Bitter Melon Extract Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bitter Melon Extract Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bitter Melon Extract Powder is a dietary supplement by Materia Organica with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter Melon Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bitter Melon Extract Powder by Materia Organica
Ask about any prescription or over-the-counter medication and we check it for interactions with Bitter Melon Extract Powder by Materia Organica — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bitter Melon Extract Powder by Materia Organica
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: bitter melon extract in powder form. Bitter melon is a tropical fruit traditionally used in herbal medicine, and the extract concentrates its bioactive compounds.
There are no inactive fillers or other ingredients listed.
Does it work?
Not established
The evidence for bitter melon isn't established in the data we hold. Our records show insufficient reliable evidence to rate it for amenorrhea, athletic performance, liver disease, constipation, diabetes, or dyspepsia — the conditions it's most often used for.
That doesn't mean it doesn't work; it means the research so far hasn't been strong enough to draw firm conclusions.
How safe is it?
Well-documented data
Bitter melon is generally well tolerated when eaten as food, but supplement doses may lower blood sugar and cause stomach upset. The most common side effects reported in clinical studies are gastrointestinal — heartburn, nausea, vomiting, diarrhea, constipation, and abdominal discomfort — occurring in roughly 3% to 16% of people.
Rarely, very low blood sugar (hypoglycemia) and seizures in children have been reported. One case also documented kidney damage (acute interstitial nephritis) after long-term high-dose use.
Traditionally, bitter melon is avoided in pregnancy because the seeds and high doses may cause harm to the uterus or fetus. There isn't enough reliable safety data to know whether it's safe while breastfeeding, so it's best avoided unless you've talked it over with your doctor or pharmacist.
Meds to double-check
Moderate interaction found
Before taking this product, check whether you take any antidiabetes drugs (insulin, metformin, glyburide, or similar), any P-glycoprotein substrate medications (a very large group — ask your pharmacist to confirm), or pazopanib (Votrient). Moderate interactions are documented for all three categories.
Use the medication search tool on this page to confirm your exact medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Bitter melon extract may be worth considering if you're interested in traditional use, but only if you don't take antidiabetes medications, P-glycoprotein substrates, or pazopanib — and even then, watch for stomach upset and dizziness. If you're pregnant or breastfeeding, skip it.
Talk to your pharmacist before you start, especially if you take any prescription drugs.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bitter Melon Extract Powder, straight from the product label.
| Brand | Materia Organica |
|---|---|
| Barcode (UPC) | BM40001-100g |
| Net contents | 3.5 Ounce(s); 100 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 336966 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bitter Melon Extract Powder by Materia Organica, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bitter Melon Extract, Powder | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Star-K (Kosher)
Formula
Star-K (Kosher)
Our water extraction and low-heat vacuum drying (wind dried, not spray dried) process preserves the natural nutrients & beneficial qualities of Bitter Melon with improved potency and bioavailability. 100% Bitter Melon Extract Also known as Karela or Momordica charantia
Certified Star-K Kosher
Also known as Karela or Momordica Charantia
Certified Star-K Kosher
General Statements
Materia Organica primarily sells bulk ingredients to manufacturers and brand owners.
Formulation
Water-extracted & water-soluble Better bioavailability and potency Vegetarian/Vegan, non-GMO, non-irradiated
No additives, fillers, or other ingredients No petroleum solvents in the extraction No pesticides used growing the Bitter Melon Vegetarian/Vegan, non-GMO, non-irradiated
No other ingredients added
Product of India 3rd party lab tested in USA
Suggested/Recommended/Usage/Directions
Suggested use: Mix 500 mg into water, milk, tea, or a smoothie.
Precautions
For best results consult your physician.
Not recommended for children.
Storage
Store in sealed container in a dry, cool area.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bitter Melon Extract Powder by Materia Organica label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bitter Melon Extract Powder by Materia Organica
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container200 Amounts shown are per serving.
Bitter Melon Extract, Powder
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Bitter Melon Extract, Powder monograph & interactionsBitter Melon Extract Powder by Materia Organica Drug Interactions
HelloPharmacist Interaction Report
Bitter Melon Extract Powder by Materia Organica does interact with medications, and the interactions we've documented span some important drug categories.
The most serious concern is with P-glycoprotein substrates (a large group of medications whose absorption your gut controls) — bitter melon may increase their blood levels, potentially making them stronger or riskier. A compound in bitter melon called 1-momopalmitin appears to block the intestinal pump that normally limits how much of these drugs you absorb.
Read the full breakdown — every affected drug type, severity by severity
The second major interaction is with antidiabetes drugs. Bitter melon itself can lower your blood sugar, so taking it with diabetes medications might push your glucose too low and cause hypoglycemia (dangerously low blood sugar).
If you're on any diabetes medication, your blood sugar will need close monitoring.
Bitter melon also carries a documented moderate interaction with pazopanib (Votrient), a cancer drug — theoretically, it could raise pazopanib levels and increase side effects, and one case report described acute pancreatitis shortly after a patient drank bitter melon juice while taking the medication.
Altogether, these interactions span 275 individual medications. Use the medication checker on this page to search your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bitter Melon Extract Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bitter Melon Extract Powder interact with 282 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bitter Melon Extract Powder interact with drugs. Each result below shows which ingredient is responsible. Bitter Melon Extract, Powder
AcalabrutinibCalquence
How Acalabrutinib interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract, Powder + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract, Powder + Acetohexamide interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Afatinib Dimaleate interactionAlbiglutideTanzeum
How Albiglutide interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract, Powder + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract, Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract, Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract, Powder + Alogliptin, Pioglitazone interactionAlvimopanEntereg
How Alvimopan interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Ambrisentan interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Amphotericin, Tetracycline interactionAmprenavirAgenerase
How Amprenavir interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApixabanEliquis
How Apixaban interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Apixaban interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Apomorphine Hydrochloride interactionArmodafinilNuvigil
How Armodafinil interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Armodafinil interactionAtogepantQulipta
How Atogepant interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Atogepant interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Atropine, Morphine Sulfate interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Avatrombopag Maleate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Beclomethasone Dipropionate interactionBelinostatBeleodaq
How Belinostat interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Belinostat interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Bitter Melon Extract Powder — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Extract, PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract, Powder + Betamethasone Valerate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bitter Melon Extract Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bitter Melon Extract, Powder
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Bitter Melon Extract Powder, from the product label.
Materia Organica
See all Materia Organica products- Name
- Materia Organica
- City
- Quitman
- State
- TX
- ZipCode
- 75783
- Phone Number
- 800-613-6311
- Web Address
- www.MateriaOrganica.com
Bitter Melon Extract Powder by Materia Organica: Common Questions
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How can one product interact with so many drugs?
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What are the most common side effects?
Does this really work for diabetes?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bitter Melon Extract Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bitter Melon Extract Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bitter Melon Extract Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC