Berberis Aristata 4500 mg Ingredients & Drug Interactions
by NusaPure
What is this page for?
First and foremost: checking Berberis Aristata 4500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Berberis Aristata 4500 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, digestive complaints.Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Berberis aristata 20:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Berberis Aristata 4500 mg by NusaPure
Ask about any prescription or over-the-counter medication and we check it for interactions with Berberis Aristata 4500 mg by NusaPure — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Berberis Aristata 4500 mg by NusaPure
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product is a single-ingredient supplement: berberis aristata extract at a 20:1 concentration, also called tree turmeric. The capsule itself contains inactive ingredients—cellulose, silica, and rice flour—which are binders and fillers.
Does it work?
Couldn't assess
The evidence for berberis aristata's effectiveness is currently insufficient to rate. The facts we hold don't establish reliable evidence that it works for burns, diabetes, high cholesterol, wound healing, or heavy menstrual bleeding.
If you're considering this supplement for any of those reasons, talk with us or your doctor about what the research actually shows and whether it's the right choice for you.
How safe is it?
Well-documented data
Berberis aristata has limited human safety data. While no adverse effects have been reported when tree turmeric is used alone, a thorough safety evaluation hasn't been completed.
One combination product (berberol) containing tree turmeric and milk thistle did report gastrointestinal symptoms, especially nausea, in users. Because berberine can pass into breast milk and may harm a nursing infant, avoid this supplement while breastfeeding.
The safety data also advises against use in pregnancy, as berberine-containing plants may harm a developing fetus.
Meds to double-check
Major interaction found
Before you start, check with us if you take tacrolimus or cyclosporine (Major risk of elevated drug levels). Also double-check any blood thinners or antiplatelet drugs, antihypertensives, CNS depressants, or medications metabolized by CYP3A4, CYP2D6, or CYP2C9—all carry Moderate interaction risk.
Use the medication checker on this page for your exact drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This supplement carries real risks if you take immunosuppressants, blood thinners, blood pressure medications, or sedatives—talk with your pharmacist before adding it. If you're pregnant or breastfeeding, skip it.
For other conditions, the evidence isn't established yet, so weigh that against the interaction burden.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Berberis Aristata 4500 mg, straight from the product label.
| Brand | NusaPure |
|---|---|
| Barcode (UPC) | X001WN18Y7 |
| Net contents | 200 Veg Cap(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 246131 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Berberis Aristata 4500 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Berberis aristata 20:1 extract | 225 mg | -- |
Other ingredients: Cellulose, Silica, Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) capsule daily preferably with a meal.
Precautions
Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Not intended for use by persons under the age of 18.
Keep out of reach of children.
Produced in a GMP facility that processes other ingredients, containing these allergens.
Storage
Store in cool dry place. Avoid excessive heat or moisture.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Premium Quality Assembled in USA Gluten Free FDA Registered Facility
Manufactured in a cGMP Inspected Facility.
Formulation
GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility
Assembled in USA Natural Supports cardiovascular health Supports a healthy immune system Supports healthy cholesterol levels Max Strength
Allergen Information: Contains no artificial coloring, artificial flavor, yeast, corn, milk, or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.
Natural color variation may occur in this product.
Formula
Berberis Aristata standardized for berberine 4500 mg equivalent per capsule
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Berberis Aristata 4500 mg by NusaPure label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Berberis Aristata 4500 mg by NusaPure
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.
Berberis aristata 20:1 extract
Interacts with1,160 drugs
Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research...
Berberis aristata 20:1 extract monograph & interactionsOther (inactive) ingredients: Cellulose, Silica, Rice Flour. These complete the product’s ingredient list but are not active constituents.
Berberis Aristata 4500 mg by NusaPure Drug Interactions
HelloPharmacist Interaction Report
NusaPure's Berberis Aristata 4500 mg contains one active ingredient—a berberis aristata extract—that interacts with a substantial number of medications.
The most serious interactions are with immunosuppressants (tacrolimus and cyclosporine); berberine, the plant's main active compound, can slow how your body breaks down these drugs and raise their levels in your blood to potentially unsafe amounts.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions affect several other drug categories. Blood pressure medications (antihypertensives) may have stronger effects if you're also taking this supplement, since berberine can lower blood pressure on its own.
Blood thinners and antiplatelet drugs (like aspirin or warfarin) could have their effects boosted, raising bleeding risk. Sedating medications and CNS depressants may hit harder because berberine appears to have mild sedative properties.
Additionally, berberine can slow the metabolism of drugs broken down by three major liver enzymes—CYP3A4, CYP2D6, and CYP2C9—which means medications processed by these pathways may accumulate in your system.
Altogether, these interactions span 1,148 individual medications. If you take any prescription drug, especially immunosuppressants or blood thinners, run it through the medication checker below before you start this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Berberis Aristata 4500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Berberis Aristata 4500 mg interact with 1,160 drugs. Click any drug to see the details.
1 of the 1 ingredient in Berberis Aristata 4500 mg interact with drugs. Each result below shows which ingredient is responsible. Berberis aristata 20:1 extract
CyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cyclosporine (neoral, Sandimmune) Major
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Cyclosporine interactionTacrolimusAstagraf XL, Envarsus XR, Prograf (capsule), Prograf (injectable), Prograf XL, Protopic
How Tacrolimus interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractTacrolimus (prograf), Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Read the full Berberis Aristata 20:1 Extract + Tacrolimus interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata 20:1 Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata 20:1 Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Read the full Berberis Aristata 20:1 Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Berberis Aristata 20:1 Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata 20:1 Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCns Depressants Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Berberis Aristata 20:1 Extract + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Berberis Aristata 4500 mg — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata 20:1 ExtractDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Read the full Berberis Aristata 20:1 Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Berberis Aristata 4500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Berberis aristata 20:1 extract
Cyclosporine (Neoral, Sandimmune)
Berberine, a constituent of tree turmeric, can reduce metabolism of cyclosporine and increase serum levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.
Tacrolimus (Prograf)
Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes tacrolimus. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with prednisone 40 mg/m2 and tacrolimus 6.5 mg twice daily, concomitant use of berberine, a constituent of tree turmeric, 200 mg three times daily increased plasma levels of tacrolimus from 8 to 22 ng/mL and increased serum creatinine levels from 0.7 to 1.2 mg/dL. Following a reduction of tacrolimus dosing to 3 mg daily, the blood concentration of tacrolimus decreased to 12 ng/mL and the serum concentration of creatinine decreased to 0.9 mg/dL.
Anticoagulant/Antiplatelet Drugs
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
In vitro and animal research suggest that berberine, a constituent of tree turmeric, can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Clinical research shows that taking a product containing tree turmeric and milk thistle extracts can lower blood glucose levels, glycated hemoglobin (HbA1c), and insulin resistance in patients with type 2 diabetes, including those on antidiabetic agents. Additionally, clinical research suggests that berberine, a constituent of tree turmeric, can lower blood glucose levels.
Antihypertensive Drugs
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that berberine, a constituent of tree turmeric, can have hypotensive effects. Also, a meta-analysis of clinical research suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.
Cns Depressants
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Animal research suggests that berberine, a constituent of tree turmeric, can have sedative effects.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, can inhibit CYP2D6.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, moderately inhibits CYP3A4.
Dextromethorphan (Robitussin Dm, Others)
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Preliminary clinical research suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan.
Midazolam (Versed)
Theoretically, tree turmeric might increase levels of midazolam and potentially increase the risk of adverse effects including sedation and respiratory depression.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam.
Pentobarbital (Nembutal)
Theoretically, tree turmeric might increase the sedative effects of pentobarbital.
Animal research suggests that berberine, a constituent of tree turmeric, can prolong pentobarbital-induced sleeping time.
Brand information
Manufacturer and brand details for Berberis Aristata 4500 mg, from the product label.
NusaPure
See all NusaPure products- Name
- Gmax Central LLC
- Street Address
- 4700 Millenia Boulevard, Suite 175 PMB 92909
- City
- Orlando
- State
- FL
- ZipCode
- 32839
Berberis Aristata 4500 mg by NusaPure: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Berberis Aristata 4500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Berberis Aristata 4500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tree Turmeric 25 references
- Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
- Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
- Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29.
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
- Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Phyto PubMed
- Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:8 PubMed
- Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. PubMed
- Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clin Nutr. 2016;35(5):1091-5. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC