Daruhaldi Powder Ingredients & Drug Interactions
by Herbal Hills
What is this page for?
First and foremost: checking Daruhaldi Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Daruhaldi Powder is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, digestive complaints.Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Daruhaldi powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Daruhaldi Powder by Herbal Hills
Ask about any prescription or over-the-counter medication and we check it for interactions with Daruhaldi Powder by Herbal Hills — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Daruhaldi Powder by Herbal Hills
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Daruhaldi Powder is a single-ingredient product: Daruhaldi powder, also known as tree turmeric. The powder contains berberine, a natural alkaloid compound with a long history in traditional medicine.
There are no other active ingredients and no inactive fillers listed.
Does it work?
Not established
The evidence for Daruhaldi's effectiveness isn't established in the data we hold. For the conditions it's traditionally used for — burns, diabetes, high cholesterol, wound healing, and heavy menstrual bleeding — we have insufficient reliable evidence to rate how well it works.
That doesn't mean it's ineffective; it means human clinical trials are limited or absent.
How safe is it?
Well-documented data
Daruhaldi has limited human safety data in modern medical literature. When used orally or topically alone, no adverse effects have been formally reported, but a thorough safety evaluation hasn't been done.
The most common side effects reported with a specific combination product (containing tree turmeric and milk thistle) were gastrointestinal symptoms, especially nausea. Berberine is not safe in pregnancy — it may harm a developing fetus.
It also passes into breast milk and may be harmful to infants, so avoid it while breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before using this product.
Meds to double-check
Major interaction found
Before taking Daruhaldi, double-check with your pharmacist if you use tacrolimus or cyclosporine (immunosuppressants for transplants) — these are Major interactions requiring dose review. Also flag any blood thinners (anticoagulants or antiplatelets), blood pressure medicines, sedatives, or any other drugs metabolized by your liver, as berberine can raise their blood levels and effects.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
Daruhaldi may appeal to those interested in traditional herbal remedies, but its modern effectiveness isn't established. The main concern is how strongly it interacts with medications — especially transplant drugs and blood thinners.
If you take any prescription medication, check it with your pharmacist before starting. It's not safe in pregnancy or while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Daruhaldi Powder, straight from the product label.
| Brand | Herbal Hills |
|---|---|
| Barcode (UPC) | 8906068412354 |
| Net contents | 1 kg |
| Market status | On market |
| Date entered into DSLD | Sep 24, 2019 |
| DSLD ID | 203363 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Daruhaldi Powder by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Daruhaldi powder | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Daruhaldi is considered as one of the best traditional herb which may help correct metabolism, improve the liver function and nourish the skin. It may also support healthy Urinary tract functions. It may help maintain electrolyte balance. It may support healthy Liver functions, thus may help to maintain healthy lipid levels. May support healthy metabolism. May support healthy Urinary tract function.
Halal India www.Halalindia.com S No. 001548
Suggested/Recommended/Usage/Directions
Dosage: Take 2-3 gms powder, 1 to 2 times a day or as advised by the physician.
Precautions
Caution: Pregnant or lactating women are advised to consume herbal products under the advice of the physician.
Keep out of reach of children.
Do not use if pouch is broken.
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Storage
Store in a cool dry place away from direct sunlight.
FDA Statement of Identity
Ayurvedic Product
General Statements
Mfg. Lic. No.: PD/AYU/002/10 (An ISO 22000:2005 Certified Company) Customer Care : 91 22 28686868 (10 a.m to 6 p.m on weekdays)
Seals/Symbols
ISO Certified Company 22000:2005 Halal India www.Halalindia.com S No. 001548 GMP Good Manufacturing Practice
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Daruhaldi Powder by Herbal Hills label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Daruhaldi Powder by Herbal Hills
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Not Present Dosage formPowder Amounts shown are per serving.
Daruhaldi powder
Interacts with1,160 drugs
Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content. Early research...
Daruhaldi powder monograph & interactionsDaruhaldi Powder by Herbal Hills Drug Interactions
HelloPharmacist Interaction Report
Daruhaldi Powder by Herbal Hills contains berberine, a compound that interacts with several important medications.
The most serious concerns are two immunosuppressant drugs: tacrolimus (Prograf) and cyclosporine (Neoral, Sandimmune). Berberine can slow how your body breaks down these drugs, causing levels to build up in your blood — a Major interaction that needs close monitoring or a dose adjustment from your doctor.
Read the full breakdown — every affected drug type, severity by severity
Beyond immunosuppressants, berberine affects how your liver metabolizes a broad range of other medications. It moderately inhibits three major enzyme systems (CYP3A4, CYP2D6, and CYP2C9), which means it can raise blood levels and effects of drugs processed through those pathways.
Additionally, it may boost the effects of blood thinners and antiplatelet drugs (raising bleeding risk), CNS depressants like sedatives (causing extra drowsiness), and blood pressure medicines (risking low blood pressure).
Altogether, these interactions span 1,148 individual medications. Before you start this product, run your exact prescriptions through the checker below — especially if you take a transplant medication, blood thinner, blood pressure drug, or sedative.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Daruhaldi Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Daruhaldi Powder interact with 1,160 drugs. Click any drug to see the details.
1 of the 1 ingredient in Daruhaldi Powder interact with drugs. Each result below shows which ingredient is responsible. Daruhaldi powder
CyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cyclosporine (neoral, Sandimmune) Major
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Cyclosporine interactionTacrolimusAstagraf XL, Envarsus XR, Prograf (capsule), Prograf (injectable), Prograf XL, Protopic
How Tacrolimus interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderTacrolimus (prograf), Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Read the full Daruhaldi Powder + Tacrolimus interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Daruhaldi Powder + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Daruhaldi Powder + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Read the full Daruhaldi Powder + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Daruhaldi Powder + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Daruhaldi Powder + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCns Depressants Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Daruhaldi Powder + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Daruhaldi Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
Read the full Daruhaldi Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Daruhaldi Powder + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Daruhaldi Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Daruhaldi Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Daruhaldi Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Read the full Daruhaldi Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Read the full Daruhaldi Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Daruhaldi Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Daruhaldi Powder — through 1 ingredient. Tap an ingredient for the detail:
Daruhaldi PowderDextromethorphan (robitussin Dm, Others), Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Read the full Daruhaldi Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Daruhaldi Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Daruhaldi powder
Cyclosporine (Neoral, Sandimmune)
Berberine, a constituent of tree turmeric, can reduce metabolism of cyclosporine and increase serum levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.
Tacrolimus (Prograf)
Berberine, a constituent of tree turmeric, can inhibit metabolism of tacrolimus and increase plasma levels.
Some clinical evidence suggests that berberine inhibits cytochrome P450 3A4 (CYP3A4), which metabolizes tacrolimus. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with prednisone 40 mg/m2 and tacrolimus 6.5 mg twice daily, concomitant use of berberine, a constituent of tree turmeric, 200 mg three times daily increased plasma levels of tacrolimus from 8 to 22 ng/mL and increased serum creatinine levels from 0.7 to 1.2 mg/dL. Following a reduction of tacrolimus dosing to 3 mg daily, the blood concentration of tacrolimus decreased to 12 ng/mL and the serum concentration of creatinine decreased to 0.9 mg/dL.
Anticoagulant/Antiplatelet Drugs
Theoretically, tree turmeric might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.
In vitro and animal research suggest that berberine, a constituent of tree turmeric, can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking antidiabetes drugs.
Clinical research shows that taking a product containing tree turmeric and milk thistle extracts can lower blood glucose levels, glycated hemoglobin (HbA1c), and insulin resistance in patients with type 2 diabetes, including those on antidiabetic agents. Additionally, clinical research suggests that berberine, a constituent of tree turmeric, can lower blood glucose levels.
Antihypertensive Drugs
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that berberine, a constituent of tree turmeric, can have hypotensive effects. Also, a meta-analysis of clinical research suggests that taking berberine in combination with amlodipine (Norvasc) can lower systolic and diastolic blood pressure when compared with taking amlodipine alone.
Cns Depressants
Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.
Animal research suggests that berberine, a constituent of tree turmeric, can have sedative effects.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2C9.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit CYP2C9.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, can inhibit CYP2D6.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
In vitro research and preliminary clinical evidence suggest that berberine, a constituent of tree turmeric, moderately inhibits CYP3A4.
Dextromethorphan (Robitussin Dm, Others)
Theoretically, tree turmeric might increase levels of dextromethorphan and potentially increase the risk of adverse effects including drowsiness, confusion, and irritability.
Preliminary clinical research suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan.
Midazolam (Versed)
Theoretically, tree turmeric might increase levels of midazolam and potentially increase the risk of adverse effects including sedation and respiratory depression.
Preliminary clinical evidence suggests that berberine, a constituent of tree turmeric, can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam.
Pentobarbital (Nembutal)
Theoretically, tree turmeric might increase the sedative effects of pentobarbital.
Animal research suggests that berberine, a constituent of tree turmeric, can prolong pentobarbital-induced sleeping time.
Brand information
Manufacturer and brand details for Daruhaldi Powder, from the product label.
Herbal Hills
See all Herbal Hills products- Name
- Isha Agro Developers Pvt. Ltd.
- Street Address
- 36A/55AB, Lonavala Co.op. Indl. Est. Ltd.
- City
- Village - Nangargaon, Lonavala, Pune
- State
- Maharashtra
- Phone Number
- 91 22 28686868
- Web Address
- www.herbalhills.in
Daruhaldi Powder by Herbal Hills: Common Questions
Does Daruhaldi Powder by Herbal Hills interact with any medications?
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What are the side effects of Daruhaldi?
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Why does Daruhaldi interact with so many medications?
Is Daruhaldi safe to take with my other supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Daruhaldi Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Daruhaldi Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tree Turmeric 25 references
- Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
- Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
- Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
- Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
- Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4.
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
- Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
- Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
- Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
- Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
- Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
- Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29.
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
- Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
- Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
- Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
- Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
- Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Phyto PubMed
- Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:8 PubMed
- Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. PubMed
- Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clin Nutr. 2016;35(5):1091-5. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC