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Dietary supplement

Organic Berberis aristata Extract Paste Ingredients & Drug Interactions

by Materia Organica

Organic Berberis aristata Extract Paste label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Berberis aristata Extract Paste against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Organic Berberis aristata Extract Paste is a dietary supplement by Materia Organica with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, digestive complaints.Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Berberis aristata extract paste. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Berberis aristata Extract Paste by Materia Organica

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Berberis aristata Extract Paste by Materia Organica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Berberis aristata Extract Paste by Materia Organica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is a single-ingredient extract paste: Berberis aristata (tree turmeric). Berberine, the active alkaloid in this plant, is what carries both the traditional uses and the interactions we know about.

There are no other active ingredients, and no inactive fillers are listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Tree Turmeric product and its label doesn't state a use — see Tree Turmeric's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that tree turmeric is effective for any condition. Studies graded its use for burns, diabetes, high cholesterol, wound healing, and heavy menstrual bleeding as having insufficient reliable evidence to rate.

That doesn't mean it doesn't work — it means the clinical proof isn't solid enough yet to call it effective.

The evidence, ingredient by ingredient Tree Turmeric

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for tree turmeric are limited. No adverse effects were reported when used alone, though a full safety review hasn't been done.

A combination product containing tree turmeric and milk thistle reported gastrointestinal upset, mainly nausea, in some users. Berberine-containing plants are rated likely unsafe in pregnancy and lactation.

If you're pregnant, planning to become pregnant, or breastfeeding, avoid this product — berberine can harm a fetus and pass into breast milk.

Side effects, ingredient by ingredient Tree Turmeric

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tree Turmeric.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,161 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Stop before you start if you take tacrolimus or cyclosporine for transplant — berberine raises their levels and toxicity risk. Also double-check blood pressure medications, sedatives, blood thinners, or any drug your doctor says is metabolized by your liver (CYP3A4, CYP2D6, or CYP2C9).

Use the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you take tacrolimus or cyclosporine, or if you're on blood pressure medications, sedatives, or blood thinners, check with your pharmacist or doctor before using this. Pregnant or breastfeeding?

Skip it. The evidence for what it treats isn't established yet, and the interaction risk is real.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Berberis aristata Extract Paste, straight from the product label.

Brand Materia Organica
Barcode (UPC) BER3120-100g
Net contents 3.5 Ounce(s); 100 Gram(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336963
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Berberis aristata Extract Paste by Materia Organica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
200
UPC/BARCODE
BER3120-100g
IngredientAmount% DV
Berberis aristata extract paste500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Seals/Symbols

USDA Organic CCOF Certified Organic Star-K (Kosher)

General Statements

Materia Organica primarily sells bulk ingredients to manufacturers and brand owners.

Product Code: BER31020

Formula

Our water extraction process preserves the natural nutrients & beneficial qualities of Berberis aristata with improved potency & bioavailability. 100% Berberis aristata

Certified organic and Star-K Kosher

Formulation

Certified organic and Star-K Kosher

Water extracted & water soluble Better bioavailability and potency Vegetarian/vegan, non-GMO, non-irradiated

No additives, fillers, or other ingredients No petroleum solvents in the extraction No pesticides used growing the Berberis Vegetarian/vegan, non-GMO, non-irradiated

Vegetarian/vegan, non-GMO, non-irradiated

Certified organic by CCOF

Product of India 3rd party lab tested in USA

Suggested/Recommended/Usage/Directions

Suggested use: Mix 500 mg into tea, juice, or your favorite smoothie.

Precautions

Not recommended for children.

Storage

Store unopened pouches in a cool area. Refrigerate in a sealed container after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Berberis aristata Extract Paste by Materia Organica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Berberis aristata Extract Paste label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Berberis aristata Extract Paste by Materia Organica

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formOther (e.g. Tea Bag) Servings per container200 Amounts shown are per serving.

Berberis aristata extract paste

Interacts with
1,160 drugs
500 mg per serving

Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research...

Berberis aristata extract paste monograph & interactions
Interaction report

Organic Berberis aristata Extract Paste by Materia Organica Drug Interactions

Want to check YOUR meds against Organic Berberis aristata Extract Paste?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,160Drugs
2 Major 1,158 Moderate

Ingredients driving the most interactions

Berberis aristata extract paste 1,160

Individual Drug Interactions

The ingredients in Organic Berberis aristata Extract Paste interact with 1,160 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Berberis aristata Extract Paste interact with drugs. Each result below shows which ingredient is responsible. Berberis aristata extract paste

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Berberis aristata Extract Paste with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Berberis aristata extract paste12 drug types · 1,160 drugs

Cyclosporine (Neoral, Sandimmune)

Berberine, a constituent of tree turmeric, can reduce metabolism of cyclosporine and increase serum levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Likely Evidence A
Tacrolimus (Prograf)

Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes tacrolimus. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with prednisone 40 mg/m2 and tacrolimus 6.5 mg twice daily, concomitant use of berberine, a constituent of tree turmeric, 200 mg three times daily increased plasma levels of tacrolimus from 8 to 22 ng/mL and increased serum creatinine levels from 0.7 to 1.2 mg/dL. Following a reduction of tacrolimus dosing to 3 mg daily, the blood concentration of tacrolimus decreased to 12 ng/mL and the serum concentration of creatinine decreased to 0.9 mg/dL.

Likelihood Likely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
In vitro and animal research suggest that berberine, a constituent of tree turmeric, can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Clinical research shows that taking a product containing tree turmeric and milk thistle extracts can lower blood glucose levels, glycated hemoglobin (HbA1c), and insulin resistance in patients with type 2 diabetes, including those on antidiabetic agents. Additionally, clinical research suggests that berberine, a constituent of tree turmeric, can lower blood glucose levels.

Likelihood Probable Evidence A
Antihypertensive Drugs

Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that berberine, a constituent of tree turmeric, can have hypotensive effects. Also, a meta-analysis of clinical research suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Animal research suggests that berberine, a constituent of tree turmeric, can have sedative effects.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, can inhibit CYP2D6.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, moderately inhibits CYP3A4.

Likelihood Probable Evidence A
Dextromethorphan (Robitussin Dm, Others)

Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Preliminary clinical research suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan.

Likelihood Possible Evidence B
Midazolam (Versed)

Theoretically, tree turmeric might increase levels of midazolam and potentially increase the risk of adverse effects including sedation and respiratory depression.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, tree turmeric might increase the sedative effects of pentobarbital.
Animal research suggests that berberine, a constituent of tree turmeric, can prolong pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Berberis aristata extract paste full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Berberis aristata Extract Paste, from the product label.

Materia Organica

See all Materia Organica products
Name
Materia Organica
City
Quitman
State
TX
ZipCode
75783
Phone Number
800-613-6311
Web Address
www.MateriaOrganica.com
Pharmacist Counseling Corner

Organic Berberis aristata Extract Paste by Materia Organica: Common Questions

Does Organic Berberis aristata Extract Paste by Materia Organica interact with any medications?
Yes. Based on its ingredients, Organic Berberis aristata Extract Paste has a known interaction with 1,160 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Berberis aristata Extract Paste contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. Berberine is rated likely unsafe in pregnancy because it may harm the fetus, and it passes into breast milk and may be harmful to infants. Talk to your OB or midwife about safe alternatives.
Does tree turmeric actually work for high cholesterol or diabetes?
The evidence we hold isn't solid enough to say it does. Studies rate it as having insufficient reliable evidence for those uses, so we can't call it effective yet.
What side effects should I watch for?
No side effects were reported from tree turmeric alone in the data we have, though safety studies haven't been thorough. A product mixing tree turmeric with milk thistle caused nausea and stomach upset in some people.
Why does this interact with so many medications?
Berberine slows down the liver enzymes that break down many drugs — especially CYP3A4, but also CYP2D6 and CYP2C9. When those drugs stay in your system longer, their levels can build up and side effects can happen.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Berberis aristata Extract Paste is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Berberis aristata Extract Paste label
Go deeper

The Full Monographs Behind Organic Berberis aristata Extract Paste’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tree Turmeric

Interacts with 1,160 drugs

Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research suggests possible benefits for blood sug...

Read the full Tree Turmeric monograph →
Sources

Sources & How We Checked

Organic Berberis aristata Extract Paste's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tree Turmeric 25 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
  3. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  4. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
  5. Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  7. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
  8. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  9. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  10. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
  11. Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
  12. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
  13. Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29.
  14. Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
  15. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
  16. Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
  17. Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
  18. Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
  19. Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
  20. Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
  21. Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
  22. Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Phyto PubMed
  23. Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:8 PubMed
  24. Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. PubMed
  25. Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clin Nutr. 2016;35(5):1091-5. PubMed

See these in context on the Tree Turmeric monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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