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Dietary supplement

Phosphatidyl Choline PC Liver & Brain Benefits Ingredients & Drug Interactions

by ProCaps Laboratories

Softgel Capsule Category: Other Combinations
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

Phosphatidyl Choline PC Liver & Brain Benefits is a dietary supplement by ProCaps Laboratories with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, liver health, brain and memory support.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Phosphatidyl Choline PC Liver & Brain Benefits by ProCaps Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Soy Lecithin Oil” is listed as a grouped ingredient — the label gives one combined amount (1,200 mg) without saying how much of each component you get.

This softgel contains 5 active ingredients that support liver and brain function. Phosphatidylcholine and choline work together as nutrient compounds — choline is a building block for cell membranes and brain chemicals, while phosphatidylcholine is a phospholipid form that may help deliver choline throughout your body.

The product also includes alpha-linolenic acid (an omega-3 fatty acid), phosphatidyl ethanolamine, and phosphatidyl inositol; soy lecithin oil serves as a source of these lipids rather than a separate active ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: liver and brain health support.
  • We looked for evidence on: Cognitive function, Memory, Age-related cognitive decline, Dementia, Alzheimer disease, Nonalcoholic fatty liver disease (NAFLD) — and 4 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Nonalcoholic fatty liver disease (NAFLD), Cognitive function, Dementia, and more.
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Alcohol-related liver disease.

The evidence is mixed. Phosphatidylcholine is possibly effective for ulcerative colitis (inflammatory bowel disease), but for other uses — including nonalcoholic fatty liver disease, alcohol-related liver disease, Alzheimer disease, and anxiety — we don't have enough reliable data to rate whether it works.

Choline shows possibly ineffective evidence for athletic performance; for other conditions like age-related cognitive decline and Alzheimer disease, the evidence isn't established in the data we hold.

The evidence, ingredient by ingredient Lecithin Phosphatidylcholine Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both phosphatidylcholine and choline are generally well tolerated at typical doses. High doses can cause digestive upset — phosphatidylcholine at 30 grams daily may cause diarrhea and bloating, and choline at 9 grams or more daily can cause nausea, vomiting, diarrhea, and a fishy body odor (from how your gut breaks it down).

Choline is needed during pregnancy and breastfeeding, but supplement doses beyond food are not well studied; talk with your doctor before taking this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Lecithin Phosphatidylcholine Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use atropine or any anticholinergic medication (drugs that block acetylcholine). This is a Minor interaction, but it's the one we have data for.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product may help support liver and brain health if ulcerative colitis is your concern, though evidence for other uses isn't clear. If you take atropine or similar anticholinergic medications, check with your doctor or pharmacist before starting.

Most people tolerate it well at normal doses, but high doses can upset your stomach. Talk it over with your own healthcare provider to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidyl Choline PC Liver & Brain Benefits, straight from the product label.

Brand ProCaps Laboratories
Net contents 360 Easy-To-Swallow Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2016
DSLD ID 57544
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidyl Choline PC Liver & Brain Benefits by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
180
IngredientAmount% DV
Calories10 {Calories}--
Calories from Fat10 {Calories}--
Total Fat1 Gram(s)2%
Trans Fat0 Gram(s)--
Phosphatidyl Choline420 mg--
Choline60 mg--
Alpha-Linolenic Acid35 mg--
Phosphatidyl Ethanolamine60 mg--
Phosphatidyl Inositol36 mg--
Soy Lecithin Oil1200 mg--

Other ingredients: Soft-Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

THIS PRODUCT IS ONLY AVAILABLE FROM HSN 800.944.9999 www.HSN.com ProCaps LABORATORIES 800.800.1200 ProCapsLabs.com

Andrew Lessman’s Phosphatidyl Choline Liver and Brain Benefits provides a concentrated, stable source of the most important phospholipids essential for healthy brain and liver function.

PC is essential for the creation of all brain and liver cells, as well as the production of our most important neurotransmitter – Acetylcholine. PC is also required to produce the protective sheath for our brain and nerve cells. The human brain is extraordinary; yet, as we age, we all experience significant changes in memory and brain function. PC is a first line of defense to help support the retention of our brain’s remarkable abilities and combat those normal, age-related changes in memory, concentration and mental acuity. As vital as the brain is, the liver is arguably our hardest working organ and PC makes up two-thirds of its enormous surface area (almost 8 acres!) where it performs protein, fat and cholesterol metabolism, as well as processing all waste products (alcohol, medicines, etc) and almost single-handedly doing all the “dirty” work required to maintain a healthy internal environment. Not surprisingly, the regenerative powers of the liver are unique among all internal organs and PC empowers the liver to rebuild and regenerate its hard-working tissues. In short, there is no more important building block to support and promote the health of our brain and liver than Phosphatidyl Choline (PC).

This product is most effective as part of a healthy diet and active lifestyle, along with one of Andrew Lessman’s multi-vitamin-mineral formulas. For answers to questions about the use of this product, call 800.808.7311.

Brand IP Statement(s)

2015 ProCaps Labs

UNSURPASSED. Purity. Quality. Integrity. Effectiveness. {signature} Andrew Lessman Founder of ProCaps Labs

General

600901-02U

Formula

Ultra-Concentrate Liquid “PC” Phosphatidyl Choline

We focus on Phosphatidyl Choline (PC), since it is the predominant phospholipid in both the brain and liver and is now recognized by the FDA as an essential nutrient because of its important role and scarcity in our diet.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

All-Solar MANUFACTURING

Formulation

CONTAINS NO Milk, yeast, corn, wheat, gluten, sodium, salt, sugar, cholesterol, color, preservative or manufacturing additive.

CONTAINS NO Milk, yeast, corn, wheat, gluten, sodium, salt, sugar, cholesterol, color, preservative or manufacturing additives. CONTAINS NO ADDITIVES OF ANY KIND.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

SUGGESTED USE Consume two or more capsules daily or as recommended by a health care professional. For best results take this product with food, preferably a complete meal.

See for yourself

Phosphatidyl Choline PC Liver & Brain Benefits by ProCaps Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Phosphatidyl Choline PC Liver & Brain Benefits by ProCaps Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha-Linolenic Acid

35 mg per serving Form: Flaxseed Oil

Soy Lecithin Oil

No known
interactions
1200 mg per serving

Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting...

Soy Lecithin Oil monograph & interactions

Other (inactive) ingredients: Soft-Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidyl Choline PC Liver & Brain Benefits by ProCaps Laboratories Drug Interactions

Want to check YOUR meds against Phosphatidyl Choline PC Liver & Brain Benefits?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidyl Choline PC Liver & Brain Benefits with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Phosphatidyl Choline PC Liver & Brain Benefits, from the product label.

ProCaps Laboratories

See all ProCaps Laboratories products
Name
ProCaps Labs
City
Henderson
State
NV
ZipCode
89011
Phone Number
800-800-1200
Web Address
ProCapsLabs.com
Pharmacist Counseling Corner

Phosphatidyl Choline PC Liver & Brain Benefits by ProCaps Laboratories: Common Questions

Does Phosphatidyl Choline PC Liver & Brain Benefits by ProCaps Laboratories interact with any medications?
Yes. Based on its ingredients, Phosphatidyl Choline PC Liver & Brain Benefits has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidyl Choline PC Liver & Brain Benefits contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Choline is important during pregnancy and breastfeeding, and the ingredient choline is rated likely safe during these times. However, supplement doses beyond what you get from food haven't been well studied for either condition. Talk with your doctor before taking this product to get personalized advice based on your needs.
What side effects might I notice?
Most people handle this well. At normal doses, mild effects like altered taste, bloating, nausea, or sweating can occur with phosphatidylcholine. Choline at very high doses (9+ grams daily) can cause nausea, vomiting, diarrhea, and a fishy body odor. The doses in this product are typically much lower than these thresholds.
Does this actually help with brain function?
The evidence isn't clear. While choline is a building block your brain needs, we don't have enough reliable data to say whether this supplement improves cognitive decline or Alzheimer disease. Phosphatidylcholine is possibly effective for ulcerative colitis, but evidence for brain benefits specifically hasn't been established in our data.
What does phosphatidylcholine do?
Phosphatidylcholine is a phospholipid — a fat compound — that's a key component of cell membranes throughout your body, including in your brain and liver. It may help your cells stay intact and functioning. It's also a source of choline, which your body uses to make brain chemicals and support memory and nerve function.
Does this product contain any fillers?
The only inactive ingredient listed is the soft-gelatin capsule itself. No other fillers or binders are included.
I take atropine for my heart. Can I use this?
Theoretically, choline in this product might decrease atropine's effects in the brain. This is a minor interaction, but it matters — check with your doctor or pharmacist before starting to make sure it won't interfere with your treatment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phosphatidyl Choline PC Liver & Brain Benefits is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidyl Choline PC Liver & Brain Benefits label
Sources

Sources & How We Checked

Phosphatidyl Choline PC Liver & Brain Benefits's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 38 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Lecithin 9 references
  1. Buchman AL, Dubin M, Jenden D, et al. Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. Gastroenterology 1992;102:1363-70.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Chatellier G, Lacomblez L. Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Francais d'Etude de la Tetrahydroaminoacridine. BMJ 1990;300:495-9.
  4. Gelenberg AJ, Dorer DJ, Wojcik JD, et al. A crossover study of lecithin treatment of tardive dyskinesia. J Clin Psychiatry 1990;51:149-53.
  5. Little A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1985;48:736-42. PubMed
  6. Palm M, Moneret-Vautrin DA, Kanny G, et al. Food allergy to egg and soy lecithins. Allergy 1999;54:1116-7. PubMed
  7. Drachman DA, Glosser G, Fleming P, et al. Memory decline in the aged: treatment with lecithin and physostigmine. Neurology 1982;32:944-50. PubMed
  8. Gelenberg, A. J., Doller-Wojcik, J. C., and Growdon, J. H. Choline and lecithin in the treatment of tardive dyskinesia: preliminary results from a pilot study. Am J Psychiatry 1979;136(6):772-776. PubMed
  9. Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 184: Direct food substances affirmed as Generally Recognized as Safe. Subpart B - listing of specific substances affirmed as GRAS. Sec. 184.1400 Lecithin. Available at: https:

See these in context on the Lecithin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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