PhosphaLine Ingredients & Drug Interactions
by XYMOGEN
What is this page for?
First and foremost: checking PhosphaLine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PhosphaLine is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for liver health, memory and brain support, ulcerative colitis.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of PhosphaLine by XYMOGEN
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
PhosphaLine is a single-ingredient softgel with polyenylphosphatidylcholine, a naturally derived form of phosphatidylcholine — a compound found in cell membranes that plays a role in cell structure and brain function. The softgel itself is made from porcine gelatin, glycerin, water, medium-chain triglyceride oil, and a small amount of ethanol.
Does it work?
Moderate evidence
The evidence for phosphatidylcholine is mixed depending on what you're using it for. It's rated possibly effective for ulcerative colitis (a type of inflammatory bowel disease), but for nonalcoholic fatty liver disease, alcohol-related liver disease, Alzheimer disease, and anxiety, the evidence we hold is insufficient to make a reliable call.
If you're considering it for one of those latter conditions, talk it over with your doctor about what the current research actually supports.
How safe is it?
Well-documented data
Phosphatidylcholine is generally well tolerated, though high doses can cause digestive upset. At normal supplement doses, the most common side effects are mild: altered taste, bloating, diarrhea, nausea, sweating, and vomiting.
Taking 30 grams or more per day raises the risk of gastrointestinal trouble; even smaller doses have occasionally triggered these symptoms in some people. For pregnancy and breastfeeding: choline (which your body gets from phosphatidylcholine) is needed during pregnancy, but the safety of taking supplements beyond what's in food hasn't been well studied.
While there's limited data on supplement use while breastfeeding, the evidence isn't complete. Check with your doctor or pharmacist before taking this product during pregnancy or while nursing.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Still, because phosphatidylcholine interaction data is not held in our monograph, you should verify your complete medication list with the interaction tool on this page or speak with your pharmacist before starting.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
PhosphaLine may be worth considering if you have ulcerative colitis and want a possibly helpful add-on — though talk with your doctor first about whether it fits your care plan. If you're pregnant, nursing, or on any regular medications, clear it with your own pharmacist or doctor before you start, since we don't have documented interactions on file.
Most people tolerate it well, but watch for digestive side effects, especially at higher doses.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PhosphaLine, straight from the product label.
| Brand | XYMOGEN |
|---|---|
| Barcode (UPC) | 871149001032 |
| Net contents | 100 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 303820 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PhosphaLine by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 30 Calorie(s) | -- |
| Total Fat | 3 Gram(s) | 4% |
| Polyenylphosphatidylcholine | 2.7 Gram(s) | -- |
Other ingredients: Porcine Gelatin, Glycerin, Water, Glycerides and Fatty Acids, Medium Chain Triglyceride Oil, Ethanol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
DIRECTIONS: Take two to three softgels daily, or as directed by your healthcare practitioner.
Precautions
Consult your healthcare practitioner prior to use.
Individuals taking medication should discuss potential interactions with their healthcare practitioner.
Do not use if tamper seal is damaged.
STORAGE: Keep tightly closed in a dry place at controlled room temperature 15-30 degrees C (59-86 degrees F), out of reach of children.
Contains: Soy.
Formula
PhosphaLine provides 2.7 g of pure polyenylphosphatidylcholine (PPC) per serving plus the highest concentrated source of 1,2 DLPC (dilinoleoylphosphatidylcholine). Unlike most other phosphatidylcholine products on the market, PhosphaLine contains no other phospholipids, aside from PPC and DLPC, that may compete for absorption. Studies suggest that PPC ingestion increases choline levels in the blood and brain and supports acetylcholine synthesis for healthy neuronal and cell function. Daily supplementation of PPC may help maintain healthy brain and liver function, healthy cholesterol levels already within the normal range, and gastric mucosal protection. PPC is widely used to support healthy aging.
100% Pure Polyenylphosphatidylcholine Concentrate
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
STORAGE: Keep tightly closed in a dry place at controlled room temperature 15-30 degrees C (59-86 degrees F), out of reach of children.
Formulation
DOES NOT CONTAIN: Wheat, gluten, yeast, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives.
Brand IP Statement(s)
Copyright 2018 XYMOGEN
Xymogen Exclusive professional formulas
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
ePV (ePedigree Verification)
GMP compliant third-party verified
General Statements
Scan to learn more! This package is completely recyclable
Servings per container: About 33
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PhosphaLine by XYMOGEN label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PhosphaLine by XYMOGEN
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container33 Amounts shown are per serving.
Polyenylphosphatidylcholine
No knowninteractions
Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...
Polyenylphosphatidylcholine monograph & interactionsOther (inactive) ingredients: Porcine Gelatin, Glycerin, Water, Glycerides and Fatty Acids, Medium Chain Triglyceride Oil, Ethanol. These complete the product’s ingredient list but are not active constituents.
PhosphaLine by XYMOGEN Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in PhosphaLine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for PhosphaLine, from the product label.
XYMOGEN
See all XYMOGEN products- Name
- XYMOGEN Exclusive Professional Formulas
- Street Address
- 6900 Kingspointe Pkwy.
- City
- Orlando
- State
- FL
- ZipCode
- 32819
- Phone Number
- 800-647-6100
- Web Address
- www.xymogen.com
PhosphaLine by XYMOGEN: Common Questions
Does PhosphaLine by XYMOGEN interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will PhosphaLine help my fatty liver?
What are the most common side effects?
Is it safe to take PhosphaLine while pregnant?
Can I take this while breastfeeding?
What is phosphatidylcholine used for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PhosphaLine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PhosphaLine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
PhosphaLine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 15 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phosphatidylcholine 15 references
- Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
- Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
- Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
- Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
- Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
- Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
- Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
- Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
- Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
- Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
- Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
- Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
- Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC