Berberis Arstata Extract Paste, Organic Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Berberis Arstata Extract Paste, Organic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Berberis Arstata Extract Paste, Organic is a dietary supplement by Omica Organics with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, digestive complaints.Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Berberis aristata extract paste. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Berberis Arstata Extract Paste, Organic by Omica Organics
Ask about any prescription or over-the-counter medication and we check it for interactions with Berberis Arstata Extract Paste, Organic by Omica Organics — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Berberis Arstata Extract Paste, Organic by Omica Organics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product is a single-ingredient extract: berberis aristata (also called tree turmeric), presented as a paste in powder form. Berberine is the active compound in this plant extract that accounts for the interactions and effects noted here.
There are no other active ingredients, and the product contains no inactive fillers or additional ingredients.
Does it work?
Not established
The evidence we hold does not establish that berberis aristata extract works for any of the conditions it's been used for traditionally — burns, diabetes, high cholesterol, wound healing, or heavy menstrual bleeding. All of these have insufficient reliable evidence to rate at this time.
How safe is it?
Well-documented data
Berberis aristata extract is generally used in traditional medicine, but human safety data are limited and a thorough evaluation of safety outcomes has not been completed. No adverse effects have been reported with tree turmeric alone, though nausea has been reported in a specific commercial product containing tree turmeric mixed with milk thistle.
The safety data advises against use in pregnancy and while breastfeeding — berberine can harm a fetus and may pass to infants.
Meds to double-check
Major interaction found
Before taking this product, check your medications against these types: transplant rejection drugs (tacrolimus, cyclosporine) — Major severity — and blood thinners (anticoagulants, antiplatelet drugs), sedatives or CNS depressants, blood pressure medications, and any drugs broken down by liver enzymes CYP3A4, CYP2D6, or CYP2C9 — all Moderate severity. Use the medication checker on this page with your exact drug names and doses.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
If you take tacrolimus, cyclosporine, blood thinners, sedatives, blood pressure medications, or any drug metabolized by common liver enzymes, you need to check your exact medications before trying this product. Because it contains only traditional-medicine uses with no established effectiveness, most people have better options.
Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or take any prescription medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Berberis Arstata Extract Paste, Organic, straight from the product label.
| Brand | Omica Organics |
|---|---|
| Net contents | 100 Gram(s); 3.5 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 238730 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Berberis Arstata Extract Paste, Organic by Omica Organics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Berberis aristata extract paste | 1.25 Gram(s) | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
10-Fold, water extracted & water soluble
Gently water-extracted, using no petroleum solvents
100% pure, no additives or fillers or other ingredients Vegetarian/Vegan, gluten-free, non-GMO, non-irradiated
Vegetarian/Vegan, gluten-free, non-GMO, non-irradiated
Product of India; Processed in a state-of-the-art Food GMP-Compliant, ISO9001: 2008-Certified, HACCP-Certified, and NOP Organic-Certified facility. Tested in independent 3rd-Party US labs.
Certified Organic by: California Certified Organic Farmers
Seals/Symbols
USDA Organic CCOF California Certified Organic Farmers Star-K (Kosher)
Formula
Berberis Aristata is known world-wide since ancient times for having benefits similar to turmeric. This potent herb has been found in Egyptian, traditional Chinese, and Ayurvedic preparations as well as American Indian herbal tonics. This less processed extract is the same base that can be spray dried to create our Berberis Aristata Extract Powders.
Certified USDA NOP Organic and Star-K Kosher
Suggested/Recommended/Usage/Directions
Directions: Mix 1/4 teaspoon (1.25 grams) into water, milk, tea, or a smoothie. For best results consult your physician.
Precautions
Keep out of reach of children.
Storage
Store in sealed container in a dry, cool area.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Berberis Arstata Extract Paste, Organic by Omica Organics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Berberis Arstata Extract Paste, Organic by Omica Organics
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1.25 Gram(s) Dosage formPowder Servings per container80 Amounts shown are per serving.
Berberis aristata extract paste
Interacts with1,160 drugs
Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research...
Berberis aristata extract paste monograph & interactionsBerberis Arstata Extract Paste, Organic by Omica Organics Drug Interactions
HelloPharmacist Interaction Report
Berberis Aristata Extract Paste by Omica Organics contains berberine, a compound that interacts with several medication types — some seriously.
The most critical concern is with transplant rejection drugs: tacrolimus (Prograf) and cyclosporine (Neoral, Sandimmune). Berberine can slow how your body breaks down these medications, raising their levels in your blood to potentially unsafe amounts.
If you take either of these, do not start this product without talking to your transplant team first.
Read the full breakdown — every affected drug type, severity by severity
Beyond transplant drugs, berberine also affects how your liver metabolizes a broad range of other medications. It can inhibit three major liver enzyme systems (CYP3A4, CYP2D6, and CYP2C9), which may increase blood levels of drugs broken down by those pathways.
Additionally, berberine may add to the effects of blood thinners (anticoagulants and antiplatelet drugs) — raising bleeding risk — and could amplify the drowsiness from sedatives or the blood-pressure-lowering effects of high blood pressure medications.
Altogether, these interactions span 1,148 individual medications. Because the list is long and touches many common drug types, you'll need to check your exact medications using the search tool below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Berberis Arstata Extract Paste, Organic?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Berberis Arstata Extract Paste, Organic interact with 1,160 drugs. Click any drug to see the details.
1 of the 1 ingredient in Berberis Arstata Extract Paste, Organic interact with drugs. Each result below shows which ingredient is responsible. Berberis aristata extract paste
CyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates, Cyclosporine (neoral, Sandimmune) Major
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Cyclosporine interactionTacrolimusAstagraf XL, Envarsus XR, Prograf (capsule), Prograf (injectable), Prograf XL, Protopic
How Tacrolimus interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteTacrolimus (prograf), Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Read the full Berberis Aristata Extract Paste + Tacrolimus interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata Extract Paste + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata Extract Paste + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Read the full Berberis Aristata Extract Paste + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Berberis Aristata Extract Paste + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata Extract Paste + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCns Depressants Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Berberis Aristata Extract Paste + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Berberis Arstata Extract Paste, Organic — through 1 ingredient. Tap an ingredient for the detail:
Berberis Aristata Extract PasteDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Read the full Berberis Aristata Extract Paste + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Berberis Arstata Extract Paste, Organic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Berberis aristata extract paste
Cyclosporine (Neoral, Sandimmune)
Berberine, a constituent of tree turmeric, can reduce metabolism of cyclosporine and increase serum levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.
Tacrolimus (Prograf)
Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes tacrolimus. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with prednisone 40 mg/m2 and tacrolimus 6.5 mg twice daily, concomitant use of berberine, a constituent of tree turmeric, 200 mg three times daily increased plasma levels of tacrolimus from 8 to 22 ng/mL and increased serum creatinine levels from 0.7 to 1.2 mg/dL. Following a reduction of tacrolimus dosing to 3 mg daily, the blood concentration of tacrolimus decreased to 12 ng/mL and the serum concentration of creatinine decreased to 0.9 mg/dL.
Anticoagulant/Antiplatelet Drugs
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
In vitro and animal research suggest that berberine, a constituent of tree turmeric, can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Clinical research shows that taking a product containing tree turmeric and milk thistle extracts can lower blood glucose levels, glycated hemoglobin (HbA1c), and insulin resistance in patients with type 2 diabetes, including those on antidiabetic agents. Additionally, clinical research suggests that berberine, a constituent of tree turmeric, can lower blood glucose levels.
Antihypertensive Drugs
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that berberine, a constituent of tree turmeric, can have hypotensive effects. Also, a meta-analysis of clinical research suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.
Cns Depressants
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Animal research suggests that berberine, a constituent of tree turmeric, can have sedative effects.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, can inhibit CYP2D6.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, moderately inhibits CYP3A4.
Dextromethorphan (Robitussin Dm, Others)
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Preliminary clinical research suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan.
Midazolam (Versed)
Theoretically, tree turmeric might increase levels of midazolam and potentially increase the risk of adverse effects including sedation and respiratory depression.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam.
Pentobarbital (Nembutal)
Theoretically, tree turmeric might increase the sedative effects of pentobarbital.
Animal research suggests that berberine, a constituent of tree turmeric, can prolong pentobarbital-induced sleeping time.
Brand information
Manufacturer and brand details for Berberis Arstata Extract Paste, Organic, from the product label.
Omica Organics
See all Omica Organics products- Name
- OMICA ORGANICS
- City
- Quitman
- State
- Texas
- ZipCode
- 75783
- Phone Number
- 800-613-6311
- Web Address
- www.OmicaOrganics.com
Berberis Arstata Extract Paste, Organic by Omica Organics: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Berberis Arstata Extract Paste, Organic’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Berberis Arstata Extract Paste, Organic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tree Turmeric 25 references
- Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
- Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
- Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29.
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
- Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Phyto PubMed
- Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:8 PubMed
- Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. PubMed
- Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clin Nutr. 2016;35(5):1091-5. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC