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Dietary supplement

Berberis Arstata Extract Paste, Organic Ingredients & Drug Interactions

by Omica Organics

Powder Category: Botanical
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Berberis Arstata Extract Paste, Organic is a dietary supplement by Omica Organics with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, digestive complaints.Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Berberis aristata extract paste. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Berberis Arstata Extract Paste, Organic by Omica Organics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is a single-ingredient extract: berberis aristata (also called tree turmeric), presented as a paste in powder form. Berberine is the active compound in this plant extract that accounts for the interactions and effects noted here.

There are no other active ingredients, and the product contains no inactive fillers or additional ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Tree Turmeric's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: traditional herb with turmeric-like benefits.
  • We looked for evidence on: Diabetes, Hypercholesterolemia, Wound healing, digestive health, liver support, eye health.
  • The closest evidence on file: Tree Turmeric is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Tree Turmeric is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Wound healing.

The evidence we hold does not establish that berberis aristata extract works for any of the conditions it's been used for traditionally — burns, diabetes, high cholesterol, wound healing, or heavy menstrual bleeding. All of these have insufficient reliable evidence to rate at this time.

The evidence, ingredient by ingredient Tree Turmeric

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Berberis aristata extract is generally used in traditional medicine, but human safety data are limited and a thorough evaluation of safety outcomes has not been completed. No adverse effects have been reported with tree turmeric alone, though nausea has been reported in a specific commercial product containing tree turmeric mixed with milk thistle.

The safety data advises against use in pregnancy and while breastfeeding — berberine can harm a fetus and may pass to infants.

Side effects, ingredient by ingredient Tree Turmeric

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tree Turmeric.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,161 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications against these types: transplant rejection drugs (tacrolimus, cyclosporine) — Major severity — and blood thinners (anticoagulants, antiplatelet drugs), sedatives or CNS depressants, blood pressure medications, and any drugs broken down by liver enzymes CYP3A4, CYP2D6, or CYP2C9 — all Moderate severity. Use the medication checker on this page with your exact drug names and doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

If you take tacrolimus, cyclosporine, blood thinners, sedatives, blood pressure medications, or any drug metabolized by common liver enzymes, you need to check your exact medications before trying this product. Because it contains only traditional-medicine uses with no established effectiveness, most people have better options.

Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or take any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Berberis Arstata Extract Paste, Organic, straight from the product label.

Brand Omica Organics
Net contents 100 Gram(s); 3.5 Ounce(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 238730
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Berberis Arstata Extract Paste, Organic by Omica Organics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.25 Gram(s)
Maximum serving Sizes:
1.25 Gram(s)
Servings per container
80
IngredientAmount% DV
Berberis aristata extract paste1.25 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

10-Fold, water extracted & water soluble

Gently water-extracted, using no petroleum solvents

100% pure, no additives or fillers or other ingredients Vegetarian/Vegan, gluten-free, non-GMO, non-irradiated

Vegetarian/Vegan, gluten-free, non-GMO, non-irradiated

Product of India; Processed in a state-of-the-art Food GMP-Compliant, ISO9001: 2008-Certified, HACCP-Certified, and NOP Organic-Certified facility. Tested in independent 3rd-Party US labs.

Certified Organic by: California Certified Organic Farmers

Seals/Symbols

USDA Organic CCOF California Certified Organic Farmers Star-K (Kosher)

Formula

Berberis Aristata is known world-wide since ancient times for having benefits similar to turmeric. This potent herb has been found in Egyptian, traditional Chinese, and Ayurvedic preparations as well as American Indian herbal tonics. This less processed extract is the same base that can be spray dried to create our Berberis Aristata Extract Powders.

Certified USDA NOP Organic and Star-K Kosher

Suggested/Recommended/Usage/Directions

Directions: Mix 1/4 teaspoon (1.25 grams) into water, milk, tea, or a smoothie. For best results consult your physician.

Precautions

Keep out of reach of children.

Storage

Store in sealed container in a dry, cool area.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Berberis Arstata Extract Paste, Organic by Omica Organics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Berberis Arstata Extract Paste, Organic by Omica Organics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.25 Gram(s) Dosage formPowder Servings per container80 Amounts shown are per serving.

Berberis aristata extract paste

Interacts with
1,160 drugs
1.25 Gram(s) per serving

Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research...

Berberis aristata extract paste monograph & interactions
Interaction report

Berberis Arstata Extract Paste, Organic by Omica Organics Drug Interactions

Want to check YOUR meds against Berberis Arstata Extract Paste, Organic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,160Drugs
2 Major 1,158 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Berberis Arstata Extract Paste, Organic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Berberis aristata extract paste12 drug types · 1,160 drugs

Cyclosporine (Neoral, Sandimmune)

Berberine, a constituent of tree turmeric, can reduce metabolism of cyclosporine and increase serum levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Likely Evidence A
Tacrolimus (Prograf)

Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes tacrolimus. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with prednisone 40 mg/m2 and tacrolimus 6.5 mg twice daily, concomitant use of berberine, a constituent of tree turmeric, 200 mg three times daily increased plasma levels of tacrolimus from 8 to 22 ng/mL and increased serum creatinine levels from 0.7 to 1.2 mg/dL. Following a reduction of tacrolimus dosing to 3 mg daily, the blood concentration of tacrolimus decreased to 12 ng/mL and the serum concentration of creatinine decreased to 0.9 mg/dL.

Likelihood Likely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
In vitro and animal research suggest that berberine, a constituent of tree turmeric, can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Clinical research shows that taking a product containing tree turmeric and milk thistle extracts can lower blood glucose levels, glycated hemoglobin (HbA1c), and insulin resistance in patients with type 2 diabetes, including those on antidiabetic agents. Additionally, clinical research suggests that berberine, a constituent of tree turmeric, can lower blood glucose levels.

Likelihood Probable Evidence A
Antihypertensive Drugs

Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that berberine, a constituent of tree turmeric, can have hypotensive effects. Also, a meta-analysis of clinical research suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Animal research suggests that berberine, a constituent of tree turmeric, can have sedative effects.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, can inhibit CYP2D6.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, moderately inhibits CYP3A4.

Likelihood Probable Evidence A
Dextromethorphan (Robitussin Dm, Others)

Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Preliminary clinical research suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan.

Likelihood Possible Evidence B
Midazolam (Versed)

Theoretically, tree turmeric might increase levels of midazolam and potentially increase the risk of adverse effects including sedation and respiratory depression.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, tree turmeric might increase the sedative effects of pentobarbital.
Animal research suggests that berberine, a constituent of tree turmeric, can prolong pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Berberis Arstata Extract Paste, Organic, from the product label.

Omica Organics

See all Omica Organics products
Name
OMICA ORGANICS
City
Quitman
State
Texas
ZipCode
75783
Phone Number
800-613-6311
Web Address
www.OmicaOrganics.com
Pharmacist Counseling Corner

Berberis Arstata Extract Paste, Organic by Omica Organics: Common Questions

Does Berberis Arstata Extract Paste, Organic by Omica Organics interact with any medications?
Yes. Based on its ingredients, Berberis Arstata Extract Paste, Organic has a known interaction with 1,160 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Berberis Arstata Extract Paste, Organic contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advise against use in pregnancy because berberine may harm a fetus, and while breastfeeding because it can pass to infants and may be harmful. Talk to your doctor if you're trying to conceive or are nursing.
Does this actually work for diabetes or high cholesterol?
We don't have reliable evidence that berberis aristata extract works for either of those — or for burns, wound healing, or heavy periods. The evidence is insufficient to rate it for any of these uses.
What side effects does this supplement cause?
No adverse effects have been reported with tree turmeric alone, though a thorough safety evaluation hasn't been done. One commercial product mixing tree turmeric with milk thistle reported nausea in some users.
Why does this interact with so many medications?
Berberine in this extract blocks three of your liver's main enzyme systems that break down hundreds of different drugs. That's why it can raise the blood levels of many medications and potentially cause problems — especially with transplant drugs and blood thinners.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Berberis Arstata Extract Paste, Organic is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Berberis Arstata Extract Paste, Organic label
Go deeper

The Full Monographs Behind Berberis Arstata Extract Paste, Organic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Berberis Arstata Extract Paste, Organic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tree Turmeric 25 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
  3. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  4. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
  5. Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  7. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
  8. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  9. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  10. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
  11. Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
  12. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
  13. Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29.
  14. Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
  15. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
  16. Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
  17. Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
  18. Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
  19. Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
  20. Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
  21. Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
  22. Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Phyto PubMed
  23. Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:8 PubMed
  24. Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. PubMed
  25. Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clin Nutr. 2016;35(5):1091-5. PubMed

See these in context on the Tree Turmeric monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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