Organic Berberis aristata Ingredients & Drug Interactions
by Herbadiet
What is this page for?
First and foremost: checking Organic Berberis aristata against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Organic Berberis aristata is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, digestive complaints.Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are organic Berberis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Organic Berberis aristata by Herbadiet
Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Berberis aristata by Herbadiet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Organic Berberis aristata by Herbadiet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: organic berberis (also called tree turmeric), which has been used in traditional medicine for various purposes. The capsule itself is made from vegetable cellulose, an inert casing that holds the plant extract.
Does it work?
Not established
The evidence we hold on berberis doesn't establish it works for any condition. Studies are rated insufficient for burns, diabetes, high cholesterol, wound healing, and heavy menstrual bleeding.
That doesn't mean it's ineffective — just that the research data isn't solid enough yet for us to vouch for it.
How safe is it?
Well-documented data
Berberis has a long history in traditional use, but human safety data are limited. The main concern: no serious adverse effects have been reported with berberis alone, though nausea and other gastrointestinal symptoms were noted in one study using a combination product with milk thistle.
Berberine can pass into breast milk and may harm an infant, and it may harm a developing fetus, so the safety data advise against this product during pregnancy and breastfeeding.
Meds to double-check
Major interaction found
Before taking this product, double-check with your pharmacist if you're on tacrolimus or cyclosporine (immunosuppressants) — berberine can raise their levels dangerously. Also flag any blood thinners, blood pressure medications, sedatives or sleep aids, or drugs processed through CYP3A4, CYP2D6, or CYP2C9 pathways.
No interactions are documented for the ingredient we could not fully check.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
This is a single botanical with Traditional medicine roots but limited modern research backing. If you take a transplant-related immunosuppressant (tacrolimus or cyclosporine), blood thinners, blood pressure medication, sedatives, or drugs metabolized by common liver pathways, talk to your pharmacist or doctor before adding this — the interactions can be serious.
Pregnant people and those breastfeeding should avoid it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Organic Berberis aristata, straight from the product label.
| Brand | Herbadiet |
|---|---|
| Barcode (UPC) | 880359449558 |
| Net contents | 60 V-Cap(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2022 |
| DSLD ID | 257901 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Organic Berberis aristata by Herbadiet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| organic Berberis | 800 mg | -- |
Other ingredients: Vegetable Cellulose Shell
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Herbadiet Berberis is made with certified organic Berberis Aristata root powder. This full spectrum herb retains all the active constituents in nature intended balanced ratio. Encapsulating this goodness in our quick release, easy to swallow vegan capsules, guarantees you a premium quality nutritional supplement.
Formulation
Promotes healthy immune system Promotes healthy blood sugar levels Maintains healthy cholesterol levels
Natural color variation may occur in this product
USDA Organic
100% natural Diabetic support
Vegan
Non-GMO
Suitable for vegetarians and vegans
Free of preservatives, binders, gluten, artificial ingredients, dairy, soy, wheat, yeast
Every batch 3rd party lab tested
FDA Disclaimer Statement
These statements have not been evaluated by FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Do not use if seal under the cap is broken or missing. Dietary supplement shouldn't be used as a substitute for a varied diet
Caution: If you are pregnant, breast feeding, or taking medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Not for medicinal use
Storage
Store in cool, dry place
Seals/Symbols
fssai Lic. No.: 20817018000147 Vcaps Plus GMP Good Manufacturing Practice Quality Product
USDA Organic
General Statements
1% for the planet
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions for Use: Take 2 capsules twice a day, 20-30 minutes before meals with full glass of water or as directed by your physician.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Organic Berberis aristata by Herbadiet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Organic Berberis aristata by Herbadiet
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Organic Berberis
Interacts with1,160 drugs
Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research...
Organic Berberis monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose Shell. These complete the product’s ingredient list but are not active constituents.
Organic Berberis aristata by Herbadiet Drug Interactions
HelloPharmacist Interaction Report
Herbadiet's Organic Berberis aristata is a single-ingredient product that does interact with medications.
The most serious concern is with immune-suppressing drugs: berberine (the active compound in this plant) can slow how your body breaks down tacrolimus and cyclosporine, raising their blood levels to potentially unsafe levels. Both are Major-severity interactions.
Read the full breakdown — every affected drug type, severity by severity
Beyond that, berberine inhibits several liver enzymes (CYP3A4, CYP2D6, and CYP2C9) that clear many other medications, so drugs metabolized by these pathways may build up in your system — these are Moderate-severity. You should also be cautious combining this with blood thinners or antiplatelet drugs (like aspirin or warfarin), since berberine may boost their effects and raise bleeding risk.
CNS depressants (sedatives, sleep aids, some pain relievers) and blood pressure medications could have stronger effects too.
Berberine was the ingredient we checked; no others in this product interact with medications, but we don't have complete interaction data on every medication out there. Run your exact drugs through the checker on this page before you start.
Altogether, these interactions span 1,148 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Organic Berberis aristata?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Organic Berberis aristata interact with 1,160 drugs. Click any drug to see the details.
1 of the 1 ingredient in Organic Berberis aristata interact with drugs. Each result below shows which ingredient is responsible. organic Berberis
CyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates, Cyclosporine (neoral, Sandimmune) Major
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Cyclosporine interactionTacrolimusAstagraf XL, Envarsus XR, Prograf (capsule), Prograf (injectable), Prograf XL, Protopic
How Tacrolimus interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisTacrolimus (prograf), Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Read the full Organic Berberis + Tacrolimus interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Organic Berberis + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Organic Berberis + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Read the full Organic Berberis + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Berberis + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Organic Berberis + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCns Depressants Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Organic Berberis + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Organic Berberis + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Organic Berberis + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Organic Berberis + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Organic Berberis + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Organic Berberis + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Organic Berberis + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Organic Berberis + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Read the full Organic Berberis + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Organic Berberis + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Organic Berberis aristata — through 1 ingredient. Tap an ingredient for the detail:
Organic BerberisDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Read the full Organic Berberis + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Organic Berberis aristata with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Berberis
Cyclosporine (Neoral, Sandimmune)
Berberine, a constituent of tree turmeric, can reduce metabolism of cyclosporine and increase serum levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.
Tacrolimus (Prograf)
Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes tacrolimus. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with prednisone 40 mg/m2 and tacrolimus 6.5 mg twice daily, concomitant use of berberine, a constituent of tree turmeric, 200 mg three times daily increased plasma levels of tacrolimus from 8 to 22 ng/mL and increased serum creatinine levels from 0.7 to 1.2 mg/dL. Following a reduction of tacrolimus dosing to 3 mg daily, the blood concentration of tacrolimus decreased to 12 ng/mL and the serum concentration of creatinine decreased to 0.9 mg/dL.
Anticoagulant/Antiplatelet Drugs
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
In vitro and animal research suggest that berberine, a constituent of tree turmeric, can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Clinical research shows that taking a product containing tree turmeric and milk thistle extracts can lower blood glucose levels, glycated hemoglobin (HbA1c), and insulin resistance in patients with type 2 diabetes, including those on antidiabetic agents. Additionally, clinical research suggests that berberine, a constituent of tree turmeric, can lower blood glucose levels.
Antihypertensive Drugs
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that berberine, a constituent of tree turmeric, can have hypotensive effects. Also, a meta-analysis of clinical research suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.
Cns Depressants
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Animal research suggests that berberine, a constituent of tree turmeric, can have sedative effects.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, can inhibit CYP2D6.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, moderately inhibits CYP3A4.
Dextromethorphan (Robitussin Dm, Others)
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Preliminary clinical research suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan.
Midazolam (Versed)
Theoretically, tree turmeric might increase levels of midazolam and potentially increase the risk of adverse effects including sedation and respiratory depression.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam.
Pentobarbital (Nembutal)
Theoretically, tree turmeric might increase the sedative effects of pentobarbital.
Animal research suggests that berberine, a constituent of tree turmeric, can prolong pentobarbital-induced sleeping time.
Brand information
Manufacturer and brand details for Organic Berberis aristata, from the product label.
Herbadiet
See all Herbadiet products- Name
- Arkure Health Care
- City
- Haryana
- State
- India
- Web Address
- www.herbadiet.in
Organic Berberis aristata by Herbadiet: Common Questions
Does Organic Berberis aristata by Herbadiet interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the side effects?
Does this actually work for what it claims?
What is berberis and why is it in here?
Why does this interact with so many medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Organic Berberis aristata is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Organic Berberis aristata’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Organic Berberis aristata's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tree Turmeric 25 references
- Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
- Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
- Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29.
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
- Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Phyto PubMed
- Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:8 PubMed
- Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. PubMed
- Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clin Nutr. 2016;35(5):1091-5. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC