Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Polypodium Extract Ingredients & Drug Interactions

by Herbadiet

Polypodium Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Polypodium Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Polypodium Extract is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for sun sensitivity and sunburn protection, skin conditions like vitiligo and melasma, polymorphic light eruption.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Polypodium whole plant extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Polypodium Extract by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Polypodium Extract by Herbadiet — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Polypodium Extract by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Polypodium whole plant extract, derived from the Polypodium leucotomos plant. The capsule itself is made from vegetable cellulose, an inactive ingredient used as the shell.

Polypodium leucotomos has been studied for a range of skin and systemic conditions, though we don't yet have strong evidence that it works for any of them.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Polypodium Leucotomos's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: skin protection from sun damage and rejuvenation.
  • We looked for evidence on: Sunburn, Melasma, Polymorphous light eruption (PMLE), Vitiligo, Atopic dermatitis (eczema), Actinic keratoses — and 3 related terms.
  • The closest evidence on file: Polypodium Leucotomos is rated "Insufficient Reliable Evidence To Rate" for Atopic dermatitis (eczema) (Natural Medicines).
  • Also on file: Polypodium Leucotomos is rated "Insufficient Reliable Evidence To Rate" for Melasma, Sunburn, Vitiligo, Actinic keratoses, and more.

The evidence for Polypodium leucotomos isn't established in our data. It's been studied for dementia, eczema (atopic dermatitis), actinic keratoses (rough, scaly patches from sun damage), and lupus skin lesions (cutaneous lupus erythematosus), as well as protection against sun-related skin damage — but for all of these, we rate the evidence as insufficient.

That doesn't mean it doesn't work; it means the research so far isn't solid enough to say.

The evidence, ingredient by ingredient Polypodium Leucotomos

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Polypodium leucotomos is generally well tolerated in studies, though long-term safety hasn't been thoroughly established. A small number of people taking it orally have experienced itching (pruritus).

During pregnancy, there isn't enough safety data, so it's best avoided. The same goes for breastfeeding — we don't know whether it's safe, so avoidance is the more cautious choice.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Polypodium Leucotomos

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Polypodium Leucotomos.
  • The most serious interaction on file is rated Minor.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any medications that are metabolized by the CYP3A4 liver enzyme — a large group that includes sedatives, many cardiac drugs, immunosuppressants, and others. While the interaction is rated Minor, a small human study supports the possibility that Polypodium leucotomos can slow the clearance of these drugs.

Your pharmacist can help you identify whether any of your medications fall into this category.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Polypodium Extract may appeal to you if you're interested in traditional herbal remedies for skin or systemic concerns, but know that solid evidence for its effectiveness isn't available yet. The main caution is that it may interact with medications broken down by your liver — especially sedatives and other CYP3A4 substrates.

Check your exact medications with your pharmacist or doctor before starting, and avoid it during pregnancy or breastfeeding unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Polypodium Extract, straight from the product label.

Brand Herbadiet
Barcode (UPC) 880239397351
Net contents 60 V-Cap(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 258048
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Polypodium Extract by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
880239397351
IngredientAmount% DV
Polypodium whole plant extract300 mg--

Other ingredients: Vegetable Cellulose Shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Polypodium Leucotomos, also known as PLE, is proven to help protect your skin from the damaging effects of the sun. Herbadiet's all natural full spectrum extract helps rejuvenate, restore & recapture the youthful skin.

Formulation

Supports skin hydration & elasticity Promotes rejuvenation of skin Protects skin against sun damage

Natural color variation may occur in this product

100% natural Healthy skin support

Non-GMO

Suitable for vegetarians and vegans

Free of preservatives, binders, gluten, artificial ingredients, dairy, soy, wheat, yeast

Every batch 3rd party lab tested

FDA Disclaimer Statement

These statements have not been evaluated by FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Do not use if seal under the cap is broken or missing. Dietary supplement shouldn't be used as a substitute for a varied diet

Caution: If you are pregnant, breast feeding, or taking medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Not for medicinal use

Storage

Store in cool, dry place

Seals/Symbols

fssai Lic. No.: 20817018000147 Vcaps Plus GMP Good Manufacturing Practice Quality Product

General Statements

1% for the planet

License Number : 10018064001315

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for Use: Take 1 capsule daily, preferably with meals or as directed by your physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Polypodium Extract by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Polypodium Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Polypodium Extract by Herbadiet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Polypodium whole plant extract

Interacts with
643 drugs
300 mg per serving

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-trigger...

Polypodium whole plant extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

Polypodium Extract by Herbadiet Drug Interactions

Want to check YOUR meds against Polypodium Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Minor

Ingredients driving the most interactions

Polypodium whole plant extract 643

Individual Drug Interactions

The ingredients in Polypodium Extract interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Polypodium Extract interact with drugs. Each result below shows which ingredient is responsible. Polypodium whole plant extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Polypodium Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polypodium whole plant extract1 drug type · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggests that Polypodium leucotomos can decrease the metabolism of midazolam by a mechanism possibly related to the inhibition of CYP3A4. However, a small study in humans suggests that taking Polypodium leucotomos with midazolam does not affect the metabolism of midazolam.

Likelihood Unlikely Evidence B
Polypodium whole plant extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Polypodium Extract, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
City
Haryana
State
India
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Polypodium Extract by Herbadiet: Common Questions

Does Polypodium Extract by Herbadiet interact with any medications?
Yes. Based on its ingredients, Polypodium Extract has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Polypodium Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Polypodium leucotomos, and what is it supposed to do?
Polypodium leucotomos is a fern extract that's been studied for skin conditions like eczema and acne-related sun damage, as well as lupus skin lesions and dementia. The evidence isn't strong enough yet to say it works for any of these, but it's used in traditional and complementary medicine.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data during pregnancy, so it's best avoided. Breastfeeding safety is also unknown, so avoidance is the safer choice. Talk with your doctor or pharmacist if you're in either situation.
What side effects does it cause?
In studies, it's been generally well tolerated. The only side effect that's been reported — and only rarely — is itching (pruritus). Long-term safety data is limited, so we don't have a complete picture of what might happen with extended use.
Does it interact with sedatives like Valium or Ativan?
Potentially, yes. Lab studies suggest Polypodium leucotomos may slow the breakdown of certain sedatives and other drugs metabolized by a liver enzyme called CYP3A4. Check with your pharmacist about your specific medications before starting this product.
Is this product safe to use long-term?
We don't have enough long-term safety data to say. While short-term studies show it's generally well tolerated, the risks and benefits of taking it over months or years haven't been well studied.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Polypodium Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Polypodium Extract label
Go deeper

The Full Monographs Behind Polypodium Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Polypodium Leucotomos

Interacts with 643 drugs

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-triggered skin conditions. Some early research...

Read the full Polypodium Leucotomos monograph →
Sources

Sources & How We Checked

Polypodium Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Polypodium Leucotomos 2 references
  1. Goh CL, Chuah SY, Tien S, Thng G, Vitale MA, Delgado-Rubin A. Double-blind, placebo-controlled trial to evaluate the effectiveness of Polypodium leucotomos extract in the treatment of melasma in Asian skin: a pilot study. J Clin Aesthet Dermatol 2018;11(3
  2. Shinya K, Nishimura Y, Ryu K, et al. Short-term administration of Polypodium leucotomos extract does not inhibit CYP3A4-mediated metabolism of midazolam in healthy subjects: an open-label, two-period, fixed-sequence study. Int J Dermatol 2022.

See these in context on the Polypodium Leucotomos monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team