographs Behind Phenibut 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phenibut

Interacts with 248 drugs

Phenibut is a synthetic, lab-made central nervous system depressant—not a natural herb—that some people use for anxiety and sleep, but it carries a serious risk of tolerance, dependence, and...

Read the full Phenibut monograph →
Sources

Sources & How We Checked

Phenibut 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phenibut 23 references
  1. Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK. Acute behavioural disturbance associated with phenibut purchased via an internet supplier. Clin Toxicol (Phila). 2015;53(7):636-8. PubMed
  2. Samokhvalov AV, Paton-Gay CL, Balchand K, Rehm J. Phenibut dependence. BMJ Case Rep. 2013 Feb 6;2013. Pii: bcr2012008381.
  3. O'Connell CW, Schneir AB, Hwang JQ, Cantrell FL. Phenibut, the appearance of another potentially dangerous product in the United States. Am J Med. 2014 Aug;127(8):e3-4. PubMed
  4. Brunner E, Levy R. Case report of physiologic phenibut dependence treated with a phenobarbital taper in a patient being treated with buprenorphine. J Addict Med. 2017 May/Jun;11(3):239-40. PubMed
  5. Sankary S, Canino P, Jackson J. Phenibut overdose. AM J Emerg Med. 2017 Mar;35(3):516.e1-516.e2.
  6. Owen DR, Wood DM, Archer JR, Dargan PI. Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity. Drug Alcohol Rev. 2016 Sep;35(5):591-6. PubMed
  7. Magsalin RM, Khan AY. Withdrawal symptoms after internet purchase of phenibut (beta-phenyl-gamma-aminobutyric acid HCl). J Clin Psychopharmacol. 2010 Oct;30(5):648-9.
  8. Rod W, Kudryk A, Brunetti L, Sun N, Nguyen M. Phenibut withdrawal management in the setting of concomitant kratom and alcohol dependence. Critical Care Med 2018;46(1):451.
  9. Li W, Madhira B. Phenibut (beta-phenyl-gamma-aminobutyric acid) psychosis. Am J Therapeut 2017;24(5):e639-640.
  10. Joshi Y, Friend S, Jimenez B, Steiger L. Dissociative intoxication and prolonged withdrawal associated with phenibut: a case report. J Clin Psychopharmacol 2017;37(4):478-80. PubMed
  11. Zheng KH, Khan A, Espiridion ED. Phenibut addiction in a patient with substance use disorder. Cureus. 2019;11(7):e5230. PubMed
  12. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: A comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2019;19(2):125-129. PubMed
  13. Ahuja T, Mgbako O, Katzman C, Grossman A. Phenibut (β-Phenyl-γ-aminobutyric Acid) dependence and management of withdrawal: Emerging nootropics of abuse. Case Rep Psychiatry. 2018;2018:9864285.
  14. Isoardi KZ, Kulawickrama S, Isbister GK. Severe phenibut poisoning: An adolescent case cluster. J Paediatr Child Health. 2020;56(2):330-331. PubMed
  15. McCabe DJ, Bangh SA, Arens AM, Cole JB. Phenibut exposures and clinical effects reported to a regional poison center. Am J Emerg Med. 2019;37(11):2066-2071. PubMed
  16. Graves JM, Dilley J, Kubsad S, Liebelt E. Notes from the field: phenibut exposures reported to poison centers - United States, 2009-2019. MMWR Morb Mortal Wkly Rep 2020;69(35):1227-8. PubMed
  17. Tamarelli C, Hosanagar A. Phenibut use in a patient prescribed gabapentinoids (letter). Pain Med 2020; Aug 4:pnaa205. doi: 10.1093/pm/pnaa205. PubMed
  18. Esposito CM, Mandolini GM, Delvecchio G, Fiorentini A, Brambilla P. Psychomotor agitation non-responsive to treatment: a case report of phenibut withdrawal syndrome. Front Psychiatry 2021;12:688147. PubMed
  19. Acosta E, Munguti C. Acute Psychosis Associated with Phenibut Ingestion. Kans J Med 2021;14:308-309. PubMed
  20. VanDreese B, Holland A, Murray A. Chronic Phenibut Use: Symptoms, Severe Withdrawal, and Recovery. WMJ 2022;121(1):E1-E4.
  21. Martin R, Buffenstein I, Cho D, Kiyokawa M. Toxidrome of an Easily Obtainable Nootropic: A Case Report of Phenibut Intoxication and Withdrawal Delirium. J Clin Psychopharmacol 2023. PubMed
  22. Morris M, Espinosa J, Lucerna A, Lahr R. A case of phenibut withdrawal and treatment with baclofen. World J Emerg Med 2023;14(4):338-340. PubMed
  23. DiFiore E, Pittman J. A Case of Phenibut Withdrawal Management and Detoxification Using Baclofen in the Outpatient Setting. Case Rep Psychiatry 2024;2024:8824770. PubMed

See these in context on the Phenibut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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